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  • Ovid Technologies (Wolters Kluwer Health)  (10)
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  • Ovid Technologies (Wolters Kluwer Health)  (10)
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  • 1
    Online Resource
    Online Resource
    Enhancement of in vitro proliferation and bioactivity of human anterior cruciate ligament fibroblasts using an in situ tissue isolation method and basic fibroblast growth factor culture conditions : A pilot analysis
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Medicine Vol. 98, No. 22 ( 2019-05), p. e15907-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 98, No. 22 ( 2019-05), p. e15907-
    Abstract: Previous studies have reported poor proliferation and bioactivity of human anterior cruciate ligament fibroblasts (hACLFs) after injury. As hACLFs are one of the most significant and indispensable source of seed cells in constructing tissue-engineered ligament, enhancing hACLF proliferation would offer favorable cellular-biological ability and induce the extracellular matrix secretion of hACLFs after loading on multiple types of scaffolds. Enhancing the bioactivity of hACLFs would improve tissue repair and functional recovery after tissue-engineered ligament transplantation. This study compared cells prepared by collagenase digestion and the in situ culture of tissue pieces and investigated the effect of basic fibroblast growth factor (bFGF) on hACLFs. Methods: Six adult patients participated in this study. Of these patients, tissues from three were compared after culture establishment through collagenase digestion or in situ tissue isolation. hACLF phenotypic characteristics were assessed, and the effect of bFGF on hACLF cultures was observed. hACLFs cultured with and without bFGF served as the experimental and control groups, respectively. Cell Counting Kit-8 was used to detect proliferation. The expression of ligament-related genes and proteins was evaluated by immunofluorescence staining, real-time polymerase chain reaction (PCR) assays, and Western blot assays. Results: The morphology of hACLFs isolated using the two methods differed after the 2nd passage. The proliferation of cells obtained by in situ culture was higher than that of cells obtained by collagenase digestion. hACLFs cultured with bFGF after the 3rd passage exhibited a higher proliferation rate than the controls. Immunofluorescence staining, real-time PCR, and Western blot analysis showed a significant increase in ligament-related gene and protein expression in the hACLFs cultured with bFGF. Conclusions: The in situ isolation of tissue pieces enhanced hACLF proliferation in vitro, and the hACLFs exhibited phenotypic characteristics of fibroblasts. hACLFs cultured with bFGF exhibited increased hACLF bioactivity.
    Type of Medium: Online Resource
    ISSN: 0025-7974 , 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000015907
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2049818-4
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  • 2
    Online Resource
    Online Resource
    Driving Ability Evaluation and Rehabilitation for People With Alzheimer’s Disease and Related Dementias
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Alzheimer Disease & Associated Disorders Vol. 36, No. 4 ( 2022-10), p. 374-381
    Details
    In: Alzheimer Disease & Associated Disorders, Ovid Technologies (Wolters Kluwer Health), Vol. 36, No. 4 ( 2022-10), p. 374-381
    Abstract: Worldwide, it is estimated that around 50 million older adults have Alzheimer’s disease and related dementias (ADRD). Cognitive deficits associated with ADRD may affect a driver’s perception and decision-making and potentially cause safety concerns. Despite much research, there lacks a comprehensive cognitive evaluation to determine the driving capability of a person with ADRD and it is unclear what are the most effective training and interventions that help to enhance driving performance for these individuals. The purpose of this article is to conduct a comprehensive literature survey to review and summarize studies of driving performance evaluation and intervention for people with ADRD and discuss perspectives for future studies. Although many studies have investigated the correlations between driving behaviors and cognitive performances for people with ADRD, it remains unclear how driving behaviors and cognitive performances are associated with psychophysiological measures. We discussed the need to develop regular driving evaluation and rehabilitation protocol for people with ADRD. We also highlighted the potential benefit to combine driving tests with psychophysiological measures to assist in characterizing personalized cognitive evaluation in the behavioral evaluation process.
