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  • 1
    Publication Date: 2013-02-02
    Description: Insertion and deletion polymorphisms (indels) are an important source of genomic variation in plant and animal genomes, but accurate genotyping from low-coverage and exome next-generation sequence data remains challenging. We introduce an efficient population clustering algorithm for diploids and polyploids which was tested on a dataset of 2000 exomes. Compared with existing methods, we report a 4-fold reduction in overall indel genotype error rates with a 9-fold reduction in low coverage regions.
    Keywords: Computational Methods, Genomics
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 2
    Publication Date: 2015-04-12
    Description: Flow-like landslides are rapidly moving fluid–solid mixtures that can cause significant destruction along paths that run far from their original sources. Existing models for run out prediction and motion simulation of flow-like landslides have many limitations. In this paper, we develop a new method named ‘Tsunami Squares’ to simulate the generation, propagation and stoppage of flow-like landslides based on conservation of volume and momentum. Landslide materials in the new method form divisible squares that are displaced, then further fractured. The squares move under the influence of gravity-driven acceleration and suffer decelerations due to basal and dynamic frictions. Distinctively, this method takes into account solid and fluid mechanics, particle interactions and flow regime transitions. We apply this approach to simulate the 1982 El Picacho landslide in San Salvador, capital city of El Salvador. Landslide products from Tsunami Squares such as run out distance, velocities, erosion and deposition depths and impacted area agree well with field investigated and eyewitness data.
    Keywords: Geodynamics and Tectonics
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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