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  • Ovid Technologies (Wolters Kluwer Health)  (16)
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  • Ovid Technologies (Wolters Kluwer Health)  (16)
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  • 1
    Online Resource
    Online Resource
    Two-Year Incidence and Associated Factors of Dry Eye Among Residents in Shanghai Communities With Type 2 Diabetes Mellitus
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Eye & Contact Lens: Science & Clinical Practice Vol. 46, No. 1 ( 2020-01), p. S42-S49
    Details
    In: Eye & Contact Lens: Science & Clinical Practice, Ovid Technologies (Wolters Kluwer Health), Vol. 46, No. 1 ( 2020-01), p. S42-S49
    Abstract: To evaluate the 2-year incidence and associated factors of dry eye (DE) among community residents with type 2 diabetes mellitus (DM). Methods: For confirmed type 2 DM residents in the Xinjing community of Shanghai in China, 2 surveys on DE and related factors were performed in 2016 and 2018. The survey content included general information, subjective symptom questionnaires, tear-film break-up time test, Schirmer I test, corneal fluorescence staining (FL), slit-lamp examination, and examination of blood and urine samples. Symptoms of depression were evaluated using the Center for Epidemiologic Studies Depression (CES-D) scale. Dry eye was diagnosed based on the diagnostic standards developed by the Asia Dry Eye Society in 2016. Results: The 2-year incidence of DE among 460 type 2 DM residents was 33.7% (95% confidence interval [CI]=29.6%–38.3%). The incidence of DE significantly increased with increasing age ( P 〈 0.01). The incidence among women (35.7%) was not statistically significant compared with that of men (31.0%). In the multivariate logistic regression model, age (odds ratio [OR]=1.03, 95% CI=1.01–1.06, P =0.04), corneal sensitivity (OR=0.97, 95% CI=0.94–0.99, P =0.03), and depressive symptom score (OR=1.04, 95% CI = 1.00–1.08, P =0.04) were associated factors for the incidence of DE. In the CES-D scale, two items, “I felt that everything I did was an effort” and “I felt sad,” were significantly correlated with DE onset. Conclusion: The incidence of DE among community residents with type 2 DM was high. Screening for DE among DM residents, especially residents with advanced age, corneal hypoesthesia, and depression, should be strengthened.
    Type of Medium: Online Resource
    ISSN: 1542-2321
    URL: Article
    DOI: 10.1097/ICL.0000000000000626
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2084291-0
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  • 2
    Online Resource
    Online Resource
    Comparison of Refractive Measures of Three Autorefractors in Children and Adolescents
    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Optometry and Vision Science Vol. 94, No. 9 ( 2017-9), p. 894-902
    Details
    In: Optometry and Vision Science, Ovid Technologies (Wolters Kluwer Health), Vol. 94, No. 9 ( 2017-9), p. 894-902
    Abstract: Our study found a good agreement between three autorefractors. Not only will readers benefit as they can now compare data measured with either device in different studies but the three devices can be used in the same study to generate one pool of data, which can be analyzed together. PURPOSE The present study aims to evaluate the agreement of three commonly used autorefractors in children and adolescents, and the potential for their interchangeable application in a large-scale study. METHODS Participants from seven schools were enrolled using cluster sampling. Refractive errors were measured using the following three autorefractors under cycloplegic conditions in random sequence: Topcon KR-8900, Nidek ARK-510A, and Huvitz HRK-7000A. Refractive errors were compared in terms of spherical equivalent refraction (SER), cylinder power, and the J 0 and J 45 by repeated-measures analysis of variance (RM-ANOVA) and Bland-Altman 95% limits of agreement (95% LoA). RESULTS A total of 2072 participants aged from 4 to 18 years were included. The mean ± SD and 95% LoA of the differences in SER between Topcon and Nidek, Topcon and Huvitz, and Nidek and Huvitz were 0.01 ± 0.24D (−0.46 to 0.48), −0.06 ± 0.31D (−0.66 to 0.54), and −0.07 ± 0.26D (−0.58 to 0.44), and those for the differences in cylinder power were −0.07 ± 0.26D (−0.57 to 0.44), 0.01 ± 0.32D (−0.63 to 0.64), and 0.07 ± 0.28D (−0.48 to 0.62), respectively (RM-ANOVA, P 〈 .001). Further, the mean differences in J 0 and J 45 between each refractor pair ranged from −0.03 to 0.01, and the 95% LoA were −0.78 to 0.74, −0.79 to 0.74, and −0.73 to 0.72 for J 0 and −0.86 to 0.87, −0.86 to 0.88, and −0.83 to 0.84 for J 45 , respectively. CONCLUSIONS Our study will allow for use of these three autorefractors interchangeably in large screening studies.
