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  • 1
    Online Resource
    Online Resource
    Non-fiducial cosmological test from geometrical and dynamical distortions around voids
    Oxford University Press (OUP) ; 2019
    In:  Monthly Notices of the Royal Astronomical Society Vol. 485, No. 4 ( 2019-06-01), p. 5761-5772
    Details
    In: Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP), Vol. 485, No. 4 ( 2019-06-01), p. 5761-5772
    Type of Medium: Online Resource
    ISSN: 0035-8711 , 1365-2966
    URL: Article
    DOI: 10.1093/mnras/stz821
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2016084-7
    SSG: 16,12
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  • 2
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    QOLP-01. OUTCOME ASSESSMENT OF MULTIDISCIPLINARY BRAIN TUMOR BOARD MEETING RECOMMENDATIONS FOR BRAIN METASTASIS: IS THERE A GAP?
    Oxford University Press (OUP) ; 2020
    In:  Neuro-Oncology Vol. 22, No. Supplement_2 ( 2020-11-09), p. ii174-ii174
    Details
    In: Neuro-Oncology, Oxford University Press (OUP), Vol. 22, No. Supplement_2 ( 2020-11-09), p. ii174-ii174
    Abstract: Brain metastasis (BM) is the most common form of brain cancer affecting 20-40% of cancer patients. Advancements in cancer therapy has prolonged survival but BM incidence has increased. BM management requires a multidisciplinary approach to individualize care via an ever-growing sum of surgical, radiation, and systemic therapy options. Consensus is achieved by multidisciplinary tumor board meeting (MTBm). Nevertheless, BM diagnosis predicts poor prognosis. Palliative Care (PC) is essential for proper BM management. Yet, formal PC assessment may not be available for MTBm. We evaluated whether MTBm consensus recommendations were followed. RESULTS Our weekly MTBm discussed 157 BM cases during 2019 (median age: 64 years [range 28-91], male/female: 82/75). The most common primary diagnosis was lung (n=49, 31%), breast (n=24, 15%), melanoma (n=16, 10%). The majority was newly diagnosed BM (n=143, 91%). MTBm recommendations were divided into three not-mutually-exclusive categories: surveillance/workup (n=78, 50%), BM-directed treatment (n=101, 64%) and GOC discussion (n=7, 4%). MTBm recommendations were fully followed in 113 cases (72%), partially in 13(8%), and not followed in 25(16%). Of the 38 patients whose recommendations were partially/not followed, the main reason was transition to hospice/death (n=26, 68%). Of the 101 patients recommended treatment, 68% (n=68) fully followed it, yet 31% (n=21) of them died within 3 months; for those living longer than 3 months (n=47, 69%), median KPS at 3 months was 70 (range 30-90). Of the entire cohort (n=157), only 20 (13%) established consistent PC follow-up ( & gt;1 outpatient visit) and 69 cases (44%) transitioned to hospice/died within 6 months, 30 of which (43%) still completed surgery (n=6) or radiotherapy (n=24) within this period. CONCLUSION Periodic assessment of MTBm recommendations is relevant for sensible BM management. Balancing treatment while focusing on QoL in a patient population with limited survival is challenging. PC assessment at MTBm could close this gap.
