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  • Springer  (4)
  • National Academy of Sciences  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 47 (1991), S. 728-730 
    ISSN: 1420-9071
    Keywords: Phenytoin ; fibroblasts ; inositol phosphates ; DNA synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Culture of L-929 fibroblasts in the presence of phenytoin (2.5–5.0 μg/ml) increased DNA synthesis, as indicated by increased [3H]thymidine uptake, while a higher dose (20 μg/ml) inhibited DNA synthesis. In like manner, a low dose of phenytoin (5.0 μg/ml) was effective in increasing inositol 1,4,5-trisphosphate formation while a higher dose (10 μg/ml) tended to inhibit this activity. These data suggest that the formation of inositol phosphate second messengers may play a role in phenytoin-induced fibroblast proliferation and connective tissue growth.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 28 (1972), S. 37-38 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Elektrolytische, ipsilaterale, kontralaterale oder bilaterale Läsionen blieben in den tiefen Kernen des Cerebellums ohne Einfluss auf Intensität oder Charakter von Dyskinesien, welche durch Injektionen von 1,5 μg Carbachol in den Caudatum-Putamen-Komplex ungehindert beweglicher Ratten hervorgerufen wurden.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 24 (1968), S. 145-146 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Deux espèces de souris (IHB et A) vécurent 1 an avec un régime d'eau de mer ad libitum et d'aliments secs. La haute osmolarité urinaire, la capacité élevée de concentrer le sodium et l'absence de diarrhée furent des facteurs qui leur permirent de supporter ce régime expérimental.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 24 (1968), S. 696-698 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Il a paru intéressant de préciser les relations de temps et de phase entre la réponse évoquée massive et la réponse des neurones du corps genouillé latéral. Des microéléctrodes ont été implantées dans le corps genouillé latéral du chat et des réponses ont été évoquées par stimulation visuelle. On a pu démontrer que la probabilité aussi bien que la fréquence de la décharge neuronique varient en raison de la première dérivée de la réponse massive à ondes lentes.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2011-08-31
    Description: Leptin has been shown to reduce hyperglycemia in rodent models of type 1 diabetes. We investigated the effects of leptin administration in University of California, Davis, type 2 diabetes mellitus (UCD-T2DM) rats, which develop adult-onset polygenic obesity and type 2 diabetes. Animals that had been diabetic for 2 mo were treated with s.c. injections of saline (control) or murine leptin (0.5 mg/kg) twice daily for 1 mo. Control rats were pair-fed to leptin-treated animals. Treatment with leptin normalized fasting plasma glucose and was accompanied by lowered HbA1c, plasma glucagon, and triglyceride concentrations and expression of hepatic gluconeogenic enzymes compared with vehicle (P 〈 0.05), independent of any effects on body weight and food intake. In addition, leptin-treated animals exhibited marked improvement of insulin sensitivity and glucose homeostasis compared with controls, whereas pancreatic insulin content was 50% higher in leptin-treated animals (P 〈 0.05). These effects coincided with activation of leptin and insulin signaling pathways and down-regulation of the PKR-like endoplasmic reticulum (ER) kinase/eukaryotic translation inhibition factor 2α (PERK-eIF2α) arm of ER stress in liver, skeletal muscle, and adipose tissue as well as increased pro-opiomelanocortin and decreased agouti-related peptide in the hypothalamus. In contrast, several markers of inflammation/immune function were elevated with leptin treatment in the same tissues (P 〈 0.05), suggesting that the leptin-mediated increase of insulin sensitivity was not attributable to decreased inflammation. Thus, leptin administration improves insulin sensitivity and normalizes fasting plasma glucose in diabetic UCD-T2DM rats, independent of energy intake, via peripheral and possibly centrally mediated actions, in part by decreasing circulating glucagon and ER stress.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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