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  • Oxford University Press (OUP)  (29)
  • 1
    Online Resource
    Online Resource
    Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia
    Oxford University Press (OUP) ; 2016
    In:  Protein & Cell Vol. 7, No. 6 ( 2016-6), p. 417-433
    Details
    In: Protein & Cell, Oxford University Press (OUP), Vol. 7, No. 6 ( 2016-6), p. 417-433
    Type of Medium: Online Resource
    ISSN: 1674-800X , 1674-8018
    URL: Article
    DOI: 10.1007/s13238-016-0269-2
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2016
    detail.hit.zdb_id: 2537093-5
    detail.hit.zdb_id: 2543451-2
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  • 2
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    The comprehensive impact on human body induced by resolution of growth hormone excess
    Oxford University Press (OUP) ; 2018
    In:  European Journal of Endocrinology Vol. 178, No. 4 ( 2018-04), p. 365-375
    Details
    In: European Journal of Endocrinology, Oxford University Press (OUP), Vol. 178, No. 4 ( 2018-04), p. 365-375
    Abstract: Chronic excess of growth hormone (GH) often leads to systemic complications. The reversibility of these complications after GH resolution is not fully understood. Objective To investigate when and to what extent will the comorbidities be ameliorated. Design We conducted a prospective study comprising 24 patients with acromegaly, who achieved remission after transsphenoidal surgery. The dynamic changes of endocrine, cardiovascular, respiratory, sleep, bone and morphology parameters were evaluated at enrollment and 1 week, 1 month, 3 months, 6 months and 12 months after surgery. Results Random GH dropped by 98.4% at the first day postoperatively. IGF-I index dropped by 50% and 64% at 1 week and 1 month respectively and remained unchanged onwards. Glucose metabolism improved significantly at 1 week and stabilized at 1 month. Testosterone in male patients recovered to normal range since 1 month. Systolic blood pressures dropped markedly at 3 months while diastolic blood pressures fell mildly at later visits. Abnormal lung function showed no improvement. The decrease of bone formation and resorption markers occurred at 1 week and 3 months, respectively. At 1 month, the tongue area declined while the airway volume increased significantly, accompanied with improved obstructive sleep apnea syndrome. Extremities, lips and nasal ala became smaller since 1 week. Liver, kidney and spleen volumes declined by 6.4, 15.9, 9.2%, respectively at 1 month. The volumes of pancreas and adrenal showed no change. Conclusions The rapid resolution of excessive GH led to the reversible changes of systemic comorbidities in a time-dependent and organ-specific manner.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/EJE-17-0872
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 2018
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    detail.hit.zdb_id: 1485160-X
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  • 3
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    Orbital parameters for an ELM white dwarf with a white dwarf companion: LAMOST J033847.06+413424.2
    Oxford University Press (OUP) ; 2023
    In:  Monthly Notices of the Royal Astronomical Society Vol. 526, No. 4 ( 2023-10-20), p. 5471-5482
    Details
    In: Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP), Vol. 526, No. 4 ( 2023-10-20), p. 5471-5482
    Abstract: Double white dwarf systems are of great astrophysical importance in the field of gravitational wave and Type Ia supernova. While the binary fraction of CO core white dwarf is about a few per cents, the extremely low mass white dwarfs are all thought to be within binary systems. In this work, we report the orbital solution of a double degenerate system: J033847.06+413424.24, an extremely low mass He core white dwarf orbiting a CO core white dwarf. With LAMOST and P200, time domain spectroscopic observations have been made and spectral atmosphere parameters are estimated to be Teff ∼ 22 500 K and log g ∼ 5.6 dex. Combining Gaia parallax, 3D extinction, and evolution tracks, we estimate a radius of ∼0.12 R⊙ and a mass of ∼0.22 M⊙. With the 37 single exposure spectra, the radial velocities are measured and the orbital parameters are estimated to be P = 0.1253132(1) d, K1 = 289 ± 4 km s−1 and Vsys = −41 ± 3 km s−1. The radial velocity based system ephemeris is also provided. The light curves from several photometric surveys show no orbital modulation. The orbital solution suggests that the invisible companion has a minimum mass of about 0.60 M⊙ and is ∼0.79 M⊙ for an inclination of 60.0°, indicating most probably a CO core white dwarf. The system is expected to merge in about 1 Gyr. With present period and distance (∼596 pc) it cannot irradiate strong enough gravitational wave for LISA. More double degenerate systems are expected to be discovered and parametrized as the LAMOST survey goes on.
