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  • Oxford University Press (OUP)  (2)
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  • Oxford University Press (OUP)  (2)
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  • 1
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2020
    In:  Geophysical Journal International Vol. 222, No. 2 ( 2020-08-01), p. 1213-1223
    In: Geophysical Journal International, Oxford University Press (OUP), Vol. 222, No. 2 ( 2020-08-01), p. 1213-1223
    Abstract: The loess from the northern piedmont of the Dabie Mountains is in a transition area between loess from the Chinese Loess Plateau, the Quaternary red soils of southern China and the Xiashu loess. Despite its significant location, the study has been inadequate. In this study, the Guangshan section in the northern piedmont of the Dabie Mountains was selected for investigation. Environmental magnetism, geochemistry, colour reflectance and optical diffuse reflection spectroscopy analyses were applied to detect the magnetic variations in the loess. The results showed that (1) the magnetic minerals consisted mainly of magnetite, maghemite, hematite and goethite, which are the same as those in the Quaternary loess from the Chinese Loess Plateau, the Xiashu loess and the Quaternary red soils of southern China. The average magnetic particles were in the pseudo-single domain, like those of the Chinese Loess Plateau loess. (2) Unit III of the Guangshan section (2.4–4 m), with high chemical index of alteration and low Ba-index, was demonstrated as the most strongly developed palaeosol in the whole section, in agreement with field observations (more Fe-Mn films and weakly vermiculated development). However, it exhibited minimal susceptibility values and the lowest concentration of fine ferrimagnetic minerals. Simultaneously, the unit had low hematite to goethite ratio (Hm/Gt), suggesting that the pedogenic environment was humid; and it also had high values of b* and Gt%, implying that there was more goethite. Therefore, we can conclude that excessive soil moisture and intensive pedogenesis dissolved the fine ferrimagnetic minerals originally produced by pedogenesis and transformed them into goethite. These results could help to trace the palaeoclimatic evolution of the study area and clarify the magnetic variations of loess in different climates throughout China.
    Type of Medium: Online Resource
    ISSN: 0956-540X , 1365-246X
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
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    SSG: 16,13
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  • 2
    In: Rheumatology, Oxford University Press (OUP), ( 2024-04-23)
    Abstract: Patients with SLE display heightened immune activation and elevated IgG autoantibody levels, indicating compromised regulatory T cell (Tregs) function. Our recent findings pinpoint CD8+ Tregs as crucial regulators within secondary lymphoid organs, operating in a NOX2-dependent mechanism. However, the specific involvement of CD8+ Tregs in SLE pathogenesis and the mechanisms underlying their role remain uncertain. Methods SLE and healthy individuals were enlisted to assess the quantity and efficacy of Tregs. CD8+CD45RA+CCR7+ Tregs were generated ex vivo, and their suppressive capability was gauged by measuring pZAP70 levels in targeted T cells. Notch1 activity was evaluated by examining activated Notch1 and HES1, with manipulation of Notch1 accomplished with Notch inhibitor DAPT, Notch1 shRNA, and Notch1-ICD. To create humanized SLE chimaeras, immune-deficient NSG mice were engrafted with PBMCs from SLE patients. Results We observed a reduced frequency and impaired functionality of CD8+ Tregs in SLE patients. There was a downregulation of NOX2 in CD8+ Tregs from SLE patients, leading to a dysfunction. Mechanistically, the reduction of NOX2 in SLE CD8+ Tregs occurred at a post-translational level rather than at the transcriptional level. SLE CD8+ Tregs exhibited heightened Notch1 activity, resulting in increased expression of STUB1, an E3 ubiquitin ligase that binds to NOX2 and facilitates its ubiquitination. Consequently, restoring NOX2 levels and inhibiting Notch1 activity could alleviate the severity of the disease in humanized SLE chimaeras. Conclusion Notch1 is the cell-intrinsic mechanism underlying NOX2 deficiency and CD8+ Treg dysfunction, serving as a therapeutic target for the clinical management of SLE.
    Type of Medium: Online Resource
    ISSN: 1462-0324 , 1462-0332
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2024
    detail.hit.zdb_id: 1474143-X
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