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  • Ovid Technologies (Wolters Kluwer Health)  (11)
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  • Ovid Technologies (Wolters Kluwer Health)  (11)
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  • 1
    Online Resource
    Online Resource
    Candidate Pathway-Based Genome-Wide Association Studies Identify Novel Associations of Genomic Variants in the Complement System Associated With Coronary Artery Disease
    Ovid Technologies (Wolters Kluwer Health) ; 2014
    In:  Circulation: Cardiovascular Genetics Vol. 7, No. 6 ( 2014-12), p. 887-894
    Details
    In: Circulation: Cardiovascular Genetics, Ovid Technologies (Wolters Kluwer Health), Vol. 7, No. 6 ( 2014-12), p. 887-894
    Abstract: Genomic variants identified by genome-wide association studies (GWAS) explain 〈 20% of heritability of coronary artery disease (CAD), thus many risk variants remain missing for CAD. Identification of new variants may unravel new biological pathways and genetic mechanisms for CAD. To identify new variants associated with CAD, we developed a candidate pathway-based GWAS by integrating expression quantitative loci analysis and mining of GWAS data with variants in a candidate pathway. Methods and Results— Mining of GWAS data was performed to analyze variants in 32 complement system genes for positive association with CAD. Functional variants in genes showing positive association were then identified by searching existing expression quantitative loci databases and validated by real-time reverse transcription polymerase chain reaction. A follow-up case–control design was then used to determine whether the functional variants are associated with CAD in 2 independent GeneID Chinese populations. Candidate pathway-based GWAS identified positive association between variants in C3AR1 and C6 and CAD. Two functional variants, rs7842 in C3AR1 and rs4400166 in C6 , were found to be associated with expression levels of C3AR1 and C6 , respectively. Significant association was identified between rs7842 and CAD ( P =3.99×10 −6 ; odds ratio, 1.47) and between rs4400166 and CAD ( P =9.30×10 −3 ; odds ratio, 1.24) in the validation cohort. The significant findings were confirmed in the replication cohort ( P =1.53×10 −5 ; odds ratio, 1.37 for rs7842; P =8.41×10 −3 ; odds ratio, 1.21 for rs4400166). Conclusions— Integration of GWAS with biological pathways and expression quantitative loci is effective in identifying new risk variants for CAD. Functional variants increasing C3AR1 and C6 expression were shown to confer significant risk of CAD for the first time.
    Type of Medium: Online Resource
    ISSN: 1942-325X , 1942-3268
    URL: Article
    DOI: 10.1161/CIRCGENETICS.114.000738
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2014
    detail.hit.zdb_id: 2927603-2
    detail.hit.zdb_id: 2457085-0
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  • 2
    Online Resource
    Online Resource
    Sex-specific impact on disease outcome and the mutational landscape in essential thrombocythemia: A retrospective cohort study
    Ovid Technologies (Wolters Kluwer Health) ; 2024
    In:  Chinese Medical Journal Vol. 137, No. 12 ( 2024-06-20), p. 1495-1497
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 137, No. 12 ( 2024-06-20), p. 1495-1497
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000003106
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2024
    detail.hit.zdb_id: 2108782-9
    SSG: 6,25
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  • 3
    Online Resource
    Online Resource
    Frequency Gradient Within Coronary Sinus Predicts the Long‐Term Outcome of Persistent Atrial Fibrillation Catheter Ablation
    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Journal of the American Heart Association Vol. 6, No. 3 ( 2017-03)
    Details
    In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 6, No. 3 ( 2017-03)
    Abstract: The coronary sinus ( CS ), as a junction of the atria, contributes to atrial fibrillation ( AF ) by developing unstable reentry, and isolating the atria by ablation at the CS could terminate AF . The present study evaluated whether AF activities at the CS in a subset of patients contributed to AF maintenance and predicted clinical outcome of ablation. Methods and Results We studied 122 consecutive patients who had a first‐time radiofrequency ablation for persistent AF . Bipolar electrograms were obtained from multiple regions of the left atrium by a Lasso mapping catheter before ablation. Pulmonary vein isolation terminated AF in 12 patients (9.8%). Sequential stepwise ablation was conducted in pulmonary vein isolation nontermination patients and succeeded in 22 patients (18%). In the stepwise termination group, AF frequency in the proximal CS ( CS p) was significantly higher (10.2±2.1 Hz versus 8.3±1.8 Hz, P 〈 0.001), and the ratio of distal CS ( CS d) to proximal CS ( CS d/ CS p ratio, 56.6%±10.11% versus 70.7%±9.8%, P 〈 0.001) was significantly lower than that in the nontermination group. The stepwise logistic regression analysis indicated that the CS d/ CS p ratio was an independent predictor with an odds ratio of 1.131 (95% CI 1.053‐1.214; P =0.001). With a cutoff of 67%, the patients with lower CS d/ CS p ratios had significantly better index and long‐term outcomes than those with higher ratios during a follow‐up of 46±18 months. Conclusions Rapid repetitive activities in the musculature of the proximal CS may contribute to maintenance of AF after pulmonary vein isolation alone in persistent AF . A cutoff at 67%, of the CS d/ CS p frequency ratio might be an indicator to stratify the subset of patients who might benefit from CS ablation.
