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  • Oxford University Press (OUP)  (6)
  • 1
    In: Stem Cells, Oxford University Press (OUP), Vol. 31, No. 12 ( 2013-12-01), p. 2607-2619
    Abstract: Tumor cells have long been observed to share several biological characteristics with normal stem/progenitor cells; however, the oncogenic mechanisms underlying the lung stem/progenitor cell signaling remain elusive. Here, we report that SOX2, a self-renewal factor in lung stem/progenitor cells, is highly expressed in a subclass of lung cancer cells, the proliferation, survival, and chemoresistance of which are dependent on SOX2 signaling. Overexpression of SOX2 promotes oncogenic phenotypes in lung cancer cells; knockdown of SOX2 attenuated cell proliferation. We observed that SOX2 increased the expression of epidermal growth factor receptor (EGFR), and EGFR activation further upregulated SOX2 levels, forming a positive feedback loop. SOX2 expression promoted chemoresistance, and silencing of SOX2 perturbed mitochondrial function, causing marked apoptosis and autophagy. SOX2 induced BCL2L1, the ectopic expression of which rescued the effects of SOX2 silencing on apoptosis, autophagy, and mitochondrial function. SOX2 promoted tumor formation, along with increased cell proliferation in a xenograft mouse model. SOX2 expression is associated with poor prognosis in lung cancer patients; moreover, SOX2, EGFR, and BCL2L1 expression levels were significantly correlated in lung tumors. Our findings support the emerging role of SOX2 in cell proliferation and survival by eliciting oncogenic EGFR and BCL2L1 signaling with potential applications as a prognosis marker and a therapeutic target in lung cancer. Stem Cells  2013;31:2607–2619
    Type of Medium: Online Resource
    ISSN: 1066-5099 , 1549-4918
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2013
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  • 2
    In: Clinical Infectious Diseases, Oxford University Press (OUP), Vol. 74, No. 11 ( 2022-06-10), p. 1899-1905
    Abstract: Variants of concern (VoCs) have the potential to diminish the neutralizing capacity of antibodies elicited by vaccines. MVC-COV1901 is a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine consisting of recombinant prefusion stabilized spike protein S-2P adjuvanted with CpG 1018 and aluminum hydroxide. We explored the effectiveness of MVC-COV1901 against the VoCs. Methods Serum samples were taken from rats and phase 1 clinical trial human subjects immunized with a low, medium, or high dose of MVC-COV1901. The neutralizing titers of serum antibodies were assayed with pseudoviruses coated with the SARS-CoV-2 spike protein of the wild-type (WT), D614G, Alpha, or Beta variants. Results Rats vaccinated twice with vaccine containing high doses of antigen retained high levels of neutralization activity against the Beta variant, albeit with a slight reduction compared to WT. After the third dose, neutralizing titers against the Beta variant were noticeably enhanced regardless of the amount of antigen used for immunization. In humans, vaccinated phase 1 subjects still showed appreciable neutralization abilities against the D614G, Alpha, and Beta variants, although neutralizing titers were significantly reduced against the Beta variant. Conclusions Two doses of MVC-COV1901 were able to elicit neutralizing antibodies against SARS-CoV-2 variants with an overall tendency of inducing higher immune response at a higher dose level. The neutralizing titers to the Beta variant in rats and humans were lower than those for WT and the Alpha variant. An additional third dose in rats was able to partially compensate for the reduction in neutralization against the Beta variant. We have demonstrated that immunization with MVC-COV1901 was effective against VoCs.
