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  • Oxford University Press (OUP)  (127)
  • 1
    Online Resource
    Online Resource
    0507 A Novel Machine Learning Model to Predict Obstructive Sleep Apnea Using Craniofacial Photography with Questionnaire
    Oxford University Press (OUP) ; 2024
    In:  SLEEP Vol. 47, No. Supplement_1 ( 2024-04-20), p. A218-A218
    Details
    In: SLEEP, Oxford University Press (OUP), Vol. 47, No. Supplement_1 ( 2024-04-20), p. A218-A218
    Abstract: Obstructive sleep apnea (OSA) is a complex and heterogeneous sleep-related breathing disorder, associated with systemic consequences such as hypertension, stroke, and cardiovascular diseases. Although initial screening tools such as STOP-BANG or the Berlin questionnaires have been developed, it is still challenging to capture the wide spectrum of the condition alone. Besides the questionnaires including clinical presentations, craniofacial abnormalities are also recognized as an important risk factor for detecting OSA. Herein we aim to develop an efficient approach to predict the risk of having moderate to severe OSA using machine learning techniques by incorporating anatomical information from 2D photographs. Methods This retrospective analysis included 348 patients, who completed answering the STOP-BANG questionnaires and took facial images at Dankook University Medical Center in South Korea between 2012 and 2022. A 1:1 Random under-sampling (RUS) method was applied to solve the imbalance problem between moderate to severe OSA cases (Apnea-Hypopnea Index ≥15 events/hour) and control. Balanced data were randomly divided into two data sets (training and validation: 80%; testing: 20%). We performed leave-one-out cross-validation (LOOCV) to seek the optimal parameters to improve the model performance and generalization using four machine learning models (logistic regression, random forest, support vector machine, XGBoost) in the training set. Thereafter, we adopted the model with the highest area under the receiver operating characteristic (AUROC) in the testing set. Finally, we evaluated the importance of each input feature in assessing OSA risk by calculating the Shapley additive explanations (SHAP) values. Results The logistic regression model achieved the best AUROC of 94.1% for predicting moderate to severe risk OSA. The value of craniofacial images built from deep learning algorithms was found to be a predominant contribution in the risk screening models of OSA with the aforementioned levels of severity. Conclusion The results of the study suggest that the proposed model improved the diagnosis of patients with moderate to severe OSA based on the combination of sleep-related questionnaires and 2D facial images by identifying the risk factors more efficiently. Support (if any)  
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsae067.0507
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2024
    detail.hit.zdb_id: 2056761-3
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  • 2
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    Gallic Acid Inhibits Histamine Release and Pro-inflammatory Cytokine Production in Mast Cells
    Oxford University Press (OUP) ; 2006
    In:  Toxicological Sciences Vol. 91, No. 1 ( 2006-05-01), p. 123-131
    Details
    In: Toxicological Sciences, Oxford University Press (OUP), Vol. 91, No. 1 ( 2006-05-01), p. 123-131
    Type of Medium: Online Resource
    ISSN: 1096-6080 , 1096-0929
    URL: Article
    DOI: 10.1093/toxsci/kfj063
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2006
    detail.hit.zdb_id: 1471974-5
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  • 3
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    Mitochondrial peroxiredoxin 5 overexpression suppresses insulin-induced adipogenesis by downregulating the phosphorylation of p38
    Oxford University Press (OUP) ; 2023
    In:  Bioscience, Biotechnology, and Biochemistry Vol. 87, No. 7 ( 2023-06-23), p. 696-706
    Details
    In: Bioscience, Biotechnology, and Biochemistry, Oxford University Press (OUP), Vol. 87, No. 7 ( 2023-06-23), p. 696-706
    Abstract: Obesity is caused by the accumulation of excess lipids due to an energy imbalance. Differentiation of pre-adipocytes induces abnormal lipid accumulation, and reactive oxygen species (ROS) generated in this process promote the differentiation of pre-adipocytes through mitogen-activated protein kinase (MAPK) signaling. Peroxiredoxin (Prx) is a potent antioxidant enzyme, and peroxiredoxin 5 (Prx5), which is mainly expressed in cytosol and mitochondria, inhibits adipogenesis by regulating ROS levels. Based on previous findings, the present study was performed to investigate whether cytosolic Prx5 (CytPrx5) or mitochondrial Prx5 (MtPrx5) has a greater effect on the inhibition of adipogenesis. In this study, MtPrx5 decreased insulin-mediated ROS levels to reduce adipogenic gene expression and lipid accumulation more effectively than CytPrx5. In addition, we found that p38 MAPK mainly participates in adipogenesis. Furthermore, we verified that MtPrx5 overexpression suppressed the phosphorylation of p38 during adipogenesis. Thus, we suggest that MtPrx5 inhibits insulin-induced adipogenesis more effectively than CytPrx5.