    Type of Medium: Online Resource
    ISSN: 2047-9980
    URL: Article
    DOI: 10.1161/JAHA.116.004869
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
    detail.hit.zdb_id: 2653953-6
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  • 4
    Online Resource
    Online Resource
    Positive relationship of hypertensive retinopathy with carotid intima--media thickness in hypertensive patients
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Journal of Hypertension Vol. 38, No. 10 ( 2020-10), p. 2028-2035
    Details
    In: Journal of Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 38, No. 10 ( 2020-10), p. 2028-2035
    Abstract: We aimed to explore the relationship of hypertensive retinopathy with carotid intima--media thickness (CIMT), and to examine the possible effect modifiers in Chinese adults with hypertension. Methods: We conducted a cross-sectional study of 12 342 hypertensive patients with complete exit site visit data from the China Stroke Primary Prevention Trial. CIMT was measured by carotid ultrasonography. Hypertensive retinopathy was diagnosed according to the Keith--Wagener--Barker classification. Results: The mean (SD) CIMT among study participants was 739.9 (111.4) μm. Compared with patients with grade 1 hypertensive retinopathy or without hypertensive retinopathy, a significantly higher CIMT level (β, 7.63, 95% CI: 2.54--12.73) was observed in patients with grade 2–4 hypertensive retinopathy. Moreover, the association between hypertensive retinopathy (grade 2–4 versus grade 1 or normal) and CIMT was stronger in participants of younger age ( 〈 60 years; β , 13.70, 95% CI: 5.65--21.75; versus ≥60 years; β , 1.03, 95% CI: −5.58 to 7.63; P interaction = 0.006); or with lower total homocysteine levels [ 〈 12.1 μmol/l (median); β , 12.70, 95% CI: 5.98--19.42; versus ≥12.1 μmol/l; β , 2.07, 95% CI: −5.63 to 9.78; P interaction = 0.030). None of the other variables, including sex, BMI, study centers, treatment group, SBP, triglycerides, total cholesterol, fasting blood glucose, folate, serum creatinine, current smoking and alcohol drinking, significantly modified the relation of hypertensive retinopathy with CIMT levels. Conclusion: Hypertensive retinopathy (grade 2 and higher) was significantly associated with increased CIMT in hypertensive patients. The association was stronger in those of younger age or with lower total homocysteine levels.
