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  • 1
    Electronic Resource
    Electronic Resource
    LKB1 modulates lung cancer differentiation and metastasis (2007)
    [s.l.] : Nature Publishing Group
    Nature 448 (2007), S. 807-810 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Germline mutation in serine/threonine kinase 11 (STK11, also called LKB1) results in Peutz–Jeghers syndrome, characterized by intestinal hamartomas and increased incidence of epithelial cancers. Although uncommon in most sporadic cancers, inactivating somatic mutations of LKB1 have been ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature06030
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  • 2
    Electronic Resource
    Electronic Resource
    Manipulating the Photoperiod to damage Insects (1969)
    [s.l.] : Nature Publishing Group
    Nature 221 (1969), S. 60-61 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Pittendrigh3, Adkisson4, Minis5 and Lees6 manipulated photoperiods in studies of response curves of eclosion (Drosophila pseudoobscura) and diapause and egg laying (Pectinophora gossypidla (Saunders) and Megoura). The insects were subjected to 8?12 h of light (L) and 12?16 h of dark (D) with a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/221060a0
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  • 3
    Electronic Resource
    Electronic Resource
    Photoperiod manipulation to control diapause in the pink bollworm,Pectinophora gossypiella (1970)
    Springer
    Cellular and molecular life sciences 26 (1970), S. 1101-1102 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Im 12-h Kurztag gehaltenePectinophora gossypiella gehen zu 78% in Diapause. Zusätzlich applizierte, einstÜndige Perioden mit 15 Lichtpulsen von je 1 min Dauer reduzieren die Diapauserate. Die besten Resultate ergeben 2 Pulsperioden, je 1,5 h vor und nach der Hellphase appliziert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02112699
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  • 4
    Electronic Resource
    Electronic Resource
    A pilot trial assessing the efficacy of paroxetine hydrochloride (Paxil®) in controlling hot flashes in breast cancer survivors (2000)
    Springer
    Annals of oncology 11 (2000), S. 17-22 
    Details
    ISSN: 1569-8041
    Keywords: breast cancer ; hot flashes ; paroxetine ; serotonin uptake inhibitors ; survivors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:Many breast cancer survivors suffer debilitating hotflashes. Estrogen, the drug of choice in perimenopausal women, is generallynot recommenced to breast cancer survivors. Nonhormonal treatments are mostlydisappointing. Anecdotal reports in our institution suggested that theselective serotonin-reuptake inhibitor, paroxetine hydrochloride, might beefficacious in alleviating hot flashes. Patients and methods:Thirty women with prior breast cancer whowere suffering at least two hot flashes a day entered a single institutionpilot trial to evaluate paroxetine's efficacy in reducing the frequency andseverity of hot flashes. After completing daily diaries for one week on notherapy, the women received open-label paroxetine, 10 mg daily for one week,followed by four weeks of paroxetine, 20 mg daily. The women completedhot-flash daily diaries throughout the study period, and a health-relatedsymptom-assessment questionnaire and a quality-of-life rating scale in thefirst and sixth week of the study. Results:Twenty-seven women completed the six-week study period.The mean reduction of hot flash frequency was 67% (95%confidence interval (95% CI): 56%–79%). The meanreduction in hot flash severity score was 75% (95% CI:66%–85%). There was a statistically significantimprovement in depression, sleep, anxiety, and quality of life scores.Furthermore, 25 (83%) of the study participants chose to continueparoxetine therapy at the end of study. The most common adverse effect wassomnolence, resulting in drug discontinuation in two women, and dose reductionin two women. One woman discontinued drug due to anxiety. Conclusions:Paroxetine hydrochloride is a promising new treatmentfor hot flashes in breast cancer survivors, and warrants further evaluationin a double-blind randomized placebo-controlled trial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008382706068
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  • 5
    Electronic Resource
    Electronic Resource
    Photoelectric photometry of the stars HD 29647 and HDE 283809 in the Taurus dark cloud (1985)
    Springer
    Astrophysics and space science 112 (1985), S. 251-257 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Photoelectric Vilnius photometry of the B-type stars HD 29 647 and HDE 283 809 in the direction of the Taurus molecular cloud indicates their brightness and energy distribution to be constant within 1–2%. The interstellar extinction law is determined for the star HDE 283 809 from the photometry data in the Vilnius andUBVRJHKL systems, which yield the ratioR=A V/EB-V=3.5 and grain sizes exceeding the average by approximately 10%. The interstellar extinction law for the two stars is found to be the same in the infrared, however, it is very different in the near ultraviolet. The new spectra of HDE 283 809 confirm the earlier classification and indicate an absence of emission in the hydrogen lines. The interstellar band at 443 nm is observed but its intensity is a half of what is expected forE B-V=1.61. The observed peculiarities of the energy distribution in the spectrum of HDE 283 809 apparently originate in interstellar or circumstellar dust, not in the star itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00653507
