In:
Oncology and Translational Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 5, No. 5 ( 2019-10), p. 242-248
Abstract:
The expression of HERG in common bone tumors is scarcely reported and there is a lack of dedicated studies. This study aimed to investigated the expression of HERG in several common musculoskeletal tumors. Methods Immunohistochemical staining, RT-PCR, and Western blotting were used to observe HERG expression differences in various tissues and cell lines. Results HERG was differentially expressed in different malignant tumors, both at a differential protein level and localization within tumors. HERG was not expressed in normal bone tissue. The HERG inhibitor E-4031 markedly inhibited the proliferation of osteosarcoma cell lines. Conclusion HERG was highly expressed in malignant tumors. Blocking of HERG can effectively inhibit the proliferation of bone tumors.
Type of Medium:
Online Resource
ISSN:
2095-9621
DOI:
10.1007/s10330-019-0376-6
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2019
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