    Type of Medium: Online Resource
    ISSN: 0263-6352 , 1473-5598
    URL: Article
    DOI: 10.1097/HJH.0000000000002509
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2017684-3
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  • 5
    Online Resource
    Online Resource
    Needs Assessment for STD/HIV Prevention Among Patients with Sexually Transmitted Diseases in Southern China
    Ovid Technologies (Wolters Kluwer Health) ; 2003
    In:  Sexually Transmitted Diseases Vol. 30, No. 8 ( 2003-08), p. 600-608
    Details
    In: Sexually Transmitted Diseases, Ovid Technologies (Wolters Kluwer Health), Vol. 30, No. 8 ( 2003-08), p. 600-608
    Type of Medium: Online Resource
    ISSN: 0148-5717
    URL: Article
    DOI: 10.1097/01.OLQ.0000081394.94426.7A
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2003
    detail.hit.zdb_id: 2055170-8
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  • 6
    Online Resource
    Online Resource
    APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults : A STROBE Article
    Ovid Technologies (Wolters Kluwer Health) ; 2015
    In:  Medicine Vol. 94, No. 52 ( 2015-12), p. e1734-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 94, No. 52 ( 2015-12), p. e1734-
    Type of Medium: Online Resource
    ISSN: 0025-7974
    URL: Article
    DOI: 10.1097/MD.0000000000001734
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2015
    detail.hit.zdb_id: 2049818-4
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  • 7
    Online Resource
    Online Resource
    Prognostic value of sarcopenic visceral obesity in hepatocellular carcinoma treated with TACE
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Medicine Vol. 102, No. 27 ( 2023-07-07), p. e34292-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 102, No. 27 ( 2023-07-07), p. e34292-
    Abstract: Although Transartial chemoembolization (TACE) is one of the recommended treatments for hepatocellular carcinoma (HCC), there is always a dispute on the selection of the best beneficiary for treatment. We studied the prognostic value of nutritional markers, obesity, visceral obesity and sarcopenia on survival outcomes under single and different combinations. In a retrospective cohort of 235 patients with HCC at different stages, more accurate comprehensive prognostic factors were obtained by combining and comparing the multifactor hazard ratios (HR) of various parameters, including skeletal muscle index (SMI) and visceral fat index (VFI) obtained by computer tomography, laboratory index albumin-to-globulin (A/G) ratio, anthropometric body mass index (BMI) and other parameters. The study cohort was dominated by men (73.6%), with a median age of 54 years. According to the survival outcome of HCC patients, we obtained the ideal sex cutoff value of VFI: ≥40.54 cm 2 /m 2 for males (the receiver operating characteristic curve [ROC] = 0.764, P   〈  .001) and ≥ 43.19 cm 2 /m 2 for females (ROC = 0.718, P   〈  .05). According to the results of multifactor analysis, sarcopenic visceral obesity (HR = 8.35, 95% confidence intervals [CI] = [4.96, 14.05] , P   〈  .001) is more effective than any single or combined prognosis assessment, including sarcopenic dystrophy (HR = 2.70, 95% CI = [1.85, 3.95], P   〈  .001), sarcopenic obesity (HR = 5.23, 95% CI = [3.41, 8.02], P   〈  .001), sarcopenia (HR = 5.74, 95% CI = [3.61, 9.11], P   〈  .001) and visceral obesity (HR = 3.44, 95% CI = [2.24, 5.27], P   〈  .001). Sarcopenic visceral obesity, defined by SMI and VFI, is a more objective and accurate prognostic indicator of HCC.
    Type of Medium: Online Resource
    ISSN: 0025-7974
    URL: Article
    DOI: 10.1097/MD.0000000000034292
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2049818-4
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  • 8
    Online Resource
    Online Resource
    Re-Establishing Brain Networks in Patients with ESRD after Successful Kidney Transplantation
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Clinical Journal of the American Society of Nephrology Vol. 13, No. 1 ( 2018-1), p. 109-117
    Details
    In: Clinical Journal of the American Society of Nephrology, Ovid Technologies (Wolters Kluwer Health), Vol. 13, No. 1 ( 2018-1), p. 109-117
    Abstract: Cognition in ESRD may be improved by kidney transplantation, but mechanisms are unclear. We explored patterns of resting-state networks with resting-state functional magnetic resonance imaging among patients with ESRD before and after kidney transplantation. Design, setting, participants, & measurements Thirty-seven patients with ESRD scheduled for kidney transplantation and 22 age-, sex-, and education-matched healthy subjects underwent resting-state functional magnetic resonance imaging. Patients were imaged before and 1 and 6 months after kidney transplantation. Functional connectivity of seven resting-state subnetworks was evaluated: default mode network, dorsal attention network, central executive network, self-referential network, sensorimotor network, visual network, and auditory network. Mixed effects models tested associations of ESRD, kidney transplantation, and neuropsychological measurements with functional connectivity. Results Compared with controls, pretransplant patients showed abnormal functional connectivity in six subnetworks. Compared with pretransplant patients, increased functional connectivity was observed in the default mode network, the dorsal attention network, the central executive network, the sensorimotor network, the auditory network, and the visual network 1 and 6 months after kidney transplantation ( P =0.01). Six months after kidney transplantation, no significant difference in functional connectivity was observed for the dorsal attention network, the central executive network, the auditory network, or the visual network between patients and controls. Default mode network and sensorimotor network remained significantly different from those in controls when assessed 6 months after kidney transplantation. A relationship between functional connectivity and neuropsychological measurements was found in specific brain regions of some brain networks. Conclusions The recovery patterns of resting-state subnetworks vary after kidney transplantation. The dorsal attention network, the central executive network, the auditory network, and the visual network recovered to normal levels, whereas the default mode network and the sensorimotor network did not recover completely 6 months after kidney transplantation. Neural resting-state functional connectivity was lower among patients with ESRD compared with control subjects, but it significantly improved with kidney transplantation. Resting-state subnetworks exhibited variable recovery, in some cases to levels that were no longer significantly different from those of normal controls.
