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  • Ovid Technologies (Wolters Kluwer Health)  (7)
  • 1
    In: Journal of Clinical Neurophysiology, Ovid Technologies (Wolters Kluwer Health), Vol. 34, No. 5 ( 2017-09), p. 427-433
    Abstract: Focal cortical dysplasia (FCD) is intrinsically epileptogenic, and an MRI-visible lesion typically constitutes the core part of the epileptogenic zone. We aimed to identify ictal EEG patterns that represent the epileptogenic zone by using subdural electrodes placed over the MRI-visible FCD lesion. Methods: We selected seven patients with frontal lobe epilepsy caused by pathologically proven FCD type IIb who underwent preoperative intracranial EEG evaluation with subdural electrodes followed by resection surgery with seizure-free outcome. The characteristics of ictal EEG patterns, interictal/ictal high-frequency oscillations, and ictal direct current shifts from intracranial electrodes placed over the MRI-visible lesion were analyzed. Results: Two seizure-onset patterns (low voltage fast activity and fast spike activity) were identified. Low voltage fast activity was seen in all patients with a lateral frontal lesion, and it was always preceded by preictal spikes. Fast spike activity occurred only in patients with a mesial frontal lesion. Interictal/ictal high-frequency oscillations and ictal direct current shifts were seen in all patients. Conclusions: The epileptogenic zone of frontal FCD type IIb may be characterized by EEG seizure-onset patterns consisting of low voltage fast activity and fast spike activity accompanied by ictal high-frequency oscillations and ictal direct current shifts. Further study is needed to determine whether other seizure-onset patterns exist in patients with FCD type IIb.
    Type of Medium: Online Resource
    ISSN: 0736-0258
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
    detail.hit.zdb_id: 2065729-8
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  • 2
    In: Hepatology Communications, Ovid Technologies (Wolters Kluwer Health), Vol. 4, No. 7 ( 2020-07), p. 1019-1033
    Abstract: Controversies and debates remain regarding the best management of severe acute‐onset autoimmune hepatitis (SA‐AIH) due to the lack of useful outcome or complication prediction systems. We conducted this clinical practice‐based observational study to clarify whether Chronic Liver Failure Consortium Organ Failure scores (CLIF‐C OFs) and the computed tomography–derived liver volume to standard liver volume (CTLV/SLV) ratio at admission to a tertiary transplant center can predict outcomes and complications due to infection. Thirty‐four consecutive corticosteroid‐treated patients with SA‐AIH from 2007 to 2018 were included. Severe hepatitis was defined as an international normalized ratio (of prothrombin time) over 1.3 any time before admission. Of the 34 corticosteroid‐treated patients with SA‐AIH inclusive of 25 (73.5%) acute liver failure cases, transplant‐free survival was observed in 24 patients (70.6%). Any infection was noticed in 10 patients (29.4%). CLIF‐C OFs, at the cutoff of 9, significantly predicted survival ( P  = 0.0002, log‐rank test), outperformed the Model for End‐stage Liver Disease system in predicting outcome ( P  = 0.0325), and significantly discriminated between liver transplant and death in a competing risk analysis. SA‐AIH was characterized as having decreased CTLV/SLV, which was also predictive of survival ( P   〈  0.0001). Interestingly, CLIF‐C OFs, especially the subscores for respiratory dysfunction, also predicted infection ( P  = 0.007). Conclusion: In corticosteroid‐treated patients with SA‐AIH, CLIF‐C OFs and CTLV/SLV ratios predicted both survival outcome and complications due to infection. Further investigation is warranted to determine whether making decisions based on CLIF‐C OFs or CTLV/SLV ratios is useful.
