GLORIA

GEOMAR Library Ocean Research Information Access

X

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
  • MDPI AG  (38)
Materialart
Verlag/Herausgeber
  • MDPI AG  (38)
Person/Organisation
Sprache
Erscheinungszeitraum
  • 1
    Online-Ressource
    Online-Ressource
    Exposure to AT1 Receptor Autoantibodies during Pregnancy Increases Susceptibility of the Maternal Heart to Postpartum Ischemia-Reperfusion Injury in Rats
    MDPI AG ; 2014
    In:  International Journal of Molecular Sciences Vol. 15, No. 7 ( 2014-06-27), p. 11495-11509
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 15, No. 7 ( 2014-06-27), p. 11495-11509
    Materialart: Online-Ressource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms150711495
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2014
    ZDB Id: 2019364-6
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 2
    Online-Ressource
    Online-Ressource
    Long-Term Effects of Different Nitrogen Levels on Growth, Yield, and Quality in Sugarcane
    MDPI AG ; 2020
    In:  Agronomy Vol. 10, No. 3 ( 2020-03-04), p. 353-
    Details
    In: Agronomy, MDPI AG, Vol. 10, No. 3 ( 2020-03-04), p. 353-
    Kurzfassung: Nitrogen (N) plays an important role in sugarcane (Saccharum spp. hybrids) growth and development; however, long-term effects of N application levels on cane and sugar production in different sugarcane cultivars under field conditions remain unclear. In this study, we investigate the agronomic, yield, and quality traits in three sugarcane cultivars (GT11, B9, and ROC22) under different N levels (0, 150, and 300 kg/ha urea) from 2015 to 2019. Continuous four-year field experiments of plant and ratoon crops were carried out by using two-factor split-plot design. The results showed that N fertilizer application improved the tillering rate, stalk diameter, plant height, stalk weight, millable stalks/ha, cane yield, sugar yield and juice rate of cane, and the difference between N application and non-N application was significant. The cane yield, millable stalks/ha, juice rate, and juice gravity purity increased with the increase of N application, but the milled juice brix and sucrose % cane decreased with the increase of N application. The sugar yield was the highest at 150 kg/ha urea application, while the cane yield was the highest at 300 kg/ha urea application. Different N fertilizer application levels significantly regulated the activities of glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT) and the contents of chlorophyll and nitrate N in plant leaves, which reflected the regulation in nitrogen metabolism and alteration in dry matter production and distribution, cane yield and sugar accumulation in different sugarcane cultivars. During the four-year experiment duration, the cane yield and sugar yield generally showed ROC22 〉 B9 〉 GT11. These data suggested that 300 kg/ha urea application was suitable for the plant and first ratoon crops, and 150 kg/ha urea application was suitable for the second and third ratoon crops. Both cane and sugar yields could be the highest in a four-year production cycle under this circumstance.
    Materialart: Online-Ressource
    ISSN: 2073-4395
    URL: Article
    DOI: 10.3390/agronomy10030353
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2020
    ZDB Id: 2607043-1
    SSG: 23
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    Protective Effect and Mechanism of Boswellic Acid and Myrrha Sesquiterpenes with Different Proportions of Compatibility on Neuroinflammation by LPS-Induced BV2 Cells Combined with Network Pharmacology
    MDPI AG ; 2019
    In:  Molecules Vol. 24, No. 21 ( 2019-10-31), p. 3946-
    Details
    In: Molecules, MDPI AG, Vol. 24, No. 21 ( 2019-10-31), p. 3946-
    Kurzfassung: Frankincense and myrrha (FM), commonly used as a classical herbal pair, have a wide range of clinical applications and definite anti-inflammatory activity. However, anti-neuroinflammation effects and mechanisms are not clear. In this study, we adopted a lipopolysaccharide (LPS)-induced microglial (BV2) cell model and a network pharmacology method to reveal the anti-neuroinflammatory effects and mechanisms of boswellic acid (BA) and myrrha sesquiterpenes (MS) with different proportions of compatibility. The data showed that the different ratios of BA and MS had different degrees of inhibition of interleukin-1β (IL-1β), IL-6, and inducible nitric oxide synthase (iNOS) mRNA expression, down-regulated the phosphor-nuclear factor kappa B/nuclear factor kappa B (p-NF-ҡB)/(NF-ҡB), phosphorylated protein kinase b/protein kinase b (p-AKT/AKT), and Toll-like receptor 4 (TLR4) protein expression levels, and increased phospho-PI3 kinase (p-PI3K) protein expression levels. When the ratios of BA and MS were 10:1, 5:1, and 20:1, better effective efficacy was exhibited. According to the correlation analysis between the effect index and bioactive substances, it was suggested that 2-methoxy-5-acetoxy -fruranogermacr-1(10)-en-6-one (Compound 1), 3α-acetyloxylanosta-8,24-dien-21-oic acid (Compound 2), 11-keto-boswellic acid (Compound 3), and 3-acetyl-11-keto-β -boswellic acid (Compound 4) made important contributions to the treatment of neuroinflammation. Furthermore, based on the network pharmacological analysis, it was found that these four active compounds acted on 31 targets related to neuroinflammation and were involved in 32 signaling pathways which mainly related to the immune system, cardiovascular system, and nervous system, suggesting that BA and MS could be used to treat neuroinflammation.
