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  • MDPI AG  (8)
  • 1
    Online Resource
    Online Resource
    A Polyoxometalate-Encapsulated Metal–Organic Framework Nanoplatform for Synergistic Photothermal–Chemotherapy and Anti-Inflammation of Ovarian Cancer
    MDPI AG ; 2022
    In:  Molecules Vol. 27, No. 23 ( 2022-11-30), p. 8350-
    Details
    In: Molecules, MDPI AG, Vol. 27, No. 23 ( 2022-11-30), p. 8350-
    Abstract: Photothermal therapy (PTT), as a noninvasive and local treatment, has emerged as a promising anti-tumor strategy with minimal damage to normal tissue under spatiotemporally controllable irradiation. However, the necrosis of cancer cells during PTT will induce an inflammatory reaction, which may motivate tumor regeneration and resistance to therapy. In this study, polyoxometalates and a chloroquine diphosphate (CQ) co-loaded metal–organic framework nanoplatform with hyaluronic acid coating was constructed for efficient ovarian cancer therapy and anti-inflammation. Our results demonstrated that this nanoplatform not only displayed considerable photothermal therapeutic capacity under 808 nm near-infrared laser, but also had an impressive anti-inflammatory capacity by scavenging reactive oxygen species in the tumor microenvironment. CQ with pH dependence was used for the deacidification of lysosomes and the inhibition of autophagy, cutting off a self-protection pathway induced by cell necrosis–autophagy, and achieving the synergistic treatment of tumors. Therefore, we combined the excellent properties of these materials to synthesize a nanoplatform and explored its therapeutic effects in various aspects. This work provides a promising novel prospect for PTT/anti-inflammation/anti-autophagy combinations for efficient ovarian cancer treatment through the fine tuning of material design.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules27238350
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2008644-1
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  • 2
    Online Resource
    Online Resource
    RNA-Seq Transcriptome Analysis of Maize Inbred Carrying Nicosulfuron-Tolerant and Nicosulfuron-Susceptible Alleles
    MDPI AG ; 2015
    In:  International Journal of Molecular Sciences Vol. 16, No. 3 ( 2015-03-13), p. 5975-5989
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 16, No. 3 ( 2015-03-13), p. 5975-5989
    Abstract: Postemergence applications of nicosulfuron can cause great damage to certain maize inbred lines and hybrids. Variation among different responses to nicosulfuron may be attributed to differential rates of herbicide metabolism. We employed RNA-Seq analysis to compare transcriptome responses between nicosulfuron-treated and untreated in both tolerant and susceptible maize plants. A total of 71.8 million paired end Illumina RNA-Seq reads were generated, representing the transcription of around 40,441 unique reads. About 345,171 gene ontology (GO) term assignments were conducted for the annotation in terms of biological process, cellular component and molecular function categories, and 6413 sequences with 108 enzyme commission numbers were assigned to 134 predicted Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways. Digital gene expression profile (DGE) analysis using Solexa sequencing was performed within the susceptible and tolerant maize between the nicosulfuron-treated and untreated conditions, 13 genes were selected as the candidates most likely involved in herbicide metabolism, and quantitative RT-PCR validated the RNA-Seq results for eight genes. This transcriptome data may provide opportunities for the study of sulfonylurea herbicides susceptibility emergence of Zea mays.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms16035975
    Language: English
    Publisher: MDPI AG
    Publication Date: 2015
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 3
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    The Feasibility and Safety of Endoscopic Submucosal Dissection for Circumferential Superficial Esophageal Squamous Cell Neoplasms
    MDPI AG ; 2023
    In:  Journal of Clinical Medicine Vol. 12, No. 2 ( 2023-01-06), p. 471-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 12, No. 2 ( 2023-01-06), p. 471-
    Abstract: Background It remains controversial whether endoscopic submucosal dissection (ESD) is still appropriate for circumferential superficial esophageal squamous cell neoplasms (SESCN), and few studies compared the short-term and long-term outcomes of ESD with radical surgery. Methods A total of 140 patients with SESCN who underwent ESD or surgery between February 2014 and October 2021 were retrospectively reviewed. The characteristics of patients, operative time, postoperative complications, overall survival (OS), recurrence-free survival (RFS), and quality of life (QOL) were compared between the ESD and surgery groups. The effect of different methods to prevent esophageal stenosis after ESD were analysed. Results Drinking, family history of cancer, macroscopic type, and intrapapillary capillary loop (IPCL) type were independent risk factors for deep submucosal invasion (SM ≥ 200 μm). Smoking and IPCL type were independent predictive factors for angiolymphatic invasion. The average operative time of ESD was significantly shorter than that of surgery (174.5 ± 51.16 min vs. 255.9 ± 88.18 min, p 〈 0.001). The incidence of perioperative complications in ESD group was significantly lower than that in surgery group (5.5% vs. 19.4%, p = 0.015). The ESD group had significantly better functional scale scores for emotional functioning, cognitive functioning, and global health status, and lower rates of pain, dyspnoea, insomnia, appetite loss, diarrhoea, reflux, and trouble with taste than the surgery group. No significant difference in OS and RFS between ESD and surgery group. Conclusions ESD can significantly shorten the operative time and reduce perioperative complications. Additionally, on the premise of using appropriate measures to prevent postoperative stenosis, ESD can be the first choice for the treatment of SESCN, which could provide better QOL, and the long-term prognosis of ESD is no less than that of surgery.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm12020471
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662592-1
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  • 4
