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  • Ovid Technologies (Wolters Kluwer Health)  (4)
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  • Ovid Technologies (Wolters Kluwer Health)  (4)
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  • 1
    Online Resource
    Online Resource
    Transvaginal ultrasound cervical length for prediction of spontaneous labor at term : A protocol for systematic review and meta-analysis
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Medicine Vol. 99, No. 52 ( 2020-12-24), p. e22237-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 99, No. 52 ( 2020-12-24), p. e22237-
    Abstract: To evaluate the predictive accuracy of transvaginal ultrasound (TVU) cervical length (CL) for spontaneous onset of labor in singleton gestation enrolled at term by a meta-analysis. Materials and methods: This protocol established in this study has been reported following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. Web of Science, PubMed, EMBASE, and the Cochrane Library were searched for all clinical trials assessing the accuracy of TVU CL in prediction of spontaneous onset of labor in singleton gestations with vertex presentation who were enrolled at term until August 15, 2020. We will use a combination of Medical Subject Heading and free-text terms with various synonyms to search based on the eligibility criteria. Two investigators independently reviewed the included studies and extracted relevant data. The 95% confidence intervals (CIs) of was used as effect estimate. I-square ( I 2 ) test, substantial heterogeneity, sensitivity analysis, and publication bias assessment will be performed accordingly. Stata 15.0 and Review Manger 5.3 are used for meta-analysis and systematic review. Results: The results will be published in a peer-reviewed journal. Conclusion: The results of this review will be widely disseminated through peer-reviewed publications and conference presentations. This evidence may also assess the accuracy of TVU CL in prediction of spontaneous onset of labor in singleton gestations with vertex presentation. Registration number: INPLASY202080065
    Type of Medium: Online Resource
    ISSN: 0025-7974 , 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000022237
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2049818-4
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  • 2
    Online Resource
    Online Resource
    Abstract 139: Nicotinic Acetylcholine Receptor Genes Contribute to Leptin Resistance
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Hypertension Vol. 74, No. Suppl_1 ( 2019-09)
    Details
    In: Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 74, No. Suppl_1 ( 2019-09)
    Abstract: Background: The mechanisms of leptin resistance among overweight/obese individuals in not fully understood. Smokers have lower body mass index (BMI) compared to non-smokers, and quit smoking results in weight gain. Therefore, we aimed to evaluate whether smoking related genes contribute to leptin resistance. Methods: A total of 541 SNPs in seven genes of the nicotinic acetylcholine receptors family ( CHRNB2-B4, CHRNA3-A6 ) were evaluated for interactions with leptin on BMI among 748 European American participants of the Multi-Ethnic Study of Atherosclerosis (MESA). Significant SNPs were evaluated for replication among 3,844 participants of the Framingham Heart Study (FHS) 3 rd generation cohort. Multivariate linear regressions were used in single SNP-based analyses controlling for age and sex. Gene-based analyses were performed using the GATES method. MESA and FHS results were combined through meta-analysis methods. Results: After Bonferroni correction, a total of 34 SNPs within genes CHRNA3 , CHRNA5 , CHRNA6 , CHRNB2, and CHRNB3 significantly ( P 〈 8.20х10 -4 , correcting for 61 linkage disequilibrium blocks) interacted with leptin on BMI, of which, 23 SNPs reached genome-wide significance ( P 〈 5.00х10 -8 ), and 34 SNPs were successfully replicated in the FHS. CHRNB2 rs2072661 (minor allele frequency=0.24) was most significant with a major G allele negatively interacting with leptin on BMI (MESA: β=-0.05, p=8.20х10 -4 ; FHS: β=-0.05, p=1.31х10 -11 ; Meta: β=-0.05, p=4.19х10 -16 ), indicating that individuals with the major alleles were less resistant to leptin. Meanwhile, gene-based analysis revealed that the seven genes were all significantly interacting with leptin on BMI with meta-analysis p values ranging from 2.62х10 -13 for CHRNB2 to 4.25х10 -5 for CHRNA4 . Conclusion: Nicotine acetylcholine receptor genes modify the sensitivity of leptin on BMI.