    Materialart: Online-Ressource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules24213946
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2019
    ZDB Id: 2008644-1
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 4
    Online-Ressource
    Online-Ressource
    Temporal Variability of Virioplankton during a Gymnodinium catenatum Algal Bloom
    MDPI AG ; 2020
    In:  Microorganisms Vol. 8, No. 1 ( 2020-01-12), p. 107-
    Details
    In: Microorganisms, MDPI AG, Vol. 8, No. 1 ( 2020-01-12), p. 107-
    Kurzfassung: Viruses are key biogeochemical engines in the regulation of the dynamics of phytoplankton. However, there has been little research on viral communities in relation to algal blooms. Using the virMine tool, we analyzed viral information from metagenomic data of field dinoflagellate (Gymnodinium catenatum) blooms at different stages. Species identification indicated that phages were the main species. Unifrac analysis showed clear temporal patterns in virioplankton dynamics. The viral community was dominated by Siphoviridae, Podoviridae, and Myoviridae throughout the whole bloom cycle. However, some changes were observed at different phases of the bloom; the relatively abundant Siphoviridae and Myoviridae dominated at pre-bloom and peak bloom stages, while at the post-bloom stage, the members of Phycodnaviridae and Microviridae were more abundant. Temperature and nutrients were the main contributors to the dynamic structure of the viral community. Some obvious correlations were found between dominant viral species and host biomass. Functional analysis indicated some functional genes had dramatic response in algal-associated viral assemblages, especially the CAZyme encoding genes. This work expands the existing knowledge of algal-associated viruses by characterizing viral composition and function across a complete algal bloom cycle. Our data provide supporting evidence that viruses participate in dinoflagellate bloom dynamics under natural conditions.
    Materialart: Online-Ressource
    ISSN: 2076-2607
    URL: Article
    DOI: 10.3390/microorganisms8010107
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2020
    ZDB Id: 2720891-6
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 5
    Online-Ressource
    Online-Ressource
    Seasonal and Spatial Variation of Mo Isotope Compositions in Headwater Stream of Xijiang River Draining the Carbonate Terrain, Southwest China
    MDPI AG ; 2019
    In:  Water Vol. 11, No. 5 ( 2019-05-23), p. 1076-
    Details
    In: Water, MDPI AG, Vol. 11, No. 5 ( 2019-05-23), p. 1076-
    Kurzfassung: The dissolved molybdenum (Mo) contents and Mo isotope in water samples from the upper Xijiang River (XJR), draining the carbonate terrain, southwest China, are reported to investigate the seasonal and spatial variations, sources, ion budget, and isotopic fractionation of dissolved Mo. The results show that the Mo concentrations (5.3–18.9 nmol/L) exhibit an extensive variation along the mainstream without significant spatial pattern, but the Mo concentrations are slightly higher in the dry season than in the wet season caused by the dilution effect. There is a slight spatial tendency for δ98/95Mo to become higher along the mainstream (0.51–1.78%), while the seasonal variations in δ98/95Mo values of NPR (Nanpanjiang River) reach and BPR (Beipanjiang River) reach can be identified higher in the dry season but lower in the wet season. Based on the hydro-geochemical analysis, the sources of dissolved Mo are identified as the carbonates and sulfide/sulfate minerals weathering with a seasonal contribution. Moreover, our results suggest there is no significant Mo isotopic fractionation during weathering and riverine transportation. The calculation of Mo budget demonstrates that the dissolved δ98/95Mo of river draining the carbonate terrain is underestimated, which could significantly influence the redox history of oceans by Mo isotope model.