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of human recombinant growth hormone (rhGH) on inflammatory responses in patients undergoing abdominal aortic aneurysm repair (1998)
    Springer
    Intensive care medicine 24 (1998), S. 128-131 
    Details
    ISSN: 1432-1238
    Keywords: Key words Growth hormone ; Insulin-like growth factor-1 ; Acute phase proteins ; C-reactive protein ; Serum amyloid A ; Interleukin-6
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Human recombinant growth hormone (rhGH) has been shown to increase skeletal muscle protein synthesis and improve nitrogen balance in critically ill patients and those undergoing surgery. rhGH effects on hepatic protein turnover in critically ill patients are less clearly understood. Objective: To examine rhGH effects on hepatic acute phase protein responses and inflammatory cytokine release in patients undergoing major surgery. Design: Prospective double blind randomised trial. Setting: Tertiary referral university teaching hospital. Patients: Patients undergoing elective abdominal aortic aneurysm repair. Intervention: Patients received rhGH (Genotropin, 0.3 IU/kg per day, n = 8) or placebo (n = 10) for 6 days prior to surgery. Results: Blood levels of growth hormone (GH) and insulin-like growth factor (IGF-1) were measured following rhGH treatment and C-reactive protein (CRP), serum amyloid A (SAA) and the cytokines interleukin-6 (IL-6) and the IL-1 receptor antagonist (IL-1ra) were measured for up to 24 h following surgery. Significant increases in plasma rhGH (0.84 ± 0.3, mean (sem) versus 52 ± 20 mU/l, p 〈 0.0008) and IGF-1 levels (119 ± 13 versus 644 ± 110 ng/ml, p 〈 0.0001) were seen prior to surgery following rhGH administration. No differences in acute phase protein or cytokine levels were seen following surgery in patients receiving rhGH. Conclusions: These results indicate that pre-operative administration of rhGH does not alter acute phase protein or inflammatory cytokine release in response to major surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050533
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  • 7
    Electronic Resource
    Electronic Resource
    Fluoride binding to humic acid (1995)
    Springer
    Journal of radioanalytical and nuclear chemistry 201 (1995), S. 135-141 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Fluoride (F−) binding to humic acid has been measured as a function of pH (5–6.6). The pH dependent binding is attributed to the anion being trapped within the large structure (territorial bound) but is not bound to a particular functional group (site bound). Studying fluoride binding provides insight to cation, anion and neutral species interactions with humic acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02163725
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  • 8
    Electronic Resource
    Electronic Resource
    Aerial robotic data acquisition system (1995)
    Springer
    Journal of radioanalytical and nuclear chemistry 193 (1995), S. 89-92 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract A small, unmanned aerial vehicle (UAV) equipped with sensors for physical and chemical measurements of remote environments, is described. A miniature helicopter airframe is used as a platform for sensor testing and development. The sensor output is integrated with the flight control system for real-time, interactive, data acquisition and analysis. Pre-programmed flight missions will be flown with several sensors to demonstrate the cost-effective surveillance capabilities of this new technology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02041920
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  • 9
    Electronic Resource
    Electronic Resource
    Is permanent pacing for dilated cardiomyopathy and congestive heart failure a viable therapeutic option? (1999)
    Springer
    Herzschrittmachertherapie & Elektrophysiologie 10 (1999), S. 7-15 
    Details
    ISSN: 1435-1544
    Keywords: Schlüsselwörter Dilatative Kardiomyopathie ; dekompensierte ; Herzinsuffizienz ; permanentes Pacing ; Zweikammer-Pacing ; Schrittmacher-Hämodynamik ; Key words Dilated cardiomyopathy ; congestive heart failure ; permanent pacing ; biventricular pacing ; pacing hemodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Enthusiasm for permanent pacing as a therapeutic option for patients with dilated cardiomyopathy (DCM) and congestive heart failure (CHF) has waxed and waned since the early 1990‘s. The clinical results of standard dual-chamber pacing in these patients have been extraordinarily mixed, which can be attributed to small patient populations, marked heterogeneity of patients included, highly variable study designs and endpoints, and limited follow-up.  Although investigators have postulated some mechanisms for improvement, there is still a great deal to learn to be able to reliably predict which patients with DCM and/or CHF will respond to permanent pacing. Biventricular pacing is emerging as having the greatest potential for patients with congestive cardiomyopathy. Although data is somewhat limited, triple-chamber, and in some cases four-chamber pacing will be the focus of future interest.
