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  • Oxford University Press (OUP)  (5)
  • 1
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2016
    In:  Journal of the Royal Statistical Society Series B: Statistical Methodology Vol. 78, No. 5 ( 2016-11-01), p. 1037-1055
    In: Journal of the Royal Statistical Society Series B: Statistical Methodology, Oxford University Press (OUP), Vol. 78, No. 5 ( 2016-11-01), p. 1037-1055
    Abstract: We propose a non-parametric variable selection method which does not rely on any regression model or predictor distribution. The method is based on a new statistical relationship, called additive conditional independence, that has been introduced recently for graphical models. Unlike most existing variable selection methods, which target the mean of the response, the method proposed targets a set of attributes of the response, such as its mean, variance or entire distribution. In addition, the additive nature of this approach offers non-parametric flexibility without employing multi-dimensional kernels. As a result it retains high accuracy for high dimensional predictors. We establish estimation consistency, convergence rate and variable selection consistency of the method proposed. Through simulation comparisons we demonstrate that the method proposed performs better than existing methods when the predictor affects several attributes of the response, and it performs competently in the classical setting where the predictors affect the mean only. We apply the new method to a data set concerning how gene expression levels affect the weight of mice.
    Type of Medium: Online Resource
    ISSN: 1369-7412 , 1467-9868
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2016
    detail.hit.zdb_id: 204795-0
    detail.hit.zdb_id: 1490719-7
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  • 2
    In: Database, Oxford University Press (OUP), Vol. 2023 ( 2023-01-19)
    Abstract: ENCD (http://www.bio-server.cn/ENCD/) is a manually curated database that provides comprehensive experimentally supported associations among endocrine system diseases (ESDs) and long non-coding ribonucleic acid (lncRNAs). The incidence of ESDs has increased in recent years, often accompanying other chronic diseases, and can lead to disability. A growing body of research suggests that lncRNA plays an important role in the progression and metastasis of ESDs. However, there are no resources focused on collecting and integrating the latest and experimentally supported lncRNA–ESD associations. Hence, we developed an ENCD database that consists of 1379 associations between 35 ESDs and 501 lncRNAs in 12 human tissues curated from literature. By using ENCD, users can explore the genetic data for diseases corresponding to the body parts of interest as well as study the lncRNA regulating mechanism for ESDs. ENCD also provides a flexible tool to visualize a disease- or gene-centric regulatory network. In addition, ENCD offers a submission page for researchers to submit their newly discovered endocrine disorders-genetic data entries online. Collectively, ENCD will provide comprehensive insights for investigating the ESDs associated with lncRNAs. Database URL http://www.bio-server.cn/ENCD
    Type of Medium: Online Resource
    ISSN: 1758-0463
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2496706-3
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  • 3
    In: G3 Genes|Genomes|Genetics, Oxford University Press (OUP), Vol. 8, No. 3 ( 2018-03-01), p. 887-897
    Abstract: Vector-borne diseases are responsible for & gt; 1 million deaths every year but genomic resources for most species responsible for their transmission are limited. This is true for neglected diseases such as sleeping sickness (Human African Trypanosomiasis), a disease caused by Trypanosoma parasites vectored by several species of tseste flies within the genus Glossina. We describe an integrative approach that identifies statistical associations between trypanosome infection status of Glossina fuscipes fuscipes (Gff) flies from Uganda, for which functional studies are complicated because the species cannot be easily maintained in laboratory colonies, and ∼73,000 polymorphic sites distributed across the genome. Then, we identify candidate genes involved in Gff trypanosome susceptibility by taking advantage of genomic resources from a closely related species, G. morsitans morsitans (Gmm). We compiled a comprehensive transcript library from 72 published and unpublished RNAseq experiments of trypanosome-infected and uninfected Gmm flies, and improved the current Gmm transcriptome assembly. This new assembly was then used to enhance the functional annotations on the Gff genome. As a consequence, we identified 56 candidate genes in the vicinity of the 18 regions associated with Trypanosoma infection status in Gff. Twenty-nine of these genes were differentially expressed (DE) among parasite-infected and uninfected Gmm, suggesting that their orthologs in Gff may correlate with disease transmission. These genes were involved in DNA regulation, neurophysiological functions, and immune responses. We highlight the power of integrating population and functional genomics from related species to enhance our understanding of the genetic basis of physiological traits, particularly in nonmodel organisms.
    Type of Medium: Online Resource
    ISSN: 2160-1836
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2018
    detail.hit.zdb_id: 2629978-1
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  • 4
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2019
    In:  Interactive CardioVascular and Thoracic Surgery Vol. 28, No. 2 ( 2019-02-01), p. 291-300
    In: Interactive CardioVascular and Thoracic Surgery, Oxford University Press (OUP), Vol. 28, No. 2 ( 2019-02-01), p. 291-300
    Type of Medium: Online Resource
    ISSN: 1569-9293 , 1569-9285
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2096257-5
    detail.hit.zdb_id: 3167862-2
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  • 5
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2016
    In:  Biometrika Vol. 103, No. 3 ( 2016-09), p. 513-530
    In: Biometrika, Oxford University Press (OUP), Vol. 103, No. 3 ( 2016-09), p. 513-530
    Type of Medium: Online Resource
    ISSN: 0006-3444 , 1464-3510
    RVK:
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    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2016
    detail.hit.zdb_id: 1119-8
    detail.hit.zdb_id: 1470319-1
    SSG: 12
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