    Materialart: Online-Ressource
    ISSN: 2073-4441
    URL: Article
    DOI: 10.3390/w11051076
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2019
    ZDB Id: 2521238-2
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 6
    Online-Ressource
    Online-Ressource
    Temperature and Diet Acclimation Modify the Acute Thermal Performance of the Largest Extant Amphibian
    MDPI AG ; 2022
    In:  Animals Vol. 12, No. 4 ( 2022-02-21), p. 531-
    Details
    In: Animals, MDPI AG, Vol. 12, No. 4 ( 2022-02-21), p. 531-
    Kurzfassung: The Chinese giant salamander (Andrias davidianus), one of the largest extant amphibian species, has dramatically declined in the wild. As an ectotherm, it may be further threatened by climate change. Therefore, understanding the thermal physiology of this species should be the priority to formulate related conservation strategies. In this study, the plasticity in metabolic rate and thermal tolerance limits of A. davidianus larvae were studied. Specifically, the larvae were acclimated to three temperature levels (7 °C, cold stress; 15 °C, optimum; and 25 °C, heat stress) and two diet items (red worm or fish fray) for 20 days. Our results indicated that cold-acclimated larvae showed increased metabolic capacity, while warm-acclimated larvae showed a decrease in metabolic capacity. These results suggested the existence of thermal compensation. Moreover, the thermal tolerance windows of cold-acclimated and warm-acclimated larvae shifted to cooler and hotter ranges, respectively. Metabolic capacity is not affected by diet but fish-fed larvae showed superiority in both cold and heat tolerance, potentially due to the input of greater nutrient loads. Overall, our results suggested a plastic thermal tolerance of A. davidianus in response to temperature and diet variations. These results are meaningful in guiding the conservation of this species.
    Materialart: Online-Ressource
    ISSN: 2076-2615
    URL: Article
    DOI: 10.3390/ani12040531
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2606558-7
    SSG: 23
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 7
    Online-Ressource
    Online-Ressource
    Seroprevalence of Epizootic Hemorrhagic Disease Virus in Guangdong Cattle Farms during 2013–2017, China
    MDPI AG ; 2023
    In:  Viruses Vol. 15, No. 6 ( 2023-05-28), p. 1263-
    Details
    In: Viruses, MDPI AG, Vol. 15, No. 6 ( 2023-05-28), p. 1263-
    Kurzfassung: Epizootic hemorrhagic disease (EHD) is an infectious viral disease caused by epizootic hemorrhagic disease virus (EHDV) and EHDV frequently circulates in wild and domestic ruminants. Sporadic outbreaks of EHD have caused thousands of deaths and stillbirths on cattle farms. However, not much is known about the circulating status of EHDV in Guangdong, southern China. To estimate the seroprevalence of EHDV in Guangdong province, 2886 cattle serum samples were collected from 2013 to 2017 and tested for antibodies against EHDV using a competitive ELISA. The overall seroprevalence of EHDV reached 57.87% and was highest in autumn (75.34%). A subset of positive samples were serotyped by a serum neutralization test, showing that EHDV serotypes 1 and 5–8 were circulating in Guangdong. In addition, EHDV prevalence always peaked in autumn, while eastern Guangdong had the highest EHDV seropositivity over the five-year period, displaying apparent temporal–spatial distribution of EHDV prevalence. A binary logistic model analysis indicated a significant association between cattle with BTV infections and seroprevalence of EHDV (OR = 1.70, p 〈 0.001). The co-infection of different serotypes of EHDV and BTV raises a high risk of potential genomic reassortment and is likely to pose a significant threat to cattle, thus urging more surveillance to monitor their circulating dynamics in China.