    Type of Medium: Online Resource
    ISSN: 0035-8711 , 1365-2966
    URL: Article
    DOI: 10.1093/mnras/stad3100
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
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  • 4
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    BRD4 as a therapeutic target for nonfunctioning and growth hormone pituitary adenoma
    Oxford University Press (OUP) ; 2020
    In:  Neuro-Oncology Vol. 22, No. 8 ( 2020-08-17), p. 1114-1125
    Details
    In: Neuro-Oncology, Oxford University Press (OUP), Vol. 22, No. 8 ( 2020-08-17), p. 1114-1125
    Abstract: Nonfunctioning pituitary adenoma (NFPA) and growth hormone pituitary adenoma (GHPA) are major subtypes of pituitary adenomas (PAs). The primary treatment is surgical resection. However, radical excision remains challenging, and few effective medical therapies are available. It is urgent to find novel targets for the treatment. Bromodomain-containing protein 4 (BRD4) is an epigenetic regulator that leads to aberrant transcriptional activation of oncogenes. Herein, we investigated the pathological role of BRD4 and evaluated the effectiveness of BRD4 inhibitors in the treatment of NFPA and GHPA. Methods The expression of BRD4 was detected in NFPA, GHPA, and normal pituitary tissues. The efficacies of BRD4 inhibitors were evaluated in GH3 and MMQ cell lines, patient-derived tumor cells, and in vivo mouse xenograft models of PA. Standard western blots, real-time PCR, and flow cytometry experiments were performed to investigate the effect of BRD4 inhibitors on cell cycle progression, apoptosis, and the expression patterns of downstream genes. Results Immunohistochemistry studies demonstrated the overexpression of BRD4 in NFPA and GHPA. In vitro and in vivo studies showed that treatment with the BRD4 inhibitor ZBC-260 significantly inhibited the proliferation of PA cells. Further mechanistic studies revealed that ZBC-260 could downregulate the expression of c-Myc, B-cell lymphoma 2 (Bcl2), and related genes, which are vital factors in pituitary tumorigenesis. Conclusion In this study, we determined the overexpression of BRD4 in NFPA and GHPA and assessed the effects of BRD4 inhibitors on PA cells in vitro and in vivo. Our findings suggest that BRD4 is a promising therapeutic target for NFPA and GHPA.
    Type of Medium: Online Resource
    ISSN: 1522-8517 , 1523-5866
    URL: Article
    DOI: 10.1093/neuonc/noaa084
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
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    detail.hit.zdb_id: 2094060-9
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  • 5
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    TIGER: A Web Portal of Tumor Immunotherapy Gene Expression Resource
    Oxford University Press (OUP) ; 2023
    In:  Genomics, Proteomics & Bioinformatics Vol. 21, No. 2 ( 2023-04-01), p. 337-348
    Details
    In: Genomics, Proteomics & Bioinformatics, Oxford University Press (OUP), Vol. 21, No. 2 ( 2023-04-01), p. 337-348
    Abstract: Immunotherapy is a promising cancer treatment method; however, only a few patients benefit from it. The development of new immunotherapy strategies and effective biomarkers of response and resistance is urgently needed. Recently, high-throughput bulk and single-cell gene expression profiling technologies have generated valuable resources. However, these resources are not well organized and systematic analysis is difficult. Here, we present TIGER, a tumor immunotherapy gene expression resource, which contains bulk transcriptome data of 1508 tumor samples with clinical immunotherapy outcomes and 11,057 tumor/normal samples without clinical immunotherapy outcomes, as well as single-cell transcriptome data of 2,116,945 immune cells from 655 samples. TIGER provides many useful modules for analyzing collected and user-provided data. Using the resource in TIGER, we identified a tumor-enriched subset of CD4+ T cells. Patients with melanoma with a higher signature score of this subset have a significantly better response and survival under immunotherapy. We believe that TIGER will be helpful in understanding anti-tumor immunity mechanisms and discovering effective biomarkers. TIGER is freely accessible at http://tiger.canceromics.org/.
