In:
Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 79, No. 8 ( 2022-08), p. 1617-1628
Abstract:
Omics data may provide a unique opportunity to discover dairy-related biomarkers and their linked cardiovascular health. Methods: Dairy-related lipidomic signatures were discovered in baseline data from a Chinese cohort study (n=2140) and replicated in another Chinese study (n=212). Dairy intake was estimated by a validated food-frequency questionnaire. Lipidomics was profiled by high-coverage liquid chromatography-tandem mass spectrometry. Associations of dairy-related lipids with 6-year changes in cardiovascular risk factors were examined in the discovery cohort, and their causalities were analyzed by 2-sample Mendelian randomization using available genome-wide summary data. Results: Of 350 lipid metabolites, 4 sphingomyelins, namely sphingomyelin (OH) C32:2, sphingomyelin C32:1, sphingomyelin (2OH) C30:2, and sphingomyelin (OH) C38:2, were identified and replicated to be positively associated with total dairy consumption (β=0.130 to 0.148; P 〈 1.43×10 −4 ), but not or weakly with nondairy food items. The score of 4 sphingomyelins showed inverse associations with 6-year changes in systolic (−2.68 [95% CI, −4.92 to −0.43]; P =0.019), diastolic blood pressures (−1.86 [95% CI, −3.12 to −0.61]; P =0.004), and fasting glucose (−0.25 [95% CI, −0.41 to −0.08]; P =0.003). Mendelian randomization analyses further revealed that genetically inferred sphingomyelin (OH) C32:2 was inversely associated with systolic (−0.57 [95% CI, −0.85 to −0.28]; P =9.16×10 −5 ) and diastolic blood pressures (−0.39 [95% CI, −0.59 to −0.20]; P =7.09×10 −5 ). Conclusions: The beneficial effects of dairy products on cardiovascular health might be mediated through specific sphingomyelins among Chinese with overall low dairy consumption.
Type of Medium:
Online Resource
ISSN:
0194-911X
,
1524-4563
DOI:
10.1161/HYPERTENSIONAHA.122.18981
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2022
detail.hit.zdb_id:
2094210-2
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