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  • 1
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    Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity (2013)
    The American Physiological Society (APS)
    Details
    Publication Date: 2013-06-02
    Description: Elevated blood branched-chain amino acids (BCAA) are often associated with insulin resistance and type 2 diabetes, which might result from a reduced cellular utilization and/or incomplete BCAA oxidation. White adipose tissue (WAT) has become appreciated as a potential player in whole body BCAA metabolism. We tested if expression of the mitochondrial BCAA oxidation checkpoint, branched-chain α-ketoacid dehydrogenase (BCKD) complex, is reduced in obese WAT and regulated by metabolic signals. WAT BCKD protein (E1α subunit) was significantly reduced by 35–50% in various obesity models ( fa/fa rats, db/db mice, diet-induced obese mice), and BCKD component transcripts significantly lower in subcutaneous (SC) adipocytes from obese vs. lean Pima Indians. Treatment of 3T3-L1 adipocytes or mice with peroxisome proliferator-activated receptor- agonists increased WAT BCAA catabolism enzyme mRNAs, whereas the nonmetabolizable glucose analog 2-deoxy- d -glucose had the opposite effect. The results support the hypothesis that suboptimal insulin action and/or perturbed metabolic signals in WAT, as would be seen with insulin resistance/type 2 diabetes, could impair WAT BCAA utilization. However, cross-tissue flux studies comparing lean vs. insulin-sensitive or insulin-resistant obese subjects revealed an unexpected negligible uptake of BCAA from human abdominal SC WAT. This suggests that SC WAT may not be an important contributor to blood BCAA phenotypes associated with insulin resistance in the overnight-fasted state. mRNA abundances for BCAA catabolic enzymes were markedly reduced in omental (but not SC) WAT of obese persons with metabolic syndrome compared with weight-matched healthy obese subjects, raising the possibility that visceral WAT contributes to the BCAA metabolic phenotype of metabolically compromised individuals.
    Print ISSN: 0193-1849
    Electronic ISSN: 1522-1555
    Topics: Medicine
    Published by The American Physiological Society (APS)
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  • 2
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    Vertical mixing, critical depths, and phytoplankton growth in the Ross Sea (2015)
    Oxford University Press
    Details
    Publication Date: 2015-07-29
    Description: Phytoplankton growth and biomass accumulation vary spatially and temporally in the Ross Sea, largely as a function of ice concentrations, vertical mixing depths, and iron concentrations. To assess the role of vertical mixing in bloom initiation, we used a high-resolution numerical model to estimate changes in mixed layer depths from October 1 through early December, the period where phytoplankton growth begins and biomass accumulates, and estimate critical depths for this period. Mixed layers in October ranged from the complete water column (〉600 m) to ca. 200 m; over a 60-day period, the mixed layers decreased on average by 70%. Estimated critical depths were exceeded in October, but would allow growth to proceed in late October due to shoaling of mixed layer depths, consistent with the known onset of the spring bloom in the Ross Sea. We also analysed a series of stations sampled near the Ross Ice Shelf during January 2012. Mean vertical profiles for the stations indicated deep vertical mixing; mixed layer depths averaged 60 m and ranged up to 96 m. Chlorophyll concentrations within the mixed layer averaged 6.60 µg l –1 , and the pigment contributions were dominated by Phaeocystis antarctica . We suggest that this mesoscale region near the ice shelf is elevated in phytoplankton biomass due to frequent mixing events that redistribute biomass to depth and replenish nutrients, which in turn are utilized by an assemblage capable of utilizing low mean irradiance levels. Thus, the deep mixed layers and high biomass concentrations represent growth over long periods under reduced mixing punctuated by short periods of deeper vertical mixing that redistribute biomass. Water column vertical mixing and phytoplankton biomass in the Ross Sea are consistent with the critical depth concept as originally proposed by Sverdrup.
    Print ISSN: 1054-3139
    Electronic ISSN: 1095-9289
    Topics: Biology , Geosciences , Physics
    Published by Oxford University Press
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  • 3
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    Sunflecks? (2013)
    Oxford University Press
    Details
    Publication Date: 2013-03-21
    Print ISSN: 0829-318X
    Electronic ISSN: 1758-4469
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Oxford University Press
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  • 4
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    Retracking CryoSat-2, Envisat and Jason-1 radar altimetry waveforms for improved gravity field recovery (2014)
    Oxford University Press
    Details
    Publication Date: 2014-02-13
    Description: Improving the accuracy of the marine gravity field requires both improved altimeter range precision and dense track coverage. After a hiatus of more than 15 yr, a wealth of suitable data is now available from the CryoSat-2, Envisat and Jason-1 satellites. The range precision of these data is significantly improved with respect to the conventional techniques used in operational oceanography by retracking the altimeter waveforms using an algorithm that is optimized for the recovery of the short-wavelength geodetic signal. We caution that this new approach, which provides optimal range precision, may introduce large-scale errors that would be unacceptable for other applications. In addition, CryoSat-2 has a new synthetic aperture radar (SAR) mode that should result in higher range precision. For this new mode we derived a simple, but approximate, analytic model for the shape of the SAR waveform that could be used in an iterative least-squares algorithm for estimating range. For the conventional waveforms, we demonstrate that a two-step retracking algorithm that was originally designed for data from prior missions (ERS-1 and Geosat) also improves precision on all three of the new satellites by about a factor of 1.5. The improved range precision and dense coverage from CryoSat-2, Envisat and Jason-1 should lead to a significant increase in the accuracy of the marine gravity field.
