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  • Ovid Technologies (Wolters Kluwer Health)  (7)
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  • Ovid Technologies (Wolters Kluwer Health)  (7)
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  • 1
    Online Resource
    Online Resource
    Association of embolization with long-term outcomes in brain arteriovenous malformations: a propensity score-matched analysis using nationwide multicenter prospective registry data
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  International Journal of Surgery Vol. Publish Ahead of Print ( 2023-05-25)
    Details
    In: International Journal of Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. Publish Ahead of Print ( 2023-05-25)
    Type of Medium: Online Resource
    ISSN: 1743-9191
    URL: Article
    DOI: 10.1097/JS9.0000000000000341
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2201966-2
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Association Between Migraine and Dry Eye: A Systematic Review and Metaanalysis
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Cornea Vol. 41, No. 6 ( 2022-06), p. 740-745
    Details
    In: Cornea, Ovid Technologies (Wolters Kluwer Health), Vol. 41, No. 6 ( 2022-06), p. 740-745
    Abstract: The purpose of this study was to assess whether migraine might be associated with the increased risk of dry eye disease and to determine the strength of the association between migraine and dry eye disease. Methods: We searched EMBASE, PubMed, Web of Science databases and China National Knowledge Infrastructure, WanFang, and VIP databases for studies that investigated the association between dry eye and migraine from inception to September 8, 2020. Relevant data were extracted by 2 investigators independently. Publication bias and heterogeneity were evaluated. Odds ratio (OR) and 95% confidence interval (CI) were computed by metaanalysis using random-effects models. Results: Of the 565 studies identified, 7 studies met the inclusion criteria and were included in this metaanalysis. Patients with migraine had significantly higher morbidity of dry eye compared with the control group (OR = 1.55; 95% CI = 1.32–1.82; P 〈 0.001). Subgroup analysis showed that the association between dry eye and migraine was stronger in hospital-based studies (OR = 1.97, P = 0.036) than population-based studies (OR = 1.42, P 〈 0.001). In addition, differences in geographic location and diagnostic criteria have no effect on the results. Conclusions: There was a significant association between dry eye and migraine. Patients with migraine are more prone to suffer from dry eye than subjects without migraine, and the association strength varies among populations studied.
    Type of Medium: Online Resource
    ISSN: 0277-3740
    URL: Article
    DOI: 10.1097/ICO.0000000000002851
    RVK:
    XA 37258
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2045943-9
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Long-term outcomes of microsurgery and stereotactic radiosurgery as the first-line treatment for arteriovenous malformations: A propensity score-matched analysis using nationwide multicenter prospective registry data
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  International Journal of Surgery
    Details
    In: International Journal of Surgery, Ovid Technologies (Wolters Kluwer Health)
    Abstract: This study aimed to compare the risk and benefit profile of microsurgery (MS) and stereotactic radiosurgery (SRS) as the first-line treatment for unruptured and ruptured arteriovenous malformations (AVMs). Materials and Methods: We included AVMs underwent MS or SRS as the first-line treatment from a nationwide prospective multicenter registry in *BLINDED*. We used propensity score-matched methods to balance baseline characteristics between MS and SRS groups. The primary outcomes were long-term hemorrhagic stroke or death, and the secondary outcomes were long-term obliteration and neurological outcomes. Subgroup analyses and sensitivity analyses with different study designs were performed to confirm the stability of our findings. Results: Of 4286 consecutive AVMs in the registry from 2011.08 to 2021.12, 1604 patients were eligible. After matching, 244 unruptured and 442 ruptured AVMs remained for the final analysis. The mean follow-up duration was 7.0 years in the unruptured group and 6.1 years in the ruptured group. In the comparison of primary outcomes, SRS was associated with a higher risk of hemorrhagic stroke or death both in the unruptured and ruptured AVMs (unruptured: hazard ratio [HR] 4.06, 95%confidence interval [CI] 1.15-14.41; ruptured: HR 4.19, 95%CI 1.58-11.15). In terms of the secondary outcomes, SRS was also observed to have a significant disadvantage in long-term obliteration (unruptured: odds ratio [OR] 0.01, 95%CI 0.00-0.04; ruptured: OR 0.09, 95%CI 0.05-0.15). However, it should be noted that SRS may have advantages in preventing neurofunctional decline (unruptured: OR 0.56, 95%CI 0.27-1.14; ruptured: OR 0.41, 95%CI 0.23-0.76). Results of subgroup analyses and sensitivity analyses were consistent in trend but with slightly varied powers. Conclusions: This clinical practice-based real-world study comprehensively compared MS and SRS for AVMs with long-term outcomes. MS is more effective in preventing future hemorrhage or death and achieving obliteration, while the risk of neurofunctional decline should not be ignored.