    Type of Medium: Online Resource
    ISSN: 1347-6947
    URL: Article
    DOI: 10.1093/bbb/zbad040
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2110940-0
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  • 4
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    Association Between Weekend Catch-up Sleep and Lower Body Mass: Population-Based Study
    Oxford University Press (OUP) ; 2017
    In:  Sleep Vol. 40, No. 7 ( 2017-07)
    Details
    In: Sleep, Oxford University Press (OUP), Vol. 40, No. 7 ( 2017-07)
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsx089
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2017
    detail.hit.zdb_id: 2056761-3
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  • 5
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    Antibiotic prescription patterns during last days of hospitalized patients with advanced cancer: the role of palliative care consultation
    Oxford University Press (OUP) ; 2023
    In:  Journal of Antimicrobial Chemotherapy Vol. 78, No. 7 ( 2023-07-05), p. 1694-1700
    Details
    In: Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), Vol. 78, No. 7 ( 2023-07-05), p. 1694-1700
    Abstract: Issues regarding antibiotic use in end-of-life patients with advanced cancer present a challenging ethical dilemma in academic referral centres. This study aimed to investigate the role of palliative care consultation on antibiotic prescription patterns among hospitalized patients with advanced cancer during their last days of life. Methods This retrospective cohort study included adult patients with metastatic solid cancer admitted to a tertiary referral hospital for at least 4 days and subsequently died and who were given antibiotics 4 days before death between January 2018 and December 2021. Patients were divided into palliative care consultation (PC) and non-consultation (non-PC) groups. The outcomes were the proportion of patients who received antibiotic combination treatment, antibiotic escalation and antibiotic de-escalation within 3 days of death. Propensity score analysis with the inverse probability of the treatment weighting method was used to compare the outcomes. Results Among the 1177 patients enrolled, 476 (40.4%) received palliative care consultation and 701 (59.6%) did not. The PC group received considerably less antibiotic combination treatment (49.0% versus 61.1%, adjusted OR: 0.69, 95% CI: 0.53–0.90, P = 0.006) and antibiotic escalation (15.8% versus 34.8%, adjusted OR: 0.41, 95% CI: 0.30–0.57, P  & lt; 0.001) than the non-PC group. Additionally, the PC group reported significantly higher antibiotic de-escalation (30.7% versus 17.4%, adjusted OR: 1.74, 95% CI: 1.28–2.36, P  & lt; 0.001). Conclusion Receiving palliative care consultation may minimize aggressive antibiotic prescription patterns in the last days of patients with advanced cancer in an academic referral centre setting.
