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  • 1
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    Online Resource
    Physical Activity, Body Mass Index, and Blood Progranulin in Older Adults: Cross-Sectional Associations in the MAPT Study
    Oxford University Press (OUP) ; 2022
    In:  The Journals of Gerontology: Series A Vol. 77, No. 6 ( 2022-06-01), p. 1141-1149
    Details
    In: The Journals of Gerontology: Series A, Oxford University Press (OUP), Vol. 77, No. 6 ( 2022-06-01), p. 1141-1149
    Abstract: Physical activity (PA) has been shown to moderate the negative effects of obesity on pro-inflammatory cytokines but its relationship with the adipokine progranulin (PGRN) remains poorly investigated. This study aimed to examine the cross-sectional main and interactive associations of body mass index (BMI) and PA level with circulating PGRN in older adults. Five-hundred and twelve participants aged 70 years and older involved in the Multidomain Alzheimer Preventive Trial (MAPT) study who underwent plasma PGRN measurements (ng/mL) were included. Self-reported PA levels were assessed using questionnaires. People were classified into 3 BMI categories: normal weight, overweight, or obesity. Further categorization using PA tertiles was used to define highly active, moderately active, and low active individuals. Multiple linear regressions were performed in order to test the associations of BMI, PA level, and their interaction with PGRN levels. Multiple linear regressions adjusted by age, sex, diabetes mellitus status, total cholesterol, creatinine level, and MAPT group demonstrated significant interactive associations of BMI status and continuous PA such that in people without obesity, higher PA levels were associated with lower PGRN concentrations, while an opposite pattern was found in individuals with obesity. In addition, continuous BMI was positively associated with circulating PGRN in highly active individuals but not in their less active peers. This cross-sectional study demonstrated reverse patterns in older adults with obesity compared to those without obesity regarding the relationships between PA and PGRN levels. Longitudinal and experimental investigations are required to understand the mechanisms that underlie the present findings. Clinical Trials Registration Number: NCT00672685
    Type of Medium: Online Resource
    ISSN: 1079-5006 , 1758-535X
    URL: Article
    DOI: 10.1093/gerona/glac018
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
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  • 2
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    LONGITUDINAL ASSOCIATIONS OF DEPRESSIVE SYMPTOM AND SUBJECTIVE MEMORY FACTORS WITH OBJECTIVE MEMORY PERFORMANCE
    Oxford University Press (OUP) ; 2019
    In:  Innovation in Aging Vol. 3, No. Supplement_1 ( 2019-11-08), p. S648-S648
    Details
    In: Innovation in Aging, Oxford University Press (OUP), Vol. 3, No. Supplement_1 ( 2019-11-08), p. S648-S648
    Abstract: Prior research demonstrated a history of depressive symptoms predicted oncoming memory deficits, and that self-evaluation of memory was associated with forthcoming memory difficulties. However, prior work lacks consistent consideration of multifaceted depressive symptoms in regards to longitudinal associations with objective memory (OM). Structural models were examined to determine how latent factors of depressive symptoms (via the CES-D) and SM factors predicted memory deficits at later time points when taking into account baseline OM performance [n=270; RMSEA=.034; CFI=.974; TLI=.965] in the Seattle Longitudinal Study (mean Age=70.33; SD=7.29; mean Education=15.30; SD=2.72; 61.9% female). The somatic complaints CES-D factor showed a significant longitudinal association with OM performance after seven years (β = -.25, p & lt; .05), while none of CES-D factors showed cross-sectional associations with the baseline OM. The general frequency of forgetting SM factor was positively associated with OM performance at baseline (β = .26, p & lt; .001), suggesting that those performing better at recalling words reported fewer memory problems. None of SM factors showed longitudinal associations with OM measured seven years later, indicating that self-evaluation of memory had no impact on future memory deficits. Overall findings suggested that a key CES-D factor, somatic complaints, was detected and that people endorsing more somatic issues experienced greater memory decline over a seven year period. Thus, extending prior work, the current study suggests that although both subjective memory and depressive symptom factors showed concurrent associations, only a specific factor of depressive symptoms, somatic complaints, was influential in regards to predicting later memory performance
    Type of Medium: Online Resource
    ISSN: 2399-5300
    URL: Article
    DOI: 10.1093/geroni/igz038.2406