    Type of Medium: Online Resource
    ISSN: 1743-9159
    URL: Article
    DOI: 10.1097/JS9.0000000000000751
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2201966-2
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    Online Resource
  • 4
    Online Resource
    Online Resource
    A novel risk variant block across introns 36–45 of CACNA1C for schizophrenia: a cohort-wise replication and cerebral region-wide validation study
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Psychiatric Genetics
    Details
    In: Psychiatric Genetics, Ovid Technologies (Wolters Kluwer Health)
    Abstract: Numerous genome-wide association studies have identified CACNA1C as one of the top risk genes for schizophrenia. As a necessary post-genome-wide association study (GWAS) follow-up, here, we focused on this risk gene, carefully investigated its novel risk variants for schizophrenia, and explored their potential functions. Methods We analyzed four independent samples (including three European and one African-American) comprising 5648 cases and 6936 healthy subjects to identify replicable single nucleotide polymorphism-schizophrenia associations. The potential regulatory effects of schizophrenia-risk alleles on CACNA1C mRNA expression in 16 brain regions ( n  = 348), gray matter volumes (GMVs) of five subcortical structures ( n  = 34 431), and surface areas and thickness of 34 cortical regions ( n  = 36 936) were also examined. Results A novel 17-variant block across introns 36–45 of CACNA1C was significantly associated with schizophrenia in the same effect direction across at least two independent samples (1.8 × 10 −4  ≤  P  ≤ 0.049). Most risk variants within this block showed significant associations with CACNA1C mRNA expression (1.6 × 10 −3  ≤  P  ≤ 0.050), GMVs of subcortical structures (0.016 ≤  P  ≤ 0.048), cortical surface areas (0.010 ≤  P  ≤ 0.050), and thickness (0.004 ≤  P  ≤ 0.050) in multiple brain regions. Conclusion We have identified a novel and functional risk variant block at CACNA1C for schizophrenia, providing further evidence for the important role of this gene in the pathogenesis of schizophrenia.
    Type of Medium: Online Resource
    ISSN: 0955-8829
    URL: Article
    DOI: 10.1097/YPG.0000000000000344
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2063156-X
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    Online Resource
  • 5
    Online Resource
    Online Resource
    Association between antibiotic use and the risk of rheumatoid arthritis : A protocol for a systematic review
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Medicine Vol. 99, No. 9 ( 2020-02), p. e19155-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 99, No. 9 ( 2020-02), p. e19155-
    Abstract: The potential association between antibiotic use and the risk of rheumatoid arthritis (RA) has drawn significant attention from clinicians and researchers in recent years due to the wild usage of antibiotic. This study aimed to perform a systematic review and meta-analysis of the literature to determine if antibiotic use is associated with an increased risk of RA, so as to provide an important reference for clinical decision-making. Methods: Case-control and nest case-control studies of assessing whether antibiotic use is associated with the onset of RA will be identified in searches of 4 databases from their inception to August 2019. All data were assessed and extracted by 2 authors independently. The Newcastle–Ottawa scale was used to assess the quality of the selected studies. Manager Software 5.3 from Cochrane Collaboration (London, UK) and Stata 15.1 (Stata Corp, College Station, TX) will be used to conduct meta-analysis, determining pooled odds ratios and evaluating heterogeneity between studies. Result: The results of this systemic review and meta-analysis will be submitted to a recognized journal for publication. Conclusion: This systemic review and meta-analysis will determine if antibiotic use is associated with an increased risk of RA. We hope this study can make a definitive conclusion for the association.
