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  • Ovid Technologies (Wolters Kluwer Health)  (9)
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  • Ovid Technologies (Wolters Kluwer Health)  (9)
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  • 1
    Online Resource
    Online Resource
    Abstract 14141: A Novel Endothelial Function Test in Predicting Late Coronary In-Stent Restenosis
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Circulation Vol. 146, No. Suppl_1 ( 2022-11-08)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. Suppl_1 ( 2022-11-08)
    Abstract: Introduction: Endothelial dysfunction is related with in-stent restenosis (ISR) of prior drug-eluting stents (DES) implanted more than 1 year ago (late ISR). EndoPAT is a novel non-invasive test quantifying endothelial function as reactive hyperemia peripheral arterial tonometry index (RHI). Hypothesis: EndoPAT is a potential predicting test for late ISR. Methods: We conducted a case control study on 186 patients with coronary DES implanted more than 1 year ago in a single medical center. Those who had contraindications to EndoPAT test, acute myocardial infarction, coronary artery bypass graft (CABG), chronic kidney disease (CKD) stage III and above, active infection and rheumatologic disease or acute decompensated heart failure were excluded. Patients were divided into ISR and non-ISR group based on coronary angiography. EndoPAT test was done at 24 to 48 hours prior to catherization. LnRHI is an index after natural log transformation of RHI. A receiver operative characteristic (ROC) curve analysis was used to determine the sensitivity and specificity of LnRHI for predicting late ISR. Results: ISR group had significantly more patients with history of ISR or triple-vessel disease, longer stent length and fewer totally occlusive lesions than non-ISR group. LnRHI was significantly lower in ISR group than in non-ISR group (0.66 vs 0.50, p 〈 0.01). Patients with diffuse ISR had lower LnRHI than those with focal ISR (0.40 vs 0.55, p=0.03). Patients without ISR but undergoing revascularization had lower LnRHI than those with patent coronary arteries (0.56 vs 0.70, p=0.02). Endothelial function quantified by LnRHI was an independent risk factor for ISR (LnRHI/0.1, OR=0.79, 95% CI 0.64-0.97, p=0.03). The ROC curve analysis showed LnRHI of 0.44 had a sensitivity of 81.7% and specificity of 53.8% for predicting late ISR. Conclusions: Endothelial dysfunction measured by EndoPAT had a clinical potential for predicting the development of late ISR.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.146.suppl_1.14141
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 1466401-X
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  • 2
    Online Resource
    Online Resource
    Long-Term Prognosis of Patients With Coexisting Obesity and Malnutrition After Acute Myocardial Infarction: A Cohort Study
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Circulation: Cardiovascular Quality and Outcomes Vol. 16, No. 4 ( 2023-04)
    Details
    In: Circulation: Cardiovascular Quality and Outcomes, Ovid Technologies (Wolters Kluwer Health), Vol. 16, No. 4 ( 2023-04)
    Abstract: The double burden of malnutrition, described as the coexistence of malnutrition and obesity, is a growing global health issue. This study examines the combined effects of obesity and malnutrition on patients with acute myocardial infarction (AMI). Methods: Patients presenting with AMI to a percutaneous coronary intervention-capable hospital in Singapore between January 2014 and March 2021 were retrospectively studied. Patients were stratified into the following: (1) nourished nonobese, (2) malnourished nonobese, (3) nourished obese, and (4) malnourished obese. Obesity and malnutrition were defined according to the World Health Organization definition (body mass index ≥27.5 kg/m 2 ) and Controlling Nutritional Status score, respectively. The primary outcome was all-cause mortality. The association between combined obesity and nutritional status with mortality was examined using Cox regression, adjusted for age, sex, AMI type, previous AMI, ejection fraction, and chronic kidney disease. Kaplan-Meier curves for all-cause mortality were constructed. Results: The study included 1829 AMI patients, of which 75.7% were male and mean age was 66 years. Over 75% of patients were malnourished. Majority were malnourished nonobese (57.7%), followed by malnourished obese (18.8%), nourished nonobese (16.9%), and nourished obese (6.6%). Malnourished nonobese had highest all-cause mortality (38.6%), followed by the malnourished obese (35.8%), nourished nonobese (21.4%), and nourished obese (9.9%, P 〈 0.001). Kaplan-Meier curves demonstrated least favorable survival in malnourished nonobese group, followed by malnourished obese, nourished nonobese, and nourished obese. With nourished nonobese group as the reference, malnourished nonobese had higher all-cause mortality (hazard ratio, 1.46 [95% CI, 1.10–1.96], P =0.010), but only a nonsignificant increase in mortality was observed in the malnourished obese (hazard ratio, 1.31 [95% CI, 0.94–1.83] , P =0.112). Conclusions: Among AMI patients, malnutrition is prevalent even in the obese. Compared to nourished patients, malnourished AMI patients have a more unfavorable prognosis especially in those with severe malnutrition regardless of obesity status, but long-term survival is the most favorable among nourished obese patients.