    Type of Medium: Online Resource
    ISSN: 1058-4838 , 1537-6591
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
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  • 3
    In: Journal of Economic Entomology, Oxford University Press (OUP), Vol. 112, No. 5 ( 2019-09-23), p. 2055-2066
    Abstract: Since 2016, Apis cerana sacbrood virus (AcSBV) has been recorded in Taiwan. It is epizootic in Apis cerana (Hymenoptera: Apidae) and causing serious loss of A. cerana. Herein, we performed a long-term survey of AcSBV prevalence in the populations of A. cerana in Northern Taiwan from January 2017 to July 2018. The surveillance of AcSBV prevalence in A. mellifera (Hymenoptera: Apidae) populations was starting and further confirmed by sequencing since April 2017; thus, these data were also included in this survey. In our survey, the average prevalence rates of AcSBV were 72 and 53% in A. cerana and A. mellifera, respectively, in 2017, which decreased to 45 and 27% in 2018. For the spatial analysis of AcSBV in two honey bee populations, Hsinchu showed the highest prevalence, followed by New Taipei, Yilan, Taipei, and Keelung, suggesting that AcSBV might have come from the southern part of Taiwan. Interestingly, the AcSBV prevalence rates from A. cerana and A. mellifera cocultured apiaries gradually synchronized. The result of phylogenetic analysis and comparison of the annual AcSBV prevalence in A. cerana-only, A. mellifera-only, and A. cerana/A. mellifera cocultured sample sites indicate cross-infection between A. cerana and A. mellifera; however, AcSBV may lose the advantage of virulence in A. mellifera. The evidence suggested that the transmission of AcSBV might occur among these two honey bee species in the field. Therefore, A. mellifera may serve as a guard species to monitor AcSBV in A. cerana, but the cross-infection still needs to be surveyed.
    Type of Medium: Online Resource
    ISSN: 0022-0493 , 1938-291X
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
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  • 4
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2006
    In:  Bioinformatics Vol. 22, No. 21 ( 2006-11-01), p. 2697-2698
    In: Bioinformatics, Oxford University Press (OUP), Vol. 22, No. 21 ( 2006-11-01), p. 2697-2698
    Abstract: Summary: ArrayFusion annotates conventional CGH results and various types of microarray data from a range of platforms (cDNA, expression, exon, SNP, array-CGH and ChIP-on-chip) and converts them into standard formats which can be visualized in genome browsers (Affymetrix™ Integrated Genome Browser and GBrowse in the HapMap Project). Converted files can then be imported simultaneously into a single genome browser to benefit a collective interpretation between different array results. ArrayFusion therefore provides a new type of tool facilitating the integration of CGH and array results to provide new experimental directions. Availability:   Contact:  hwwang@ym.edu.tw
    Type of Medium: Online Resource
    ISSN: 1367-4811 , 1367-4803
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2006
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  • 5
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2001
    In:  Journal of Mechanics Vol. 17, No. 3 ( 2001-09), p. 139-147
    In: Journal of Mechanics, Oxford University Press (OUP), Vol. 17, No. 3 ( 2001-09), p. 139-147
    Abstract: The flow-induced vibration of tubes in a rotated triangular array subject to cross flow is simulated numerically. In the study, the flow field around the tube bundle is computed by solving the continuity and Navier-Stokes equations with assumption of constant fluid properties, and the kε-model for turbulent Reynolds stress. With the flow field known, the fluid forces on the tube surfaces can be calculated, and then the displacement of each tube due to the fluid force can be evaluated. Iteration is needed to obtain the dynamic response of the tube structure in the fluid flow. The parameters in the study are inlet velocity of the cross flow and properties of the tube bundle including natural frequency, damping factor, and mass. Based on the tube response, the critical flow conditions of tube vibration are determined for varying mass damping. Once tube vibrations occur, it is shown that the vibrations of the tubes in the second and fourth tube rows are significant as compared to other tubes. The orbits of the tube vibration look like an ellipse with major axis in the cross-stream direction, implying large lift force on the tubes. The dominant frequency in the spectrum of lift coefficients of the tubes is the same as the natural frequency, and the corresponding amplitude is increased with increasing the inlet velocity. The calculated data predicted for the critical reduced velocity agrees well with the data by Kassera and Strohmeier [17].
    Type of Medium: Online Resource
    ISSN: 1727-7191 , 1811-8216
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2001
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  • 6
    In: The Journal of Infectious Diseases, Oxford University Press (OUP), Vol. 216, No. 2 ( 2017-07-15), p. 245-253
    Type of Medium: Online Resource
    ISSN: 0022-1899 , 1537-6613
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2017
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