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  • MDPI AG  (43)
  • 1
    Online Resource
    Online Resource
    A Novel Reperfusion Strategy for Primary Percutaneous Coronary Intervention in Patients with Acute ST-Segment Elevation Myocardial Infarction: A Prospective Case Series
    MDPI AG ; 2023
    In:  Journal of Clinical Medicine Vol. 12, No. 2 ( 2023-01-05), p. 433-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 12, No. 2 ( 2023-01-05), p. 433-
    Abstract: Background: Ischemia reperfusion injury (IRI) remains a major problem in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). We have developed a novel reperfusion strategy for PCI and named it “volume-controlled reperfusion (VCR)”. The aim of the current study was to assess the safety and feasibility of VCR in patients with STEMI. Methods: Consecutive patients admitted to Beijing Chaoyang Hospital with STEMI were prospectively enrolled. The feasibility endpoint was procedural success. The safety endpoints included death from all causes, major vascular complications, and major adverse cardiac event (MACE), i.e., a composite of cardiac death, myocardial reinfarction, target vessel revascularization (TVR), and heart failure. Results: A total of 30 patients were finally included. Procedural success was achieved in 28 (93.3%) patients. No patients died during the study and no major vascular complications or MACE occurred during hospitalization. With the exception of one patient (3.3%) who underwent TVR three months after discharge, no patient encountered death (0.0%), major vascular complications (0.0%), or and other MACEs (0.0%) during the median follow-up of 16 months. Conclusion: The findings of the pilot study suggest that VCR has favorable feasibility and safety in patients with STEMI. Further larger randomized trials are required to evaluate the effectiveness of VCR in STEMI patients.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm12020433
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662592-1
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  • 2
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    Synthesis and Biological Activity of Benzamides Substituted with Pyridine-Linked 1,2,4-Oxadiazole
    MDPI AG ; 2020
    In:  Molecules Vol. 25, No. 15 ( 2020-07-31), p. 3500-
    Details
    In: Molecules, MDPI AG, Vol. 25, No. 15 ( 2020-07-31), p. 3500-
    Abstract: To find pesticidal lead compounds with high activity, a series of novel benzamides substituted with pyridine-linked 1,2,4-oxadiazole were designed by bioisosterism, and synthesized easily via esterification, cyanation, cyclization and aminolysis reactions. The structures of the target compounds were confirmed by 1H-NMR, 13C-NMR and HRMS. The preliminary bioassay showed that most compounds had good larvicidal activities against mosquito larvae at 10 mg/L, especially compound 7a, with a larvicidal activity as high as 100%, and even at 1 mg/L was still 40%; at 50 mg/L, all the target compounds showed good fungicidal activities against the eight tested fungi. Moreover, compound 7h exhibited better inhibitory activity (90.5%) than fluxapyroxad (63.6%) against Botrytis cinereal. Therefore, this type of compound can be further studied.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules25153500
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2008644-1
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  • 3
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    Two-Branch Feature Interaction Fusion Method Based on Generative Adversarial Network
    MDPI AG ; 2023
    In:  Electronics Vol. 12, No. 16 ( 2023-08-15), p. 3442-
    Details
    In: Electronics, MDPI AG, Vol. 12, No. 16 ( 2023-08-15), p. 3442-
    Abstract: This study proposes a fusion method of infrared and visible images based on feature interaction. Existing fusion methods can be classified into two categories based on a single-branch network and a two-branch network. Generative adversarial networks are widely used in single-branch-based fusion methods, which ignore the difference in feature extraction caused by different input images. Most two-branch-based fusion methods use convolutional neural networks, which do not take into account the inverse promotion of fusion results and lack the interaction between different input features. To remedy the shortcomings of these fusion methods and better utilize the feature from source images, this study proposes a two-branch feature interactions method based on a generative adversarial network for visible and infrared image fusion. In the generator part, a two-branch feature interaction approach was designed to extract features from different inputs and realize feature interaction through the network connection of different branches. In the discriminator part, a double-classification discriminator was used for visible images and infrared images. Extensive comparison experiments with state-of-the-art methods have demonstrated the advantages of this proposed generative adversarial network based on two-branch feature interaction, which can enhance the texture details of objects in fusion results and reduce the interference of noise information from source inputs. In addition, the above advantages were also confirmed in generalization experiments of object detection.