    Type of Medium: Online Resource
    ISSN: 0305-7453 , 1460-2091
    URL: Article
    DOI: 10.1093/jac/dkad156
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1467478-6
    SSG: 15,3
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  • 6
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    Noninterventional Observational Study Using High-Dose Controlled-Release Oxycodone (CR Oxycodone) for Cancer Pain Management in Outpatient Clinics
    Oxford University Press (OUP) ; 2013
    In:  Pain Medicine Vol. 14, No. 12 ( 2013-12), p. 1866-1872
    Details
    In: Pain Medicine, Oxford University Press (OUP), Vol. 14, No. 12 ( 2013-12), p. 1866-1872
    Type of Medium: Online Resource
    ISSN: 1526-2375 , 1526-4637
    URL: Article
    DOI: 10.1111/pme.12228
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2013
    detail.hit.zdb_id: 2023869-1
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  • 7
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    The impact of palliative care consultation on reducing antibiotic overuse in hospitalized patients with terminal cancer at the end of life: a propensity score-weighting study
    Oxford University Press (OUP) ; 2023
    In:  Journal of Antimicrobial Chemotherapy Vol. 78, No. 1 ( 2023-01-05), p. 302-308
    Details
    In: Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), Vol. 78, No. 1 ( 2023-01-05), p. 302-308
    Abstract: A substantial number of hospitalized patients with terminal cancer at the end-of-life phase receive antibiotics, even with imminent death. We evaluated the impact of palliative care consultation on antibiotic use in hospitalized patients with terminal cancer during the end-of-life phase. Methods We identified adult patients with metastatic solid cancer who died at a tertiary medical centre in Seoul, Republic of Korea, following at least 4 days of hospitalization (January 2018–December 2020). Patients were divided into palliative and non-palliative care consultation groups. Propensity score-weighted, multivariable logistic regression analysis was used to compare the proportion of patients receiving antibiotics within 3 days before death between the two groups. Results Among 1143 patients analysed, 940 (82.2%) received antibiotics within 3 days before death. The proportion of patients receiving antibiotics was significantly lower (propensity score-weighted P  & lt; 0.001) in the palliative care consultation group (344/468; 73.5%) than in the non-palliative care consultation group (596/675; 88.3%). The decrease in the proportion of patients receiving antibiotics in the palliative care consultation group was significant for a carbapenem (42.4% versus 22.4%; P  & lt; 0.001), a glycopeptide (23.3% versus 11.1%; P  & lt; 0.001) and a quinolone (30.5% versus 19.4%; P = 0.012). In the multivariable logistic regression analysis, receiving palliative care consultation (adjusted OR 0.46, 95% CI 0.33–0.65; P  & lt; 0.001) was independently associated with reduced antibiotic use during the end-of-life phase. Conclusions Palliative care consultation may reduce aggressive antibiotic use in hospitalized patients with terminal cancer during the end-of-life phase.
    Type of Medium: Online Resource
    ISSN: 0305-7453 , 1460-2091
    URL: Article
    DOI: 10.1093/jac/dkac405
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1467478-6
    SSG: 15,3
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  • 8
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    Induction of Thioredoxin Is Required for Nodule Development to Reduce Reactive Oxygen Species Levels in Soybean Roots
    Oxford University Press (OUP) ; 2005
    In:  Plant Physiology Vol. 139, No. 4 ( 2005-12-01), p. 1881-1889
    Details
    In: Plant Physiology, Oxford University Press (OUP), Vol. 139, No. 4 ( 2005-12-01), p. 1881-1889
    Abstract: Nodules are formed on legume roots as a result of signaling between symbiotic partners and in response to the activities of numerous genes. We cloned fragments of differentially expressed genes in spot-inoculated soybean (Glycine max) roots. Many of the induced clones were similar to known genes related to oxidative stress, such as thioredoxin and β-carotene hydroxylase. The deduced amino acid sequences of full-length soybean cDNAs for thioredoxin and β-carotene hydroxylase were similar to those in other species. In situ RNA hybridization revealed that the thioredoxin gene is expressed on the pericycle of 2-d-old nodules and in the infected cells of mature nodules, suggesting that thioredoxin is involved in nodule development. The thioredoxin promoter was found to contain a sequence resembling an antioxidant responsive element. When a thioredoxin mutant of yeast was transformed with the soybean thioredoxin gene it became hydrogen peroxide tolerant. These observations prompted us to measure reactive oxygen species levels. These were decreased by 3- to 5-fold in 7-d-old and 27-d-old nodules, coincident with increases in the expression of thioredoxin and β-carotene hydroxylase genes. Hydrogen peroxide-producing regions identified with cerium chloride were found in uninoculated roots and 2-d-old nodules, but not in 7-d-old and 27-d-old nodules. RNA interference-mediated repression of the thioredoxin gene severely impaired nodule development. These data indicate that antioxidants such as thioredoxin are essential to lower reactive oxygen species levels during nodule development.
