In:
Acta Dermato-Venereologica, Medical Journals Sweden AB, Vol. 73, No. 4 ( 1993-08-01), p. 286-292
Abstract:
The presence and distribution of several cytokeratins (CKs) in 20 solid basal cell epitheliomas (BCEs) were investigated and compared with the pattern of CKs in normal epidermis, perilesional skin and in the outer root sheath (ORS) of the human hair follicle. Tissue samples were stained with monoclonal antibodies (MoAbs) against human CKs, using the APAAP technique. Additionally, CK profiles were assessed by gel electrophoresis and immunoblot technique. Cells of BCE and ORS were positively stained with the MoAb KL1, whereas the basal layer of normal epidermis remained negative. Six out of 20 BCEs were partially stained with the MoAb RPN1165, which also stained the lower ORS, but not the epidermal basal layer. Using SDS/PAGE and immunoblot, the CK profiles of BCE and ORS were almost identical, showing the presence of CKs 5, 6, 14, 16 and 17
Type of Medium:
Online Resource
ISSN:
1651-2057
,
0001-5555
DOI:
10.2340/0001555573286292
Language:
Unknown
Publisher:
Medical Journals Sweden AB
Publication Date:
1993
detail.hit.zdb_id:
1492617-9
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