    Type of Medium: Online Resource
    ISSN: 2471-254X , 2471-254X
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2881134-3
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  • 3
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. Suppl_1 ( 2022-11-08)
    Abstract: Introduction: Aortic dissection and aneurysm rupture are aortic emergencies. Surgical outcomes and interventional procedures have improved over the past two decades; however, whether this has translated into lower mortality across countries remains an open question. Hypothesis: We hypothesized that given improved surgical mortality, there will be improvement in mortality from aortic dissection and rupture in the UK, Japan, USA, and Canada. Methods: We analyzed the WHO mortality database to determine trends in mortality from aortic dissection and rupture in 4 countries from 2000 to 2019. Crude mortality rate and age-standardized mortality rate per 100,000 persons were calculated, and annual percentage change was estimated using joinpoint regression. Results: In 2019, crude and age-standardized mortality rates from aortic dissection were 2.15 and 1.04 in UK, 8.67 and 2.66 in Japan, 1.21 and 0.76 in USA, and 1.30 and 0.67 in Canada, respectively. In 2019, crude and age-standardized mortality rates from aortic rupture were 4.86 and 1.80 in UK, 5.22 and 1.16 in Japan, 1.04 and 0.52 in USA, and 1.99 and 0.81 in Canada, respectively. There was a significantly decreasing trend in age-standardized mortality from aortic aneurysm rupture in all 4 countries over the study period, and a decreasing trend in age-standardized mortality from aortic dissection in the UK over the study period, in USA until 2010, and in Canada until 2012. There was a significantly increasing trend in mortality from aortic dissection in Japan over the study period, in the USA after 2010, and in Canada after 2012. Joinpoint regression identified significant changes in the trends from decreasing to increasing in USA and Canada. In sensitivity analyses stratified by sex, similar trends were observed. Conclusions: Trends in mortality from aortic aneurysm rupture are decreasing, however, mortality from aortic dissection is increasing in Japan, USA, and Canada. Further study to explain these trends is warranted.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 1466401-X
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  • 4
    In: Hepatology, Ovid Technologies (Wolters Kluwer Health), Vol. 73, No. 6 ( 2021-06), p. 2594-2597
    Type of Medium: Online Resource
    ISSN: 0270-9139 , 1527-3350
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 1472120-X
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  • 5
    In: ASAIO Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 69, No. 5 ( 2023-05), p. 483-489
    Abstract: There is controversy regarding appropriate surgical ablation procedures concomitant with nonmitral valve surgery. We retrospectively investigated the impact of surgical ablation for atrial fibrillation during aortic valve replacement between 2010 and 2015 in 16 institutions registered through the Japanese Society for Arrhythmia Surgery. Clinical data of 171 patients with paroxysmal and nonparoxysmal atrial fibrillation undergoing aortic valve replacement were collected and classified into full maze operation (n = 79), pulmonary vein isolation (PVI) (n = 56), and no surgical ablation (n = 36) groups. All patients were followed up and electrocardiograms were recorded in 68% at 2 years. The myocardial ischemia time was significantly longer in the maze group than the others during isolated aortic valve replacement ( p ≤ 0.01), but there were no significant differences in 30-day or 2-year mortality rates between groups. The ratios of sinus rhythm at 2 years in paroxysmal and nonparoxysmal atrial fibrillation in the maze group versus PVI group were 87% versus 97%, respectively ( p = 0.24) and 53% versus 42%, respectively ( p = 0.47). No patients with nonparoxysmal atrial fibrillation in the no surgical ablation group maintained sinus rhythm at 2 years. In conclusion, both maze and PVI during aortic valve replacement are valuable strategies to restore sinus rhythm at 2 years and result in favorable early and midterm survival rates.
    Type of Medium: Online Resource
    ISSN: 1058-2916
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2083312-X
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  • 6
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2007
    In:  Journal of Thoracic Imaging Vol. 22, No. 4 ( 2007-11), p. 369-373
    In: Journal of Thoracic Imaging, Ovid Technologies (Wolters Kluwer Health), Vol. 22, No. 4 ( 2007-11), p. 369-373
    Type of Medium: Online Resource
    ISSN: 0883-5993
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2007
    detail.hit.zdb_id: 2048799-X
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  • 7
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 116, No. suppl_16 ( 2007-10-16)
    Abstract: Background: Midkine (MK) protein is a heparin-binding growth factor. We reported recently endogenous MK ameliorates not only acute myocardial infarction (MI) but also long-term survival after MI using MK knockout mice (MKKO). We aim to assess the therapeutic potential of MK protein after MI by exogenous application. Method and results: MI was created in C57BL/6 mice (n=29) by ligation of the left coronary artery. In 11/29 mice, human recombinant MK protein was administrated for 28 days by osmotic pump intraperitoneally (MK-T). Saline was administrated in the same manner for control group (Control) (n=18). Survival rate 28 days after MI in MK-T was significantly higher than Control (82% vs. 44%, p 〈 0.05). In echocardiography 28 days after MI, MK-T showed significantly better LV function compared to Control ( LVEDd; 4.3±0.5 vs. 6.0±0.4 mm, LVESd; 3.6±1.0 vs. 5.3±0.4 mm, EF; 44.3±10.1, vs. 32.1±0.6%, FS; 21.2±5.4 vs.15.3±0.3%, P 〈 0.05). The serum BNP levels 28 days after MI in MK-T was significantly lower than that of Control (129 ± 5 pg/dl vs. 370 ± 98 pg/dl, P 〈 0.05). Size of scar volume quantified by fibrosis area (picrosirius red) in MK-T was significantly smaller than Control (30.3 ± 5 vs. 52.3± 5%, p 〈 0.05). The number of CD31-immunopositive cells in peri-infarct area of LV at 28 days in MK-T was significantly higher than those of Control (45.2 ± 5 V.S. 27.3 ± 5, p 〈 0.05). These changes were associated with an activation of Akt phosphorylation (1.61 fold higher than control, p 〈 0.05) in LV tissue. In-vitro experiments using human umbilical vein endothelial cells (HUVEC) with 100 ng/ml MK caused a significant increase of tube formation with enhacement of Akt phosphorylation (1.68 fold higher than control, P 〈 0.05), and this upregulation was reversed completely by wortmannin, a specific inhibitor of PI3K. Conclusion: MK protein prevents the cardiac remodeling after MI and improves the survival through enhancement of angiogenesis via PI3K/Akt pathway. Exogenous application of MK protein might be a new therapeutic strategy for treatment of heart failure.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2007
    detail.hit.zdb_id: 1466401-X
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