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  • 1
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    Effect of vinpocetine alone and in combination with enalapril in experimental model of diabetic cardiomyopathy in rats: possible involvement of PDE-1/TGF-β/ Smad 2/3 signalling pathways
    Oxford University Press (OUP) ; 2023
    In:  Journal of Pharmacy and Pharmacology Vol. 75, No. 9 ( 2023-09-01), p. 1198-1211
    Details
    In: Journal of Pharmacy and Pharmacology, Oxford University Press (OUP), Vol. 75, No. 9 ( 2023-09-01), p. 1198-1211
    Abstract: Diabetic cardiomyopathy (DC) is one of the severe secondary complications of diabetes mellitus in humans. Vinpocetine is an alkaloid having pleiotropic pharmacological effects. The present study is designed to investigate the effect of vinpocetine in DC in rats. Methods Rats were fed a high-fat diet for nine weeks along with single dose of streptozotocin after the second week to induce DC. The haemodynamic evaluation was performed to assess the functional status of rats using the Biopac system. Cardiac echocardiography, biochemical, oxidative stress parameters and inflammatory cytokine level were analysed in addition to haematoxylin–eosin and Masson’s trichome staining to study histological changes, cardiomyocyte diameter and fibrosis, respectively. Phosphodiesterase-1 (PDE-1), transforming growth factor-β (TGF-β) and p-Smad 2/3 expression in cardiac tissues were quantified using western blot/RT-PCR. Key finding Vinpocetine treatment and its combination with enalapril decreased the glucose levels compared to diabetic rats. Vinpocetine improved the echocardiographic parameters and cardiac functional status of rats. Vinpocetine decreased the cardiac biochemical parameters, oxidative stress, inflammatory cytokine levels, cardiomyocyte diameter and fibrosis in rats. Interestingly, expressions of PDE-1, TGF-β and p-Smad 2/3 were ameliorated by vinpocetine alone and in combination with enalapril. Conclusions Vinpocetine is a well-known inhibitor of PDE-1 and the protective effect of vinpocetine in DC is exerted by inhibition of PDE-1 and subsequent inhibition of the expression of TGF-β/Smad 2/3.
    Type of Medium: Online Resource
    ISSN: 0022-3573 , 2042-7158
    URL: Article
    DOI: 10.1093/jpp/rgad043
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2041988-0
    detail.hit.zdb_id: 2050532-2
    SSG: 15,3
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  • 2
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    Abundance of Ticks (Acari: Ixodidae) and Presence of Rickettsia and Anaplasma in Ticks Infesting Domestic Animals From Northern India
    Oxford University Press (OUP) ; 2021
    In:  Journal of Medical Entomology Vol. 58, No. 3 ( 2021-05-15), p. 1370-1375
    Details
    In: Journal of Medical Entomology, Oxford University Press (OUP), Vol. 58, No. 3 ( 2021-05-15), p. 1370-1375
    Abstract: Rickettsia and Anaplasma are bacteria that can be transmitted by hematophagous arthropods such as ticks infesting animals in close proximity to humans. The main objective of the present study was to investigate abundance of common tick species infesting domestic animals and presence of Rickettsia and Anaplasma in tick populations. Adult ticks were collected from domestic animals in rural areas and screened by molecular detection of bacterial DNA for these two genera of bacteria. A total of 1,778 adult ixodid tick specimens were collected from 200 cattle, 200 buffaloes, 200 goats, and 40 dogs. The collection consisted of four species of ixodid ticks, Rhipicephalus (Boophilus) microplus (Canestrini) (83.8%), Hyalomma kumari (Sharif) (7.1%), Rhipicephalus sanguineus (Latreille) (6.4%), and Dermacentor auratus (Supino) (2.7%) infesting the domestic animals. The prevalence of all the collected tick species was highest in the month of October. Anaplasma spp. was the most frequently identified bacteria (3.3%) in tested ticks. Of 17 positive tick pools for Anaplasma spp., 14 pools were from ticks infesting cattle, 2 pools of ticks collected from buffalo, and the remaining pool were ticks infesting a goat at the time of collection. Although 1.6% tick pools of R. microplus collected from cattle tested positive for Rickettsia spp., present investigation provides evidence of the most prevalent ixodid ticks infesting domestic animals and the presence of obligate intracellular bacteria, Rickettsia and Anaplasma, in these ticks collected in the Gorakhpur division of Northern India.
