In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 45, No. 4_Suppl ( 1964-04), p. S35-S56
Abstract:
A human hypophysial gonadotrophin (HHG) and three human menopausal gonadotrophin (HMG) preparations were administered to 6 amenorrhoeic women for 8 to 10 days in 19 experiments. This was followed by daily injections of human chorionic gonadotrophin (HCG) for 4 days. The clinical and steroid metabolic effects of the preparations were assessed by serial endometrial biopsies, daily vaginal smears and by the determination of urinary oestrone, 17β-oestradiol, oestriol, pregnane3α,20α-diol, 17-ketosteroids and 17-hydroxycorticosteroids in 48-hour samples. There was a four-fold difference in the follicle stimulating hormone (FSH) activity of two commercial HMG preparations, although their »total gonadotrophin« activity was identical. The clinical effectiveness of the various gonadotrophin preparations was found to be a function of the amount of FSH– rather than »total gonadotrophic« activity administered. When a total dose of some 15 000 International Reference Preparation (I. R. P.) units of FSH activity of whatever origin was administered prior to HCG, there was invariably a marked clinical and steroid metabolic effect, suggesting very strongly that ovulation had indeed been induced. In such experiments the urinary oestrogen and pregnanediol excretion always significantly exceeded the values found in non-pregnant women. Four patients attempted to conceive during the period when ovulation was presumed to occur. Two of them became pregnant; one delivered a normal child, the other aborted in the third month of gestation. It is concluded that in addition to human hypophysial gonadotrophins, human menopausal gonadotrophin preparations in combination with HCG are also completely satisfactory for the induction of ovulation in amenorrhoeic women. A prerequisite for the successful clinical use of such preparations is, however, adequate information on their specific FSH (and perhaps also ICSH) activity.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.045S035
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1964
detail.hit.zdb_id:
1485160-X
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