GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Association of thyroid function with estimated glomerular filtration rate in a population-based study: the HUNT study
    Oxford University Press (OUP) ; 2011
    In:  European Journal of Endocrinology Vol. 164, No. 1 ( 2011-01), p. 101-105
    Details
    In: European Journal of Endocrinology, Oxford University Press (OUP), Vol. 164, No. 1 ( 2011-01), p. 101-105
    Abstract: Low thyroid function may be associated with reduced glomerular filtration rate (GFR). We therefore studied the association of thyroid function with estimated GFR (eGFR) in a population-based study. Design A cross-sectional, population-based study of 29 480 individuals above 40 years of age, without previously known thyroid disease. Methods We calculated geometric mean eGFR and odds ratio (OR) of chronic kidney disease (CKD; eGFR 〈 60 ml/min per 1.73 m 2 ) according to categories of thyroid function, using people with TSH in the lower third of the reference range (0.50–1.4 mU/l) as the comparison group. Results TSH within the reference range (0.50–3.5 mU/l) was negatively associated with eGFR ( P for trend 〈 0.001). Compared with people with TSH in the lower third of the reference range (83.0 ml/min per 1.73 m 2 ), eGFR was lower in people with TSH in the middle (81.6 ml/min per 1.73 m 2 ) and highest third (80.3 ml/min per 1.73 m 2 ) of the reference range, and in people with subclinical (79.3 ml/min per 1.73 m 2 , P 〈 0.001) or overt hypothyroidism (76.5 ml/min per 1.73 m 2 , P 〈 0.001). The prevalence of CKD was higher in people with TSH in the middle (OR 1.20, 95% confidence interval (CI) 1.07–1.35) or highest third (OR 1.31, 95% CI 1.13–1.52) of the reference range, compared with people in the reference group. Also, CKD was more common in people with subclinical (OR 1.63, 95% CI 1.38–1.93) or overt (OR 1.98, 95% CI 1.22–3.20) hypothyroidism. Conclusions These findings suggest that low thyroid function, also within the clinically normal range, is associated with reduced GFR.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/EJE-10-0705
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 2011
    detail.hit.zdb_id: 1485160-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Epidermal growth factor stimulates the prolactin synthesis and secretion in rat pituitary cells in culture (GH4C1 cells) by increasing the intracellular concentration of free calcium
    Oxford University Press (OUP) ; 1993
    In:  Acta Endocrinologica Vol. 128, No. 4 ( 1993-04), p. 361-366
    Details
    In: Acta Endocrinologica, Oxford University Press (OUP), Vol. 128, No. 4 ( 1993-04), p. 361-366
    Abstract: Epidermal growth factor (EGF) stimulated the prolactin (PRL) synthesis and release from the GH 4 C 1 cells in a dose-dependent manner. The ED 50 was between 10 −11 and 10 −10 mol/l. The maximal effect was obtained at 10 −9 mol/l EGF for the release, and 10 −8 mol/l EGF for the synthesis. EGF stimulated the release of PRL from cell perfusion columns after a lag period of about 30 s. The maximal secretion of PRL occurred about 60 s after the start of stimulation. The PRL secretion declined to basal levels within 2 min. The EGF-stimulated PRL release was additive to the secretion evoked by thyrotropin-releasing hormone (TRH) and vasoactive intestinal peptide (VIP). An instantaneous increase in the intracellular concentration of free calcium, [Ca 2+ ] i , of the GH 4 C 1 cells was observed after the administration of EGF. EGF modified neither the basal nor the TRH-stimulated inositoltrisphosphate production in the GH 4 C 1 cells, and EGF did not show any effect on the cyclic adenosine monophosphate production of these cells.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/acta.0.1280361
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 1993
    detail.hit.zdb_id: 1485160-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Hyperthyroid levels of TSH correlate with low bone mineral density: the HUNT 2 study
    Oxford University Press (OUP) ; 2009
    In:  European Journal of Endocrinology Vol. 161, No. 5 ( 2009-11), p. 779-786
    Details
    In: European Journal of Endocrinology, Oxford University Press (OUP), Vol. 161, No. 5 ( 2009-11), p. 779-786