    Type of Medium: Online Resource
    ISSN: 0022-2585 , 1938-2928
    URL: Article
    DOI: 10.1093/jme/tjaa296
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2031006-7
    SSG: 12
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  • 3
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    CBL-interacting protein kinase 25 contributes to root meristem development
    Oxford University Press (OUP) ; 2019
    In:  Journal of Experimental Botany Vol. 70, No. 1 ( 2019-01-01), p. 133-147
    Details
    In: Journal of Experimental Botany, Oxford University Press (OUP), Vol. 70, No. 1 ( 2019-01-01), p. 133-147
    Type of Medium: Online Resource
    ISSN: 0022-0957 , 1460-2431
    URL: Article
    DOI: 10.1093/jxb/ery334
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 1466717-4
    SSG: 12
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  • 4
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    The genetic admixture and assimilation of Ahom: a historic migrant from Thailand to India
    Oxford University Press (OUP) ; 2024
    In:  Human Molecular Genetics ( 2024-03-27)
    Details
    In: Human Molecular Genetics, Oxford University Press (OUP), ( 2024-03-27)
    Abstract: The Northeastern region of India is considered a gateway for modern humans’ dispersal throughout Asia. This region is a mixture of various ethnic and indigenous populations amalgamating multiple ancestries. One reason for such amalgamation is that, South Asia experienced multiple historic migrations from various parts of the world. A few examples explored genetically are Jews, Parsis and Siddis. Ahom is a dynasty that historically migrated to India during the 12th century. However, this putative migration has not been studied genetically at high resolution. Therefore, to validate this historical evidence, we genotyped autosomal data of the Modern Ahom population residing in seven sister states of India. Principal Component and Admixture analyses haave suggested a substantial admixture of the Ahom population with the local Tibeto-Burman populations. Moreover, the haplotype-based analysis has linked these Ahom individuals mainly with the Kusunda (a language isolated from Nepal) and Khasi (an Austroasiatic population of Meghalaya). Such unexpected presence of widespread population affinities suggests that Ahom mixed and assimilated a wide variety of Trans-Himalayan populations inhabiting this region after the migration. In summary, we observed a significant deviation of Ahom from their ancestral homeland (Thailand) and extensive admixture and assimilation with the local South Asian populations.
    Type of Medium: Online Resource
    ISSN: 0964-6906 , 1460-2083
    URL: Article
    DOI: 10.1093/hmg/ddae054
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2024
    detail.hit.zdb_id: 1474816-2
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  • 5
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    De novo genomic analysis of Enterobacter asburiae EBRJ12, a plant growth-promoting rhizobacteria isolated from the rhizosphere of Phaseolus vulgaris L
    Oxford University Press (OUP) ; 2023
    In:  Journal of Applied Microbiology Vol. 134, No. 2 ( 2023-02-16)
    Details
    In: Journal of Applied Microbiology, Oxford University Press (OUP), Vol. 134, No. 2 ( 2023-02-16)
    Abstract: Environmental stresses such as water deficit induced stress are one of the major limiting factors in crop production. However, some plant growth-promoting rhizobacteria (PGPR) can promote plant growth in such adverse condition. Therefore, the objective was to isolate rhizospheric bacteria from Phaseolus vulgaris L. growing in a drought-affected soil and to analyze its plant growth promoting (PGP) efficacy to black gram (Vigna mungo L.) and Bhut jolokia (Capsicum chinense Jacq.). Whole-genome sequencing of the potential bacteria was targeted to analyze the genetic potential of the isolate as a plant growth-promoting agent. Methods and results The isolate Enterobacter asburiae EBRJ12 was selected based on its PGP efficacy, which significantly improved plant growth and development. The genomic analysis revealed the presence of one circular chromosome of size 4.8 Mb containing 16 genes for osmotic stress regulation including osmotically inducible protein osmY, outer membrane protein A precursor ompA, aquaporin Z, and an operon for osmoprotectant ABC transporter yehZYXW. Moreover, the genome has a complete genetic cluster for biosynthesis of siderophore Enterobactin and siderophore Aerobactin. The PGP effects were verified with black gram and Bhut jolokia in pot experiments. The isolate significantly increased the shoot length by 35.0% and root length by 58.0% of black gram, while 41.0% and 57.0% of elevation in shoot and root length were observed in Bhut jolokia compared to non-inoculated plants. Conclusions The EBRJ12 has PGP features that could improve the growth in host plants, and the genomic characterization revealed the presence of genetic potential for plant growth promotion.