    Notes: Zusammenfassung Die Begeisterung für das permanente Pacing als therapeutische Option bei der dilatativen Kardiomyopathie (DCM) und bei der dekompensierten Herzinsuffizienz (CHF) hat seit den frühen 90er Jahren deutlich nachgelassen. Die klinischen Ergebnisse des üblichen Zweikammer-Pacings fielen bei diesen Patienten außergewöhnlich gemischt aus. Dies kann auf kleine Patientenpopulationen, eine ausgeprägte Heterogenität der teilnehmenden Patienten, auf eine große Variabilität der Studiendesigns und Endpunkte sowie auf eine begrenzte Nachbeobachtungszeit zurückgeführt werden.  Obwohl Wissenschaftler einige Mechanismen für eine Besserung postulieren, sind viele Punkte noch offen, bis man zuverlässig voraussagen kann, welche Patienten mit DCM und/oder CHF auf ein permanentes Pacing ansprechen werden.  Es scheint so als ob das Zweikammer-Pacing das größte Potential für Patienten mit dekompensierter Herzinsuffizienz bietet. Obwohl erst limitierte Daten zur Verfügung stehen, wird in Zukunft das Dreikammer-Pacing und in manchen Fällen das Vierkammer-Pacing von Interesse sei.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003990050043
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  • 10
    Electronic Resource
    Electronic Resource
    Genetic implications in the decline of red spruce (1992)
    Springer
    Water, air & soil pollution 62 (1992), S. 233-248 
    Details
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Despite substantial increases in atmospheric pollution and significant correlations between specific inputs and red spruce (Picea rubens Sarg.) decline at certain locations in eastern North America, it has not been possible to demonstrate a consistent relationship between severity of decline and either pollution inputs or climatic factors throughout the region of decline. These results indicate that different pollutants or environmental features may be associated with red spruce deterioration in different regions and raise the question of why red spruce, and not other sympatric species, might be predisposed to injury from a diversity of inputs and over a large geographic area. In this paper we present data to indicate red spruce is a relatively uniform species genetically, and we discuss the possibility that it may be deteriorating because it lacks the genetic flexibility to cope with and respond to abrupt environmental modification. Estimates of genetic variability in red spruce were determined from electrophoretic assessments of 30 trees from each of 10 populations distributed throughout the region of red spruce decline. An examination of genetic variation at 36 loci revealed an average observed heterozygosity for red spruce of 6.9% with only 21.3% polymorphic loci and 1.43 alleles per locus. These genetic variability estimates are considerably lower than those reported for other north-temperate woody plant species, including conifer species that are sympatric with red spruce and are presumably exposed to similar selection pressures. In one population, individual trees that were high in observed heterozygosity were generally more vigorous (as estimated from sapwood area/basal area ratios) than less genetically variable individuals. As a result, it appears highly heterozygous individuals may be more resilient and capable of surviving and reconstituting viable populations in the future. We discuss five additional lines of evidence that are consistent with a hypothesis of insufficient genetic variability and limited adaptability in red spruce.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00480258
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