    Type of Medium: Online Resource
    ISSN: 2079-9292
    URL: Article
    DOI: 10.3390/electronics12163442
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662127-7
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  • 4
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    Adsorption of Cu(II) and Zn(II) Ions from Aqueous Solution by Gel/PVA-Modified Super-Paramagnetic Iron Oxide Nanoparticles
    MDPI AG ; 2018
    In:  Molecules Vol. 23, No. 11 ( 2018-11-15), p. 2982-
    Details
    In: Molecules, MDPI AG, Vol. 23, No. 11 ( 2018-11-15), p. 2982-
    Abstract: Super-paramagnetic iron oxide nanoparticles (SPIONs)/gelatin (gel)/polyvinyl alcohol (PVA) nanoparticles were designed and synthesized by the co-precipitation method and further modified with gel and PVA. These nanoparticles were used for the removal of Cu(II) and Zn(II) from aqueous solutions. The adsorbents were rich in different functional groups for chemisorption and showed effective adsorption properties. The adsorption of Cu(II) and Zn(II) on the SPIONs/gel and SPIONs/gel/PVA materials were investigated with respect to pH, adsorption kinetics, and adsorption isotherms. The adsorption data was fitted to the Langmuir, Freundlich, and Sips models at the optimum pH 5.2 (±0.2) over 60 min; SPIONs/gel showed maximum adsorption capacities of 47.594 mg/g and 40.559 mg/g for Cu(II) and Zn(II); SPIONs/gel/PVA showed those of 56.051 mg/g and 40.865 mg/g, respectively. The experimental data fitted the pseudo-second-order model, indicating that the process followed chemical monolayer adsorption. In addition, the SPIONs/gel/PVA showed better stability and Cu(II) adsorption efficiency than SPIONs/gel.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules23112982
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2008644-1
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  • 5
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    A Comparison of Negative Pressure and Conventional Therapy in Spine Infections: A Single-Center Retrospective Study
    MDPI AG ; 2023
    In:  Journal of Personalized Medicine Vol. 13, No. 2 ( 2023-01-17), p. 162-
    Details
    In: Journal of Personalized Medicine, MDPI AG, Vol. 13, No. 2 ( 2023-01-17), p. 162-
    Abstract: Purpose: To investigate the effectiveness and safety of negative-pressure wound therapy (NPWT) in treating primary spinal infections. Methods: Patients who underwent surgical treatment for primary spinal infection between January 2018 and June 2021 were retrospectively evaluated. They were divided into two groups based on the type of surgery: one that underwent negative-pressure wound therapy (NPWT) and another that underwent conventional surgery (CVSG-Posterior debridement, bone grafting, fusion, and internal fixation in one stage). The two groups were compared in terms of the total operation time, total blood loss, total postoperative drainage, postoperative pain score, time for the postoperative erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) to return to normal, postoperative complications, treatment time, and recurrence rate. Results: A total of 43 cases of spinal infection were evaluated, with 19 in the NPWT group and 24 in the CVSG group. The NPWT group had a superior postoperative drainage volume, antibiotic use time, erythrocyte sedimentation rate and CRP recovery times, VAS score at 3 months after the operation, and cure rate at 3 months after operation compared with the CVSG group. There were no significant variations in the total hospital stay and intraoperative blood loss between the two groups. Conclusions: This study supports the use of negative pressure in the treatment of a primary spinal infection and indicates that it has a notably better short-term clinical effect than conventional surgery. Additionally, its mid-term cure rate and recurrence rate are more desirable than those of conventional treatments.