    Type of Medium: Online Resource
    ISSN: 1365-2672
    URL: Article
    DOI: 10.1093/jambio/lxac090
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2020421-8
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  • 6
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    A seminatural approach towards restoration, classification, and pattern extraction from heritage Hindi poetry: A probabilistic case study with Dohā chanda
    Oxford University Press (OUP) ; 2023
    In:  Digital Scholarship in the Humanities ( 2023-07-21)
    Details
    In: Digital Scholarship in the Humanities, Oxford University Press (OUP), ( 2023-07-21)
    Abstract: Indian literary heritage is vast and is of great importance; to explore it, one has to devote them in studying dialects (Khariboli, Haryanavi, Brajbhasha, Awadhi, Bhojpuri, Marwari, etc.) especially when old Hindi is under the lens of observation. Chanda are poetic compositions that have well-defined structures. Dohā is a kind of chanda which, in our work, has been explored using Kabir’s compositions as a case study. Kabir represents the cult of poets who relied on oral means for the propagation and consumption of poetry. The poems were communicated to the later generation through simple acts of recitation and hearing, leading to obvious mutation and multiple versions of the same compositions when documented later and hence needs restoration (at least metrically). Using the knowledge from the state-of-art models metadata generator, Text2Mātrā, and RPaGen and extending beyond them, this article is first of its kind to present Kabir’s dohā within the scope of restoration, metrical computation, and statistics. Starting with the restoration process, the proposed algorithms generate data that are subjected to suitable statistical models. These models highlight the trends in the dataset, which is helpful in realizing abstract patterns inside the textual data.
    Type of Medium: Online Resource
    ISSN: 2055-7671 , 2055-768X
    URL: Article
    DOI: 10.1093/llc/fqad048
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2805934-7
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  • 7
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    726Examining mediation effect of comprehensive knowledge on people’s attitudes towards HIV-infected people in India
    Oxford University Press (OUP) ; 2021
    In:  International Journal of Epidemiology Vol. 50, No. Supplement_1 ( 2021-09-01)
    Details
    In: International Journal of Epidemiology, Oxford University Press (OUP), Vol. 50, No. Supplement_1 ( 2021-09-01)
    Abstract: Improvement in people’s knowledge of HIV/AIDS and reduction in stigma and discrimination have been key factors in the fight against HIV/AIDS. The objective of the present paper is to examine the mediation effect of comprehensive knowledge on people’s attitudes towards HIV positives in India. Methods Data for the study have been drawn from nationally representative India’s National Family Health Survey, 2015-16. Statistical methods of data analysis included odds ratio and logistic regression models. Results Two in every five men and of women with comprehensive knowledge held a positive attitude towards PLHIVs. The people in rural areas and females against their counterparts are less likely (OR: 0.85, p  & lt; 0.05) to have positive attitude. The mediation by comprehensive knowledge, contributed to 46% of direct effect from gender perspective on comprehensive positive attitude. Among males, aged group 25-44 and among females age & lt;25 had most positive attitude towards people living with HIV (PLHIV) as compared to their counterparts. Conclusions There existed a difference between males and females in attaining comprehensive knowledge and having comprehensive positive attitude. The mediation by comprehensive knowledge contributed, though partially, direct effects from gender perspective on comprehensive positive attitude. The findings are programmatically relevant to device content analysis of the material in the information, education and communication strategies. Key messages The mediation effect of comprehensive knowledge on people’s attitudes towards HIV positives has been substantial in India.