    Type of Medium: Online Resource
    ISSN: 0893-0341
    URL: Article
    DOI: 10.1097/WAD.0000000000000524
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2048789-7
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  • 3
    Online Resource
    Online Resource
    Surgical Treatment of Severe Sprengel's Deformity : A Case Report
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  JBJS Case Connector Vol. 13, No. 1 ( 2023-3-16)
    Details
    In: JBJS Case Connector, Ovid Technologies (Wolters Kluwer Health), Vol. 13, No. 1 ( 2023-3-16)
    Abstract: This article was updated on May 19, 2023, because of a previous error. One of the authors, Ziming Yao, MD, was accidently left off of the article pdf. An erratum (JBJS Case Connect. 2023;13[2]:e22.00648ER) has been published for this article. Case: An adolescent girl who presented with obviously impaired shoulder abduction due to untreated severe Sprengel's deformity underwent deformity correction surgery. Intraoperative neuromonitoring was used to warn of potential brachial plexus injury during a modified Woodward procedure. At 3-month follow-up, range of shoulder abduction had improved significantly. Conclusion: Sprengel's deformity is a rare congenital shoulder deformity, and the Woodward procedure could cause nerve injury in patients with severe Sprengel's deformity. Neuromonitoring can be performed intraoperatively to avoid brachial plexus injury.
    Type of Medium: Online Resource
    ISSN: 2160-3251
    URL: Article
    DOI: 10.2106/JBJS.CC.22.00648
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
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  • 4
    Online Resource
    Online Resource
    Outcomes and Safety of Traditional Growing Rod Technique in the Treatment of Early-onset Dystrophic Scoliosis Secondary to Type 1 Neurofibromatosis With Intraspinal Rib Head Dislocation in Children
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Journal of Pediatric Orthopaedics Vol. 43, No. 3 ( 2023-03), p. e223-e229
    Details
    In: Journal of Pediatric Orthopaedics, Ovid Technologies (Wolters Kluwer Health), Vol. 43, No. 3 ( 2023-03), p. e223-e229
    Abstract: The purpose of this study was to investigate the outcomes and safety of traditional growing rod (TGR) in the treatment of early-onset dystrophic scoliosis secondary to type 1 neurofibromatosis (NF1-EOS) with intraspinal rib head dislocation (IRH) in children. Methods: From September 2006 to June 2020, 21 patients with NF1-EOS were treated with TGR. The patients comprised 13 boys and 8 girls with a mean age of 7.1±1.5 years. Two patients had IRH-induced nerve injury [American Spinal Injury Association (ASIA) grade D] . No neurological symptoms were found in the other patients. The intraspinal rib proportion, apical vertebral rotation, apical vertebral translation, coronal main thoracic curve, trunk shift, thoracic kyphosis, lumbar lordosis, sagittal balance, and T1-S1 height were measured before and after TGR implantation and at the last follow-up. Complications were also evaluated. Results: The mean follow-up time was 3.4±2.0 years. An average of 3.1 times (range: 1 to 8 times) lengthening procedures were performed in each patient. The intraspinal rib proportion was significantly lower postoperatively than preoperatively (22±11% vs. 33±18%, respectively; P 〈 0.001), and no significant correction loss was found at the last follow-up (24±12%, P= 0.364). Compared with the measurements before TGR implantation, the major coronal curve and T1-S1 height after TGR implantation and at the last follow-up were significantly different ( P 〈 0.05). Significant correction of apical vertebral translation, thoracic kyphosis, lumbar lordosis, and sagittal balance were noted after TGR implantation, and no significant correction loss was found at the last follow-up ( P 〉 0.05). Ten complications occurred in 7 patients. Two patients with nerve injury recovered after the operation. No neurological complications were found during the follow-up. Conclusions: TGR is a safe and effective therapy for NF1-EOS with IRH where there was no direct compression of the spinal cord, which was confirmed by preoperative magnetic resonance imaging. Through this procedure, IRH could be partly removed from the spinal canal. Level of Evidence: Level III.