    Type of Medium: Online Resource
    ISSN: 1538-9235 , 1040-5488
    URL: Article
    DOI: 10.1097/OPX.0000000000001113
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
    detail.hit.zdb_id: 2083924-8
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  • 3
    Online Resource
    Online Resource
    CHOROIDAL THICKNESS IN HEALTHY CHINESE CHILDREN AGED 6 to 12 : The Shanghai Children Eye Study
    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Retina Vol. 37, No. 2 ( 2017-02), p. 368-375
    Details
    In: Retina, Ovid Technologies (Wolters Kluwer Health), Vol. 37, No. 2 ( 2017-02), p. 368-375
    Type of Medium: Online Resource
    ISSN: 0275-004X
    URL: Article
    DOI: 10.1097/IAE.0000000000001168
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
    detail.hit.zdb_id: 2071014-8
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  • 4
    Online Resource
    Online Resource
    Deep learning-based analysis of infrared fundus photography for automated diagnosis of diabetic retinopathy with cataracts
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Journal of Cataract and Refractive Surgery Vol. 49, No. 10 ( 2023-10), p. 1043-1048
    Details
    In: Journal of Cataract and Refractive Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 49, No. 10 ( 2023-10), p. 1043-1048
    Abstract: To develop deep learning-based networks for the diagnosis of diabetic retinopathy (DR) with cataracts based on infrared fundus images. Setting: Shanghai General Hospital, Shanghai Eye Disease Prevention & Treatment Center, Shanghai, China. Design: Development and evaluation of an artificial intelligence (AI) diagnostic method. Methods: A total of 10 665 infrared fundus images from 4553 patients with diabetes were used to train and test the model. For image quality assessment, left and right eye classification, DR diagnosis and grading, and segmentation of 3 DR lesions, an end-to-end software using EfficientNet and UNet was developed. The accuracy and performance of the software in comparison to human experts was evaluated. Results: The model achieved an accuracy of 75.31% for left and right eye classification, 100% for DR grading and diagnosis tasks, and 73.67% for internal test set, with corresponding areas under the curve (AUCs) of 0.88, 1.00, and 0.89, respectively. For DR lesion segmentation, the AUCs of hemorrhagic, microangioma, and exudative lesions were 0.86, 0.66, and 0.84, respectively. In addition, a contrast test of human-machine film reading confirmed the software's high sensitivity (96.3%) and specificity (90.0%) and consistency with the manual film reading group (κ = 0.869, P 〈 .001). This easily deployable software generated reports quickly and promoted efficient DR screening with cataracts in clinical and community settings. Conclusions: AI-assisted software can perform automatic analysis of infrared fundus images and has substantial application value for the diagnosis of DR patients with cataracts.
    Type of Medium: Online Resource
    ISSN: 0886-3350 , 1873-4502
    URL: Article
    DOI: 10.1097/j.jcrs.0000000000001269
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
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  • 5
    Online Resource
    Online Resource
    Anterior-Chamber Angle and Axial Length Measurements in Normal Chinese Children
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Journal of Glaucoma Vol. 25, No. 8 ( 2016-08), p. 692-697
    Details
    In: Journal of Glaucoma, Ovid Technologies (Wolters Kluwer Health), Vol. 25, No. 8 ( 2016-08), p. 692-697
    Abstract: To establish the physiological distribution of anterior-chamber angle parameters and axial length (AL) in a randomly sampled cohort of Chinese children. Patients and Methods: This was a prospective, cross-sectional study on randomly sampled Chinese children ages 7 to 15 years. Complete ophthalmologic examination was carried out on all participants; anterior-segment parameters and ALs were measured using Fourier-domain optical coherence tomography and automated biometers. Associations between the age, the sex, the refractive error, the iris thickness, the AL, and anterior-chamber depth (ACD) and angle measurements were analyzed using multiple correlation and regression tests. The relationship between the AL and other factors was studied by a linear regression analysis. Only the right eye data were analyzed for statistical purpose. Results: A total of 541 children were enrolled in this study. There were no differences in angle parameters between sexes ( P 〉 0.05), but boys had a longer AL ( P 〈 0.01). The AL increased logarithmically with age in children ( P 〈 0.01, R 2 =0.5552, b =6.18). Although the magnitude of myopia also increased with AL, this association was less robust ( P 〈 0.05, R 2 =0.0917, b =−0.88). A multiple regression test indicated that the age and the ACD were independently associated with the increase in angle width ( b =0.37 to 0.50 and 0.51 to 0.60, respectively; P 〈 0.001). Conclusions: All angle measurements increased with age and were positively correlated with the ACD in children 7 to 15 years of age. The AL increased logarithmically with age.