    Materialart: Online-Ressource
    ISSN: 1999-4915
    URL: Article
    DOI: 10.3390/v15061263
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2023
    ZDB Id: 2516098-9
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 8
    Online-Ressource
    Online-Ressource
    Molecular Targeting of the Oncoprotein PLK1 in Pediatric Acute Myeloid Leukemia: RO3280, a Novel PLK1 Inhibitor, Induces Apoptosis in Leukemia Cells
    MDPI AG ; 2015
    In:  International Journal of Molecular Sciences Vol. 16, No. 1 ( 2015-01-07), p. 1266-1292
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 16, No. 1 ( 2015-01-07), p. 1266-1292
    Materialart: Online-Ressource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms16011266
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2015
    ZDB Id: 2019364-6
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 9
    Online-Ressource
    Online-Ressource
    MoCbp7, a Novel Calcineurin B Subunit-Binding Protein, Is Involved in the Calcium Signaling Pathway and Regulates Fungal Development, Virulence, and ER Homeostasis in Magnaporthe oryzae
    MDPI AG ; 2023
    In:  International Journal of Molecular Sciences Vol. 24, No. 11 ( 2023-05-26), p. 9297-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 11 ( 2023-05-26), p. 9297-
    Kurzfassung: Calcineurin, a key regulator of the calcium signaling pathway, is involved in calcium signal transduction and calcium ion homeostasis. Magnaporthe oryzae is a devastating filamentous phytopathogenic fungus in rice, yet little is known about the function of the calcium signaling system. Here, we identified a novel calcineurin regulatory-subunit-binding protein, MoCbp7, which is highly conserved in filamentous fungi and was found to localize in the cytoplasm. Phenotypic analysis of the MoCBP7 gene deletion mutant (ΔMocbp7) showed that MoCbp7 influenced the growth, conidiation, appressorium formation, invasive growth, and virulence of M. oryzae. Some calcium-signaling-related genes, such as YVC1, VCX1, and RCN1, are expressed in a calcineurin/MoCbp7-dependent manner. Furthermore, MoCbp7 synergizes with calcineurin to regulate endoplasmic reticulum homeostasis. Our research indicated that M. oryzae may have evolved a new calcium signaling regulatory network to adapt to its environment compared to the fungal model organism Saccharomyces cerevisiae.
    Materialart: Online-Ressource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms24119297
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2023
    ZDB Id: 2019364-6
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 10
    Online-Ressource
    Online-Ressource
    The Impact of Quarantine on Pain Sensation among the General Population in China during the COVID-19 Pandemic
    MDPI AG ; 2022
    In:  Brain Sciences Vol. 12, No. 1 ( 2022-01-05), p. 79-
    Details
    In: Brain Sciences, MDPI AG, Vol. 12, No. 1 ( 2022-01-05), p. 79-
    Kurzfassung: During the pandemic era, quarantines might potentially have negative effects and disproportionately exacerbate health condition problems. We conducted this cross-sectional, national study to ascertain the prevalence of constant pain symptoms and how quarantines impacted the pain symptoms and identify the factors associated with constant pain to further guide reducing the prevalence of chronic pain for vulnerable people under the pandemic. The sociodemographic data, quarantine conditions, mental health situations and pain symptoms of the general population were collected. After adjusting for potential confounders, long-term quarantine (≥15 days) exposures were associated with an increased risk of constant pain complaints compared to those not under a quarantine (Odds Ratio (OR): 1.26; 95% Confidence Interval (CI): 1.03, 1.54; p = 0.026). Risk factors including unemployment (OR: 1.55), chronic disease history (OR: 2.38) and infection with COVID-19 (OR: 2.15), and any of mental health symptoms including depression, anxiety, insomnia and PTSD (OR: 5.44) were identified by a multivariable logistic regression. Additionally, mediation analysis revealed that the effects of the quarantine duration on pain symptoms were mediated by mental health symptoms (indirect effects: 0.075, p 〈 0.001). These results advocated that long-term quarantine measures were associated with an increased risk of experiencing pain, especially for vulnerable groups with COVID-19 infection and with mental health symptoms. The findings also suggest that reducing mental distress during the pandemic might contribute to reducing the burden of pain symptoms and prioritizing interventions for those experiencing a long-term quarantine.
    Materialart: Online-Ressource
    ISSN: 2076-3425
    URL: Article
    DOI: 10.3390/brainsci12010079
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2651993-8
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...