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  • Oxford University Press (OUP)  (11)
  • 1
    Online Resource
    Online Resource
    A piggyBac insertion disrupts Foxl2 expression that mimics BPES syndrome in mice
    Oxford University Press (OUP) ; 2014
    In:  Human Molecular Genetics Vol. 23, No. 14 ( 2014-07-15), p. 3792-3800
    Details
    In: Human Molecular Genetics, Oxford University Press (OUP), Vol. 23, No. 14 ( 2014-07-15), p. 3792-3800
    Type of Medium: Online Resource
    ISSN: 1460-2083 , 0964-6906
    URL: Article
    DOI: 10.1093/hmg/ddu092
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2014
    detail.hit.zdb_id: 1474816-2
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Determination of Parent and Oxygenated Polycyclic Aromatic Hydrocarbons (PAHs) in Waste Cooking Oil and Oil Deodorizer Distillate by GC–QQQ–MS
    Oxford University Press (OUP) ; 2019
    In:  Journal of AOAC INTERNATIONAL Vol. 102, No. 6 ( 2019-11-01), p. 1884-1891
    Details
    In: Journal of AOAC INTERNATIONAL, Oxford University Press (OUP), Vol. 102, No. 6 ( 2019-11-01), p. 1884-1891
    Abstract: Background: Polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (OPAHs) are classes of contaminants that are present in the environment and food. They pose a great threat to human health because of their carcinogenicity and mutagenicity. Very few studies have focused on their concentration in waste cooking oil (WCO) and oil deodorizer distillate (ODD). Objective: This study aimed (1) to design a reliable method to determine 16 PAHs and 4 OPAHs in both WCO and ODD and (2) to determine and analyze PAH and OPAH concentrations in actual samples to provide references for further research. Method: The PAH determination approach included double liquid–liquid extraction, double solid-phase extraction, and GC–triple quadrupole tandem MS determination. Oxidation indices were determined by titrimetry. Results: The method reached good linearity (R2 & gt; 0.99) and an acceptable recovery rate (55.01–126.16% for WCO and 57.48–128.97% for ODD). Ten WCO and five ODD samples were determined, and the total concentration of 16 PAHs varied from 16.34 to 239.01 and 101.08 to 198.04 μg/kg in WCO and ODD, respectively. Among the 16 PAHs, three-ring PAHs typically contributed the most. It was also found that the acid value has a strong correlation with the concentration of OPAHs, probably because of the contribution of free fatty acids to OPAH formation. Conclusions: The proposed method was effective in the analysis of PAHs and OPAHs in WCO and ODD.
    Type of Medium: Online Resource
    ISSN: 1060-3271 , 1944-7922
    URL: Article
    DOI: 10.1093/jaoac/102.6.1884
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
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  • 3
    Online Resource
    Online Resource
    Determination of Parent and Oxygenated Polycyclic Aromatic Hydrocarbons (PAHs) in Waste Cooking Oil and Oil Deodorizer Distillate by GC–QQQ–MS
    Oxford University Press (OUP) ; 2019
    In:  Journal of AOAC International Vol. 102, No. 6 ( 2019-11-01), p. 1884-1891
    Details
    In: Journal of AOAC International, Oxford University Press (OUP), Vol. 102, No. 6 ( 2019-11-01), p. 1884-1891
    Abstract: Background: Polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (OPAHs) are classes of contaminants that are present in the environment and food. They pose a great threat to human health because of their carcinogenicity and mutagenicity. Very few studies have focused on their concentration in waste cooking oil (WCO) and oil deodorizer distillate (ODD). Objective: This study aimed ( 1 ) to design a reliable method to determine 16 PAHs and 4 OPAHs in both WCO and ODD and ( 2 ) to determine and analyze PAH and OPAH concentrations in actual samples to provide references for further research. Method: The PAH determination approach included double liquid–liquid extraction, double solid-phase extraction, and GC–triple quadrupole tandem MS determination. Oxidation indices were determined by titrimetry. Results: The method reached good linearity ( R 2 〉 0.99) and an acceptable recovery rate (55.01–126.16% for WCO and 57.48–128.97% for ODD). Ten WCO and five ODD samples were determined, and the total concentration of 16 PAHs varied from 16.34 to 239.01 and 101.08 to 198.04 μg/kg in WCO and ODD, respectively. Among the 16 PAHs, three-ring PAHs typically contributed the most. It was also found that the acid value has a strong correlation with the concentration of OPAHs, probably because of the contribution of free fatty acids to OPAH formation. Conclusions: The proposed method was effective in the analysis of PAHs and OPAHs in WCO and ODD.