    Type of Medium: Online Resource
    ISSN: 1057-0829
    URL: Article
    DOI: 10.1097/IJG.0000000000000404
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
    detail.hit.zdb_id: 2060541-9
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  • 6
    Online Resource
    Online Resource
    Distribution of Anterior Chamber Parameters in Normal Chinese Children and the Associated Factors
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Journal of Glaucoma Vol. 27, No. 4 ( 2018-04), p. 357-363
    Details
    In: Journal of Glaucoma, Ovid Technologies (Wolters Kluwer Health), Vol. 27, No. 4 ( 2018-04), p. 357-363
    Abstract: To describe the distribution of anterior chamber depth (ACD), anterior chamber volume (ACV), and anterior chamber angle (ACA) and establish the associated factors in the pediatric population in Shanghai, China. Materials and Methods: In this cross-sectional study, children aged 6 to 18 years from 9 primary and middle schools in Shanghai were enrolled. The Pentacam Scheimpflug camera was used to measure anterior eye chamber parameters. The distribution of ACD, ACV, ACA, and their associations with age, sex, body mass index, cycloplegic refractive error, axial length, intraocular pressure, and other parameters were analyzed. Results: A total of 1321 children were included, with a mean age of 9.65±2.95 years. The mean ACA, ACD, and ACV values were 37.95±7.96 degrees, 3.22±0.23 mm and 194.89±28.95 mm 3 , respectively, and were higher in boys than in girls. ACV and ACD had similar growth trend curves with age, whereas ACA was stable. Overall, 5% of the tested children had ACA values ≤24.91 degrees. Greater ACV, deeper ACD, shorter pupil diameter, shorter axial length, and thinner apex corneal thickness were the independent factors associated with wider ACA ( R 2 =13.0%, P 〈 0.001). Conclusions: As one of diagnostic indicators of angle closure, ACA was stable with age. The results of this study should improve the current understanding of the distribution of anterior chamber parameters and the main factors affecting their variation.
    Type of Medium: Online Resource
    ISSN: 1057-0829
    URL: Article
    DOI: 10.1097/IJG.0000000000000890
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 2060541-9
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  • 7
    Online Resource
    Online Resource
    Combination of iris vessel area density and surgery interval as the predictor of perceived pain during consecutive second-eye cataract surgery
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Journal of Cataract and Refractive Surgery Vol. 49, No. 8 ( 2023-08), p. 858-863
    Details
    In: Journal of Cataract and Refractive Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 49, No. 8 ( 2023-08), p. 858-863
    Abstract: To explore clinical indicators to predict perceived pain during second-eye phacoemulsification surgery in patients with bilateral cataracts. Setting: Shanghai General Hospital, China. Design: A case‒control study and a prospective cohort study. Methods: Patients with age-related cataract who underwent first-eye or second-eye uneventful phacoemulsification surgery were enrolled. Before surgery, ocular examination results, including vessel area density (VAD) and vessel skeleton density (VSD), obtained by optical coherence tomography angiography examination of the iris were performed. Patients completed a visual analog scale pain survey 3 times postoperatively: 1 hour, 3 hours, and 24 hours postoperatively. Results: 70 patients were enrolled in the case‒control study, and the pain scores of the second-eye surgery group under local anesthesia were significantly greater than those of the first-eye surgery group ( P = .0005). Preoperative iris VAD in the second-eye group affected perioperative pain scores ( P = .0047). The optimal cutoff value of VAD was 0.2167 with a specificity of 76% and a sensitivity of 62%. In the prospective cohort study, 124 patients were included in the second-eye group. Preoperative iris VAD ( P = .0361) and the time interval ( P = .0221) were independent factors for second-eye surgery pain. Combined with preoperative iris VAD and surgical interval, the negative predictive value and positive predictive value were 0.95 and 0.29 for predicting moderate pain or above, the sensitivity and specificity were 0.97 and 0.23, respectively. Conclusions: The combination of iris VAD and the time interval between both eye surgeries can be an effective method to predict the timing of the second-eye cataract surgery and to avoid intraoperative pain.
