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  • Ovid Technologies (Wolters Kluwer Health)  (18)
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  • 1
    Online Resource
    Online Resource
    Genetic aspects of early menopause
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Journal of Bio-X Research Vol. 2, No. 3 ( 2019-09-12), p. 105-111
    Details
    In: Journal of Bio-X Research, Ovid Technologies (Wolters Kluwer Health), Vol. 2, No. 3 ( 2019-09-12), p. 105-111
    Abstract: Menopause is a biological event associated with the complete cessation of a woman's reproductive ability. Early menopause is defined as entry into menopause between the ages of 40 and 45 years, and has a significant impact on the fertility of affected women. Early menopause is a complex and heterogeneous disorder that is influenced by multiple genetic and environmental factors, as well as the interactions between these factors. Genome-wide association study (GWAS) is a novel strategy that has recently come into use as a way to overcome the limitations of genome-wide linkage analyses and candidate gene association approaches to discover novel susceptibility loci for early menopause. GWAS has identified many new candidate genes or loci associated with early menopause. In this review, we provide an overview of the current understanding of the genetic factors associated with early menopause that have been identified by GWAS. We also discuss potential approaches that could be used in the future to identify new genes associated with early menopause.
    Type of Medium: Online Resource
    ISSN: 2096-5672 , 2577-3585
    URL: Article
    DOI: 10.1097/JBR.0000000000000043
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 3025541-7
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  • 2
    Online Resource
    Online Resource
    Association between plasma endothelial microparticles and contrast-induced nephropathy in patients underwent coronary angiography
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Medicine Vol. 100, No. 28 ( 2021-07-16), p. e24004-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 100, No. 28 ( 2021-07-16), p. e24004-
    Abstract: We aim to investigate the association between plasma endothelial microparticles (EMPs) and contrast-induced nephropathy of patients underwent coronary angiography. The patients were divided into normal renal function group and renal dysfunction group based on the estimated glomerular filtration rate (eGFR). Among the 180 cases, 117 received determination of EMP and serum creatinine after percutaneous coronary intervention (PCI) and/or coronary angiography. The patients were divided into contrast-induced-nephropathy (CIN) group and non-CIN group. EMPs collection and determination were performed, together with biochemical analysis and digital subtraction angiography (DSA) analysis. Spearman correlation showed that the expression of EMP was negatively correlated with eGFR ( r  = –0.201, P   〈  .01). The serum hypersensitive C-reactive protein (hs-CRP), cystatin C (Cys-C), uric acid (UA) were significantly higher in CIN group than that in the non CIN group. Spearman correlation showed that the expression of EMP was positively correlated with serum interleukin-6 (IL-6, r  = 0.393, P   〈  .01). The expression of EMP was positively correlated with serum hs-CRP ( r  = 0.360, P   〈  .01). Logistic regression analysis showed that the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), eGFR, UA, and Cys-C were correlated with the incidence of contrast induced nephropathy. In patients with contrast-induced-nephropathy, the plasma EMPs were significantly increased after coronary angiography. The expression of plasma EMPs may play a role in the occurrence of contrast-induced-nephropathy.