    Type of Medium: Online Resource
    ISSN: 0025-7974 , 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000019155
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2049818-4
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    Online Resource
  • 6
    Online Resource
    Online Resource
    Early Drastic Decrease in White Blood Count Can Predict Uroseptic Shock Induced by Upper Urinary Tract Endoscopic Lithotripsy: A Translational Study
    Ovid Technologies (Wolters Kluwer Health) ; 2015
    In:  Journal of Urology Vol. 193, No. 6 ( 2015-06), p. 2116-2122
    Details
    In: Journal of Urology, Ovid Technologies (Wolters Kluwer Health), Vol. 193, No. 6 ( 2015-06), p. 2116-2122
    Type of Medium: Online Resource
    ISSN: 0022-5347 , 1527-3792
    URL: Article
    DOI: 10.1016/j.juro.2015.01.071
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2015
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    Online Resource
  • 7
    Online Resource
    Online Resource
    Synaptic Dynamics of the Feed-forward Inhibitory Circuitry Gating Mechanical Allodynia in Mice
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Anesthesiology Vol. 132, No. 5 ( 2020-05-01), p. 1212-1228
    Details
    In: Anesthesiology, Ovid Technologies (Wolters Kluwer Health), Vol. 132, No. 5 ( 2020-05-01), p. 1212-1228
    Abstract: The authors’ previous studies have found that spinal protein kinase C γ expressing neurons are involved in the feed-forward inhibitory circuit gating mechanical allodynia in the superficial dorsal horn. The authors hypothesize that nerve injury enhances the excitability of spinal protein kinase C γ expressing interneurons due to disinhibition of the feed-forward inhibitory circuit, and enables Aβ primary inputs to activate spinal protein kinase C γ expressing interneurons. Methods Prkcg-P2A-tdTomato mice were constructed using the clustered regularly interspaced short palindromic repeats and clustered regularly interspaced short palindromic repeats-associated nuclease 9 technology, and were used to analyze the electrophysiologic properties of spinal protein kinase C γ expressing neurons in both normal conditions and pathologic conditions induced by chronic constriction injury of the sciatic nerve. Patch-clamp whole cell recordings were used to identify the nature of the dynamic synaptic drive to protein kinase C γ expressing neurons. Results Aβ fiber stimulation evoked a biphasic synaptic response in 42% (31 of 73) of protein kinase C γ expressing neurons. The inhibitory components of the biphasic synaptic response were blocked by both strychnine and bicuculline in 57% (16 of 28) of neurons. Toll-like receptor 5 immunoreactive fibers made close contact with protein kinase C γ expressing neurons. After nerve injury, the percentage of neurons double-labeled for c-fos and Prkcg-P2A-tdTomato in animals walking on a rotarod was significantly higher than that in the nerve injury animals (4.1% vs. 9.9%, 22 of 539 vs. 54 of 548,P & lt; 0.001). Aβ fiber stimulation evoked burst action potentials in 25.8% (8 of 31) of protein kinase C γ expressing neurons in control animals, while the proportion increased to 51.1% (23 of 45) in nerve injury animals (P = 0.027). Conclusions The Prkcg-P2A-tdTomato mice the authors constructed provide a useful tool for further analysis on how the spinal allodynia gate works. The current study indicated that nerve injury enhanced the excitability of spinal protein kinase C γ expressing interneurons due to disinhibition of the feed-forward inhibitory circuit, and enabled Aβ primary inputs to activate spinal protein kinase C γ expressing interneurons. Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New
    Type of Medium: Online Resource
    ISSN: 0003-3022
    URL: Article
    DOI: 10.1097/ALN.0000000000003194
    RVK:
    XA 22600
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2016092-6
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    Online Resource
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