    Type of Medium: Online Resource
    ISSN: 1522-8517 , 1523-5866
    URL: Article
    DOI: 10.1093/neuonc/noaa215.726
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2094060-9
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  • 3
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    Online Resource
    Detection of HCV-related Structures in the Mitochondria of Apoptotic Hepatocytes in Liver Biopsies from Chronically HCV-infected Patients
    Oxford University Press (OUP) ; 2003
    In:  Microscopy and Microanalysis Vol. 9, No. S02 ( 2003-08), p. 1424-1425
    Details
    In: Microscopy and Microanalysis, Oxford University Press (OUP), Vol. 9, No. S02 ( 2003-08), p. 1424-1425
    Type of Medium: Online Resource
    ISSN: 1431-9276 , 1435-8115
    URL: Article
    DOI: 10.1017/S1431927603447120
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2003
    detail.hit.zdb_id: 1481716-0
    SSG: 11
    SSG: 12
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  • 4
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    A 10-Year Review of Surgical Outcomes at the Johns Hopkins and University of Maryland Resident Aesthetic Clinic
    Oxford University Press (OUP) ; 2022
    In:  Aesthetic Surgery Journal Open Forum Vol. 4 ( 2022-01-01)
    Details
    In: Aesthetic Surgery Journal Open Forum, Oxford University Press (OUP), Vol. 4 ( 2022-01-01)
    Abstract: In 2014, the Plastic Surgery Residency Review Committee of the Accreditation Council for Graduate Medical Education (ACGME) increased minimum aesthetic surgery requirements. Consequently, the resident aesthetic clinic (RAC) has become an ever more important modality for training plastic surgery residents. Objectives To analyze demographics and long-term surgical outcomes of aesthetic procedures performed at the Johns Hopkins and University of Maryland (JH/UM) RAC. A secondary objective was to evaluate the JH/UM RAC outcomes against those of peer RACs as well as board-certified plastic surgeons. Methods We performed a retrospective chart review of all patients who underwent aesthetic procedures at the JH/UM RAC between 2011 and 2020. Clinical characteristics, minor complication rates, major complication rates, and revision rates from the JH/UM RAC were compared against 2 peer RACs. We compared the incidence of major complications between the JH/UM RAC and a cohort of patients from the CosmetAssure (Birmingham, AL) database. Pearson's chi-square test was used to compare complication rates between patient populations, with a significance set at 0.05. Results Four hundred ninety-five procedures were performed on 285 patients. The major complications rate was 1.0% (n = 5). Peer RACs had total major complication rates of 0.2% and 1.7% (P = .07 and P = .47, respectively). CosmetAssure patients matched to JH/UM RAC patients were found to have comparable total major complications rates of 1.8% vs 0.6% (P = .06), respectively. At JH/UM, the minor complication rate was 13.9%, while the revision rate was 5.9%. Conclusions The JH/UM RAC provides residents the education and training necessary to produce surgical outcomes comparable to peer RACs as well as board-certified plastic surgeons. Level of Evidence: 3
    Type of Medium: Online Resource
    ISSN: 2631-4797
    URL: Article
    DOI: 10.1093/asjof/ojac074
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 3036519-3
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  • 5
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    Redshift-space effects in voids and their impact on cosmological tests. Part I: the void size function
    Oxford University Press (OUP) ; 2020
    In:  Monthly Notices of the Royal Astronomical Society Vol. 500, No. 1 ( 2020-11-17), p. 911-925
    Details
    In: Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP), Vol. 500, No. 1 ( 2020-11-17), p. 911-925
    Abstract: Voids are promising cosmological probes. Nevertheless, every cosmological test based on voids must necessarily employ methods to identify them in redshift space. Therefore, redshift-space distortions (RSD) and the Alcock–Paczyński effect (AP) have an impact on the void identification process itself generating distortion patterns in observations. Using a spherical void finder, we developed a statistical and theoretical framework to describe physically the connection between the identification in real and redshift space. We found that redshift-space voids above the shot noise level have a unique real-space counterpart spanning the same region of space, they are systematically bigger and their centres are preferentially shifted along the line of sight. The expansion effect is a by-product of RSD induced by tracer dynamics at scales around the void radius, whereas the off-centring effect constitutes a different class of RSD induced at larger scales by the global dynamics of the whole region containing the void. The volume of voids is also altered by the fiducial cosmology assumed to measure distances, this is the AP change of volume. These three systematics have an impact on cosmological statistics. In this work, we focus on the void size function. We developed a theoretical framework to model these effects and tested it with a numerical simulation, recovering the statistical properties of the abundance of voids in real space. This description depends strongly on cosmology. Hence, we lay the foundations for improvements in current models of the abundance of voids in order to obtain unbiased cosmological constraints from redshift surveys.
