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  • 1
    Online Resource
    Online Resource
    High incidence of low O6-methylguanine DNA methyltransferase expression in invasive macroadenomas of Cushing's disease
    Oxford University Press (OUP) ; 2009
    In:  European Journal of Endocrinology Vol. 161, No. 4 ( 2009-10), p. 553-559
    Details
    In: European Journal of Endocrinology, Oxford University Press (OUP), Vol. 161, No. 4 ( 2009-10), p. 553-559
    Abstract: Crooke's cell adenoma (CCA), characterized by massive Crooke's hyaline change in corticotroph adenoma, causes a rare subtype of Cushing's disease. In contrast to ordinary corticotroph adenomas, CCAs are generally aggressive and present as invasive macroadenomas, which are refractory to both surgery and radiotherapy and have a high-recurrence rate. Moreover, some patients with CCA present with distant or craniospinal metastases. Currently, there are no effective standard therapies for CCA. Objective We report a patient with Crooke's cell carcinoma who presented with local invasion and liver metastases, which was refractory to conventional therapeutic modalities including transsphenoidal surgery, radiosurgery, medications, and hepatic transcatheter arterial embolization. After all these treatments failed, the patient had monthly temozolomide administrations, resulting in gradual clinical improvement and biochemical data that were consistent with tumor shrinkage. In glioblastoma, low O 6 -methylguanine DNA methyltransferase (MGMT) expression is associated with epigenetic gene silencing and predicts a better response to temozolomide. Methods We thus investigated MGMT expression, immunohistochemically, in seven CCAs (five invasive macroadenomas and two invasive microadenomas) and 17 ordinary-type adenomas (OTAs; three noninvasive macroadenomas, 12 noninvasive microadenomas, and two invasive microadenomas) from patients with Cushing's disease. Results In seven CCAs, all five invasive macroadenomas exhibited low MGMT expression, defined as 〈 5% nuclear MGMT staining. In 17 OTAs, only one adenoma showed low MGMT expression. Conclusion In Cushing's disease, invasive macroadenomas including CCA usually have low-MGMT expression. Temozolomide thus may be a new therapeutic option for invasive macroadenomas such as CCA particularly when conventional treatments are ineffective.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/EJE-09-0414
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 2009
    detail.hit.zdb_id: 1485160-X
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  • 2
    Online Resource
    Online Resource
    Serum diiodotyrosine – a biomarker to differentiate destructive thyroiditis from Graves’ disease
    Oxford University Press (OUP) ; 2022
    In:  European Journal of Endocrinology Vol. 186, No. 2 ( 2022-02-01), p. 245-253
    Details
    In: European Journal of Endocrinology, Oxford University Press (OUP), Vol. 186, No. 2 ( 2022-02-01), p. 245-253
    Abstract: Conventional diagnostic methods are limited in their ability to differentiate destructive thyroiditis from Graves’ disease. We hypothesised that serum diiodotyrosine (DIT) and monoiodotyrosine (MIT) levels could be biomarkers for differentiating destructive thyroiditis from Graves’ disease. Design Patients with destructive thyroiditis ( n   = 13) and Graves’ disease ( n   = 22) were enrolled in this cross-sectional study. Methods We assayed the serum DIT and MIT levels using liquid chromatography-tandem mass spectrometry. A receiver operating characteristic (ROC) curve analysis was used to determine the sensitivity and specificity of the serum DIT and MIT levels as biomarkers for differentiating destructive thyroiditis from Graves’ disease. Results The serum DIT and MIT levels were significantly higher in patients with destructive thyroiditis than in those with Graves’ disease. The ROC curve analysis showed that the serum DIT levels (≥359.9 pg/mL) differentiated destructive thyroiditis from Graves’ disease, significantly, with 100.0% sensitivity and 95.5% specificity ( P 〈 0.001). The diagnostic accuracy of the serum MIT levels (≥119.4 pg/mL) was not as high as that of the serum DIT levels (sensitivity, 84.6%; specificity, 77.3%; P  = 0.001). Conclusions The serum DIT levels may serve as a novel diagnostic biomarker for differentiating destructive thyroiditis from Graves’ disease.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/EJE-21-0901
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1485160-X
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  • 3
    Online Resource
    Online Resource
    Emission Mechanism of Floral Scent in Petunia axillaris
    Oxford University Press (OUP) ; 2005
    In:  Bioscience, Biotechnology, and Biochemistry Vol. 69, No. 4 ( 2005-01), p. 773-777
    Details
    In: Bioscience, Biotechnology, and Biochemistry, Oxford University Press (OUP), Vol. 69, No. 4 ( 2005-01), p. 773-777
    Type of Medium: Online Resource
    ISSN: 0916-8451 , 1347-6947
    URL: Article
    DOI: 10.1271/bbb.69.773
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2005
    detail.hit.zdb_id: 2110940-0
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Differential gene expression in ACTH -secreting and non-functioning pituitary tumors
    Oxford University Press (OUP) ; 2007
    In:  European Journal of Endocrinology Vol. 157, No. 6 ( 2007-12), p. 717-724
    Details
    In: European Journal of Endocrinology, Oxford University Press (OUP), Vol. 157, No. 6 ( 2007-12), p. 717-724
    Abstract: Differential expression of several genes between ACTH-secreting pituitary tumors causing Cushing' disease (CD), silent corticotroph adenoma (SCA), and non-functioning pituitary tumors (NFT) was investigated. Design and methods We used tissue specimens from 35 pituitary tumors (12 CD, 8 SCA, and 15 NFT). Steady-state mRNA levels of the genes related to proopiomelanocortin (POMC) transcription, synthesis, processing, and secretion, such as neurogenic differentiation 1 (NeuroD1), T-box 19 (Tpit), corticotropin releasing hormone receptor (CRHR), vasopressin receptor 1b (V1bR), prohormone convertase (PC) 1/3 and PC2, 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 and type 2, glucocorticoid receptor α (GRα), annexin A1, histone deacetylase 2 (HDAC2), and BRM/SWI2-related gene 1, were determined by real-time RT-PCR. Results and conclusion POMC and Tpit mRNA levels were greater in CD and SCA than those in NFT. NeuroD1 mRNA levels were less in CD than those in NFT, but almost comparable between SCA and NFT. PC1/3 mRNA levels were greater in CD, but less in SCA than those in NFT. PC2 mRNA levels in CD and SCA were less than those in NFT. CRHR, V1bR, and 11β-HSD2 mRNA levels in CD were greater than those in SCA and NFT. HDAC2 mRNA levels in CD and SCA were lower than those in NFT. In conclusion, our study demonstrated that the genes related to transcription, synthesis, processing, and secretion of POMC are differentially regulated in ACTH-secreting pituitary tumors causing CD and SCA compared with those in NFT. This may partly explain the development of clinically active and inactive CD.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/EJE-07-0428
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 2007
    detail.hit.zdb_id: 1485160-X
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