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 5
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    Comparing health status in Belarus between 2001-10: a novel method using surveys with different response categories (2013)
    Oxford University Press
    Details
    Publication Date: 2013-09-28
    Description: Background: Two population surveys were conducted in Belarus: The Living Conditions, Lifestyle and Health (LLH) in 2001 ( n = 2000) and The Health in Times of Transition (HITT) in 2010 ( n = 1800). Each survey included a question on health status. The LLH questionnaire provided a 4-point Verbal Response Scale, but the HITT questionnaire used a 5-point scale. When translated into Russian, only two response categories of these scales had identical wording. These differences made a direct comparison of self-reported health status between 2001 and 2010 difficult. Methods: We conducted a Health Category Response Scale (HCRS) survey in 2010 ( n = 570) using a 100ths graduated Visual Analogue Scale (VAS) to understand how the response categories of different scales are perceived by Russian speakers. We implemented the HCRS survey’s data to calculate the weighted health status (WHS) for each of the original surveys and to compare health status in Belarus between 2001and 2010. Results: The WHS in Belarus showed a small, but statistically significant, improvement of 2.9 points on a 0–100 scale between 2001 and 2010 (56.2 vs. 59.1). Identical response categories were perceived differently on a 4-point and 5-point VAS. The category ‘good’ (‘opoee’) measured ~12 points higher, and the category ‘bad/poor’ (‘ooe’) measured ~16 points lower, on the 4-point compared with the 5-point VAS. Conclusion: Our HCRS survey and novel method enabled a direct comparison of questions with different response options. When applied to the LLH and HITT projects, we concluded that health status in Belarus has improved between 2001 and 2010.
    Print ISSN: 1101-1262
    Electronic ISSN: 1464-360X
    Topics: Medicine
    Published by Oxford University Press
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  • 6
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    Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity (2014)
    The American Physiological Society (APS)
    Details
    Publication Date: 2014-02-03
    Description: The extracellular matrix (ECM) plays an important role in the maintenance of white adipose tissue (WAT) architecture and function, and proper ECM remodeling is critical to support WAT malleability to accomodate changes in energy storage needs. Obesity and adipocyte hypertrophy place a strain on the ECM remodeling machinery, which may promote disordered ECM and altered tissue integrity and could promote proinflammatory and cell stress signals. To explore these questions, new methods were developed to quantify omental and subcutaneous WAT tensile strength and WAT collagen content by three-dimensional confocal imaging, using collagen VI knockout mice as a methods validation tool. These methods, combined with comprehensive measurement of WAT ECM proteolytic enzymes, transcript, and blood analyte analyses, were used to identify unique pathophenotypes of metabolic syndrome and type 2 diabetes mellitus in obese women, using multivariate statistical modeling and univariate comparisons with weight-matched healthy obese individuals. In addition to the expected differences in inflammation and glycemic control, approximately 20 ECM-related factors, including omental tensile strength, collagen, and enzyme transcripts, helped discriminate metabolically compromised obesity. This is consistent with the hypothesis that WAT ECM physiology is intimately linked to metabolic health in obese humans, and the studies provide new tools to explore this relationship.
    Print ISSN: 0193-1849
    Electronic ISSN: 1522-1555
    Topics: Medicine
    Published by The American Physiological Society (APS)
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  • 7
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    Anesthesia and bariatric surgery gut preparation alter plasma acylcarnitines reflective of mitochondrial fat and branched-chain amino acid oxidation (2017)
    The American Physiological Society (APS)
    Details
    Publication Date: 2017-12-02
    Description: The period around bariatric surgery offers a unique opportunity to characterize metabolism responses to dynamic shifts in energy, gut function, and anesthesia. We analyzed plasma acylcarnitines in obese women ( n = 17) sampled in the overnight fasted/postabsorptive state approximately 1–2 wk before surgery ( condition A ), the morning of surgery (prior restriction to a 48-h clear liquid diet coupled in some cases a standard polyethylene glycol gut evacuation: condition B ), and following induction of anesthesia ( condition C ). Comparisons tested if 1 ) plasma acylcarnitine derivatives reflective of fatty acid oxidation (FAO) and xenometabolism would be significantly increased and decreased, respectively, by preoperative gut preparation/negative energy balance ( condition A vs. B ), and 2 ) anesthesia would acutely depress markers of FAO. Acylcarnitines associated with fat mobilization and FAO were significantly increased in condition B : long-chain acylcarnitines (i.e., C18:1, ~70%), metabolites from active but incomplete FAO [i.e., C14:1 (161%) and C14:2 (102%)] and medium- to short-chain acylcarnitines [i.e., C2 (91%), R -3-hydroxybutyryl-(245%), C6 (45%), and cis -3,4-methylene-heptanoyl-(17%), etc.]. Branched-chain amino acid markers displayed disparate patterns [i.e., isobutyryl-(40% decreased) vs. isovaleryl carnitine (51% increased)]. Anesthesia reduced virtually every acylcarnitine. These results are consistent with a fasting-type metabolic phenotype coincident with the presurgical "gut preparation" phase of bariatric surgery, and a major and rapid alteration of both fat and amino acid metabolism with onset of anesthesia. Whether presurgical or anesthesia-associated metabolic shifts in carnitine and fuel metabolism impact patient outcomes or surgical risks remains to be evaluated experimentally.