    Type of Medium: Online Resource
    ISSN: 0271-6798
    URL: Article
    DOI: 10.1097/BPO.0000000000002319
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2049057-4
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  • 5
    Online Resource
    Online Resource
    Proposal for a Treatment-oriented Classification System for Congenital Kyphosis in Children
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Spine Vol. 47, No. 15 ( 2022-08-1), p. 1071-1076
    Details
    In: Spine, Ovid Technologies (Wolters Kluwer Health), Vol. 47, No. 15 ( 2022-08-1), p. 1071-1076
    Abstract: Proposal of a new classification system for pediatric congenital kyphosis. Objective. To propose a new treatment-oriented classification system for pediatric congenital kyphosis based on radiographic findings and evaluates the reliability of this new classification system. Summary of Background Data. The classification of congenital kyphosis described by Winter is the one most commonly used. However, this classification of congenital kyphosis cannot direct the surgical options and the treatment choices remain controversial. Methods. For each type of congenital kyphosis, we propose a set of radiological criteria that are suggestive for diagnosis as well as the corresponding surgical options. To evaluate the reliability of this new classification system, 35 patients with congenital kyphosis were reviewed and classified by four attending spine surgeons and five spine fellows. Results. Our new classification system divides congenital kyphosis into five types. The overall Fleiss kappa coefficient ( κ ) value for the new classification system was 0.755, which indicates significant agreement. The interobserver and intraob-server κ values were 0.755 and 0.828, respectively, and there were no significant differences in the k values between the attending spine surgeons and spine fellows. Conclusion. The proposed classification system provides clear descriptions and surgical options for various types of pediatric congenital kyphotic deformities. The reliability study confirmed that the classification system is both simple and consistent, although further research may be needed to validate the system.
    Type of Medium: Online Resource
    ISSN: 0362-2436
    URL: Article
    DOI: 10.1097/BRS.0000000000004304
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2002195-1
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  • 6
    Online Resource
    Online Resource
    Relationship between controlled attenuated parameter and magnetic resonance imaging–proton density fat fraction for evaluating hepatic steatosis in patients with NAFLD
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Hepatology Communications Vol. 6, No. 8 ( 2022-08), p. 1975-1986
    Details
    In: Hepatology Communications, Ovid Technologies (Wolters Kluwer Health), Vol. 6, No. 8 ( 2022-08), p. 1975-1986
    Abstract: We used cross‐sectional and longitudinal studies to comprehensively compare hepatic steatosis measurements obtained with magnetic resonance imaging–proton density fat fraction (MRI‐PDFF) and controlled attenuated parameter (CAP) in hepatic steatosis in adults with nonalcoholic fatty liver disease (NAFLD). A total of 185 participants with NAFLD and 12 non‐NAFLD controls were recruited. CAP and MRI‐PDFF data were collected at baseline from all participants and from 95 patients included in the longitudinal study after 24 weeks of drug or placebo intervention. Pearson correlation, linear regression, and piecewise linear regression analyses were used to evaluate the relationship between the two modalities. Linear analysis suggested a positive correlation between CAP and MRI‐PDFF ( r = 0.577, p 〈 0.0001); however, piecewise linear regression showed no correlation when CAP was ≥331 dB/m ( p = 0.535). In the longitudinal study, both the absolute and relative change measurements were correlated between the two modalities; however, the correlation was stronger for the relative change (relative r = 0.598, absolute r = 0.492; p 〈 0.0001). Piecewise linear regression analysis revealed no correlation when CAP was reduced by more than 53 dB/m ( p = 0.193). Conclusions: We found a correlation between CAP and MRI‐PDFF measurements for grading hepatic steatosis when CAP was 〈 331 dB/m. While the measured absolute change and relative change were correlated, it was stronger for the relative change. These findings have implications for the clinical utility of CAP or MRI‐PDFF in the clinical diagnosis and assessment of NAFLD.
