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  • Ovid Technologies (Wolters Kluwer Health)  (5)
  • 1
    Online Resource
    Online Resource
    Effect of neurotropin on Alzheimer’s disease-like changes and cognitive function in rats with chronic cerebral hypoperfusion
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  NeuroReport Vol. 34, No. 3 ( 2023-02-1), p. 170-177
    Details
    In: NeuroReport, Ovid Technologies (Wolters Kluwer Health), Vol. 34, No. 3 ( 2023-02-1), p. 170-177
    Abstract: Chronic cerebral hypoperfusion (CCH) is a main mechanism of cerebrovascular disease and is associated with various cerebrovascular and neurodegenerative diseases, including Alzheimer’s disease. However, treatment of CCH in clinical practice is not ideal, but neurotropin (NTP) has been shown to have a neuroprotective effect. Therefore, this study examined the effect and possible mechanism of NTP in nerve injury caused by CCH. A rat CCH model was established by bilateral common carotid artery occlusion (2VO), and rats were treated with intragastric administration of NTP (200 nu/kg/day) for 28 consecutive days. After treatment, rats were subjected to the Morris water maze and novel object recognition test. Subsequently, an ELISA was applied to detect amyloid-β (Aβ) 1–40 and Aβ1–42 levels in rat hippocampal tissues, quantitative reverse transcription PCR assays were used to detect the mRNA expression levels of brain-derived neurotrophic factor (BDNF) and Trk B, and Western blots were used to detect the protein expression levels of BACE1, tau, p-tau, and protein kinase B (Akt)/glycogen synthase kinase 3β (GSK3β) pathway-related proteins. The rat model of CCH was successfully established by 2VO. Behavioral tests indicated that the cognitive ability of 2VO rats was severely impaired. NTP treatment greatly ameliorated the cognitive disability, reduced Aβ1–40 and Aβ1–42 levels and tau phosphorylation, and upregulated BACE1, Trk B, and BDNF expression in the hippocampus of 2VO rats. Finally, we found that NTP markedly activated Akt/GSK3β pathway activity. NTP can ameliorate cognitive disability in CCH rats possibly by reducing Aβ accumulation and tau phosphorylation in the hippocampus. These effects of NTP may be related to the Akt/GSK3β pathway activation. NTP may be a promising new drug candidate for CCH patients.
    Type of Medium: Online Resource
    ISSN: 0959-4965
    URL: Article
    DOI: 10.1097/WNR.0000000000001875
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2031485-1
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  • 2
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    Online Resource
    Preimplantation genetic testing guidelines of International Society of Reproductive Genetics
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Reproductive and Developmental Medicine Vol. 7, No. 1 ( 2023-03), p. 3-11
    Details
    In: Reproductive and Developmental Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 7, No. 1 ( 2023-03), p. 3-11
    Abstract: The International Society of Reproductive Genetics (ISRG) assembled a workgroup made up of clinicians, clinical laboratory directors, and scientists for the purpose of creating the guidelines for preimplantation genetic testing (PGT). The most up-to-date information and clinical insights for the optimal PGT practice were incorporated in these guidelines. Recommendations are provided for embryologists, medical geneticists, clinical laboratorians, and other healthcare providers to improve the wellbeing of patients seeking assisted reproductive treatment and their offspring.
