Publication Date:
2018-06-20
Description:
DNA methylation as a mediator of HLA-DRB1*15 : 01 and a protective variant in multiple sclerosis DNA methylation as a mediator of 〈i〉HLA-DRB1*15〈/i〉:〈i〉01〈/i〉 and a protective variant in multiple sclerosis, Published online: 19 June 2018; doi:10.1038/s41467-018-04732-5 The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here the authors find that DNA methylation at HLA-DRB1 gene mediates the effect of DRB1*15:01 and of a protective HLA variant on HLA-DRB1 expression and the risk of MS.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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