    Type of Medium: Online Resource
    ISSN: 2471-254X , 2471-254X
    URL: Article
    DOI: 10.1002/hep4.1948
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2881134-3
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  • 7
    Online Resource
    Online Resource
    Surgical management of retroperitoneal schwannoma complicated with severe hydronephrosis : A case report
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Medicine Vol. 97, No. 39 ( 2018-09), p. e12528-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 97, No. 39 ( 2018-09), p. e12528-
    Type of Medium: Online Resource
    ISSN: 0025-7974
    URL: Article
    DOI: 10.1097/MD.0000000000012528
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 2049818-4
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  • 8
    Online Resource
    Online Resource
    The Spontaneous Development of Cosmetic Shoulder Balance and Shorter Segment Fusion in Adolescent Idiopathic Scoliosis With Lenke I Curve : A Consecutive Study Followed Up for 2 to 5 Years
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Spine Vol. 41, No. 12 ( 2016-06-15), p. 1028-1035
    Details
    In: Spine, Ovid Technologies (Wolters Kluwer Health), Vol. 41, No. 12 ( 2016-06-15), p. 1028-1035
    Type of Medium: Online Resource
    ISSN: 0362-2436 , 1528-1159
    URL: Article
    DOI: 10.1097/BRS.0000000000001442
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
    detail.hit.zdb_id: 2002195-1
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  • 9
    Online Resource
    Online Resource
    Surgical Treatment of the Intraspinal Rib Head Dislocation in Children With Dystrophic Scoliosis Secondary to Type 1 Neurofibromatosis
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Journal of Pediatric Orthopaedics Vol. 42, No. 3 ( 2022-03), p. e242-e249
    Details
    In: Journal of Pediatric Orthopaedics, Ovid Technologies (Wolters Kluwer Health), Vol. 42, No. 3 ( 2022-03), p. e242-e249
    Abstract: The purpose of this study was to explore the surgical treatment of intraspinal rib head dislocation (IRH) in children with dystrophic scoliosis secondary to type 1 neurofibromatosis (NF1-DS). Methods: From 2006 to 2019, 32 of 128 patients with NF1-DS were found to have IRH and enrolled in this study. There were 19 boys and 13 girls with an average age of 8.8±2.6 years. Patients were divided into 2 groups: group A (n=25) without IRH resection and group B (n=7) with IRH resection. The intraspinal rib proportion (IRP), apical vertebra rotation, apical vertebral translation, main thoracic curve Cobb angle, trunk shift and thoracic kyphosis, lumbar lordosis, and sagittal vertebral axis were measured before and after the operation. Spinal injury was graded based on the American Spinal Injury Association (ASIA) Impairment Scale. Results: The study group had a total of 42 IRH. The mean follow-up duration was 46.1±28.7 months. The preoperative IRP in both groups was similar (35.5±14.3% vs. 31.2±15.3%, P =0.522). The postoperative IRP was lower in group B (18.5±11.2% vs. 0%, P =0.002). The IRP in group A decreased from preoperative (31.2±15.3%) to postoperative (18.5±11.2%) ( P 〈 0.05). There was no significant difference in the apical vertebra rotation, apical vertebral translation, main thoracic curve Cobb angle, trunk shift, thoracic kyphosis, lumbar lordosis, and sagittal vertebral axis between the 2 groups before surgery and after surgery. Four patients with nerve injury caused by the IRH had full neurological recovery postoperatively. All patients were ASIA grade E at the last follow-up. Conclusions: The surgical treatment of IRH in children with NF1-DS should be determined on the basis of the presence of preoperative neurological symptoms. This study supports the practice of correcting spinal deformities only in patients with mild or no spinal cord injury. If there are obvious neurological symptoms, IRH resection is necessary to relieve spinal cord compression to recover nerve function. Level of Evidence: Level III.
    Type of Medium: Online Resource
    ISSN: 0271-6798
    URL: Article
    DOI: 10.1097/BPO.0000000000002048
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2049057-4
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  • 10
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    Online Resource
    Scoliosis Secondary to Neurofibromatosis Type I Combined With Moyamoya Syndrome : A Case Report
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  JBJS Case Connector Vol. 12, No. 3 ( 2022-9-22)
    Details
    In: JBJS Case Connector, Ovid Technologies (Wolters Kluwer Health), Vol. 12, No. 3 ( 2022-9-22)
    Abstract: A 13-year-old girl presenting with scoliosis accompanied by type I neurofibromatosis (NF1) underwent deformity correction surgery. On the second postoperative day, she had sudden-onset acute cerebral infarctions and was diagnosed with moyamoya syndrome. After neurological conservative treatment, at the sixth month after surgery, her symptoms and signs were significantly improved and the daily life was not affected by herself. Conclusion: NF1 scoliosis with moyamoya syndrome is an uncommon inherited disorder. Intracranial vasculopathy is hardly detected from routine preoperative examinations. The specific intracranial vascular examination should be performed for patients with NF1 scoliosis, especially those who have a positive history of cerebral ischemic or hemorrhagic symptoms.
    Type of Medium: Online Resource
    ISSN: 2160-3251
    URL: Article
    DOI: 10.2106/JBJS.CC.22.00304
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
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