    Type of Medium: Online Resource
    ISSN: 1941-7713 , 1941-7705
    URL: Article
    DOI: 10.1161/CIRCOUTCOMES.122.009340
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2453882-6
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  • 3
    Online Resource
    Online Resource
    Global trends and current status of amputation: Bibliometrics and visual analysis of publications from 1999 to 2021
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Prosthetics & Orthotics International ( 2023-8-23)
    Details
    In: Prosthetics & Orthotics International, Ovid Technologies (Wolters Kluwer Health), ( 2023-8-23)
    Abstract: To generalize the research status, hotspots, and development trends of amputation-related research. Methods: The data from 1999 to 2021 were collected from the Web of Science core collection database, and analyzed through bibliometrics software (CiteSpace and VOSviewer) for the dual-map overlay of journals, top 25 references with the strongest citation bursts, top 25 keywords with the strongest citation bursts, and timeline of keywords. Results: A total of 8,588 literature studies were involved in this study. The United States ranks the first in terms of H-index, total number of publications, and total citations. US Department of Veterans Affairs, Veterans Health Administration, and University of Washington are the major contributors to amputation. Prosthetics and Orthotics International , Archives of Physical Medicine and Rehabilitation , and Journal of Rehabilitation Research and Development are the main publication channels for articles related to amputation. Geertzen JHB, Czerniecki J, and Dijkstra PU are major contributors to amputation. In addition, research on limb salvage treatment and surgical methods for amputation will become a hotspot in the future. Conclusion: The total number of publications for amputation has generally increased from 1999 to 2021. Our study is beneficial for scientists to specify the research hotspot and development direction of amputation.
    Type of Medium: Online Resource
    ISSN: 0309-3646 , 1746-1553
    URL: Article
    DOI: 10.1097/PXR.0000000000000271
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2205993-3
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  • 4
    Online Resource
    Online Resource
    Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Circulation Research Vol. 130, No. 7 ( 2022-04), p. 1038-1055
    Details
    In: Circulation Research, Ovid Technologies (Wolters Kluwer Health), Vol. 130, No. 7 ( 2022-04), p. 1038-1055
    Abstract: The transcription factor BACH1 (BTB and CNC homology 1) suppressed endothelial cells (ECs) proliferation and migration and impaired angiogenesis in the ischemic hindlimbs of adult mice. However, the role and underlying mechanisms of BACH1 in atherosclerosis remain unclear. Methods: Mouse models of atherosclerosis in endothelial cell (EC)-specific-Bach1 knockout mice were used to study the role of BACH1 in the regulation of atherogenesis and the underlying mechanisms. Results: Genetic analyses revealed that coronary artery disease-associated risk variant rs2832227 was associated with BACH1 gene expression in carotid plaques from patients. BACH1 was upregulated in ECs of human and mouse atherosclerotic plaques. Endothelial Bach1 deficiency decreased turbulent blood flow- or western diet-induced atherosclerotic lesions, macrophage content in plaques, expression of endothelial adhesion molecules (ICAM1 [intercellular cell adhesion molecule-1] and VCAM1 [vascular cell adhesion molecule-1] ), and reduced plasma TNF-α (tumor necrosis factor-α) and IL-1β levels in atherosclerotic mice. BACH1 deletion or knockdown inhibited monocyte–endothelial adhesion and reduced oscillatory shear stress or TNF-α-mediated induction of endothelial adhesion molecules and/or proinflammatory cytokines in mouse ECs, human umbilical vein ECs, and human aortic ECs. Mechanistic studies showed that upon oscillatory shear stress or TNF-α stimulation, BACH1 and YAP (yes-associated protein) were induced and translocated into the nucleus in ECs. BACH1 upregulated YAP expression by binding to the YAP promoter. BACH1 formed a complex with YAP inducing the transcription of adhesion molecules. YAP overexpression in ECs counteracted the antiatherosclerotic effect mediated by Bach1-deletion in mice. Rosuvastatin inhibited BACH1 expression by upregulating microRNA let-7a in ECs, and decreased Bach1 expression in the vascular endothelium of hyperlipidemic mice. BACH1 was colocalized with YAP, and the expression of BACH1 was positively correlated with YAP and proinflammatory genes, as well as adhesion molecules in human atherosclerotic plaques. Conclusions: These data identify BACH1 as a mechanosensor of hemodynamic stress and reveal that the BACH1-YAP transcriptional network is essential to vascular inflammation and atherogenesis. BACH1 shows potential as a novel therapeutic target in atherosclerosis.