    Print ISSN: 0193-1849
    Electronic ISSN: 1522-1555
    Topics: Medicine
    Published by The American Physiological Society (APS)
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  • 8
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    Missing and presumed lost: extinction in the ocean and its inference (2011)
    Oxford University Press
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    Publication Date: 2011-12-08
    Description: Smith, W. K., and Solow, A. R. 2012. Missing and presumed lost: extinction in the ocean and its inference. – ICES Journal of Marine Science, 69: 89–94. The number of modern extinctions in the ocean is unknown. The actual demise of the last individual of a species is essentially unobservable, so extinction can only be inferred. Statistical methods are described for inferring extinction from sighting records, species–area considerations, and taxonomic samples collected at two different times. The methods are illustrated using a variety of real datasets, including a sighting record of the Caribbean monk seal and results from three surveys of benthic invertebrates.
    Print ISSN: 1054-3139
    Electronic ISSN: 1095-9289
    Topics: Biology , Geosciences , Physics
    Published by Oxford University Press
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  • 9
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    Leaf/shoot level ecophysiology in two broadleaf and two needle-leaf species under representative cloud regimes at alpine treeline (2016)
    Oxford University Press
    Details
    Publication Date: 2016-12-06
    Description: Aims The effects of clouds are now recognized as critically important to the understanding of climate change impacts on ecosystems. Regardless, few studies have focused specifically on the ecophysiological responses of plants to clouds. Most continental mountain ranges are characterized by common convective cloud formation in the afternoons, yet little is known regarding this influence on plant water and carbon relations. Here we compare the ecophysiology of two contrasting, yet ubiquitous growth forms, needle-leaf and broadleaf, under representative cloud regimes of the Snowy Range, Medicine Bow Mountains, southeastern Wyoming, USA. Methods Photosynthetic gas exchange, water use efficiency, xylem water potentials and micrometeorological data were measured on representative clear, overcast and partly cloudy days during the summers of 2012 and 2013 for two indigenous broadleaf ( Caltha leptosepala and Arnica parryi ) and two needle-leaf species ( Picea engelmannii and Abies lasiocarpa ) that co-occur contiguously. Important Findings Reductions in sunlight with cloud cover resulted in more dramatic declines in photosynthesis for the two broadleaf species (ca. 50–70% reduction) versus the two conifers (no significant difference). In addition, the presence of clouds corresponded with lower leaf conductance, transpiration and plant water status in all species. However, the more constant photosynthesis in conifers under all cloud conditions, coupled with reduced transpiration, resulted in greater water use efficiency (ca. 25% higher) than the broadleaf species. These differences appear to implicate the potential importance of natural cloud patterns in the adaptive ecophysiology of these two contrasting, but common, plant growth forms.
    Print ISSN: 1752-993X
    Electronic ISSN: 1752-9921
    Topics: Biology
    Published by Oxford University Press
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  • 10
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    Effect of climate on lodgepole pine stem taper in British Columbia, Canada (2012)
    Oxford University Press
    In: Forestry
    Details
    Publication Date: 2012-10-31
    Description: The taper equations used by the Ministry of Forests, Lands and Natural Resource Operations in British Columbia (BC), Canada, date back to the mid-1950s. Very little work has been done on examining the effect of climate on taper, particularly for BC but elsewhere as well. The objective of our research was to determine whether climate has an effect on tree taper for lodgepole pine ( Pinus contorta Dougl. ex Loud.) in BC. The data for this project consisted of multiple diameter inside bark measurements along the stems of 270 trees across eight biogeoclimatic zones. In addition, 20 climate variables for the sample sites were predicted from the ClimateWNA model. Kozak's variable-exponent taper model was refitted with the climate variables in the exponent of the model. The single temperature- and precipitation-related variables that provided the best fit were incorporated into the final taper model. The model was analysed as a mixed-effects model, with spatial correlation and heteroscedastic errors being explicitly modelled. Mean annual precipitation and the Julian date of the first frost after the summer growing period were the best predictors of taper. Further work is required to understand why these variables are important predictors of taper, but a possible linkage is through the tree's crown.
    Print ISSN: 0015-752X
    Electronic ISSN: 1464-3626
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Oxford University Press
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