In:
Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 98, No. 50 ( 2019-12), p. e18229-
Abstract:
The relationships between chorioamnionitis (CA) and neurodevelopmental outcomes in preterm infants remain controversial. The meta-analysis aims to evaluate the associations between CA and neurodevelopmental deficits in preterm infants. Methods: All studies exploring the associations between CA and neurodevelopmental deficits in preterm infants were retrieved from the following databases: PubMed, Embase, OVID, EBSCO, ProQuest, CDSR, and CENTRAL. The NOS was used to evaluate the quality of the studies, RevMan was adopted to analyze the data. Results: Twelve studies involving 4267 preterm infants were included. The ORs across studies was 0.95 ( P = .77, I 2 = 51%) for cognitive deficits, 1.09 ( P = .44, I 2 = 10%) for psychomotor deficits, 1.21 ( P = .08, I 2 = 25%) for language deficits, 2.34 ( P = .02, I 2 = 0%) for performance intelligence quotient impairment and 2.81 ( P = .03, I 2 = 0%) for verbal intelligence quotient impairment. Subgroup analyses based on the severity of cognitive deficits indicated that CA might be correlated with severe cognitive deficits ( P = .01, I 2 = 0%) but not with mild cognitive deficits ( P = .40, I 2 = 19%). In terms of the CA category, clinical CA may be related to overall psychomotor deficits ( P = .01, I 2 = 25%) and overall language deficits ( P 〈 .00001, I 2 = 23%) other than histological CA. Conclusion: In preterm infants, CA might be a risk factor for performance and verbal intelligence quotient impairment and severe cognitive deficits, and clinical CA might be a risk factor for overall psychomotor and language deficits.
Type of Medium:
Online Resource
ISSN:
0025-7974
,
1536-5964
DOI:
10.1097/MD.0000000000018229
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2019
detail.hit.zdb_id:
2049818-4
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