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  • Nature Publishing Group  (2)
  • The American Society for Biochemistry and Molecular Biology (ASBMB)  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of Cyclophosphamide on the Production of Interferon (1968)
    [s.l.] : Nature Publishing Group
    Nature 217 (1968), S. 178-179 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We describe here experiments which show that cyclo-phosphamide depresses interferon in the intact animal but is without activity in tissue culture systems. Preliminary experiments indicated that 1 mg/ml. of Cyclophosphamide was not toxic for cultured monkey kidney cells. It was also shown that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/217178a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Sensory Evoked Responses Recorded Simultaneously from Human Cortex and Scalp (1966)
    [s.l.] : Nature Publishing Group
    Nature 212 (1966), S. 1535-1537 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] COOPER et al.1 have observed that potentials evoked from human subdura and scalp by flashing are dissimilar when recorded over sensory specific cortex (occipital), but similar when recorded over unspecific cortex (frontal). Domino et al.z, however, found that sensory specific responses recorded ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2121535a0
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    Paper (German National Licenses)
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  • 3
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    Small Molecule Inhibitor of Monoubiquitinated PCNA [DNA and Chromosomes] (2014)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Details
    Publication Date: 2014-03-08
    Description: Small molecule inhibitors of proliferating cell nuclear antigen (PCNA)/PCNA interacting protein box (PIP-Box) interactions, including T2 amino alcohol (T2AA), inhibit translesion DNA synthesis. The crystal structure of PCNA in complex with T2AA revealed that T2AA bound to the surface adjacent to the subunit interface of the homotrimer of PCNA in addition to the PIP-box binding cavity. Because this site is close to Lys-164, which is monoubiquitinated by RAD18, we postulated that T2AA would affect monoubiquitinated PCNA interactions. Binding of monoubiquitinated PCNA and a purified pol η fragment containing the UBZ and PIP-box was inhibited by T2AA in vitro. T2AA decreased PCNA/pol η and PCNA/REV1 chromatin colocalization but did not inhibit PCNA monoubiquitination, suggesting that T2AA hinders interactions of pol η and REV1 with monoubiquitinated PCNA. Interstrand DNA cross-links (ICLs) are repaired by mechanisms using translesion DNA synthesis that is regulated by monoubiquitinated PCNA. T2AA significantly delayed reactivation of a reporter plasmid containing an ICL. Neutral comet analysis of cells receiving T2AA in addition to cisplatin revealed that T2AA significantly enhanced formation of DNA double strand breaks (DSBs) by cisplatin. T2AA promoted colocalized foci formation of phospho-ATM and 53BP1 and up-regulated phospho-BRCA1 in cisplatin-treated cells, suggesting that T2AA increases DSBs. When cells were treated by cisplatin and T2AA, their clonogenic survival was significantly less than that of those treated by cisplatin only. These findings show that the inhibitors of monoubiquitinated PCNA chemosensitize cells by inhibiting repair of ICLs and DSBs.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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