    Type of Medium: Online Resource
    ISSN: 0035-8711 , 1365-2966
    URL: Article
    DOI: 10.1093/mnras/staa3252
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2016084-7
    SSG: 16,12
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  • 6
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    Online Resource
    Redshift-space distortions with split densities
    Oxford University Press (OUP) ; 2021
    In:  Monthly Notices of the Royal Astronomical Society Vol. 505, No. 4 ( 2021-07-05), p. 5731-5752
    Details
    In: Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP), Vol. 505, No. 4 ( 2021-07-05), p. 5731-5752
    Abstract: Accurate modelling of redshift-space distortions (RSD) is challenging in the non-linear regime for two-point statistics e.g. the two-point correlation function (2PCF). We take a different perspective to split the galaxy density field according to the local density, and cross-correlate those densities with the entire galaxy field. Using mock galaxies, we demonstrate that combining a series of cross-correlation functions (CCFs) offers improvements over the 2PCF as follows: (1) The distribution of peculiar velocities in each split density is nearly Gaussian. This allows the Gaussian streaming model for RSD to perform accurately within the statistical errors of a ($1.5\, h^{-1}$ Gpc)3 volume for almost all scales and all split densities. (2) The probability distribution of the density contrast at small scales is non-Gaussian, but the CCFs of split densities capture the non-Gaussianity, leading to improved cosmological constraints over the 2PCF. We can obtain unbiased constraints on the growth parameter fσ12 at the per cent level, and Alcock–Paczynski (AP) parameters at the sub-per cent level with the minimal scale of $15\, h^{-1}{\rm Mpc}$. This is a ∼30 per cent and ∼6 times improvement over the 2PCF, respectively. The diverse and steep slopes of the CCFs at small scales are likely to be responsible for the improved constraints of AP parameters. (3) Baryon acoustic oscillations (BAO) are contained in all CCFs of split densities. Including BAO scales helps to break the degeneracy between the line-of-sight and transverse AP parameters, allowing independent constraints on them. We discuss and compare models for RSD around spherical densities.
    Type of Medium: Online Resource
    ISSN: 0035-8711 , 1365-2966
    URL: Article
    DOI: 10.1093/mnras/stab1654
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2016084-7
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  • 7
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    Evolution mapping: a new approach to describe matter clustering in the non-linear regime
    Oxford University Press (OUP) ; 2022
    In:  Monthly Notices of the Royal Astronomical Society Vol. 514, No. 4 ( 2022-07-12), p. 5673-5685
    Details
    In: Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP), Vol. 514, No. 4 ( 2022-07-12), p. 5673-5685
    Abstract: We present a new approach to describe statistics of the non-linear matter density field that exploits a degeneracy in the impact of different cosmological parameters on the linear dimensionless matter power spectrum, $\Delta ^2_{\rm L}(k)$. We classify all cosmological parameters into two groups, shape parameters, which determine the shape of $\Delta ^2_{\rm L}(k)$, and evolution parameters, which only affect its amplitude at any given redshift. With this definition, the time evolution of $\Delta ^2_{\rm L}(k)$ in models with identical shape parameters but different evolution parameters can be mapped from one to the other by relabelling the redshifts that correspond to the same clustering amplitude, which we characterize by the linear mass fluctuation in spheres of radius $12\, {\rm Mpc}$, σ12(z). We use N-body simulations to show that the same evolution-mapping relation gives a good description of the non-linear power spectrum, the halo mass function, or the full density field. The deviations from the exact degeneracy are the result of the different structure formation histories experienced by each model to reach the same clustering amplitude and can be accurately described in terms of differences in the suppression factor g(a) = D(a)/a. These relations can be used to drastically reduce the number of parameters required to describe the cosmology dependence of the power spectrum. We show how this can help to speed up the inference of parameter constraints from cosmological observations. We also present a new design of an emulator of the non-linear power spectrum whose predictions can be adapted to an arbitrary choice of evolution parameters and redshift.