    Type of Medium: Online Resource
    ISSN: 0009-7330 , 1524-4571
    URL: Article
    DOI: 10.1161/CIRCRESAHA.121.319540
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 1467838-X
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  • 5
    Online Resource
    Online Resource
    The RAISE Trial: A Novel Device and First-in-Man Trial
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Circulation: Heart Failure Vol. 15, No. 4 ( 2022-04)
    Details
    In: Circulation: Heart Failure, Ovid Technologies (Wolters Kluwer Health), Vol. 15, No. 4 ( 2022-04)
    Abstract: Currently, standard medical therapies have limited effects on heart failure with preserved ejection fraction (HFpEF), which impacts on the life quality and survival of patients. This study aimed to evaluate the safety and efficacy of the percutaneous radiofrequency ablation–based interatrial shunting for HFpEF with a novel atrial septostomy device. Methods: A preclinical study in 11 normal domestic pigs and the first-in-man study in 10 patients with HFpEF were performed. The major safety events and interatrial shunt performance were evaluated at baseline, 1 month, 3 months, and 6 months post-procedure in both animals and human patients. The clinical functional status was also assessed in the first-in-man study. Results: Percutaneous radiofrequency ablation–based interatrial shunting therapy was performed successfully both in animals and patients. In the animal study, a left-to-right interatrial shunt was created with a mean defect size of 5.5±2.2 mm without procedure-related safety events. Seven pigs showed the continuous shunting with a mean defect size of 4.1±1.5 mm at 6 months. In the first-in-man study, a median interatrial defect diameter of 5.0 (4.0–6.0) mm was measured immediately. No major safety events including death and thromboembolism were observed. The continuous shunting with the defect size of 4.0 (3.0–4.0) mm could still be observed in 7 patients at 6 months. The clinical status was significantly improved with NT-proBNP (N-terminal pro-B-type natriuretic peptide) reduced by 2149 pg/mL ([95% CI, 204–3301] P =0.028), with 6-minute walk distance increased by 88 m ([95% CI, 50–249] P =0.008) and with New York Heart Association class improved in 8 patients at 6 months. Conclusions: The present results showed that percutaneous radiofrequency ablation–based interatrial shunting was a safe and potentially effective therapy for HFpEF, providing a nonpharmacological and nonimplanted option for HFpEF management. Registration: URL: https://www.chictr.org.cn ; Unique identifier: ChiCTR1900027664.
    Type of Medium: Online Resource
    ISSN: 1941-3289 , 1941-3297
    URL: Article
    DOI: 10.1161/CIRCHEARTFAILURE.121.008362
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2428100-1
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  • 6
    Online Resource
    Online Resource
    Stage 1 hypertension defined by the 2017 American College of Cardiology/American Heart Association guideline and risk of adverse birth outcomes in Eastern China
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Journal of Hypertension Vol. 38, No. 6 ( 2020-06), p. 1090-1102
    Details
    In: Journal of Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 38, No. 6 ( 2020-06), p. 1090-1102
    Abstract: The 2017 American College of Cardiology/American Heart Association (ACC/AHA) guideline recommended a lower threshold (130/80 mmHg) for hypertension in nonpregnant adults. However, the influence of this guideline in Chinese pregnant women is not well characterized. Methods: Data of 32 742 and 14 479 mothers who had blood pressure (BP) less than 130/80 mmHg and no proteinuria before 20 gestational weeks and delivered live singletons between 1 January 2014 and 30 November 2019 were extracted from Taizhou and Taicang register-based cohorts, respectively. The average measured BP in the third trimester was obtained and categorized according to the 2017 ACC/AHA guideline. The association between BP and risk of adverse birth outcomes was assessed by multivariate logistic regression analysis. Results: In the third trimester, 331 (1.01%) and 378 (2.61%) women had mean BP at least 140/90 mmHg, but 2435 (7.44%) and 1054 (7.28%) had stage 1 hypertension (130–139/80–89 mmHg) in Taizhou and Taicang, respectively. Significant associations between stage 1 hypertension and small for gestational age [odds ratio (OR) = 1.32, 95% confidence interval (CI) = 1.14–1.52] and low birth weight (OR = 1.81, 95% CI = 1.46–2.25) were observed in the Taizhou population. Consistent results were also shown in the Taicang population [OR (95% CI), of 1.46 (1.18–1.79) and 1.50 (1.07–2.11), respectively] . Conclusion: Stage 1 hypertension in the third trimester defined by the 2017 ACC/AHA guideline was associated with an increased risk for adverse birth outcomes in Eastern Chinese pregnant women, suggesting that this guideline may improve the detection of high BP and surveillance of adverse neonatal outcomes in China.