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2905697-4
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  • 3
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    Leptomeninges-Derived Induced Pluripotent Stem Cells and Directly Converted Neurons From Autopsy Cases With Varying Neuropathologic Backgrounds
    Oxford University Press (OUP) ; 2018
    In:  Journal of Neuropathology & Experimental Neurology Vol. 77, No. 5 ( 2018-05-01), p. 353-360
    Details
    In: Journal of Neuropathology & Experimental Neurology, Oxford University Press (OUP), Vol. 77, No. 5 ( 2018-05-01), p. 353-360
    Type of Medium: Online Resource
    ISSN: 0022-3069 , 1554-6578
    URL: Article
    DOI: 10.1093/jnen/nly013
    RVK:
    XA 55250
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2018
    detail.hit.zdb_id: 2033048-0
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  • 4
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    0083 Longitudinal sleep instability is associated with increased MRI-visible perivascular space burden
    Oxford University Press (OUP) ; 2023
    In:  SLEEP Vol. 46, No. Supplement_1 ( 2023-05-29), p. A38-A38
    Details
    In: SLEEP, Oxford University Press (OUP), Vol. 46, No. Supplement_1 ( 2023-05-29), p. A38-A38
    Abstract: Emerging data from our group found longitudinal sleep variability within the Seattle Longitudinal Study was significantly associated with cognitive impairment and predicted cognitive impairment 10-years downstream. While this data supports a link between sleep instability, aging, and cognitive decline, the mechanism linking these processes is unknown. MRI-visible perivascular space (PVS) burden is a putative marker of glymphatic dysfunction, and previous studies suggest that sleep disruption is associated with PVS burden. Methods This a secondary analysis of subjects who a) participated in the Seattle Longitudinal Study and b) had T1-weighted 3 T MRI and FLAIR scans available for PVS analysis (n=250). We evaluated the variability (standard deviation) in each participant’s longitudinal self-reported sleep duration. White matter MRI-visible PVS were evaluated with a semi-automated segmentation algorithm, accounting PVS total burden (number/cm3), volume (mm3/cm3), as well as average PVS width, length, and median volume across participants, blinded by group. Participants were stratified into low or high-sleep variability groups. Results Preliminary analysis (n=37) demonstrated a significant association between high sleep variability and increased whole-brain PVS burden (p=0.04), with low sleep variability participants exhibiting an average of 7 PVS and high sleep variability participants an average of 11.33. Follow-up analysis evaluated PVS features within the wider cohort. Conclusion These findings suggest that variability in longitudinal sleep duration may exert a previously unappreciated influence on pathological processes, potentially including glymphatic dysfunction. Future studies within this cohort will seek to evaluate longitudinal changes in PVS burden across longitudinally-collected MRIs. Additional studies should be performed evaluating these findings on an independent cohort to assess whether sleep variability of different time scales (weeks, years, decades) exerts similar effects on these outcomes. Support (if any)  
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsad077.0083
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2056761-3
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  • 5
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    OVERVIEW OF THE ACTIVE STUDY AT 20 YEARS
    Oxford University Press (OUP) ; 2019
    In:  Innovation in Aging Vol. 3, No. Supplement_1 ( 2019-11-08), p. S432-S432
    Details
    In: Innovation in Aging, Oxford University Press (OUP), Vol. 3, No. Supplement_1 ( 2019-11-08), p. S432-S432
    Abstract: ACTIVE (1998-2019), the largest NIA-funded clinical trial of cognitively normal elderly, was designed to test if cognitive intervention maintains functional independence in older adults (N = 2,802, aged 65-94) by improving basic mental abilities. In this paper we overview major aims of ACTIVE to investigate 1) effectiveness and durability (through 1,2,3,5, and 10 years of follow-up) of three cognitive interventions (memory, reasoning, processing speed) in improving basic measures of cognition; 2) if training in specific cognitive abilities improves or maintains cognitively demanding daily living skills (e.g., medication use, driving); and 3) impact of intervention on everyday mobility, health-related quality of life, and health service utilization. We also review aims of a recent NIA-funded 20-year follow-up of ACTIVE to examine whether improved cognition and daily function results in long-term reduction in dementia risk, years of disability, health care utilization and costs, and increased active years of life in advanced old age.