    Type of Medium: Online Resource
    ISSN: 0035-8711 , 1365-2966
    URL: Article
    DOI: 10.1093/mnras/stac1656
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2016084-7
    SSG: 16,12
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  • 8
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    Online Resource
    A Potent Recombinant Polyclonal Antibody Therapeutic for Protection Against New Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern
    Oxford University Press (OUP) ; 2023
    In:  The Journal of Infectious Diseases Vol. 228, No. 5 ( 2023-08-31), p. 555-563
    Details
    In: The Journal of Infectious Diseases, Oxford University Press (OUP), Vol. 228, No. 5 ( 2023-08-31), p. 555-563
    Abstract: Emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) possess mutations that prevent antibody therapeutics from maintaining antiviral binding and neutralizing efficacy. Monoclonal antibodies (mAbs) shown to neutralize Wuhan-Hu-1 SARS-CoV-2 (ancestral) strain have reduced potency against newer variants. Plasma-derived polyclonal hyperimmune drugs have improved neutralization breadth compared with mAbs, but lower titers against SARS-CoV-2 require higher dosages for treatment. We previously developed a highly diverse, recombinant polyclonal antibody therapeutic anti-SARS-CoV-2 immunoglobulin hyperimmune (rCIG). rCIG was compared with plasma-derived or mAb standards and showed improved neutralization of SARS-CoV-2 across World Health Organization variants; however, its potency was reduced against some variants relative to ancestral, particularly omicron. Omicron-specific antibody sequences were enriched from yeast expressing rCIG-scFv and exhibited increased binding and neutralization to omicron BA.2 while maintaining ancestral strain binding and neutralization. Polyclonal antibody libraries such as rCIG can be utilized to develop antibody therapeutics against present and future SARS-CoV-2 threats.
    Type of Medium: Online Resource
    ISSN: 0022-1899 , 1537-6613
    URL: Article
    DOI: 10.1093/infdis/jiad102
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1473843-0
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  • 9
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    Dentate Gyrus Somatostatin Cells are Required for Contextual Discrimination During Episodic Memory Encoding
    Oxford University Press (OUP) ; 2021
    In:  Cerebral Cortex Vol. 31, No. 2 ( 2021-01-05), p. 1046-1059
    Details
    In: Cerebral Cortex, Oxford University Press (OUP), Vol. 31, No. 2 ( 2021-01-05), p. 1046-1059
    Abstract: Memory systems ought to store and discriminate representations of similar experiences in order to efficiently guide future decisions. This problem is solved by pattern separation, implemented in the dentate gyrus (DG) by granule cells to support episodic memory formation. Pattern separation is enabled by tonic inhibitory bombardment generated by multiple GABAergic cell populations that strictly maintain low activity levels in granule cells. Somatostatin-expressing cells are one of those interneuron populations, selectively targeting the distal dendrites of granule cells, where cortical multimodal information reaches the DG. Nonetheless, somatostatin cells have very low connection probability and synaptic efficacy with both granule cells and other interneuron types. Hence, the role of somatostatin cells in DG circuitry, particularly in the context of pattern separation, remains uncertain. Here, by using optogenetic stimulation and behavioral tasks in mice, we demonstrate that somatostatin cells are required for the acquisition of both contextual and spatial overlapping memories.
    Type of Medium: Online Resource
    ISSN: 1047-3211 , 1460-2199
    URL: Article
    DOI: 10.1093/cercor/bhaa273
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 1483485-6
    SSG: 12
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  • 10
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    Clustering tomography: measuring cosmological distances through angular clustering in thin redshift shells
    Oxford University Press (OUP) ; 2014
    In:  Monthly Notices of the Royal Astronomical Society Vol. 443, No. 4 ( 2014-10-01), p. 3612-3623
    Details
    In: Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP), Vol. 443, No. 4 ( 2014-10-01), p. 3612-3623
    Type of Medium: Online Resource
    ISSN: 1365-2966 , 0035-8711
    URL: Article
    DOI: 10.1093/mnras/stu1428
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2014
    detail.hit.zdb_id: 2016084-7
    SSG: 16,12
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