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  • MDPI AG  (4)
  • 1
    Online Resource
    Online Resource
    Buckling Behavior of Loosely Fitted Formed-In-Place Pipe Liner in Circular Host Pipe under External Pressure
    MDPI AG ; 2023
    In:  Applied Sciences Vol. 13, No. 2 ( 2023-01-04), p. 679-
    Details
    In: Applied Sciences, MDPI AG, Vol. 13, No. 2 ( 2023-01-04), p. 679-
    Abstract: The formed-in-place pipe (FIPP) is a trenchless technology used for pipeline rehabilitation. It is a folded PVC pipe that expands through thermoforming to fit tightly inside the host pipe. However, the deficiencies during the construction of FIPP liners such as insufficient inflation, pipe misalignment and initial deformation will lead to elliptical deformation of the FIPP liner, which affects the load-bearing performance of the liner and makes it susceptible to buckling failure. In this paper, the buckling behavior of loosely fitted FIPP liners under uniform external pressure was investigated by the external pressure resistance test and finite element model. The pre- and post-buckling equilibrium paths verified the finite element model. The results indicated that the value of the dimension ratio will significantly reduce the critical buckling pressure. With the increasing value of liner major axis ratio to host pipe, the reduction effect on the critical buckling pressure caused by the increase in the ovality will diminish. Different values of liner major axis ratio to host pipe and ovality changed the range of the detached portion, which affected the critical buckling pressure. The parametric studies modified the design model from ASTM F1216, which was established to predict the critical buckling pressure of a loosely fitted FIPP liner and reduced the average difference rate from 23.43% to 5.52%.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app13020679
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2704225-X
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Buckling Behavior of Thin-Walled Stainless-Steel Lining Wrapped in Water-Supply Pipe under Negative Pressure
    MDPI AG ; 2021
    In:  Applied Sciences Vol. 11, No. 15 ( 2021-07-23), p. 6781-
    Details
    In: Applied Sciences, MDPI AG, Vol. 11, No. 15 ( 2021-07-23), p. 6781-
    Abstract: This paper presents a study about the buckling behavior of thin stainless-steel lining (SSL) for trenchless repair of urban water supply networks under negative pressure. The critical buckling pressure and displacement (p–δ) curves, temperature changing curves, hoop and axial strain of the lining monitoring section and the strain changes with system pressure (p–ε) of the lining under the action of different diameters, different lining wall thickness and different ventilation modes were obtained through five groups of full-scale tests. The variation principles of the post-buckling pressure and the reduction regularity of the flowing section of the lining were further investigated. By comparing different pipeline buckling models and introducing thin-shell theory, the buckling model of liner supported by existing pipe was established. The comparison between the test results and thin-shell theory indicates that one of the significances of the enhancement coefficient k value is to change the constraint condition of the aspect ratio, l/R, thus increasing the critical buckling pressure of the lining. Finally, an improved lining buckling prediction model (enhancement model) is presented. A previous test is used as a case study with the results showing that the enhanced model is able to predict critical buckling pressure and lobe-starting amount of the liner, which can provide guidance for trenchless restoration of the liner with thin-walled stainless steel.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app11156781
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2704225-X
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  • 3
    Online Resource
    Online Resource
    Phloridzin Reveals New Treatment Strategies for Liver Fibrosis
    MDPI AG ; 2022
    In:  Pharmaceuticals Vol. 15, No. 7 ( 2022-07-20), p. 896-
    Details
    In: Pharmaceuticals, MDPI AG, Vol. 15, No. 7 ( 2022-07-20), p. 896-
    Abstract: Liver fibrosis is an urgent public health problem which is difficult to resolve. However, various drugs for the treatment of liver fibrosis in clinical practice have their own problems during use. In this study, we used phloridzin to treat hepatic fibrosis in the CCl4-induced C57/BL6N mouse model, which was extracted from lychee core, a traditional Chinese medicine. The therapeutic effect was evaluated by biochemical index detections and ultrasound detection. Furthermore, in order to determine the mechanism of phloridzin in the treatment of liver fibrosis, we performed high-throughput sequencing of mRNA and lncRNA in different groups of liver tissues. The results showed that compared with the model group, the phloridzin-treated groups revealed a significant decrease in collagen deposition and decreased levels of serum alanine aminotransferase, aspartate aminotransferase, laminin, and hyaluronic acid. GO and KEGG pathway enrichment analysis of the differential mRNAs was performed and revealed that phloridzin mainly affects cell ferroptosis. Gene co-expression analysis showed that the target genes of lncRNA were obvious in cell components such as focal adhesions, intercellular adhesion, and cell–substrate junctions and in metabolic pathways such as carbon metabolism. These results showed that phloridizin can effectively treat liver fibrosis, and the mechanism may involve ferroptosis, carbon metabolism, and related changes in biomechanics.
    Type of Medium: Online Resource
    ISSN: 1424-8247
    URL: Article
    DOI: 10.3390/ph15070896
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2193542-7
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Hydroxysafflor Yellow A Phytosomes Administered via Intervaginal Space Injection Ameliorate Pulmonary Fibrosis in Mice
    MDPI AG ; 2022
    In:  Pharmaceuticals Vol. 15, No. 11 ( 2022-11-12), p. 1394-
    Details
    In: Pharmaceuticals, MDPI AG, Vol. 15, No. 11 ( 2022-11-12), p. 1394-
    Abstract: Idiopathic pulmonary fibrosis is a fatal interstitial disease characterized by fibroblast proliferation and differentiation and abnormal accumulation of extracellular matrix, with high mortality and an increasing annual incidence. Since few drugs are available for the treatment of pulmonary fibrosis, there is an urgent need for high-efficiency therapeutic drugs and treatment methods to reduce the mortality associated with pulmonary fibrosis. The interstitium, a highly efficient transportation system that pervades the body, plays an important role in the occurrence and development of disease, and can be used as a new route for disease diagnosis and treatment. In this study, we evaluated the administration of hydroxysafflor yellow A phytosomes via intervaginal space injection (ISI) as an anti-pulmonary fibrosis treatment. Our results show that this therapeutic strategy blocked the activation of p38 protein in the MAPK-p38 signaling pathway and inhibited the expression of Smad3 protein in the TGF-β/Smad signaling pathway, thereby reducing secretion of related inflammatory factors, deposition of collagen in the lungs of mice, and destruction of the alveolar structure. Use of ISI in the treatment of pulmonary fibrosis provides a potential novel therapeutic modality for the disease.
    Type of Medium: Online Resource
    ISSN: 1424-8247
    URL: Article
    DOI: 10.3390/ph15111394
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2193542-7
    SSG: 15,3
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