    Type of Medium: Online Resource
    ISSN: 2399-5300
    URL: Article
    DOI: 10.1093/geroni/igz038.1616
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2905697-4
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  • 6
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    SOMATIC COMPLAINTS, A KEY FACTOR OF DEPRESSIVE SYMPTOMS ASSOCIATED WITH SUBJECTIVE MEMORY
    Oxford University Press (OUP) ; 2019
    In:  Innovation in Aging Vol. 3, No. Supplement_1 ( 2019-11-08), p. S648-S648
    Details
    In: Innovation in Aging, Oxford University Press (OUP), Vol. 3, No. Supplement_1 ( 2019-11-08), p. S648-S648
    Abstract: Prior research found depressive symptoms and subjective memory to be associated with objective memory (OM) performance. One key factor of subjective memory, as measured by the Memory Functioning Questionnaire (MFQ), is General Frequency of Forgetting (GFF). However, few studies focused on identifying specific factors of depressive symptoms when examining associations between depressive symptoms, subjective memory and OM. Using structural equation modeling, cross-sectional associations of factors in the CES-D (depressive symptoms) to the MFQ (subjective memory) and OM were investigated in the Seattle Longitudinal Study (mean Age=72.39; SD=8.28; mean Education=15.12; SD=2.76; 58.4% female). Differential associations of the CES-D factors with the MFQ factors [n=389; RMSEA=.031; CFI=.973; TLI=.966] and the GFF subscales [n=389; RMSEA=.033; CFI=.971; TLI=.964] resulted. Only the CES-D somatic complaints factor was significantly associated with the GFF factor (β= -.45, p & lt;.001), suggesting that people with more somatic complaints reported more memory concerns. The CES-D somatic complaints factor was negatively associated with the frequency of forgetting in daily life (β=-.36, p & lt; .001) and forgetting while reading subscales (β= -.33, p & lt; .001), indicating individuals that reported more somatic complaints experienced more frequent memory failures when performing daily activities and reading. Overall, a key CES-D factor, somatic complaints, emerged as influential to subjective memory, whereas there was no relation to OM. Further study of the longitudinal associations between the CES-D factors and subjective and objective memory is essential to determine the potential impact on memory deficits.
    Type of Medium: Online Resource
    ISSN: 2399-5300
    URL: Article
    DOI: 10.1093/geroni/igz038.2405
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
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  • 7
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    APOEε4 Genotype and Hypertension Modify 8-year Cortical Thinning: Five Occasion Evidence from the Seattle Longitudinal Study
    Oxford University Press (OUP) ; 2018
    In:  Cerebral Cortex Vol. 28, No. 6 ( 2018-06-01), p. 1934-1945
    Details
    In: Cerebral Cortex, Oxford University Press (OUP), Vol. 28, No. 6 ( 2018-06-01), p. 1934-1945
    Type of Medium: Online Resource
    ISSN: 1047-3211 , 1460-2199
    URL: Article
    DOI: 10.1093/cercor/bhx099
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2018
    detail.hit.zdb_id: 1483485-6
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  • 8
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    Innovative Experiences at Work Support Hippocampal Maintenance in Late Life
    Oxford University Press (OUP) ; 2020
    In:  Innovation in Aging Vol. 4, No. Supplement_1 ( 2020-12-16), p. 406-406
    Details
    In: Innovation in Aging, Oxford University Press (OUP), Vol. 4, No. Supplement_1 ( 2020-12-16), p. 406-406
    Abstract: Prior research has demonstrated the positive impact of occupational complexity on cognitive aging, however, neural underpinnings remain unclear. There is emerging evidence linking midlife managerial experience to slower hippocampal atrophy (Suo et al., 2012, 2017), supporting the brain maintenance model (i.e. preservation of young-like brain structure). However, occupational complexity, along with education, is known to be a proxy of cognitive reserve (i.e. mind’s resistance to brain aging). The current study examined the influence of midlife work environment factors (i.e., autonomy, control, and innovation; Work Environment Scale, Moos, 1981) on change in hippocampal thickness, while controlling for education and age. We studied 150 participants (60-78 years, M = 66.27, SD = 5.20, 61% female) from the Seattle Longitudinal Study who had at least one MRI scan and remained cognitively normal between 2006 and 2014. Hypotheses were tested using multilevel modeling in Mplus; gender differences were examined. There was no substantial drop in model fit as a result of adding any of the significant effects. Innovation at work slowed the decrease in hippocampal thickness over time demonstrating the protective effect of more novelty, variety and change in work activities. There was a significant age by gender interaction, such that the decrease in hippocampal thickness was stronger for older women. Together, findings suggest that long-term impact of work environment on the hippocampus extends beyond the effects of education, particularly in men, supporting the brain maintenance hypothesis. Innovation at work should be considered in understanding protective/risk factors in hippocampal atrophy in older age.