    Type of Medium: Online Resource
    ISSN: 1532-2548 , 0032-0889
    URL: Article
    DOI: 10.1104/pp.105.067884
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2005
    detail.hit.zdb_id: 2004346-6
    detail.hit.zdb_id: 208914-2
    SSG: 12
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  • 9
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    Rice Aldehyde Dehydrogenase7 Is Needed for Seed Maturation and Viability    
    Oxford University Press (OUP) ; 2009
    In:  Plant Physiology Vol. 149, No. 2 ( 2009-02-06), p. 905-915
    Details
    In: Plant Physiology, Oxford University Press (OUP), Vol. 149, No. 2 ( 2009-02-06), p. 905-915
    Abstract: Aldehyde dehydrogenases (ALDHs) catalyze the irreversible oxidation of a wide range of reactive aldehydes to their corresponding carboxylic acids. Although the proteins have been studied from various organisms and at different growth stages, their roles in seed development have not been well elucidated. We obtained T-DNA insertional mutants in OsALDH7, which is remarkably inducible by oxidative and abiotic stresses. Interestingly, endosperms from the osaldh7 null mutants accumulated brown pigments during desiccation and storage. Extracts from the mutant seeds showed a maximum absorbance peak at 360 nm, the wavelength that melanoidin absorbs. Under UV light, those extracts also exhibited much stronger fluorescence than the wild type, suggesting that the pigments are melanoidin. These pigments started to accumulate in the late seed developmental stage, the time when OsALDH7 expression began to increase significantly. Purified OsALDH7 protein showed enzyme activities to malondialdehyde, acetaldehyde, and glyceraldehyde. These results suggest that OsALDH7 is involved in removing various aldehydes formed by oxidative stress during seed desiccation. The mutant seeds were more sensitive to our accelerated aging treatment and accumulated more malondialdehyde than the wild type. These data imply that OsALDH7 plays an important role in maintaining seed viability by detoxifying the aldehydes generated by lipid peroxidation.
    Type of Medium: Online Resource
    ISSN: 1532-2548
    URL: Article
    DOI: 10.1104/pp.108.130716
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2009
    detail.hit.zdb_id: 2004346-6
    detail.hit.zdb_id: 208914-2
    SSG: 12
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  • 10
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    Efficacy and Safety of FOLFIRI Regimen in Elderly Versus Nonelderly Patients with Metastatic Colorectal or Gastric Cancer
    Oxford University Press (OUP) ; 2017
    In:  The Oncologist Vol. 22, No. 3 ( 2017-03-01), p. 293-303
    Details
    In: The Oncologist, Oxford University Press (OUP), Vol. 22, No. 3 ( 2017-03-01), p. 293-303
    Abstract: Irinotecan-based chemotherapy is a standard backbone of therapy in patients with metastatic colorectal cancer (CRC) or gastric cancer (GC). However, there is still a paucity of information concerning the efficacy and safety of irinotecan-based regimens in elderly patients. Patients and Methods Using the patient cohort (n = 1,545) from the UGT1A1 genotype study, we compared the efficacy and safety between elderly and nonelderly patients with metastatic CRC (n = 934) or GC (n = 611) who received first- or second-line FOLFIRI (irinotecan, leucovorin, and 5-fluorouracil) chemotherapy. Results Despite lower relative dose intensity in elderly patients, progression-free survival and overall survival were similar between elderly (age ≥70 years) and nonelderly ( & lt;70 years) patients in the CRC cohort (hazard ratio [HR], 1.117; 95% confidence interval [CI] , 0.927–1.345; p = .244, and HR, 0.989; 95% CI, 0.774–1.264; p = .931, respectively) and the GC cohort (HR, 1.093; 95% CI, 0.854–1.400; p = .479, and HR, 1.188; 95% CI, 0.891–1.585; p = .241, respectively). In both cohorts, febrile neutropenia (22.1% vs. 14.6% in CRC cohort and 35.2% vs. 22.5% in GC cohort) and asthenia (grade 3: 8.4% vs. 1.7% in CRC cohort and 5.5% vs. 2.9% in GC cohort) were more frequent in elderly patients. In the CRC cohort, mucositis and anorexia were more frequent in elderly patients. In the GC cohort, nausea and vomiting were less frequent in elderly patients. Conclusion The efficacy of the FOLFIRI regimen was similar between elderly and nonelderly patients in both the CRC and the GC cohorts. However, special attention should be paid to elderly patients because of increased risk for febrile neutropenia and asthenia.
    Type of Medium: Online Resource
    ISSN: 1083-7159 , 1549-490X
    URL: Article
    DOI: 10.1634/theoncologist.2016-0166
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2017
    detail.hit.zdb_id: 2023829-0
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