    Type of Medium: Online Resource
    ISSN: 0194-911X , 1524-4563
    URL: Article
    DOI: 10.1161/hyp.74.suppl_1.139
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2094210-2
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  • 3
    Online Resource
    Online Resource
    Abstract MP47: Genome-wide Gene-leptin Interaction Study Identifies Loci Contributing to Leptin Resistance
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Circulation Vol. 141, No. Suppl_1 ( 2020-03-03)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 141, No. Suppl_1 ( 2020-03-03)
    Abstract: Background: In a preliminary candidate genes study, we robustly identified that the nicotinic acetylcholine receptor genes modified obesity’s sensitivity to leptin. However, the finding only explained a small proportion of the heritability of leptin resistance. Therefore, the current study expanded our preliminary work to the entire human genome to identify additional novel mechanisms of leptin resistance in humans. Methods: Discovery stage analyses were conducted among 3,838 White participants of the Framingham Heart Study (FHS) 3 rd generation. SNPs contributing to leptin resistance were identified by examining interactions between the SNPs and leptin on body mass index (BMI) and waist circumference (WC), controlling for age, gender, and the first 3 genetic principal components. Gene-based analyses were conducted by combining SNP-based p values using the GATES method. Promising SNPs ( P 〈 1х10 -6 ) and genes ( P 〈 1х10 -4 ) of the FHS were further evaluated for replication among 667 White participants of the Multi-Ethnic Study of Atherosclerosis (MESA) study. Analysis results of the FHS and MESA were combined using inverse-variance-weighted meta-analysis method for SNPs and Fisher’s method for genes. Genomic control was applied before meta-analysis. Results: Single SNP-based analyses identified that PCTP rs78580870, 17:53899497 (FHS P =1.90х10 -8 , MESA P =0.01, Meta P =8.23х10 -10 ) interacted with leptin on BMI. Gene-based analyses robustly identified 4 genes interacting with leptin on WC, including MED9 (FHS P =5.60х10 -6 , MESA P =1.79х10 -3 , Meta P =1.95х10 -7 ) at 17p11.2, RASD1 (FHS P =3.92х10 -6 , FHS P =1.33х10 -3 , Meta P =1.05х10 -7 ) at 17p11.2, DTX3 (FHS P =5.27х10 -7 , MESA P =3.57х10 -2 , Meta P =3.53х10 -7 ) at 12q13.3, and ARHGEF25 (FHS P =7.55х10 -7 , MESA P =4.96х10 -2 , Meta P =6.79х10 -7 ) at 12q13.3. These 4 genes have related biological functions of leptin or obesity. Conclusion: We identified 1 novel genomic locus and 4 novel genes explaining leptin resistance among White. Future large scale genomic studies of leptin resistance among multiple ethnic groups are warranted.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.141.suppl_1.MP47
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 1466401-X
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  • 4
    Online Resource
    Online Resource
    Membranous nephropathy and thymoma in a patient with ankylosing spondylitis : A case report
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Medicine Vol. 99, No. 18 ( 2020-05), p. e20111-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 99, No. 18 ( 2020-05), p. e20111-
    Abstract: We report a rare case with ankylosing spondylitis (AS), thymoma, and membranous glomerulonephritis. The pathogenic mechanisms of these 3 diseases may be associated with each other. Here, we discuss the course of diagnosis and treatment. Patient concerns: A 64-year-old woman with bilateral pain of the sacroiliac joints for 10 years and anasarca for 10 days. Diagnoses: A diagnosis of AS by HLA-B27 and pelvic X-ray tests, thymoma based on computed tomography and pathological diagnosis, and membranous glomerulonephritis based on renal biopsy. Interventions: We administered methylprednisolone 500 mg/d for 3 consecutive days, followed by methylprednisolone 40 mg oral QD, for a month. Outcomes: The patient was followed up once a month. In the sixth month, the patient's serum creatinine had decreased to 0.96 mg/dL, urine microalbumin/creatinine decreased to 173.3 mg/g, and albumin had risen to 33.1 g/L. Pain and morning stiffness were relieved, and the Bath Ankylosing Spondylitis Disease Activity Index score dropped to 4.0. Lessons: Although the causal relationship between AS, thymoma, and membranous nephropathy in this patient still needs to be established, the pathogenesis between the 3 diseases may have some association. In clinical practice, patients with AS need to be screened for tumors and renal complications.
    Type of Medium: Online Resource
    ISSN: 0025-7974 , 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000020111
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2049818-4
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