    Type of Medium: Online Resource
    ISSN: 1060-3271
    URL: Article
    DOI: 10.5740/jaoacint.19-0085
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
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  • 4
    Online Resource
    Online Resource
    Developing an authentication approach using SPME-GC-IRMS based on compound-specific δ 13C analysis of six typical volatiles in wine
    Oxford University Press (OUP) ; 2021
    In:  Food Quality and Safety Vol. 5 ( 2021-01-01)
    Details
    In: Food Quality and Safety, Oxford University Press (OUP), Vol. 5 ( 2021-01-01)
    Abstract: An analytical method using gas chromatography isotope ratio mass spectrometry (GC-IRMS) combined with solid phase micro-extraction (SPME) was developed to measure the δ 13C values of six typical volatiles commonly occurring in wine (isoamyl acetate, 2-octanone, limonene, 2-phenylethanol, ethyl octanoate and ethyl decanoate) for the first time. SPME selected with a divinylbenzene/carboxen/polydimethylsiloxane fiber was combined with the GC-IRMS for pretreatment optimization. The optimized SPME parameters of extraction time, extraction temperature and salt concentration were 40 min, 40 °C and 10%, respectively. The δ 13C values measured by SPME-GC-IRMS were in good agreement with those measured via elemental analyzer (EA)-IRMS and GC-IRMS. The differences range from 0.02 to 0.44‰ with EA-IRMS and from 0 to 0.28‰ with GC-IRMS, indicating the high accuracy of the method. This newly established method measured the precision within 0.30‰ and was successfully validated to discriminate imported real wine samples with identical label but amazing price differences from different importers.
    Type of Medium: Online Resource
    ISSN: 2399-1399 , 2399-1402
    URL: Article
    DOI: 10.1093/fqsafe/fyaa031
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2899899-6
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  • 5
    Online Resource
    Online Resource
    Structure transformation from Sierpiński triangles to chains assisted by gas molecules
    Oxford University Press (OUP) ; 2023
    In:  National Science Review Vol. 10, No. 7 ( 2023-05-31)
    Details
    In: National Science Review, Oxford University Press (OUP), Vol. 10, No. 7 ( 2023-05-31)
    Abstract: Reversible transformations between fractals and periodic structures are of fundamental importance for understanding the formation mechanism of fractals. Currently, it is still a challenge to controllably achieve such a transformation. We investigate the effect of CO and CO2 molecules on Sierpiński triangles (STs) assembled from Fe atoms and 4,4″-dicyano-1,1′:3′,1″-terphenyl (C3PC) molecules on Au surfaces. Using scanning tunneling microscopy, we discover that the gas molecules induce a transition from STs into 1D chains. Based on density functional theory modeling, we propose that the atomistic mechanism involves the transformation of a stable 3-fold coordination Fe(C3PC)3 motif to Fe(C3PC)4 with an axially bonded CO molecule. CO2 causes the structural transformation through a molecular catassembly process.
