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  • Ovid Technologies (Wolters Kluwer Health)  (3)
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  • Ovid Technologies (Wolters Kluwer Health)  (3)
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  • 1
    Online Resource
    Online Resource
    Therapeutic time window and effect of intracarotid neural stem cells transplantation for intracerebral hemorrhage
    Ovid Technologies (Wolters Kluwer Health) ; 2007
    In:  NeuroReport Vol. 18, No. 10 ( 2007-07-2), p. 1019-1023
    Details
    In: NeuroReport, Ovid Technologies (Wolters Kluwer Health), Vol. 18, No. 10 ( 2007-07-2), p. 1019-1023
    Type of Medium: Online Resource
    ISSN: 0959-4965
    URL: Article
    DOI: 10.1097/WNR.0b013e328165d170
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2007
    detail.hit.zdb_id: 2031485-1
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  • 2
    Online Resource
    Online Resource
    Circulating miR‐19b‐3p as a Novel Prognostic Biomarker for Acute Heart Failure
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Journal of the American Heart Association Vol. 10, No. 20 ( 2021-10-19)
    Details
    In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 10, No. 20 ( 2021-10-19)
    Abstract: Circulating microRNAs are emerging biomarkers for heart failure (HF). Our study aimed to assess the prognostic value of microRNA signature that is differentially expressed in patients with acute HF. Methods and Results Our study comprised a screening cohort of 15 patients with AHF and 5 controls, a PCR‐discovery cohort of 50 patients with AHF and 26 controls and a validation cohort of 564 patients with AHF from registered study DRAGON‐HF (Diagnostic, Risk Stratification and Prognostic Value of Novel Biomarkers in Patients With Heart Failure). Through screening by RNA‐sequencing and verification by reverse‐transcription quantitative polymerase chain reaction, 9 differentially expressed microRNAs were verified (miR‐939‐5p, miR‐1908‐5p, miR‐7706, miR‐101‐3p, miR‐144‐3p, miR‐4732‐3p, miR‐3615, miR‐484 and miR‐19b‐3p). Among them, miR‐19b‐3p was identified as the microRNA signature with the highest fold‐change of 8.4 and the strongest prognostic potential (area under curve with 95% CI, 0.791, 0.654–0.927). To further validate its prognostic value, in the validation cohort, the baseline level of miR‐19b‐3p was measured. During a follow‐up period of 19.1 (17.7, 20.7) months, primary end point comprising of all‐cause mortality or readmission due to HF occurred in 48.9% patients, while patients in the highest quartile of miR‐19b‐3p level presented the worst survival (Log‐rank P 〈 0.001). Multivariate Cox model showed that the level of miR‐19b‐3p could independently predict the occurrence of primary end point (adjusted hazard ratio,1.39; 95% CI, 1.18–1.64). In addition, miR‐19b‐3p positively correlated with soluble suppression of tumorigenicity 2 and echocardiographic indexes of left ventricular hypertrophy. Conclusions Circulating miR‐19b‐3p could be a valuable prognostic biomarker for AHF. In addition, a high level of circulating miR‐19b‐3p might indicate ventricular hypertrophy in AHF subjects. Registration URL: https://www.clinicaltrials.gov . Unique Identifier: NCT03727828.
    Type of Medium: Online Resource
    ISSN: 2047-9980
    URL: Article
    DOI: 10.1161/JAHA.121.022304
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2653953-6
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  • 3
    Online Resource
    Online Resource
    Clinical Course of 195 Critically Ill COVID-19 Patients: A Retrospective Multicenter Study
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Shock Vol. 54, No. 5 ( 2020-11), p. 644-651
    Details
    In: Shock, Ovid Technologies (Wolters Kluwer Health), Vol. 54, No. 5 ( 2020-11), p. 644-651
    Abstract: Coronavirus disease-2019 (COVID-19) outbreak has spread around the world. However, the dynamic course of critically ill COVID-19 has not been described thoroughly. Patients and Methods: We retrospectively analyzed 195 critically ill COVID-19 patients in Hubei province, China, between January 5, 2020 and April 3, 2020. Epidemiologic data, clinical features, treatments, and outcomes were collected and analyzed. Results: Most critically ill patients were older with higher Acute Physiology and Chronic Health Evaluation II scores. After critical illness onset, a total of 181 (92.8%) patients received ventilation support, of which 84 (43.1%) received noninvasive and 97 (49.7%) received invasive mechanic ventilation (IMV). Among the 97 patients with IMV, 28 (28.9%) received prone ventilation, 57 (58.8%) received neuromuscular blocked therapy, and 22 (11.3%) received tracheostomy due to prolonged ventilator use. Early hypoxemia, subsequent hypercapnia, pulmonary hypertension, and finally pulmonary fibrosis were notable in the clinical course of acute respiratory distress syndrome (ARDS). Eighty-nine (45.6%) patients presented with shock. Acute kidney injury (29.7%) and secondary infection (28.2%) were also notable. The overall mortality of critically ill patients at day 28 was 42.1%. Intensive care unit (ICU) mortality was around 33%, as 16 patients died prior to ICU admission. A low PaO 2 /FiO 2 ratio was an independent risk factor for death. High viral load was observed in most non-survivors. Conclusion: ARDS and shock were notable in the critical illness of COVID-19. Ventilation support and hemodynamic support were the cornerstones for critical care. High viral load was associated with death of critically ill COVID-19 patients.
    Type of Medium: Online Resource
    ISSN: 1073-2322 , 1540-0514
    URL: Article
    DOI: 10.1097/SHK.0000000000001629
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2011863-6
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