In:
Kidney360, Ovid Technologies (Wolters Kluwer Health), Vol. 3, No. 1 ( 2022-01), p. 74-82
Abstract:
Despite interest in low-grade albuminuria and poor clinical outcomes, evidence from a large-scale population is lacking. Therefore, we identified the association of low-grade albuminuria within the normal range with all-cause and cardiovascular (CV) mortality. Methods After excluding individuals with urine albumin-creatinine ratio (ACR) ≥30 mg/g ( n =6094), this cohort study analyzed 43,396 adults who participated in the National Health and Nutrition Examination Survey (1999–2016). Participants were divided into four quartiles of ACR. The primary outcome was all-cause mortality, and the secondary outcome was CV mortality. Multivariable Cox proportional hazards models were used. Results During a median 7.9 years of follow-up, 3516 (9%) participants died. Compared with the reference group (Q1, ACR 〈 4.171 mg/g), low-grade albuminuria groups were associated with all-cause mortality (Q3, ACR ≥6.211 to 〈 10.010 mg/g, hazard ratio [HR], 1.25 [95% CI, 1.11 to 1.41] ; Q4, ACR ≥10.010 mg/g, HR, 1.57 [95% CI, 1.41 to 1.76]) in a multivariable hazards model. A similar pattern was also seen in the association of low-grade albuminuria with CV mortality. Subgroup analyses showed that low-grade albuminuria was also associated with all-cause mortality in the nondiabetic group, nonhypertensive group, and non-CKD group (eGFR ≥60 ml/min per 1.73 m 2 ). Conclusions Our findings suggest that low-grade albuminuria is associated with all-cause and CV mortality. Low-grade albuminuria should be monitored, even for patients with low CV risk.
Type of Medium:
Online Resource
ISSN:
2641-7650
DOI:
10.34067/KID.0003912021
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2022
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