    Type of Medium: Online Resource
    ISSN: 2399-5300
    URL: Article
    DOI: 10.1093/geroni/igaa057.1307
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
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  • 9
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    COHORT DIFFERENCES IN COGNITIVE AGING: THE ROLE OF PERCEIVED WORK ENVIRONMENT
    Oxford University Press (OUP) ; 2019
    In:  Innovation in Aging Vol. 3, No. Supplement_1 ( 2019-11-08), p. S24-S24
    Details
    In: Innovation in Aging, Oxford University Press (OUP), Vol. 3, No. Supplement_1 ( 2019-11-08), p. S24-S24
    Abstract: Studies of historical change on cognitive aging generally document that later-born cohorts outperform earlier-born cohorts on tests of fluid cognitive performance. It is often noted how advances in educational attainment contribute to this finding. Over the last century, work demands and characteristics have changed profoundly, with shifts from a manufacturing to service and technical economy. We used data from the Seattle Longitudinal Study to compare trajectories of cognitive change between earlier-born (1901-1938) and later-born cohorts (1939-1966). Our findings show that (a) later-born cohorts had higher levels of performance on most cognitive tasks and exhibited less decline in word fluency, (b) had more enriched perceived work environment as indicated by higher levels of worker control and innovation, with no cohort differences in work autonomy (c) these experiences were associated with higher levels of cognitive performance independent of education and consistently across cohorts. We discuss potential mechanisms underlying these associations.
    Type of Medium: Online Resource
    ISSN: 2399-5300
    URL: Article
    DOI: 10.1093/geroni/igz038.091
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
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  • 10
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    INCIDENT DIFFICULTY IN INSTRUMENTAL ACTIVITIES OF DAILY LIVING: WHICH COMES FIRST?
    Oxford University Press (OUP) ; 2019
    In:  Innovation in Aging Vol. 3, No. Supplement_1 ( 2019-11-08), p. S522-S522
    Details
    In: Innovation in Aging, Oxford University Press (OUP), Vol. 3, No. Supplement_1 ( 2019-11-08), p. S522-S522
    Abstract: Background: Instrumental activities of daily living (IADLs) are necessary for successful independent living. Older adults may develop difficulty completing IADLs as they become physically and/or cognitively frail. The relative ordering in which IADLs deteriorate, and the importance of this ordering, is not well understood. Methods: Participants from the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study who reported no difficulty with IADLs at baseline were included. Individuals were followed up to 10 years for incidence of self-reported difficulty in 19 specific IADLs. The outcome of interest was time to any incident difficulty. We used Cox proportional hazards regression to estimate the hazard ratio (HR) of incident IADL difficulty for each IADL. Results: Of N=1,273 participants who contributed 6,144 person-years to the analysis, 887 developed difficulty with at least 1 IADL during the study period. The tasks in which participants reported difficulty earliest included giving self-injections (HR=5.69, [4.77, 6.79]), balancing checkbooks (HR=5.56, [4.32-7.16] ), remembering often called numbers without having to look them up (HR=5.47, [4.55-6.59]), and household chores (HR=4.18, [3.43-5.11] ). The last tasks to become difficult included keeping household expenses balanced (HR=0.07, [0.04-0.14]) and hanging up at the end of a phone call (HR=0.23, [0.09-0.56] ). Conclusion: Independent older adults reported earlier difficulty with balancing checkbooks, remembering often called phone numbers, and doing household cleaning. Recognizing these early difficult tasks may facilitate early planning for family members and adoption of compensatory strategies.
    Type of Medium: Online Resource
    ISSN: 2399-5300
    URL: Article
    DOI: 10.1093/geroni/igz038.1924
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2905697-4
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