    Type of Medium: Online Resource
    ISSN: 1672-0229 , 2210-3244
    URL: Article
    DOI: 10.1016/j.gpb.2022.08.004
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
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    detail.hit.zdb_id: 2240213-5
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  • 6
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    Characterization of the novel plasmid-encoded MBL gene bla AFM-1, integrated into a bla IMP-45-bearing transposon Tn 6485e in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate
    Oxford University Press (OUP) ; 2021
    In:  Journal of Antimicrobial Chemotherapy Vol. 77, No. 1 ( 2021-12-24), p. 83-88
    Details
    In: Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), Vol. 77, No. 1 ( 2021-12-24), p. 83-88
    Abstract: To characterize the novel subclass B1 MBL AFM-1, encoded by a blaIMP-45-bearing megaplasmid from a carbapenem-resistant Pseudomonas aeruginosa (CRPA) clinical isolate. Methods CRPA HS17-127 and its transconjugant were discovered to carry blaAFM-1 in our previous study. blaAFM-1 and blaNDM-1 were cloned and expressed in Escherichia coli TOP10 and P. aeruginosa PAO1, respectively, to test the resistance phenotype. Kinetic studies were performed to elucidate the biochemical characteristics of the AFM-1 enzyme. Comparative genomic analysis was applied to investigate the genetic context of blaAFM-1. Results PAO1 transconjugant TcHS17-127 exhibited carbapenem resistance with an imipenem MIC of 64 mg/L. E. coli transformants with cloned blaAFM-1 or blaNDM-1 had increased MICs of all β-lactams tested (except aztreonam) and imipenem MICs of 4–8 mg/L. Kinetic studies showed that AFM-1 had greater catalytic efficiency against cephalosporins than carbapenems. blaAFM-1 was located on a 486 963 bp IncP-2 plasmid, pHS17-127, containing a 57.3 kb MDR Tn1403-derivative transposon, Tn6485e, which is genetically closest to the blaIMP-45-bearing Tn6485 transposon but has acquired an extra ISCR27n3-blaAFM-1 module. Multicentre surveillance of 605 P. aeruginosa clinical isolates identified three blaAFM carriers from different STs. Two of them co-carried blaAFM-1 and blaIMP-45. A BLAST search against the NCBI database showed six blaAFM carriers on various plasmids and the chromosomes of different Gram-negative species. Conclusions The blaAFM-1 gene confers carbapenem resistance and has been captured in distinct species of non-fermenters. Co-carriage of blaAFM-1 and blaIMP-45 in an MDR transposon on a conjugative plasmid can be expected to promote further dissemination of blaMBLs.
    Type of Medium: Online Resource
    ISSN: 0305-7453 , 1460-2091
    URL: Article
    DOI: 10.1093/jac/dkab342
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
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    SSG: 15,3
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  • 7
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    The Activity of Benzyl and Allyl α-H Sites in p -Cresol-grafted Fluorinated Poly(aryl ether oxadiazole) toward the Bromination Reaction
    Oxford University Press (OUP) ; 2014
    In:  Chemistry Letters Vol. 43, No. 12 ( 2014-12-05), p. 1943-1945
    Details
    In: Chemistry Letters, Oxford University Press (OUP), Vol. 43, No. 12 ( 2014-12-05), p. 1943-1945
    Abstract: The energy barrier for the bromination reaction of the benzyl α-H and allyl α-H sites of p-cresol-grafted fluorinated poly(aryl ether oxadiazole) was obtained using density functional theory calculations. The simulation results indicated that the energy barrier for the bromination reaction at the benzyl α-H site was 80.6 kcal mol−1, while the corresponding value for the allyl α-H site was 88.4 kcal mol−1, indicating that the former site was likely to be selectively brominated. This was confirmed by the bromination of p-cresol-grafted fluorinated poly(aryl ether oxadiazole) followed by 1H NMR characterization. This result suggests that upon derivatizing benzyl α-H sites with a cation group (to yield an anion-exchange membrane), the allyl α-H sites would remain free for subsequent crosslinking. This result has positive implications for the synthesis of robust and crosslinked anion-exchange membranes based on this platform.
    Type of Medium: Online Resource
    ISSN: 0366-7022 , 1348-0715
    URL: Article
    DOI: 10.1246/cl.140771
    RVK:
    VA 3560
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2014
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    detail.hit.zdb_id: 184719-3
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  • 8
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    Reductive Alkylation and Arylation of Single-walled Carbon Nanotubes in Ethylenediamine via Benkeser Reaction
    Oxford University Press (OUP) ; 2009
    In:  Chemistry Letters Vol. 38, No. 3 ( 2009-03-05), p. 220-221
    Details
    In: Chemistry Letters, Oxford University Press (OUP), Vol. 38, No. 3 ( 2009-03-05), p. 220-221
    Abstract: Single-walled carbon nanotubes (SWNTs) were functionalized with alkyl and aryl groups using lithium in ethylenediamine under moderate conditions. This Benkeser reaction was convenient and scalable because no liquid ammonia was used. Raman, infrared spectra, scanning electron microscopy, transmission electron microscopy, and thermogravimetric analysis as well as UV–vis–NIR spectra were used to characterize the functionalized SWNTs.