    Type of Medium: Online Resource
    ISSN: 0263-6352 , 1473-5598
    URL: Article
    DOI: 10.1097/HJH.0000000000002380
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2017684-3
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  • 7
    Online Resource
    Online Resource
    Optogenetic Inhibition of Striatal GABAergic Neuronal Activity Improves Outcomes After Ischemic Brain Injury
    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Stroke Vol. 48, No. 12 ( 2017-12), p. 3375-3383
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 48, No. 12 ( 2017-12), p. 3375-3383
    Abstract: Striatal GABAergic neuron is known as a key regulator in adult neurogenesis. However, the specific role of striatal GABAergic neuronal activity in the promotion of neurological recovery after ischemic stroke remains unknown. Here, we used optogenetic approach to investigate these effects and mechanism. Methods— Laser stimulation was delivered via an implanted optical fiber to inhibit or activate the striatal GABAergic neurons in Gad2-Arch-GFP or Gad2-ChR2-tdTomato mice (n=80) 1 week after 60-minute transient middle cerebral artery occlusion. Neurological severity score, brain atrophy volume, microvessel density, and cell morphological changes were examined using immunohistochemistry. Gene expression and protein levels of related growth factors were further examined using real-time polymerase chain reaction and Western blotting. Results— Inhibiting striatal GABAergic neuronal activity improved functional recovery, reduced brain atrophy volume, and prohibited cell death compared with the control ( P 〈 0.05). Microvessel density and bFGF (basic fibroblast growth factor) expression in the inhibition group were also increased ( P 〈 0.05). In contrast, activation of striatal GABAergic neurons resulted in adverse effects compared with the control ( P 〈 0.05). Using cocultures of GABAergic neurons, astrocytes, and endothelial cells, we further demonstrated that the photoinhibition of GABAergic neuronal activity could upregulate bFGF expression in endothelial cells, depending on the presence of astrocytes. The conditioned medium from the aforementioned photoinhibited 3-cell coculture system protected cells from oxygen glucose deprivation injury. Conclusions— After ischemic stroke, optogenetic inhibition of GABAergic neurons upregulated bFGF expression by endothelial cells and promoted neurobehavioral recovery, possibly orchestrated by astrocytes. Optogenetically inhibiting neuronal activity provides a novel approach to promote neurological recovery.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/STROKEAHA.117.019017
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
    detail.hit.zdb_id: 1467823-8
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  • 8
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    Online Resource
    Abstract 567: Insulin Reverses Mcp-1 Suppressed Cholesterol Efflux to Hdl3/apoa1 Through Up-regulation of Abca1, Abcg1 and Sr-bi in Differentiated 3t3-l1 Adipocytes
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Arteriosclerosis, Thrombosis, and Vascular Biology Vol. 38, No. Suppl_1 ( 2018-05)
    Details
    In: Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 38, No. Suppl_1 ( 2018-05)
    Abstract: Aims: Insulin has been reported to influence cholesterol removal from different cells, but the results have been controversial. Based on our previous study, which we found that insulin promote cholesterol efflux from HepG2 cells and can reverse the decreased cholesterol efflux to HDL though PI3K-Akt pathway, we further investigate the effects of insulin on damaged cholesterol efflux by MCP-1 in this report. Methods: 3T3-L1 preadipocytes were differentiated into adipocytes as described previously. Fully differentiated adipocytes (day 13) were labeled with 3 H-cholesterol (1 Ci/ml) for 24 h. Cellular cholesterol efflux was initiated by 20μg/ml human apoA1 or 50 μg/ml HDL 3 with the indicated dose of MCP-1 for the indicated period of time in the presence or absence of insulin. After incubation, the radioactivity of the medium and cells was measured using a liquid scintillation counter. Cholesterol efflux was calculated as the percentage of total [ 3 H]-cholesterol released into the medium after subtraction of the values obtained in the absence of a cholesterol acceptor. 