    Abstract: To study the relationship between TSH and forearm bone mineral density (BMD) in a general female population. Design Cross-sectional, population-based study. Methods In a substudy of the Nord-Trøndelag Health Study 1995–1997 (HUNT 2), 5778 women without and 944 with self-reported thyroid disease aged ≥40 years had their serum TSH and distal and ultra-distal forearm BMD measured. In range-based categories of TSH, excluding women with previous thyroid disease, a general linear model was used to calculate adjusted mean BMD, and a logistic regression model to compute adjusted odds ratio (OR) for osteopenia and osteoporosis. Corresponding models were used to compare BMD in women with self-reported hypothyroidism or hyperthyroidism to euthyroid women. Results In women without self-reported thyroid disease, those with TSH 〈 0.5 mU/l had 10.7 mg/cm 2 (95% confidence interval (CI) 0.2–21.1) lower distal and 9.1 mg/cm 2 (95% CI −0.7–18.9) lower ultra-distal BMD than women in the reference category (TSH 0.50–1.49 mU/l). No differences were found between the categories with TSH ≥0.50 mU/l. Compared to self-reported euthyroid women, self-reported hyperthyroid women had increased odds for osteoporosis both distally (OR 1.35, 95% CI 1.00–1.82) and ultra-distally (OR 1.48, 95% CI 1.10–1.99). Conclusion Women with the lowest TSH ( 〈 0.5 mU/l) had lower forearm BMD than the reference category. No differences were observed between the TSH categories ≥0.50 mU/l. The prevalence of osteoporosis was higher in women who reported hyperthyroidism than in women without self-reported thyroid disease.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/EJE-09-0139
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 2009
    detail.hit.zdb_id: 1485160-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Association of thyroid function with estimated glomerular filtration rate in a population-based study: the HUNT study
    Oxford University Press (OUP) ; 2011
    In:  European Journal of Endocrinology Vol. 164, No. 2 ( 2011-02), p. 316-
    Details
    In: European Journal of Endocrinology, Oxford University Press (OUP), Vol. 164, No. 2 ( 2011-02), p. 316-
    Abstract: The journal and the authors apologise for an error in this article published in the European Journal of Endocrinology (2011) 164 101–105 . The caption to Table 4 on page 104 was wrongly printed and the correct caption and table is printed in full below. Table 4 Geometric mean eGFR (ml/min per 1.73 m2) by categories of thyroid function and age, adjusted for sex, age and smoking. Age 〈 70 years ( n =22 071) Age ≥70 years ( n =7409) eGFR 95% CI eGFR 95% CI Hyperthyroidism Overt 120.5 113.5 128.0 87.0 78.9 96.0 Subclinical 91.7 89.9 93.4 76.4 73.4 79.5 TSH (mU/l) 0.50–1.4 89.9 89.6 90.3 75.3 74.4 76.2 1.5–2.4 88.5 88.1 88.9 73.5 72.6 74.4 2.5–3.5 87.0 86.3 87.7 72.6 71.4 73.8 Hypothyroidism Subclinical 86.5 85.5 87.4 70.7 69.3 72.2 Overt 83.3 80.5 86.4 68.3 63.3 73.6
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/EJE-10-0705e
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 2011
    detail.hit.zdb_id: 1485160-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Ovarian stimulation in previous failures from in-vitro fertilization: distinction of two groups of poor responders
    Oxford University Press (OUP) ; 1990
    In:  Human Reproduction Vol. 5, No. 7 ( 1990-10), p. 811-815
    Details
    In: Human Reproduction, Oxford University Press (OUP), Vol. 5, No. 7 ( 1990-10), p. 811-815
    Type of Medium: Online Resource
    ISSN: 1460-2350 , 0268-1161
    URL: Article
    DOI: 10.1093/oxfordjournals.humrep.a137188
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1990
    detail.hit.zdb_id: 1484864-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function
    Oxford University Press (OUP) ; 2012
    In:  Human Molecular Genetics Vol. 21, No. 14 ( 2012-7-15), p. 3275-3282
    Details
    In: Human Molecular Genetics, Oxford University Press (OUP), Vol. 21, No. 14 ( 2012-7-15), p. 3275-3282
    Type of Medium: Online Resource
    ISSN: 1460-2083 , 0964-6906
    URL: Article
    DOI: 10.1093/hmg/dds136
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2012
    detail.hit.zdb_id: 1474816-2
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study
    Oxford University Press (OUP) ; 2007
    In:  European Journal of Endocrinology Vol. 156, No. 2 ( 2007-02), p. 181-186
    Details