    Type of Medium: Online Resource
    ISSN: 0025-7974 , 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000024004
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2049818-4
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  • 3
    Online Resource
    Online Resource
    Effects of qiming granule for diabetic macular edema : A protocol for systematic review and meta-analysis
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Medicine Vol. 98, No. 42 ( 2019-10), p. e17496-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 98, No. 42 ( 2019-10), p. e17496-
    Abstract: Diabetic macular edema is a further complication of diabetes. It is an important type of diabetic eye disease and the main cause of blindness of diabetic patients. Qiming granule is a Chinese patent medicine widely used in the treatment of diabetic macular edema. There are some reports about this medicine for macular edema. At present, there is only 1 systematic review on qiming granule in the treatment of diabetic macular edema. However, there are many defects in this article, so it is necessary to re-summarize and evaluate the existing evidence. Methods and analysis: Three English database and 4 Chinese databases other sources will be searched. Two methodological trained researchers will read the title, abstract and full texts, and independently select the qualified literature according to inclusion and exclusion criteria. After assessment of the risk of bias and data extraction, we will conduct meta-analyses for outcomes including central macular thickness, optimum corrected vision, overall effect rates, and adverse effects. The heterogeneity of data will be investigated by Cochrane χ 2 and I 2 tests. We build 3 hypotheses for subgroup analysis according to the guidance for a credible subgroup effect: Disease status at baseline, duration of intervention, type of concomitant medication. Sensitivity analysis will be conducted to evaluate the stability of the results. Then publication bias assessment will be conducted by funnel plot analysis and Egger test. Finally, we will use the Grading of Recommendations Assessment, Development and Evaluate system to evaluate the quality of evidence. Results: The results of our research will be published in a peer-reviewed journal. Conclusion: In our study, the evidence of qiming granule in the treatment of macular edema was comprehensively summarized and carefully evaluated. It will provide more options for clinical treatment of the disease. PROSPERO registration number: CRD42018108626.
    Type of Medium: Online Resource
    ISSN: 0025-7974 , 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000017496
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2049818-4
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  • 4
    Online Resource
    Online Resource
    Companied P16 genetic and protein status together providing useful information on the clinical outcome of urinary bladder cancer
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Medicine Vol. 97, No. 15 ( 2018-04), p. e0353-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 97, No. 15 ( 2018-04), p. e0353-
    Type of Medium: Online Resource
    ISSN: 0025-7974
    URL: Article
    DOI: 10.1097/MD.0000000000010353
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 2049818-4
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  • 5
    Online Resource
    Online Resource
    An open, parallel, randomized, comparative, multicenter investigation evaluating the efficacy and tolerability of Mepilex Ag versus silver sulfadiazine in the treatment of deep partial-thickness burn injuries
    Ovid Technologies (Wolters Kluwer Health) ; 2015
    In:  Journal of Trauma and Acute Care Surgery Vol. 78, No. 5 ( 2015-05), p. 1000-1007
    Details
    In: Journal of Trauma and Acute Care Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 78, No. 5 ( 2015-05), p. 1000-1007
    Type of Medium: Online Resource
    ISSN: 2163-0755
    URL: Article
    DOI: 10.1097/TA.0000000000000620
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2015
    detail.hit.zdb_id: 2651313-4
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  • 6
    Online Resource
    Online Resource
    Fibroblast-Specific β-Catenin Signaling Dictates the Outcome of AKI
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Journal of the American Society of Nephrology Vol. 29, No. 4 ( 2018-4), p. 1257-1271
    Details
    In: Journal of the American Society of Nephrology, Ovid Technologies (Wolters Kluwer Health), Vol. 29, No. 4 ( 2018-4), p. 1257-1271
    Abstract: AKI is a devastating condition with high morbidity and mortality. The pathologic features of AKI are characterized by tubular injury, inflammation, and vascular impairment. Whether fibroblasts in the renal interstitium have a role in the pathogenesis of AKI is unknown. In this study, we investigated the role of fibroblast-specific β -catenin signaling in dictating the outcome of AKI, using conditional knockout mice in which β -catenin was specifically ablated in fibroblasts (Gli1- β -cat−/−). After ischemia-reperfusion injury (IRI), Gli1- β -cat−/− mice had lower serum creatinine levels and less morphologic injury than Gli1- β -cat+/+ littermate controls. Moreover, we detected fewer apoptotic cells, as well as decreased cytochrome C release; reduced expression of Bax, FasL, and p53; and increased phosphorylation of Akt, in the Gli1- β -cat−/− kidneys. Gli1- β -cat−/− kidneys also exhibited upregulated expression of proliferating cell nuclear antigen and Ki-67, which are markers of cell proliferation. Furthermore, Gli1- β -cat−/− kidneys displayed suppressed NF-κB signaling and cytokine expression and reduced infiltration of inflammatory cells. Notably, loss of β -catenin in fibroblasts induced renal expression of hepatocyte growth factor (HGF) and augmented the tyrosine phosphorylation of c-met receptor after IRI. In vitro , treatment with Wnt ligands or ectopic expression of active β -catenin inhibited HGF mRNA and protein expression and repressed HGF promoter activity. Collectively, these results suggest that fibroblast-specific β -catenin signaling can control tubular injury and repair in AKI by modulating HGF expression. Our studies uncover a previously unrecognized role for interstitial fibroblasts in the pathogenesis of AKI.
