GLORIA

GEOMAR Library Ocean Research Information Access

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Ovid Technologies (Wolters Kluwer Health)  (6)
Material
Publisher
  • Ovid Technologies (Wolters Kluwer Health)  (6)
Language
Years
Subjects(RVK)
  • 1
    In: Coronary Artery Disease, Ovid Technologies (Wolters Kluwer Health), Vol. 31, No. 2 ( 2020-03), p. 124-129
    Abstract: An elevated fibrinogen level has been demonstrated to be a predictor of adverse coronary heart disease outcome. This study aimed to assess whether fibrinogen is a useful marker to predict the prognosis of patients with non-ST-elevation acute coronary syndromes (NSTE-ACS) undergoing percutaneous coronary intervention (PCI). Additionally, the prognostic accuracy of fibrinogen level was compared with that of the Global Registry of Acute Coronary Events (GRACE) score. Methods A total of 1211 patients with NSTE-ACS undergoing PCI were analyzed in a prospective cohort study. The enrolled patients were divided into a low fibrinogen group ( n  = 826, fibrinogen ≤ 3.49 mg/dl) and a high fibrinogen group ( n  = 385, fibrinogen  〉  3.49 mg/dl) based on a receiver operating characteristic (ROC) curve. The clinical endpoints were death and death/nonfatal reinfarction. An ROC curve analysis was performed and the area under the curve with a 95% confidence interval (CI) was derived and compared with those for the GRACE score to determine the diagnostic value of the serum fibrinogen level. Results Multivariate analysis showed that an elevated baseline fibrinogen level was an independent predictor of death/nonfatal reinfarction (hazard ratio = 1.498, 95% CI: 1.030–2.181, P  = 0.035). The prognostic performance of fibrinogen was equivalent to that of the GRACE system in predicting clinical endpoints (C-statistic: z  = 1.486, P  = 0.14). Conclusion Fibrinogen is an independent predictor of death/nonfatal reinfarction in patients with NSTE-ACS undergoing PCI, and its accuracy is similar to that of the GRACE system.
    Type of Medium: Online Resource
    ISSN: 0954-6928
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2042449-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    In: Circulation Research, Ovid Technologies (Wolters Kluwer Health), Vol. 131, No. Suppl_1 ( 2022-08-05)
    Abstract: Introduction: Ischemic stroke caused a heavy burden on public health. NMDA receptor (NMDAR) mediated excitotoxicity was thought to be the culprit for neuronal death during ischemic stroke. However, NMDAR antagonists all failed to show protective effects in human patients. The heat-sensitive ion channel TRPM2 is Ca 2+ -permeable and usually activated under oxidative stress conditions. TRPM2 is abundantly expressed in the brain and promotes neuronal death during ischemic stroke, whereas the underlying mechanisms remain elusive. Hypothesis: Oxidative stress is a hallmark of brain damage during ischemic stroke. We hypothesized that TRPM2 is important in magnifying NMDAR-mediated excitotoxicity. Methods: Neuron specific TRPM2 knockout was achieved by crossing nestin-cre mice with Trpm2 fl/fl mice. Middle cerebral artery occlusion (MCAO) and oxygen-glucose deprivation (OGD) were performed to mimic ischemic stroke in vivo and in vitro, respectively. Co-immunoprecipitation and direct binding assay were used to examine protein-protein interaction. Subcloning and mutagenesis were used to identify interaction details. Interfering peptide specifically disrupting TRPM2-NMDAR interaction was designed and synthesized. Cortical neurons were isolated and cultured, Fura-2-AM and Rhodamine-123 imaging were used to examine Ca 2+ overload and mitochondrial dysfunction, respectively. Synaptic and extrasynaptic NMDAR mediated responses were separated, and synaptosome was isolated to examine the influence of TRPM2 on NMDAR and expression of TRPM2 in neurons at different sites, respectively. Results: Neuron specific TRPM2 knockout alleviates ischemic stroke in mice. TRPM2 physically and functionally interacts with extrasynaptic NMDAR, which enhances excitotoxity. The EE 3 motif in TRPM2 directly associates with the KKR motif in NMDAR. Uncoupling of TRPM2-NMDAR association using a disrupting peptide TAT-EE 3 prevents OGD-induced Ca 2+ overload and mitochondrial dysfunction in neurons, and protects mice against MCAO-induced brain injury. Conclusion: Therapeutic interfering peptide TAT-EE 3 attenuates ischemic stroke. Targeting the TRPM2-NMDAR coupling could be a promising strategy for screening more effective therapies for ischemic stroke.