    Type of Medium: Online Resource
    ISSN: 2096-2924
    URL: Article
    DOI: 10.1097/RD9.0000000000000033
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 3046168-6
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  • 3
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    Online Resource
    Relationship of sleep duration and annual changes in sleep duration with the incidence of gastrointestinal cancers: a prospective cohort study
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Chinese Medical Journal Vol. 134, No. 24 ( 2021-11-24), p. 2976-2984
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 134, No. 24 ( 2021-11-24), p. 2976-2984
    Abstract: Prospective analyses have yet to identify a consistent relationship between sleep duration and the incidence of gastrointestinal (GI) cancers. The effect of changes in sleep duration on GI cancer incidence has scarcely been studied. Therefore, we aimed to examine the association between baseline sleep duration and annual changes in sleep duration and GI cancer risk in a large population-based cohort study. Methods: A total of 123,495 participants with baseline information and 83,511 participants with annual changes in sleep duration information were prospectively observed from 2006 to 2015 for cancer incidence. Cox proportional-hazards models were used to calculate hazard ratios (HRs) and their confidence intervals (CIs) for GI cancers according to sleep duration and annual changes in sleep duration. Results: In baseline sleep duration analyses, short sleep duration (≤5 h) was significantly associated with a lower risk of GI cancer in females (HR: 0.31, 95% CI: 0.10–0.90), and a linear relationship between baseline sleep duration and GI cancer was observed ( P  = 0.010), especially in males and in the 〉 50-year-old group. In the annual changes in sleep duration analyses, with stable category (0 to −15 min/year) as the control group, decreased sleep duration (≤−15 min/year) was significantly associated with the development of GI cancer (HR: 1.29; 95% CI: 1.04–1.61), especially in the 〉 50-year-old group (HR: 1.32; 95% CI: 1.01–1.71), and increased sleep duration ( 〉 0 min/year) was significantly associated with GI cancer in females (HR: 2.89; 95% CI: 1.14–7.30). Conclusions: Both sleep duration and annual changes in sleep duration were associated with the incidence of GI cancer.
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000001770
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2108782-9
    SSG: 6,25
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  • 4
    Online Resource
    Online Resource
    Positron emission computed tomography/single photon emission computed tomography in Parkinson disease
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Chinese Medical Journal Vol. 133, No. 12 ( 2020-05-11), p. 1448-1455
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 133, No. 12 ( 2020-05-11), p. 1448-1455
    Abstract: Parkinson disease (PD) is the second-most common neurodegenerative disorder. Its main pathological mechanism is the selective degeneration and deletion of dopaminergic neurons in the dense part of the substantia nigra and the damage of dopaminergic neurons caused by the abnormal deposition of a Lewy body, leading to a decreased dopamine level. Positron emission computed tomography (PET)/single photon emission computed tomography (SPECT) is a molecular imaging technology that can directly or indirectly reflect changes in molecular levels by using a specific tracer. With the research and development on the tracers of related enzymes for labeling dopamine transporter and dopamine receptor and for being involved in dopamine formation, this imaging technology has been applied to all aspects of PD research. It not only contributes to clinical work but also provides an important theoretical basis for exploring the pathological mechanism of PD at a molecular level. Therefore, this review discusses the application value of PET/SPECT in PD in terms of early diagnosis, disease severity evaluation, clinical manifestations, differential diagnosis, and pathological mechanism.
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000000836
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2108782-9
    SSG: 6,25
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  • 5
    Online Resource
    Online Resource
    Effect of pelvic floor muscles exercises by Extracorporeal Magnetic Innervations on the bladder neck and urinary symptoms
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Journal of the Chinese Medical Association
    Details
    In: Journal of the Chinese Medical Association, Ovid Technologies (Wolters Kluwer Health)
    Abstract: This study aimed to investigate the changes in the bladder neck (BN) and urinary symptoms using extracorporeal magnetic innervations (ExMI) therapy before and after performing passive pelvic floor exercises. Methods: Twenty women with stress urinary incontinence (SUI) were assessed by transperineal ultrasound and questionnaires before and after the ExMI therapy from January 2011 to February 2021. Results: The incidence of urinary frequency and SUI were significantly decreased following the therapy (McNemar's test; P 〈 0.01). The therapeutic efficacy of SUI was 75%. A significant decrease was noted in pad test results (paired t-test, p 〈 0.05). At the same time, there was a considerable difference in Urinary Distress Inventory scale measures (UDI-6) (paired t-test, p 〈 0.001). However, results for the Incontinence Impact Questionnaire (IIQ-7) showed a marginally significant difference (paired t-test, p = 0.066). Three domains of lubrication, orgasm, and satisfaction in the female sexual function index (FSFI) showed significant differences (paired t-test, p 〈 0.05). Transperineal ultrasound found that bladder neck mobility and Q-tip straining angle were not statistically significant (paired t-test, p 〉 0.05). Conclusion The ExMI is effective for SUI by strengthening the pelvic floor muscle without significantly decreasing bladder neck mobility.
    Type of Medium: Online Resource
    ISSN: 1726-4901
    URL: Article
    DOI: 10.1097/JCMA.0000000000001003
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2202774-9
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