In:
Journal of Industrial Microbiology and Biotechnology, Oxford University Press (OUP), Vol. 43, No. 8 ( 2016-08-01), p. 1159-1165
Kurzfassung:
New lantibiotic cinnamycin B was isolated from the extract of Actinomadura atramentaria NBRC 14695T, based on genome mining and chemical investigation. The partial structure of cinnamycin B was established by 2D NMR experiments, which indicated that cinnamycin B had same methyl lanthionine bridging pattern with cinnamycin. The reduction with NaBH4-NiCl2 afforded the reduced cinnamycin B, and MS/MS experiment indicated the presence of hydroxy asparatic acid in the molecule. Cinnamycin B showed an antibacterial activity against Streptomyces antibioticus with dosage of 5 μg (0.5μL, 10 mg/mL solution) at spot-on-lawn testing method. The gene cluster of cinnamycin B on the genome of A. atramentaria was identified and discussed in comparison with that of cinnamycin.
Materialart:
Online-Ressource
ISSN:
1476-5535
,
1367-5435
DOI:
10.1007/s10295-016-1788-9
Sprache:
Englisch
Verlag:
Oxford University Press (OUP)
Publikationsdatum:
2016
ZDB Id:
1482484-X
SSG:
12
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