    Type of Medium: Online Resource
    ISSN: 0886-3350 , 1873-4502
    URL: Article
    DOI: 10.1097/j.jcrs.0000000000001229
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
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  • 8
    Online Resource
    Online Resource
    The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves’ disease in the Chinese population
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Medicine Vol. 101, No. 45 ( 2022-11-11), p. e31501-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 101, No. 45 ( 2022-11-11), p. e31501-
    Abstract: Previously, a case series study was conducted on our part in which 5 patients with Graves’ disease (GD) were collected from a 3-generation family to screen for susceptibility genes responsible for GD. The single nucleotide variants of Microtubule-associated protein 7 domain containing 2 c. 452C  〉  T, p. Ala151Val, Solute carrier family 1 member 7 c. 1204C  〉  T, p. Arg402Cys, tumor necrosis factor receptor-associated factor 3 interacting protein 3 (TRAF3IP3) c. 209A  〉  T, p. Asn70Ile, protein tyrosine phosphatase receptor type B (PTPRB) c. 3472A  〉  G, p. Ser1158Gly, Phosphoinositide-3-kinase regulatory subunit 3 c. 121C  〉  T, p. Pro41Ser, disrupted in schizophrenia 1 (DISC1), c. 1591G  〉  C p. Gly531Arg were associated with the familial GD. We then further confirmed these variants and investigated whether other mutations render susceptibility to GD. The case-control study collected patients with sporadic GD or no GD family history. A snapshot program was used for genotyping the selected SNPs in 235 GD patients (GD group 1) and 284 healthy patients (control group). Furthermore, another 184 GD patients were recruited (GD group 2) to sequence the specified exons of these genes. The sequenced data was compared with Chinese Millionome Database (CMDB). Several variants of PTPRB, phosphoinositide-3-kinase regulatory subunit 3, TRAF3IP3, and DISC1 were found in GD group 2 but not in CMDB. Moreover, the allele frequency of SNP rs2076150 (TRAF3IP3) and rs2492367 DISC1 in GD group 2 was significantly higher than that of in CMDB (all P 〈 .05). When the control group or CMDB was set as a reference group, a significantly higher frequency in alter allele C of SNP rs186466118 PTPRB was observed in GD group 1 and GD group (constituted by GD group 1 and GD group 2). Equally importantly, there was a correlation between the allele C of SNP rs186466118 and the increased risk of GD susceptibility (all P 〈 .05). PTPRB, TRAF3IP3, and DISC1 may be susceptibility genes for GD, and more variants of PTPRB, TRAF3IP3, and DISC1 were found in GD patients.
    Type of Medium: Online Resource
    ISSN: 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000031501
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2049818-4
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  • 9
    Online Resource
    Online Resource
    Reply
    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Journal of Cataract and Refractive Surgery Vol. 43, No. 10 ( 2017-10), p. 1364-1365
    Details
    In: Journal of Cataract and Refractive Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 43, No. 10 ( 2017-10), p. 1364-1365
    Type of Medium: Online Resource
    ISSN: 0886-3350
    URL: Article
    DOI: 10.1016/j.jcrs.2017.08.007
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
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  • 10
    Online Resource
    Online Resource
    Artificial intelligence for diabetic retinopathy
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Chinese Medical Journal Vol. 135, No. 3 ( 2021-12-08), p. 253-260
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 135, No. 3 ( 2021-12-08), p. 253-260
    Abstract: Diabetic retinopathy (DR) is an important cause of blindness globally, and its prevalence is increasing. Early detection and intervention can help change the outcomes of the disease. The rapid development of artificial intelligence (AI) in recent years has led to new possibilities for the screening and diagnosis of DR. An AI-based diagnostic system for the detection of DR has significant advantages, such as high efficiency, high accuracy, and lower demand for human resources. At the same time, there are shortcomings, such as the lack of standards for development and evaluation and the limited scope of application. This article demonstrates the current applications of AI in the field of DR, existing problems, and possible future development directions.
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000001816
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2108782-9
    SSG: 6,25
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