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  • 1
    Online Resource
    Online Resource
    Fear of cancer recurrence, distress, depressive symptoms, and quality of life in hematopoietic stem cell transplantation patients
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Journal of Psychosocial Oncology Research & Practice Vol. 1, No. 2 ( 2019-09-24), p. e12-
    Details
    In: Journal of Psychosocial Oncology Research & Practice, Ovid Technologies (Wolters Kluwer Health), Vol. 1, No. 2 ( 2019-09-24), p. e12-
    Abstract: Symptoms of psychological distress, including fear of cancer recurrence (FCR) and quality of life (QOL) deficits are common along the hematopoietic stem cell transplantation (HCT) survivorship trajectory. Identifying patterns over time could contribute to timely interventions. Materials and Methods: HCT recipients completed the Distress Thermometer (DT), the Center for Epidemiologic Studies-Depression scale (CES-D), the Fear of Relapse and Recurrence Scale, and the Functional Assessment of Cancer Therapy (FACT-BMT) at hospital admission, discharge, 3, 6, 12, and 24 months post-HCT. Demographic data and performance status (PS) were collected at baseline. Mean scores (standard deviation) and frequencies were calculated. We utilized a linear mixed model approach on the repeated measures data (outcome of FCR, with predictors of distress, depressive symptoms and QOL). A multivariate repeated measures regression was constructed to assess what variables were associated with FCR. Results: A total of 198 patients completed questionnaires at admission. A total of 144 patients were deceased or lost to follow-up at 2 years. Both CES-D ( P  = .006) and DT ( P  = .0019) scores changed significantly over time and were higher at hospital discharge. FCR did not change significantly ( P  = .28). QOL was most impaired at hospital discharge. FCR did not correlate with actual recurrence. A significant percentage of recipients were afraid of cancer recurrence; however, a much greater percentage did not feel that fear of recurrence got in the way of enjoying life. QOL ( P   〈  .0001) and PS ( P  = .014) were significant predictors of FCR. A substantial percentage of patients reported significant ( 〉 16) depressive symptoms and distress levels (≥4) during the 2-year study period. Conclusions: Depressive symptoms and distress were highest at discharge, whereas overall QOL was lowest. FCR was prominent; yet for the majority, it was not an impediment to enjoying life. A psychosocial intervention may be most useful if introduced at hospital discharge and initiated during the first 3 months following HCT when distress is high.
    Type of Medium: Online Resource
    ISSN: 2637-5974
    URL: Article
    DOI: 10.1097/OR9.0000000000000012
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
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  • 2
    Online Resource
    Online Resource
    Laparoscopic Endometriosis Treatment: Is It Better?
    Ovid Technologies (Wolters Kluwer Health) ; 1993
    In:  Obstetrical & Gynecological Survey Vol. 48, No. 6 ( 1993-06), p. 432-434
    Details
    In: Obstetrical & Gynecological Survey, Ovid Technologies (Wolters Kluwer Health), Vol. 48, No. 6 ( 1993-06), p. 432-434
    Type of Medium: Online Resource
    ISSN: 0029-7828
    URL: Article
    DOI: 10.1097/00006254-199306000-00022
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1993
    detail.hit.zdb_id: 2043471-6
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  • 3
    Online Resource
    Online Resource
    Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Journal of the American Society of Nephrology Vol. 29, No. 1 ( 2018-1), p. 335-348
    Details
    In: Journal of the American Society of Nephrology, Ovid Technologies (Wolters Kluwer Health), Vol. 29, No. 1 ( 2018-1), p. 335-348
    Abstract: Magnesium (Mg 2+ ) homeostasis is critical for metabolism. However, the genetic determinants of the renal handling of Mg 2+ , which is crucial for Mg 2+ homeostasis, and the potential influence on metabolic traits in the general population are unknown. We obtained plasma and urine parameters from 9099 individuals from seven cohorts, and conducted a genome-wide meta-analysis of Mg 2+ homeostasis. We identified two loci associated with urinary magnesium (uMg), rs3824347 ( P= 4.4×10 −13 ) near TRPM6 , which encodes an epithelial Mg 2+ channel, and rs35929 ( P= 2.1×10 −11 ), a variant of ARL15 , which encodes a GTP-binding protein. Together, these loci account for 2.3% of the variation in 24-hour uMg excretion. In human kidney cells, ARL15 regulated TRPM6-mediated currents. In zebrafish, dietary Mg 2+ regulated the expression of the highly conserved ARL15 ortholog arl15b , and arl15b knockdown resulted in renal Mg 2+ wasting and metabolic disturbances. Finally, ARL15 rs35929 modified the association of uMg with fasting insulin and fat mass in a general population. In conclusion, this combined observational and experimental approach uncovered a gene–environment interaction linking Mg 2+ deficiency to insulin resistance and obesity.
    Type of Medium: Online Resource
    ISSN: 1046-6673 , 1533-3450
    URL: Article
    DOI: 10.1681/ASN.2017030267
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 2029124-3
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