    Type of Medium: Online Resource
    ISSN: 0366-7022 , 1348-0715
    URL: Article
    DOI: 10.1246/cl.2009.220
    RVK:
    VA 3560
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2009
    detail.hit.zdb_id: 2063626-X
    detail.hit.zdb_id: 184719-3
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  • 9
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    A Roche lobe-filling hot subdwarf and white dwarf binary: possible detection of an ejected common envelope
    Oxford University Press (OUP) ; 2022
    In:  Monthly Notices of the Royal Astronomical Society Vol. 515, No. 3 ( 2022-08-05), p. 3370-3382
    Details
    In: Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP), Vol. 515, No. 3 ( 2022-08-05), p. 3370-3382
    Abstract: Binaries consisting of a hot subdwarf star and an accreting white dwarf (WD) are sources of gravitational wave radiation at low frequencies and possible progenitors of Type Ia supernovae if the WD mass is large enough. Here, we report the discovery of the third binary known of this kind: It consists of a hot subdwarf O (sdO) star and a WD with an orbital period of 3.495 h and an orbital shrinkage of 0.1 s in 6 yr. The sdO star overfills its Roche lobe and likely transfers mass to the WD via an accretion disc. From spectroscopy, we obtain an effective temperature of $T_{\mathrm{eff}}=54\, 240\pm 1840$ K and a surface gravity of log g = 4.841 ± 0.108 for the sdO star. From the light curve analysis, we obtain an sdO mass of MsdO = 0.55 M⊙ and a mass ratio of q = MWD/MsdO = 0.738 ± 0.001. Also, we estimate that the disc has a radius of $\sim\!0.41\ \mathrm{R}_\odot$ and a thickness of $\sim\!0.18\ \mathrm{R}_\odot$. The origin of this binary is probably a common envelope ejection channel, where the progenitor of the sdO star is either a red giant branch star or, more likely, an early asymptotic giant branch star; the sdO star will subsequently evolve into a WD and merge with its WD companion, likely resulting in an R Coronae Borealis (R CrB) star. The outstanding feature in the spectrum of this object is strong Ca H & K lines, which are blueshifted by ∼200 km s−1 and likely originate from the recently ejected common envelope, and we estimated that the remnant common envelope (CE) material in the binary system has a density $\sim\!6\times 10^{-10}\ {\rm g\, cm}^{-3}$.
    Type of Medium: Online Resource
    ISSN: 0035-8711 , 1365-2966
    URL: Article
    DOI: 10.1093/mnras/stac1768
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 207232-4
    detail.hit.zdb_id: 2016084-7
    SSG: 16,12
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  • 10
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    Impact of mass transfer schemes on mass–orbital period relation
    Oxford University Press (OUP) ; 2021
    In:  Monthly Notices of the Royal Astronomical Society Vol. 502, No. 1 ( 2021-01-27), p. 383-389
    Details
    In: Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP), Vol. 502, No. 1 ( 2021-01-27), p. 383-389
    Abstract: Binaries that evolved from red giant (RG) binaries through stable Roche lobe overflow follow the mass–orbital period relation if the donor’s core is degenerate. This relation is important for the studies of long orbital period blue stragglers, subdwarf B stars, and millisecond pulsars. To examine the influence of mass transfer schemes on this relation, we model the evolution of RG binaries at metallicity Z = 0.02 and Z = 0.001 with two different mass transfer schemes. In one of the scheme, it is assumed that mass transfer only occurs when the donor star’s radius is just larger than its Roche lobe radius (‘classical’ scheme). In another mass transfer scheme, the mass transfer can also occur when the donor’s radius is smaller than its Roche lobe radius as proposed by Ritter (1988) and further studied by Kolb & Ritter (1990; ‘Kolb’ scheme). We find that the mass transfer scheme has a significant influence on the evolution of RG binaries. In these RG binaries initiating mass transfer on the upper part of the RG branch, the final donor masses are smaller and orbital periods are larger in the models with the ‘Kolb’ scheme, compared with the models with the ‘classical’ scheme. The difference between orbital periods (donor masses) at the end of mass transfer under two different mass transfer schemes can be up to 500 d (0.04 M⊙) for the same donor mass (orbital period). The mass–orbital period relation from these models with the ‘Kolb’ scheme is above the relation from models with the ‘classical’ scheme. Additionally, similar to previous studies, we find that the final orbital period at metallicity Z = 0.02 is larger than that at metallicity Z = 0.001 for a given donor mass.
    Type of Medium: Online Resource
    ISSN: 0035-8711 , 1365-2966
    URL: Article
    DOI: 10.1093/mnras/stab020
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 207232-4
    detail.hit.zdb_id: 2016084-7
    SSG: 16,12
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