    Type of Medium: Online Resource
    ISSN: 2075-4426
    URL: Article
    DOI: 10.3390/jpm13020162
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662248-8
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  • 6
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    Testing Seven Hypotheses to Determine What Explains the Current Planthopper (Fulgoridae) Geographical and Species Richness Patterns in China
    MDPI AG ; 2020
    In:  Insects Vol. 11, No. 12 ( 2020-12-17), p. 892-
    Details
    In: Insects, MDPI AG, Vol. 11, No. 12 ( 2020-12-17), p. 892-
    Abstract: Although many hypotheses have been proposed to understand the mechanisms underlying large-scale richness patterns, the environmental determinants are still poorly understood, particularly in insects. Here, we tested the relative contributions of seven hypotheses previously proposed to explain planthopper richness patterns in China. The richness patterns were visualized at a 1° × 1° grid size, using 14,722 distribution records for 1335 planthoppers. We used ordinary least squares and spatial error simultaneous autoregressive models to examine the relationships between richness and single environmental variables and employed model averaging to assess the environmental variable relative roles. Species richness was unevenly distributed, with high species numbers occurring in the central and southern mountainous areas. The mean annual temperature change since the Last Glacial Maximum was the most important factor for richness patterns, followed by mean annual temperature and net primary productivity. Therefore, historical climate stability, ambient energy, and productivity hypotheses were supported strongly, but orogenic processes and geological isolation may also play a vital role.
    Type of Medium: Online Resource
    ISSN: 2075-4450
    URL: Article
    DOI: 10.3390/insects11120892
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2662247-6
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  • 7
    Online Resource
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    Global Crop Monitoring: A Satellite-Based Hierarchical Approach
    MDPI AG ; 2015
    In:  Remote Sensing Vol. 7, No. 4 ( 2015-04-01), p. 3907-3933
    Details
    In: Remote Sensing, MDPI AG, Vol. 7, No. 4 ( 2015-04-01), p. 3907-3933
    Type of Medium: Online Resource
    ISSN: 2072-4292
    URL: Article
    DOI: 10.3390/rs70403907
    Language: English
    Publisher: MDPI AG
    Publication Date: 2015
    detail.hit.zdb_id: 2513863-7
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  • 8
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    An Artifact-Resistant Feature SKNAER for Quantifying the Burst of Skin Sympathetic Nerve Activity Signal
    MDPI AG ; 2022
    In:  Biosensors Vol. 12, No. 5 ( 2022-05-20), p. 355-
    Details
    In: Biosensors, MDPI AG, Vol. 12, No. 5 ( 2022-05-20), p. 355-
    Abstract: Evaluation of sympathetic nerve activity (SNA) using skin sympathetic nerve activity (SKNA) signal has attracted interest in recent studies. However, signal noises may obstruct the accurate location for the burst of SKNA, leading to the quantification error of the signal. In this study, we use the Teager–Kaiser energy (TKE) operator to preprocess the SKNA signal, and then candidates of burst areas were segmented by an envelope-based method. Since the burst of SKNA can also be discriminated by the high-frequency component in QRS complexes of electrocardiogram (ECG), a strategy was designed to reject their influence. Finally, a feature of the SKNA energy ratio (SKNAER) was proposed for quantifying the SKNA. The method was verified by both sympathetic nerve stimulation and hemodialysis experiments compared with traditional heart rate variability (HRV) and a recently developed integral skin sympathetic nerve activity (iSKNA) method. The results showed that SKNAER correlated well with HRV features (r = 0.60 with the standard deviation of NN intervals, 0.67 with low frequency/high frequency, 0.47 with very low frequency) and the average of iSKNA (r = 0.67). SKNAER improved the detection accuracy for the burst of SKNA, with 98.2% for detection rate and 91.9% for precision, inducing increases of 3.7% and 29.1% compared with iSKNA (detection rate: 94.5% (p 〈 0.01), precision: 62.8% (p 〈 0.001)). The results from the hemodialysis experiment showed that SKNAER had more significant differences than aSKNA in the long-term SNA evaluation (p 〈 0.001 vs. p = 0.07 in the fourth period, p 〈 0.01 vs. p = 0.11 in the sixth period). The newly developed feature may play an important role in continuously monitoring SNA and keeping potential for further clinical tests.