3T3-L1 adipocytes were harvested for PCR , western blotting, cell-surface protein assays and Confocal microscopy. Results: 1. MCP-1 reduced cholesterol efflux to HDL3 and apoA1 in differentiated 3T3-L1 adipocytes. 2. In differentiated 3T3-L1 adipocytes, MCP-1 reduced cholesterol efflux to HDL 3 mainly by inhibiting SR-BI and ABCG1 and to apoA1 mainly by inhibiting ABCA1. 3. MCP-1 decreased ABCA1 and SR-BI mRNA expression but not ABCG1. 4. MCP-1 decreased total and cell surface ABCA1, ABCG1, and SR-BI protein expression as shown by Western blotting and confocal microscopy in differentiated 3T3-L1 adipocytes. 5. Insulin increased MCP-1 suppressed cholesterol efflux to HDL 3 and apoA1 depending on Akt phosphorylation. 6. Insulin reversed MCP-1 suppressed ABCA1 and SR-BI mRNA expression, and ABCA1, ABCG1 and SR-BI protein expression via PI3K/Akt pathway. Conclusions: Insulin reverses the suppressed cholesterol efflux to HDL3 and apoA1 by MCP-1 through up-regulation of ABCA1, ABCG1 and SR-BI through PI3K/Akt pathway in 3T3-L1 adipocytes, which provides evidences that insulin may improve the MCP-1-induced adipocyte cholesterol imbalance to exert the anti-inflammatory effect.
    Type of Medium: Online Resource
    ISSN: 1079-5642 , 1524-4636
    URL: Article
    DOI: 10.1161/atvb.38.suppl_1.567
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 1494427-3
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  • 9
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    Online Resource
    Preoperative Axillary Ultrasound Helps in the Identification of a Limited Nodal Burden in Breast Cancer Patients
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Ultrasound Quarterly Vol. 36, No. 2 ( 2020-6), p. 173-178
    Details
    In: Ultrasound Quarterly, Ovid Technologies (Wolters Kluwer Health), Vol. 36, No. 2 ( 2020-6), p. 173-178
    Abstract: Since the Z0011 trial, the clinical evaluation of axillary status has been redirected to predicting nodal tumor burden rather than nodal metastases. Our study aimed to evaluate the value of clinicopathological factors and axillary ultrasound (US) for the prediction of a high nodal burden (≥3 metastatic lymph nodes) in breast cancer patients. A total of 532 consecutive patients who underwent preoperative axillary US and subsequent surgery for clinical T1–2 breast cancer with a final pathologic analysis were included. Clinical and pathologic variables were retrospectively evaluated. Univariate and multivariate statistical analyses were performed to identify the variables that were associated with a high nodal burden. Among the 532 patients, 110 (20.7%) had a high axillary nodal burden and 422 (79.3%) had a limited nodal burden. The multivariate analysis showed that suspicious axillary US findings ( P 〈 0.001), clinical T2 stage ( P = 0.011), the presence of lymphovascular invasion ( P 〈 0.001), and estrogen receptor positivity ( P 〈 0.001) were significantly associated with a high nodal burden. Patients with negative axillary US findings seldom had a high nodal burden, with a negative predictive value of 93.0% (294/316). Patients with suspicious axillary US findings, clinical T2 stage, lymphovascular invasion, and estrogen receptor positivity are more likely to have a high nodal burden, which may provide additional information for the treatment plan of breast cancer patients. Preoperative axillary US helps identify a limited nodal burden in breast cancer patients and has implications for axillary lymph node dissection and adjuvant treatment.
    Type of Medium: Online Resource
    ISSN: 1536-0253
    URL: Article
    DOI: 10.1097/RUQ.0000000000000495
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2060555-9
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