    Type of Medium: Online Resource
    ISSN: 2095-5138 , 2053-714X
    URL: Article
    DOI: 10.1093/nsr/nwad088
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2745465-4
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  • 6
    Online Resource
    Online Resource
    Earlier Degraded Tapetum1 ( EDT1 ) Encodes an ATP-Citrate Lyase Required for Tapetum Programmed Cell Death
    Oxford University Press (OUP) ; 2019
    In:  Plant Physiology Vol. 181, No. 3 ( 2019-11), p. 1223-1238
    Details
    In: Plant Physiology, Oxford University Press (OUP), Vol. 181, No. 3 ( 2019-11), p. 1223-1238
    Type of Medium: Online Resource
    ISSN: 0032-0889 , 1532-2548
    URL: Article
    DOI: 10.1104/pp.19.00202
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2004346-6
    detail.hit.zdb_id: 208914-2
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Identification of distinct cytokine/chemokine profiles in dermatomyositis with anti-transcriptional intermediary factor 1-γ antibody
    Oxford University Press (OUP) ; 2022
    In:  Rheumatology Vol. 61, No. 5 ( 2022-05-05), p. 2176-2184
    Details
    In: Rheumatology, Oxford University Press (OUP), Vol. 61, No. 5 ( 2022-05-05), p. 2176-2184
    Abstract: DM and clinically amyopathic DM (CADM) patients with positive expression of anti-transcription intermediary factor 1-γ (anti-TIF1-γ) antibody (Ab) are characterized by distinct clinicopathological features. We aimed to determine the role of cytokine/chemokine profiles in the classification of anti-TIF1-γ positive DM/CADM patients. Methods Serum levels of 24 cytokines/chemokines were measured in 27 anti-TIF1-γ positive DM/CADM patients by a Luminex 200 system. Principal components analysis and unsupervised hierarchical clustering were used to reduce variables and establish patient subgroups. Spearman’s correlation coefficient was calculated between cytokine/chemokine levels and disease activity markers. Results Among anti-TIF1-γ positive DM/CADM patients, two distinct patient clusters were identified. The diagnosis of CADM was more common in cluster 1 than in cluster 2 (58.3% vs 6.7%, P = 0.008). Skin disease activity was higher in cluster 2 than in cluster 1 as measured by Cutaneous DM Disease Area and Severity Index–Activity [38.6  (10.4) vs 25.3  (10.0), P = 0.003]. Patients within cluster 2 exhibited significant muscle weakness (Medical Research Council scale ≤ 3, 33.3% vs 0.0%, P = 0.047), higher levels of anti-TIF1-γ Ab [92.4  (20.6) vs 66.9  (13.9), P = 0.001] and an increased malignancy rate (73.3% vs 25.0%, P = 0.021). Cluster 2 exhibited higher serum levels of CXCL10 [564.2  (258.8) vs 122.0  (97.8), P  & lt; 0.001], CCL2 [1136.6  (545.4) vs 441.6  (163.3), P  & lt; 0.001], galectin-9 [38879.6  (20009.3) vs 12612.4  (6640.0), P  & lt; 0.001], IL-18 [436.1  (188.9) vs 243.0  (114.5), P = 0.003] , TNF-α [9.3  (3.8) vs 5.6  (2.4), P = 0.007] and TNFRI [1385.1  (338.2) vs 2605.6  (928.5), P  & lt; 0.001] than cluster 1. Conclusion In anti-TIF1-γ positive DM/CADM, we identified a ‘skin-predominant’ cluster and a ‘hyperinflammation’ cluster based on the cytokine/chemokine profiles.Cytokine/chemokine profiles in anti-TIF1-γ positive DM/CADM can identify discrete clusters of patients with different disease patterns, organ involvements and clinical outcomes.
    Type of Medium: Online Resource
    ISSN: 1462-0324 , 1462-0332
    URL: Article
    DOI: 10.1093/rheumatology/keab625
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1474143-X
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  • 8
    Online Resource
    Online Resource
    Wine Authentication Using Integration Assay of MIR, NIR, E-tongue, HS-SPME-GC-MS, and Multivariate Analyses: A Case Study for a Typical Cabernet Sauvignon Wine
    Oxford University Press (OUP) ; 2019
    In:  Journal of AOAC INTERNATIONAL Vol. 102, No. 4 ( 2019-07-01), p. 1174-1180
    Details
    In: Journal of AOAC INTERNATIONAL, Oxford University Press (OUP), Vol. 102, No. 4 ( 2019-07-01), p. 1174-1180
    Abstract: Background: Cabernet Sauvignon wine enjoys large market in China, and its adulteration has become a well-known problem and challenge. Objective: This study aims to evaluate the capabilities of multiple techniques, including headspace–solid-phase microextraction–GC-MS (HS-SPME-GC-MS), electronic tongue (E-tongue) spectroscopy, mid-infrared (MIR) spectroscopy, and near-infrared (NIR) spectroscopy, to differentiate this popular imported wine in China. Methods: MIR spectroscopy, NIR spectroscopy, E-tongue spectroscopy, and HS-SPME-GC-MS were used. Multivariate analysis techniques were applied to further explore the instrumental determination data for the wine discrimination. Results: Joint use of MIR and NIR with Grey relational analysis (GRA), E-tongue with principal component analysis (PCA) and hierarchical cluster analysis, and HS-SPME-GC-MS with PCA allowed unanimous differentiation of the wines. Conclusions: The approach described herein offers both ecologically friendly and multiperspective mutual corroboration techniques for Cabernet Sauvignon wine discrimination. The integrative methodology could be used as a reference for wine authentication. Highlights: GRA was first applied to discriminate the wine samples. Mutual corroboration was verified by multivariate statistics combined with MIR, NIR, E-tongue, and SPME-GC/MS. Integrated techniques pointed to a unanimous authentication of the wine samples.