    Type of Medium: Online Resource
    ISSN: 1046-6673 , 1533-3450
    URL: Article
    DOI: 10.1681/ASN.2017080903
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 2029124-3
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  • 7
    Online Resource
    Online Resource
    Abstract NS8: Predictors Of Complete Oral Feeding Resumption After Stroke Based On The Modified Volume-viscosity Swallow Test In A Rehabilitation Hospital
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Stroke Vol. 54, No. Suppl_1 ( 2023-02)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 54, No. Suppl_1 ( 2023-02)
    Abstract: Objective: Although the importance of early tube feeding after stroke has been established, many risks and problems such as negative impacts on swallow function, respiratory infections and feeling uncomfortable, also warrant attention. The trajectory of swallowing function recovery may be related to each patient’s characteristics. There is still no systematic predictors for clinical decision-making regarding oral feeding resumption. The aim is to explore predictors of complete oral feeding resumption after feeding tube with stroke based on the modified V-VST. Methods: A total of 86 stroke patients with tube feeding were enrolled after admission in rehabilitation hospital from 2020 to 2021. The swallowing function was screened with modified V-VST. If a patient complete every viscosity more than 5ml, feeding tube will be removed. Oral feeding was begun using mechanical soft diet and thickener to ensure every meal safe. 55 patients(63.95%) resumed complete oral intake, while 31 patients(36.05%) presented a more permanent way of tube feeding. We compared the baseline and clinical characteristics between the groups. To analyze oral feeding resumption probability, the Kaplan-Meier method was used. Results: The days of onset to rehabilitation hospital admission was significantly shorter in the complete oral resumption group(20.89±11.27 vs 37.16±27.37; P 〈 0.001). The group was also measured better performance in activities of daily living (Barthel Index). Patients in the tube feeding group have high rate of previous stroke. Kaplan-Meier estimated oral feeding resumption rates, patients with longer days( 〉 21days) tolerated tube feeding longer.(P 〈 0.001). Conclusion: Days of onset to rehabilitation hospital was the strongest predictor of complete oral feeding resumption. Patients might benefit from early recovery in rehabilitation hospital and start oral intake as early as possible.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.54.suppl_1.NS8
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 1467823-8
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  • 8
    Online Resource
    Online Resource
    Abstract WMP34: Impact of Complete Oral Feeding Resumption on Nutrition and Hydration in the Rehabilitation Inpatient With Stroke
    Ovid Technologies (Wolters Kluwer Health) ; 2024
    In:  Stroke Vol. 55, No. Suppl_1 ( 2024-02)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 55, No. Suppl_1 ( 2024-02)
    Abstract: Objective: Oral feeding resumption after feeding tube placement is an important therapeutic goal for stroke patients with dysphagia. Available information on nutrition and hydration status in stroke is limited after changing intake from commercial formula for tube feeding to dysphagia diet for oral. The aim is to explore the impact on nutrition and hydration after complete oral feeding. Methods: A total of 134 stroke patients who recovered from tube feeding to complete oral feeding were enrolled in rehabilitation hospital from Jan. 2020 to Jul. 2023. The swallow function was detected by the modified Volume-viscosity Swallow Test (V-VST). If a patient completed every viscosity more than 5 mL, feeding tube would be removed. We assessed the nutritional status of stroke patients and provided strategies of dysphagia diet for patients’ food and fluid intakes. Thickeners were used to prevent the risk of aspiration. Serum biochemical measures