    Type of Medium: Online Resource
    ISSN: 1555-9041 , 1555-905X
    URL: Article
    DOI: 10.2215/CJN.00420117
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 2216582-4
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  • 9
    Online Resource
    Online Resource
    The effect of ginsenoside Rg3 combined with chemotherapy on immune function in non-small cell lung cancer: A systematic review and meta-analysis of randomized controlled trials
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Medicine Vol. 102, No. 14 ( 2023-04-07), p. e33463-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 102, No. 14 ( 2023-04-07), p. e33463-
    Abstract: The occurrence and development of non-small cell lung cancer (NSCLC) are closely related to the immune status of the tumor-host. The immunosuppression caused by tumor cells and toxic side effects produced by chemotherapeutic drugs results in a decrease in immune function, ultimately leading to the failure of clinical chemotherapy treatment. Ginsenoside Rg3 has been clinically reported to have positive effects in enhancing immune function in patients. Thus, we screened and evaluated the quality of the evidence regarding the benefits of ginsenoside Rg3 and conducted a meta-analysis to assess the impact on improving immune function in NSCLC. Methods: The PubMed, EMBASE, Cochrane Library, CNKI, Weipu (VIP), and Wanfang databases were searched in this study, all from the time of library construction to January 2023. Results: In total,12 trials with a sample size of 1008 cases were included based on the eligible criteria. The results showed that compared with first-line chemotherapy alone, the combination of ginsenoside Rg3 and first-line chemotherapy could better improve level of the CD3 + T lymphocytes [mean difference (MD) = 4.72; 95% confidence intervals (CI): 3.92, 5.53; P 〈 .00001], CD4 + T lymphocytes (MD = 4.93; 95% CI: 4.61, 5.26; P 〈 .00001), CD8 + T lymphocytes (MD = 2.67; 95% CI: 0.93, 4.37; P = .003), CD4 + /CD8 + T lymphocytes (MD = 0.20; 95% CI: 0.09, 0.32; P = .0006), increase the activity of nature killer cells (MD = 2.11; 95% CI: 0.58, 3.63; P = .007), recover the decline of the white blood cell count induced by chemotherapy, and improve the clinical efficacy for patients. Conclusion: This study confirmed that ginsenoside Rg3 has some efficacy advantages for improving immune function in patients with NSCLC.
    Type of Medium: Online Resource
    ISSN: 0025-7974
    URL: Article
    DOI: 10.1097/MD.0000000000033463
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2049818-4
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  • 10
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    Unexpected favorable outcome to sintilimab monotherapy in a relapse pancreatic ductal adenocarcinoma patient with high tumor mutational burden: a case report
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Anti-Cancer Drugs Vol. 33, No. 9 ( 2022-10), p. 975-978
    Details
    In: Anti-Cancer Drugs, Ovid Technologies (Wolters Kluwer Health), Vol. 33, No. 9 ( 2022-10), p. 975-978
    Abstract: The reason that immune checkpoint inhibitors have not been widely applied to pancreatic cancer treatment is probably because of low immunogenicity or dense stromal fibrosis. Recently, only pembrolizumab was recommended for DNA mismatch repair deficiency or high microsatellite instability by National Comprehensive Cancer Network guideline. Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of pancreatic cancer, with a poor overall survival rate, the value of immunotherapy for PDAC needs more research. Here, we report a 56-year-old man suffered from PDAC with liver metastasis after radical surgery. The next-generation sequencing result demonstrated that it had remarkably high tumor mutational burden (TMB) of 49.92 Muts/Mb and microsatellite stability. Sintilimab (anti-PD-1) monotherapy was continuously administrated after failure of combined chemotherapy in second line, achieving stable disease within 22 months and few immunotherapy-related adverse events. To our knowledge, this is the first time to report a good outcome achieving 22 months with progression-free survival after PDAC metastasis with monotherapy of sintilimab. TMB may serve as a potential efficacy-related predictor in PDAC patients with sintilimab and help physicians make optimum clinical strategy.
    Type of Medium: Online Resource
    ISSN: 0959-4973
    URL: Article
    DOI: 10.1097/CAD.0000000000001334
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2025803-3
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