    Type of Medium: Online Resource
    ISSN: 1060-3271 , 1944-7922
    URL: Article
    DOI: 10.5740/jaoacint.18-0327
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
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  • 9
    Online Resource
    Online Resource
    Faecalibacterium prausnitzii produces butyrate to decrease c-Myc-related metabolism and Th17 differentiation by inhibiting histone deacetylase 3
    Oxford University Press (OUP) ; 2019
    In:  International Immunology Vol. 31, No. 8 ( 2019-07-30), p. 499-514
    Details
    In: International Immunology, Oxford University Press (OUP), Vol. 31, No. 8 ( 2019-07-30), p. 499-514
    Abstract: Decreased levels of Faecalibacterium prausnitzii (F. prausnitzii), whose supernatant plays an anti-inflammatory effect, are frequently found in inflammatory bowel disease (IBD) patients. However, the anti-inflammatory products in F. prausnitzii supernatant and the mechanism have not been fully investigated. Here we found that F. prausnitzii and F. prausnitzii-derived butyrate were decreased in the intestines of IBD patients. Supplementation with F. prausnitzii supernatant and butyrate could ameliorate colitis in an animal model. Butyrate, but not other substances produced by F. prausnitzii, exerted an anti-inflammatory effect by inhibiting the differentiation of T helper 17 (Th17) cells. The mechanism underlying the anti-inflammatory effects of the butyrate produced by F. prausnitzii involved the enhancement of the acetylation-promoted degradation of c-Myc through histone deacetylase 3 (HDAC3) inhibition. In conclusion, F. prausnitzii produced butyrate to decrease Th17 differentiation and attenuate colitis through inhibiting HDAC3 and c-Myc-related metabolism in T cells. The use of F. prausnitzii may be an effective new approach to decrease the level of Th17 cells in the treatment of inflammatory diseases.
    Type of Medium: Online Resource
    ISSN: 1460-2377
    URL: Article
    DOI: 10.1093/intimm/dxz022
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 1467474-9
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  • 10
    Online Resource
    Online Resource
    An effector of ‘ Candidatus Liberibacter asiaticus’ manipulates autophagy to promote bacterial infection
    Oxford University Press (OUP) ; 2023
    In:  Journal of Experimental Botany Vol. 74, No. 15 ( 2023-08-17), p. 4670-4684
    Details
    In: Journal of Experimental Botany, Oxford University Press (OUP), Vol. 74, No. 15 ( 2023-08-17), p. 4670-4684
    Abstract: Autophagy functions in plant host immunity responses to pathogen infection. The molecular mechanisms and functions used by the citrus Huanglongbing (HLB)-associated intracellular bacterium ‘Candidatus Liberibacter asiaticus’ (CLas) to manipulate autophagy are unknown. We identified a CLas effector, SDE4405 (CLIBASIA_04405), which contributes to HLB progression. ‘Wanjincheng’ orange (Citrus sinensis) transgenic plants expressing SDE4405 promotes CLas proliferation and symptom expression via suppressing host immunity responses. SDE4405 interacts with the ATG8-family of proteins (ATG8s), and their interactions activate autophagy in Nicotiana benthamiana. The occurrence of autophagy is also significantly enhanced in SDE4405-transgenic citrus plants. Interrupting NbATG8s-SDE4405 interaction by silencing of NbATG8c reduces Pseudomonas syringae pv. tomato strain DC3000ΔhopQ1-1 (Pst DC3000ΔhopQ1-1) proliferation in N. benthamiana, and transient overexpression of CsATG8c and SDE4405 in citrus promotes Xanthomonas citri subsp. citri (Xcc) multiplication, suggesting that SDE4405-ATG8s interaction negatively regulates plant defense. These results demonstrate the role of the CLas effector protein in manipulating autophagy, and provide new molecular insights into the interaction between CLas and citrus hosts.
    Type of Medium: Online Resource
    ISSN: 0022-0957 , 1460-2431
    URL: Article
    DOI: 10.1093/jxb/erad176
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1466717-4
    SSG: 12
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