were obtained for nutrition (prealbumin) and hydration status (BUN/Cr ratio) at admission, before removing feeding tube and within the first week following oral feeding resumption. Results: 48.51% patients could regain oral intake within 14 days from admission. Compared to admission and tube feeding phase, the level of prealbumin (mg/L) after oral feeding was significantly higher. (19.26±5.32. vs 22.57±5.03; P 〈 0.001) (20.68±5.10 v 22.57±5.03; P=0.003). Based on prealbumin 20 mg/dL, 58.21 % of patients demonstrated poor nutrition at admission and 34.33 % after oral feeding resumption. BUN/Cr 〉 20:1 identified deficient hydration in 53.72 % of patients in tube feeding phase and 46.27 % of patients after oral intake. Differences in nutrition and hydration status were attributed to complete oral feeding resumption. Conclusion: Clinical practice of complete oral feeding resumption including evaluating swallow function of varying viscosities, dietary and fluid recommendations could achieve better nutrition and hydration status.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.55.suppl_1.WMP34
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2024
    detail.hit.zdb_id: 1467823-8
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  • 9
    Online Resource
    Online Resource
    Scales for Evaluating Depressive Symptoms in Chinese Patients With Schizophrenia
    Ovid Technologies (Wolters Kluwer Health) ; 2009
    In:  Journal of Nervous & Mental Disease Vol. 197, No. 2 ( 2009-02), p. 140-142
    Details
    In: Journal of Nervous & Mental Disease, Ovid Technologies (Wolters Kluwer Health), Vol. 197, No. 2 ( 2009-02), p. 140-142
    Type of Medium: Online Resource
    ISSN: 0022-3018
    URL: Article
    DOI: 10.1097/NMD.0b013e31819636a5
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2009
    detail.hit.zdb_id: 2071032-X
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  • 10
    Online Resource
    Online Resource
    Inflammation-related Gene Polymorphisms Associated With Childhood Acute Lymphoblastic Leukemia
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Journal of Pediatric Hematology/Oncology Vol. 45, No. 1 ( 2023-01), p. e9-e13
    Details
    In: Journal of Pediatric Hematology/Oncology, Ovid Technologies (Wolters Kluwer Health), Vol. 45, No. 1 ( 2023-01), p. e9-e13
    Abstract: Acute lymphoblastic leukemia (ALL) is a malignant hematological disease and is often accompanied by a variety of genetic abnormalities. The pathogenesis of inflammation-related single-nucleotide polymorphism (SNP) in children with ALL remains unclear. Objective: This study was to discover the association of the SNP sites of some inflammation-related genes and the susceptibility and treatment response of ALL in children, so as to provide personalized treatment for ALL in children. Procedure: One hundred sixty-five childhood ALL patients and 175 age-matched healthy participants were recruited in this study. We investigated the involvement of 31 SNPs of the inflammation-related genes in the pathogenesis and treatment response of childhood ALL. Results: Statistical analysis revealed that rs2280714 in IRF5, rs2297630 in SDF-1, rs4353135 in NLRP3, rs1946518 in interleukin-18 were related to the susceptibility to pediatric ALL. Interleukin-1β rs16944 SNP was correlated with ALL risk stage in children. Rs7633631 in CD226 and rs10818488 in TRAF1 were related to the minimal residual disease (MRD) on day 15 and day 33. Conclusions: Certain SNPs of inflammation genes were associated with the susceptibility and treatment response of ALL children. These findings may help in the early detection, diagnostic evaluation, and making individual chemotherapy regimen for ALL children according to the genotype of these sites at the time of initial diagnosis.
    Type of Medium: Online Resource
    ISSN: 1077-4114
    URL: Article
    DOI: 10.1097/MPH.0000000000002533
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2047125-7
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