    Type of Medium: Online Resource
    ISSN: 0300-5771 , 1464-3685
    URL: Article
    DOI: 10.1093/ije/dyab168.520
    RVK:
    XF 4100
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 1494592-7
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  • 8
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    Lithospheric structure of southern Indian shield and adjoining oceans: integrated modelling of topography, gravity, geoid and heat flow data
    Oxford University Press (OUP) ; 2013
    In:  Geophysical Journal International Vol. 194, No. 1 ( 2013-07-01), p. 30-44
    Details
    In: Geophysical Journal International, Oxford University Press (OUP), Vol. 194, No. 1 ( 2013-07-01), p. 30-44
    Type of Medium: Online Resource
    ISSN: 1365-246X , 0956-540X
    URL: Article
    DOI: 10.1093/gji/ggt080
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2013
    detail.hit.zdb_id: 3042-9
    detail.hit.zdb_id: 2006420-2
    detail.hit.zdb_id: 1002799-3
    SSG: 16,13
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  • 9
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    SP11.9 A Vascular Surgeon's Dilemma - Biodegradable Versus Non-Biodegradable Drug Eluting Stents: A Systematic Review and Meta Analysis
    Oxford University Press (OUP) ; 2023
    In:  British Journal of Surgery Vol. 110, No. Supplement_6 ( 2023-08-21)
    Details
    In: British Journal of Surgery, Oxford University Press (OUP), Vol. 110, No. Supplement_6 ( 2023-08-21)
    Abstract: Vascular stents are the best-known interventional treatment for cardiovascular disease, with variation in available stents increasing significantly over time. Despite the rapidity of new prototype releases, critical cross-comparisons fail to maintain the same rate, therefore causing confusion for vascular surgeons. Research is most notably lacking between biodegradable-polymer sirolimus-eluting stents (BP-SESs) and permanent-polymer sirolimus-eluting stents (PP-SESs). Therefore, a systematic review with meta-analysis was conducted evaluating clinical outcomes. Methods Using relevant synonyms of “biodegradable”, “sirolimus” and “stent”, the databases Medline, Embase, and Scopus were searched, with the final search being conducted on the 4th of November 2022. Reference lists were also screened. The clinical outcomes investigated were stent thrombosis (ST), myocardial infarction (MI), target vessel revascularisation (TVR), target lesion revascularisation (TLR), and death. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Results Five clinical trials directly comparing clinical outcomes between BP-SESs and PP-SESs were ultimately identified for inclusion. For all five outcomes investigated, no statistically significant difference (p & gt;0.05) was found between the BP-SES and the PP-SES recipients. Pooled odds ratios of 0.86 (95% CI:0.44-1.65), 0.75 (95% CI:0.32-1.74), 1.12 (95% CI:0.54-2.32), 1.14 (95% CI:0.38-3.38) and 0.95 (95% CI:0.51-1.77) were calculated for ST, MI, TVR, TLR and death respectively. Conclusions Although there is some evidence to suggest BP-SESs are noninferior to PP-SESs, concrete conclusions cannot yet be drawn due to the paucity of research in this field. Further clarity from randomised control trials will aid additional examination and improvement in stent materials and outcomes.
    Type of Medium: Online Resource
    ISSN: 0007-1323 , 1365-2168
    URL: Article
    DOI: 10.1093/bjs/znad241.137
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2006309-X
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  • 10
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    SP11.13 A Systematic Review on the Effectiveness of Augmented Reality for Medical Students’ Surgical Training
    Oxford University Press (OUP) ; 2023
    In:  British Journal of Surgery Vol. 110, No. Supplement_6 ( 2023-08-21)
    Details
    In: British Journal of Surgery, Oxford University Press (OUP), Vol. 110, No. Supplement_6 ( 2023-08-21)
    Abstract: Interest in augmented reality (AR) technologies within an educational setting has surged in recent years. However, few studies evaluate the use of AR in a primarily medical student population. This systematic review with meta-analysis was conducted to evaluate the existing literature on this topic. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were adhered to during this review. Using relevant synonyms for the terms “augmented reality”, “medical students” and “surgery”, the databases Embase, Medline and Scopus were searched. Data was extracted for outcome measures such as errors/fails, attempts/retries, time for task completion, motion sickness/nausea and focus shifts. Results 826 records were initially retrieved; 19 studies were included in the final review, with a total of 485 participants. The AR group performed better than the comparator group in 84% of the statistically significant main outcomes. The groups showed no statistically significant difference in likelihood of failing assessment, with a pooled odds ratio of 1.76 (95% CI:0.06-51.71, p=0.74, I2=81%). One study reported 57% fewer critical errors in the AR group than the comparator group. Two studies reported nausea/motion sickness as an outcome (12% (n=3) and mean Likert-scale score of 3 (out of 10) in the AR groups). Conclusions AR can be an effective surgical teaching and training tool for medical students. However, the limitations of AR, including visually induced motion sickness, have not been explored extensively by primary studies. Gradual integration of AR is therefore proposed until further studies elucidating benefits and risks can be undertaken.
    Type of Medium: Online Resource
    ISSN: 0007-1323 , 1365-2168
    URL: Article
    DOI: 10.1093/bjs/znad241.141
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2006309-X
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