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  • 1
    Online Resource
    Online Resource
    Fatigue in multiple sclerosis is a diagnostic challenge: A cross-sectional study
    Maad Rayan Publishing Company ; 2022
    In:  Journal of Research in Clinical Medicine Vol. 10 ( 2022-11-06), p. 23-
    Details
    In: Journal of Research in Clinical Medicine, Maad Rayan Publishing Company, Vol. 10 ( 2022-11-06), p. 23-
    Abstract: Introduction: Multiple sclerosis (MS) is a chronic and unpredictable demyelinating disease of the central nervous system (CNS). While MS is mostly known for muscle weakness, numbness, and pain, but fatigue is the most common complaint of this condition. Despite this fact, MS related fatigue is one of the most misunderstood symptoms. Methods: A non-interventional study of 100 individuals was conducted in the MS clinic, Tabriz University of Medical Sciences. Patients were divided into groups with and without complaints of fatigue. The course of the disease was determined for all patients. To quantify fatigue, the Modified Fatigue Impact Scale (MFIS) was used. Furthermore, mood disorders, pain, disability, nocturia, insomnia, and spasticity were evaluated among the patients. Results: Overall, fatigue was diagnosed in 61 through 100 patients. Depression was reported in 23 patients of whom 19 had fatigue (P=0.015). 40 patients showed anxiety 33 of which had fatigue (P 〉 0.001). 53 patients of whom reported to have pain (76 patients) showed fatigue (P=0.001). Insomnia was reported in 27 patients, where 21 of them had fatigue (P=0.036). Nocturia was reported in 10 patients, of whom 9 had fatigue (P=0.047). Spasticity was detected in 9 patients, all of whom had fatigue (P=0.012). Conclusion: There are several factors directly and indirectly associated with fatigue that are either fatigue-induced, caused by fatigue, or showing a two-way relationship with it. Understanding these links and attempting to reduce them will improve the quality of life for these patients.
    Type of Medium: Online Resource
    ISSN: 2717-0616
    URL: Article
    DOI: 10.34172/jrcm.2022.023
    Language: English
    Publisher: Maad Rayan Publishing Company
    Publication Date: 2022
    detail.hit.zdb_id: 3040523-3
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  • 2
    Online Resource
    Online Resource
    Molecular Detection of Epstein–Barr Virus, Human Herpes Virus 6, Cytomegalovirus, and Hepatitis B Virus in Patients with Multiple Sclerosis
    Maad Rayan Publishing Company ; 2020
    In:  Middle East Journal of Digestive Diseases Vol. 12, No. 3 ( 2020-07-19), p. 171-177
    Details
    In: Middle East Journal of Digestive Diseases, Maad Rayan Publishing Company, Vol. 12, No. 3 ( 2020-07-19), p. 171-177
    Abstract: BACKGROUND Multiple sclerosis (MS) is a chronic disease with significant morbidity. A wide spectrum of risk factors has been suggested that triggers the development of MS. Among them, several viral infections have been implicated to play a role in MS pathogenesis. We aimed to evaluate the relationship between viral diseases, including Epstein–Barr virus (EBV), human herpes virus 6 (HHV-6), cytomegalovirus (CMV), and hepatitis B virus (HBV) and MS in the present case-control study. METHODS About 100 patients with confirmed MS and age- and sex-matched individuals were selected as case and control groups, respectively. The patients were randomly selected from individuals diagnosed by neurologists based on the clinical signs and symptoms and imaging procedures. RESULTS More than 100 patients with MS and patients who were referred for other causes were analyzed for the presence of DNA of EBV, HHV6, CMV, and HBV separately. 9.37% of the control group had a positive test for the DNA of EBV in a real-time polymerase chain reaction (PCR), while the frequency of positive test result was zero in the case group (p = 0.0012). HBV DNA was not detected in both the case and control groups. The prevalence of CMV was 0.88 and zero in the control and case groups, respectively (p = 0.3410). For HHV6, 9.73 % of the control group had a positive result, while this test was positive in 5.88% of the patients with MS (p = 0.2959). CONCLUSION We detected a significantly higher number of individuals with DNA of EBV in their blood among the control group compared with the case group. In conclusion, the results suggest a surprisingly adverse association between MS and EBV, and no association was found between the presence of DNA of HBV, CMV, and HHV6 and MS.
    Type of Medium: Online Resource
    ISSN: 2008-5249
    URL: Article
    DOI: 10.34172/mejdd.2020.179
    Language: English
    Publisher: Maad Rayan Publishing Company
    Publication Date: 2020
    detail.hit.zdb_id: 2623796-9
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  • 3
    Online Resource
    Online Resource
    Rehabilitation Recommendations for Multiple Sclerosis Patients during the COVID-19 Pandemic
    Maad Rayan Publishing Company ; 2020
    In:  Archives of Iranian Medicine Vol. 23, No. 7 ( 2020-07-01), p. 509-510
    Details
    In: Archives of Iranian Medicine, Maad Rayan Publishing Company, Vol. 23, No. 7 ( 2020-07-01), p. 509-510
    Type of Medium: Online Resource
    ISSN: 1029-2977 , 1735-3947
    URL: Article
    DOI: 10.34172/aim.2020.51
    Language: English
    Publisher: Maad Rayan Publishing Company
    Publication Date: 2020
    detail.hit.zdb_id: 2059531-1
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