    Type of Medium: Online Resource
    ISSN: 0009-7330 , 1524-4571
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 1467838-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Medicine Vol. 95, No. 8 ( 2016-02), p. e2859-
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 95, No. 8 ( 2016-02), p. e2859-
    Type of Medium: Online Resource
    ISSN: 0025-7974
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
    detail.hit.zdb_id: 2049818-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Plastic & Reconstructive Surgery Vol. Publish Ahead of Print ( 2023-03-21)
    In: Plastic & Reconstructive Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. Publish Ahead of Print ( 2023-03-21)
    Type of Medium: Online Resource
    ISSN: 0032-1052
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2037030-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Plastic & Reconstructive Surgery Vol. 151, No. 1 ( 2023-01), p. 47e-55e
    In: Plastic & Reconstructive Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 151, No. 1 ( 2023-01), p. 47e-55e
    Abstract: Because of the availability of highly active antiretroviral therapy, individuals infected with human immunodeficiency virus (HIV) are enjoying greater longevity with chronic conditions including abnormal adipose distribution. However, prior data on postoperative outcomes of liposuction in HIV-positive patients were limited by small sample size. Therefore, the authors aimed to compare differences in temporary trend, clinical characteristics, and outcomes between patients with and without HIV who underwent liposuction. Methods: The National Inpatient Sample database from 2010 to 2017 was queried to identify patients who underwent liposuction. Univariate, multivariate logistic regression and 1:4 propensity score–matched analyses were used to assess the primary outcomes (i.e., in-hospital mortality and postoperative outcomes) and secondary outcomes (i.e., discharge disposition, prolonged length of stay, and total cost). Results: Overall, 19,936 patients who underwent liposuction were identified, among whom 61 patients (0.31%) were infected with HIV. Patients with HIV were more likely to be male, insured by Medicare, and had more comorbidities and lower income. Unadjusted length of stay was longer among patients with HIV (OR, 1.81; 95% CI, 1.09 to 2.99; P = 0.020); nevertheless, multivariable models and propensity score–matched analysis demonstrated that patients with HIV were no more likely to have complications than the general population. This was also the case for length of stay and total costs. Conclusions: The authors’ findings indicated that patients with HIV who underwent liposuction did not experience an increased risk of major complication or mortality. Liposuction could be safely considered as a surgical treatment for HIV-positive patients with local fat deposition. CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, II.
    Type of Medium: Online Resource
    ISSN: 0032-1052
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2037030-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 8, No. 13 ( 2019-07-02)
    Abstract: The uptake of proven stroke treatments varies widely. We aimed to determine the association of evidence‐based processes of care for acute ischemic stroke ( AIS ) and clinical outcome of patients who participated in the HEADPOST (Head Positioning in Acute Stroke Trial), a multicenter cluster crossover trial of lying flat versus sitting up, head positioning in acute stroke. Methods and Results Use of 8 AIS processes of care were considered: reperfusion therapy in eligible patients; acute stroke unit care; antihypertensive, antiplatelet, statin, and anticoagulation for atrial fibrillation; dysphagia assessment; and physiotherapist review. Hierarchical, mixed, logistic regression models were performed to determine associations with good outcome (modified Rankin Scale scores 0–2) at 90 days, adjusted for patient and hospital variables. Among 9485 patients with AIS, implementation of all processes of care in eligible patients, or “defect‐free” care, was associated with improved outcome (odds ratio, 1.40; 95% CI, 1.18–1.65) and better survival (odds ratio, 2.23; 95% CI , 1.62–3.09). Defect‐free stroke care was also significantly associated with excellent outcome (modified Rankin Scale score 0–1) (odds ratio, 1.22; 95% CI , 1.04–1.43). No hospital characteristic was independently predictive of outcome. Only 1445 (15%) of eligible patients with AIS received all processes of care, with significant regional variations in overall and individual rates. Conclusions Use of evidence‐based care is associated with improved clinical outcome in AIS . Strategies are required to address regional variation in the use of proven AIS treatments. Clinical Trial Registration URL : https://www.clinicaltrials.gov . Unique Identifier: NCT 02162017.
    Type of Medium: Online Resource
    ISSN: 2047-9980
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2653953-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...