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  • MDPI AG  (2)
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  • MDPI AG  (2)
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  • 1
    In: Pharmaceutics, MDPI AG, Vol. 14, No. 6 ( 2022-06-08), p. 1217-
    Kurzfassung: Development of nanotheranostic agents with near-infrared (NIR) absorption offers an effective tool for fighting malignant diseases. Lanthanide ion neodymium (Nd3+)-based nanomaterials, due to the maximum absorption at around 800 nm and unique optical properties, have caught great attention as potential agents for simultaneous cancer diagnosis and therapy. Herein, we employed an active nanoplatform based on gadolinium-ion-doped NdVO4 nanoplates (NdVO4:Gd3+ NPs) for multiple-imaging-assisted photothermal therapy. These NPs exhibited enhanced NIR absorption and excellent biocompatibility after being grafted with polydopamine (pDA) and bovine serum albumin (BSA) layers on their surface. Upon expose to an 808 nm laser, these resulting NPs were able to trigger hyperthermia rapidly and cause photo-destruction of cancer cells. In a xenograft tumor model, tumor growth was also significantly inhibited by these photothermal agents under NIR laser irradiation. Owing to the multicomponent nanostructures, we demonstrated these nanoagents as being novel contrast agents for in vivo magnetic resonance (MR) imaging, X-ray computed tomography (CT), photoacoustic (PA) imaging, and second biological window fluorescent imaging of tumor models. Thus, we believe that this new kind of nanotherapeutic will benefit the development of emerging nanosystems for biological imaging and cancer therapy.
    Materialart: Online-Ressource
    ISSN: 1999-4923
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2527217-2
    SSG: 15,3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    MDPI AG ; 2022
    In:  Remote Sensing Vol. 14, No. 2 ( 2022-01-11), p. 329-
    In: Remote Sensing, MDPI AG, Vol. 14, No. 2 ( 2022-01-11), p. 329-
    Kurzfassung: Sea ice motion is an essential parameter when determining sea ice deformation, regional advection, and the outflow of ice from the Arctic Ocean. The Robeson Channel, which is located between Ellesmere Island and northwest Greenland, is a narrow but crucial channel for ice outflow. Only three Eulerian sea ice motion products derived from ocean/sea ice reanalysis are available: GLORYS12V1, PSY4V3, and TOPAZ4. In this study, we used Lagrangian ice motion in the Robeson Channel derived from Sentinel-1 images to assess GLORYS12V1, PSY4V3, and TOPAZ4. The influence of the presence of ice arches, and wind and tidal forcing on the accuracies of the reanalysis products was also investigated. The results show that the PSY4V3 product performs the best as it underestimates the motion the least, whereas TOPAZ4 grossly underestimates the motion. This is particularly true in regimes of free drift after the formation of the northern arch. In areas with slow ice motion or grounded ice floes, the GLORYS12V1 and TOPAZ4 products offer a better estimation. The spatial distribution of the deviation between the products and ice floe drift is also presented and shows a better agreement in the Robeson Channel compared to the packed ice regime north of the Robeson Channel.
    Materialart: Online-Ressource
    ISSN: 2072-4292
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2513863-7
    Standort Signatur Einschränkungen Verfügbarkeit
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