    Type of Medium: Online Resource
    ISSN: 2079-6374
    URL: Article
    DOI: 10.3390/bios12050355
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662125-3
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  • 9
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    The Landscape of Nucleic-Acid-Based Aptamers for Treatment of Hematologic Malignancies: Challenges and Future Directions
    MDPI AG ; 2022
    In:  Bioengineering Vol. 9, No. 11 ( 2022-11-02), p. 635-
    Details
    In: Bioengineering, MDPI AG, Vol. 9, No. 11 ( 2022-11-02), p. 635-
    Abstract: Hematologic malignancies, including leukemia, lymphoma, myeloproliferative disorder and plasma cell neoplasia, are genetically heterogeneous and characterized by an uncontrolled proliferation of their corresponding cell lineages in the bone marrow, peripheral blood, tissues or plasma. Although there are many types of therapeutic drugs (e.g., TKIs, chemotherapy drugs) available for treatment of different malignancies, the relapse, drug resistance and severe side effects due to the lack of selectivity seriously limit their clinical application. Currently, although antibody–drug conjugates have been well established as able to target and deliver highly potent chemotherapy agents into cancer cells for the reduction of damage to healthy cells and have achieved success in leukemia treatment, they still also have shortcomings such as high cost, high immunogenicity and low stability. Aptamers are ssDNA or RNA oligonucleotides that can also precisely deliver therapeutic agents into cancer cells through specifically recognizing the membrane protein on cancer cells, which is similar to the capabilities of monoclonal antibodies. Aptamers exhibit higher binding affinity, lower immunogenicity and higher thermal stability than antibodies. Therefore, in this review we comprehensively describe recent advances in the development of aptamer–drug conjugates (ApDCs) with cytotoxic payload through chemical linkers or direct incorporation, as well as further introduce the latest promising aptamers-based therapeutic strategies such as aptamer–T cell therapy and aptamer–PROTAC, clarifying their bright application, development direction and challenges in the treatment of hematologic malignancies.
    Type of Medium: Online Resource
    ISSN: 2306-5354
    URL: Article
    DOI: 10.3390/bioengineering9110635
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2746191-9
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  • 10
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    Evaluation of 20 Elements in Soils and Sediments by ED-XRF of Monochromatic Excitation
    MDPI AG ; 2022
    In:  Metals Vol. 12, No. 11 ( 2022-10-24), p. 1798-
    Details
    In: Metals, MDPI AG, Vol. 12, No. 11 ( 2022-10-24), p. 1798-
    Abstract: There is an urgent need for the accurate analysis of heavy metal contamination in the field of ecology and environmental sciences, especially in the case of trace heavy metals, such as cadmium. Using doubly curved crystals (DCC) to achieve the monochromatic X-ray excitation of the sample to be measured and a silicon drift detector (SDD) to collect the fluorescence of the sample elements, combined with an algorithm analysis of the fundamental parameters (FP), the monochromatic energy-dispersive X-ray fluorescence (MED-XRF) system significantly improved the detection limits of the target elements. The detection limits, precision, and accuracy of the MED-XRF acquisition for 20 elements, including cadmium, lead, and arsenic, were evaluated and compared with the Determination of Inorganic Elements in Soil and Sediment Wavelength-Dispersive X-ray Fluorescence Spectrometry report and tested on the actual samples. The test results showed that the detection limit of the inorganic elements in soil and sediment determined by MED-XRF was mostly better than the industry standard, especially the detection limit of Cd, which was 0.04 mg/kg. The accuracy and correctness fully met the requirements for daily laboratory testing and, as a quality control tool, the actual sample testing and laboratory ICP-MS results were consistent. The research conducted in this project constituted a useful attempt to expand and improve the analytical methods for inorganic elements in soil and sediment, showing that MED-XRF is superior to conventional ED-XRF and WD-XRF and is the current new method of analysis for a low content of Cd in soil. MED-XRF offers a very important contribution to research on soil census, conservation, the rational use of agricultural land, and soil restoration and improvement, and provides strong support for field testing.
    Type of Medium: Online Resource
    ISSN: 2075-4701
    URL: Article
    DOI: 10.3390/met12111798
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662252-X
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