    In: European Journal of Endocrinology, Oxford University Press (OUP), Vol. 156, No. 2 ( 2007-02), p. 181-186
    Abstract: Objective : The association between TSH and serum lipids in people with no apparent thyroid disease is insufficiently understood. We have studied the association between normal thyroid function, defined as TSH within the reference range of a general population, and concentrations of serum lipids. Design : Cross-sectional, population-based study with 30 656 individuals without known thyroid disease. Methods : Using general linear models, we calculated mean concentrations of total serum cholesterol, low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (HDL) cholesterol, HDL cholesterol and triglycerides across categories of TSH. Results : Within the reference range of TSH, there was a linear and significant ( P for trend 〈 0.001) increase in total serum cholesterol, LDL cholesterol, non-HDL cholesterol and triglycerides, and a linear decrease ( P for trend 〈 0.001) in HDL cholesterol with increasing TSH. Subgroup analyses showed statistically significant associations for all lipids in men above 50 years of age, and for triglycerides in all age groups. For women, associations were statistically significant in all age groups except for HDL cholesterol in women below 50 years of age. The associations with triglycerides and HDL cholesterol were stronger among overweight than normal weight individuals. Conclusions : Within the range of TSH that is considered clinically normal, we found that increasing level of TSH was associated with less favourable lipid concentrations. The association with serum lipids was linear across the entire reference range of TSH.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/eje.1.02333
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 2007
    detail.hit.zdb_id: 1485160-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Associations of TSH levels within the reference range with future blood pressure and lipid concentrations: 11-year follow-up of the HUNT study
    Oxford University Press (OUP) ; 2013
    In:  European Journal of Endocrinology Vol. 169, No. 1 ( 2013-07), p. 73-82
    Details
    In: European Journal of Endocrinology, Oxford University Press (OUP), Vol. 169, No. 1 ( 2013-07), p. 73-82
    Abstract: In cross-sectional studies, TSH levels within the reference range have been positively associated with blood pressure and adverse serum lipid levels. In a prospective study, we aimed to determine whether differences in TSH levels within the reference range are associated with future levels of blood pressure and lipids. Design We conducted a prospective population-based study. Methods In 9709 women and 4644 men without previous thyroid disease who had a baseline TSH level of 0.45–4.5 mU/l, we studied the associations of baseline TSH levels with blood pressure and lipid levels at follow-up 11 years later. Results Higher TSH levels at baseline were associated with higher systolic ( P =0.002 in women) and diastolic ( P =0.03 in women) blood pressure, non-HDL cholesterol ( P =0.01 in men) and triglyceride ( P =0.008 in men) levels and lower HDL cholesterol levels ( P 〈 0.001 in women and men) at follow-up, but the associations were very modest and not consistent between the sexes. Among people who remained free of thyroid disease, changes in TSH levels during follow-up were associated with concomitant changes in systolic and diastolic blood pressure, non-HDL cholesterol and triglyceride levels (all P 〈 0.001), with similar results being observed for women and men. Thus, blood pressure and lipid levels increased among people with an increase in TSH levels and decreased among people with a decrease in TSH levels compared with people with no change in TSH levels. Conclusions High TSH levels within the reference range may be associated with modestly higher future levels of blood pressure and adverse serum lipids. TSH levels may co-vary with blood pressure and lipid levels among people with apparently normal thyroid function.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/EJE-13-0087
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 2013
    detail.hit.zdb_id: 1485160-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Changes in the prevalence of hypothyroidism: the HUNT Study in Norway
    Oxford University Press (OUP) ; 2013
    In:  European Journal of Endocrinology Vol. 169, No. 5 ( 2013-11), p. 613-620
    Details
    In: European Journal of Endocrinology, Oxford University Press (OUP), Vol. 169, No. 5 ( 2013-11), p. 613-620
    Abstract: Untreated hypothyroidism is common in iodine-replete areas. Frequent thyroid function testing and use of levothyroxine treatment for subclinical hypothyroidism suggest that the prevalence may have decreased. Therefore, in this study, we examined changes in the prevalence of hypothyroidism in a Norwegian county from 1995–1997 to 2006–2008. Design Population surveys of 33 917 individuals in 1995–1997 and 49 180 individuals in 2006–2008 were carried out. Methods We compared the prevalence of untreated overt, untreated subclinical, and treated hypothyroidism between 1995–1997 and 2006–2008. Results The prevalence of untreated overt hypothyroidism among women decreased by 84% from 1995–1997 (0.75%) to 2006–2008 (0.12%) (prevalence ratio (PR) 0.16; 95% CI 0.10–0.26). The corresponding decrease among men was 43% from 0.21 to 0.12% (PR 0.57; 95% CI 0.28–1.16). The prevalence of untreated subclinical hypothyroidism decreased by 64% from 3.0 to 1.1% in women (PR 0.36; 95% CI 0.31–0.42) and decreased by 54% from 2.1 to 1.0% in men (PR 0.46; 95% CI 0.38–0.56). Conversely, the prevalence of treated hypothyroidism among women increased by 60% from 5.0 to 8.0% (PR 1.60, 95% CI 1.50–1.71), and the corresponding prevalence in men doubled from 1.0 to 2.0% (PR 1.96; 95% CI 1.59–2.41). The prevalence of any form of hypothyroidism remained essentially similar at 9% in women and 3% in men. Conclusions The prevalence of untreated hypothyroidism in this Norwegian county decreased strongly from 1995–1997 to 2006–2008. The findings suggest that the prevalence of untreated hypothyroidism in populations with easy access to thyroid function testing and levothyroxine treatment may now be low.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/EJE-13-0459
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 2013
    detail.hit.zdb_id: 1485160-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Low thyroid function is not associated with an accelerated deterioration in renal function
    Oxford University Press (OUP) ; 2019
    In:  Nephrology Dialysis Transplantation Vol. 34, No. 4 ( 2019-04-01), p. 650-659
    Details
    In: Nephrology Dialysis Transplantation, Oxford University Press (OUP), Vol. 34, No. 4 ( 2019-04-01), p. 650-659
    Abstract: Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone alterations on renal function in cross-sectional and longitudinal analyses in individuals from all adult age groups. Methods Individual participant data (IPD) from 16 independent cohorts having measured thyroid stimulating hormone, free thyroxine levels and creatinine levels were included. Thyroid hormone status was defined using clinical cut-off values. Estimated glomerular filtration rates (eGFR) were calculated by means of the four-variable Modification of Diet in Renal Disease (MDRD) formula. For this IPD meta-analysis, eGFR at baseline and eGFR change during follow-up were computed by fitting linear regression models and linear mixed models in each cohort separately. Effect estimates were pooled using random effects models. Results A total of 72 856 individuals from 16 different cohorts were included. At baseline, individuals with overt hypothyroidism (n = 704) and subclinical hypothyroidism (n = 3356) had a average (95% confidence interval) −4.07 (−6.37 to −1.78) and −2.40 (−3.78 to −1.02) mL/min/1.73 m2 lower eGFR as compared with euthyroid subjects (n = 66 542). In (subclinical) hyperthyroid subjects (n = 2254), average eGFR was 3.01 (1.50–4.52) mL/min/1.73 m2 higher. During 329 713 patient years of follow-up, eGFR did not decline more rapidly in individuals with low thyroid function compared with individuals with normal thyroid function. Conclusions Low thyroid function is not associated with a deterioration of renal function. The cross-sectional association may be explained by renal dysfunction causing thyroid hormone alterations.
    Type of Medium: Online Resource
    ISSN: 0931-0509 , 1460-2385
    URL: Article
    DOI: 10.1093/ndt/gfy071
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 1465709-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...