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    Comparison of Endoscopic Submucosal Dissection and Radical Surgery for Early Gastric Cancer in Remnant Stomach
    MDPI AG ; 2022
    In:  Journal of Clinical Medicine Vol. 11, No. 18 ( 2022-09-14), p. 5403-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 11, No. 18 ( 2022-09-14), p. 5403-
    Abstract: (1) Background: Endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in the remnant stomach or gastric tube is not yet widespread and few studies have compared the short-term and long-term outcomes with radical surgery. (2) Methods: A total of 73 consecutive patients with EGC in the remnant stomach or gastric tube who underwent ESD or radical surgery between October 2009 and October 2020 were retrospectively analyzed in this study. Baseline characteristics, post-operative complications, quality of life (QOL), recurrence rate, overall survival (OS) and disease-free survival (DFS) were compared between the ESD and surgery groups. (3) Results: Among the 73 patients with EGC in the remnant stomach or gastric tube, 48 (65.8%) underwent ESD and 25 (34.2%) underwent surgery. The operation time (p = 0.000) and post-operative hospital stay (p = 0.002) of the ESD group were significantly shorter than those in the surgery group. The incidence of post-operative complications in the ESD group was significantly lower than that in surgery group (p = 0.001). The ESD group had significantly better functional scale scores and lower rates of fatigue, pain, appetite loss, financial difficulties, dysphagia, eating restrictions, hair loss, and poor body image than the surgery group. There was no significant difference in OS or DFS between the ESD and surgery groups (p = 0.124 and 0.344, respectively). (4) Conclusion: ESD can significantly shorten the operation time and hospital stay, reduce surgical complications, and provide better QOL for patients with EGC in the remnant stomach or gastric tube, and its long-term prognosis is no shorter than that of radical surgery.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm11185403
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662592-1
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  • 5
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    A Submucosal Tumor-like Lesion of the Cervical Esophagus Similar to the Tonsillar Structures of Waldeyer’s Ring: A Case Report
    MDPI AG ; 2022
    In:  Medicina Vol. 58, No. 12 ( 2022-12-07), p. 1804-
    Details
    In: Medicina, MDPI AG, Vol. 58, No. 12 ( 2022-12-07), p. 1804-
    Abstract: Esophageal submucosal tumors are rare, but their pathological types are diverse. In addition to the relatively common leiomyomas, some rare submucosal lesions are occasionally reported. Waldeyer’s ring is described as a unique subtype of mucosa-associated lymphoid tissue, located in the naso-oropharynx. Studies have reported that Waldeyer’s ring is the most common site of primary extranodal lymphoma in the head and neck. Interestingly, we encountered an esophageal submucosal tumor-like lesion similar to the tonsillar structures of Waldeyer’s ring. A 38-year-old man underwent esophagoscopy after experiencing swallowing discomfort for 3 months. A protruding submucosal mass with slightly rough mucosa was found at the cervical esophagus approximately 20 cm from the incisors. Considering the possibility of the coexistence of a submucosal tumor and a mucosal lesion, as well as the continuous symptoms of swallowing discomfort, the patient underwent endoscopic submucosal dissection. The lesion was removed en bloc. However, histology revealed a lesion similar to the tonsillar structure of Waldeyer’s ring between the lamina propria and submucosa. The patient was followed up for 6 months without recurrence or complaints. We report a new submucosal lesion and discuss its origin and treatment. Diagnostic ESD might be an effective option until its malignant potential is clarified.
    Type of Medium: Online Resource
    ISSN: 1648-9144
    URL: Article
    DOI: 10.3390/medicina58121804
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2088820-X
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  • 6
    Online Resource
    Online Resource
    Influence of Aggregate Pollution in Truck Escape Ramps on Stopping Distance of Uncontrolled Vehicles
    MDPI AG ; 2022
    In:  Sustainability Vol. 14, No. 18 ( 2022-09-15), p. 11593-
    Details
    In: Sustainability, MDPI AG, Vol. 14, No. 18 ( 2022-09-15), p. 11593-
    Abstract: Migration of fine materials such as soil from the roadbed and the ground will gradually pollute the aggregate in the arrester bed of truck escape ramps. However, there are few studies on the impact of aggregate pollution of the arrester bed on the stopping distance of runaway vehicles. This paper uses the discrete element method to study the influence of aggregates with different degrees of pollution on stopping distance by taking silty cohesive soil as a typical pollutant. In this paper, the stopping process of the uncontrolled vehicle on the arrester bed with different pollution levels was numerically simulated. The simulation results show that the uncontrolled vehicle’s stopping distance increases with the contaminated aggregate’s soil content. The simulation results show that when the soil content in the contaminated aggregate is less than 15%, the increase in the stopping distance of the uncontrol vehicle is less than 5%; when the soil content is 20–25%, the stopping distance of the uncontrolled vehicle increases by more than 20%; and when the soil content is 30–35%, the stopping distance of uncontrol vehicle increases by more than 50%. Different maintenance measures should be taken according to the increase in stopping distance.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su141811593
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518383-7
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  • 7
    Online Resource
    Online Resource
    Role of ZmGST Gene Family Involved in Nicosulfuron Stress Tolerance Revealed by Genomic and Transcriptomic Analyses
    MDPI AG ; 2022
    In:  Agronomy Vol. 12, No. 11 ( 2022-10-22), p. 2598-
    Details
    In: Agronomy, MDPI AG, Vol. 12, No. 11 ( 2022-10-22), p. 2598-
    Abstract: Glutathione S-transferases (GST) are a large family of polymorphous proteins that play important roles in herbicide detoxification and stress response. Nicosulfuron is the most broadly used herbicide in maize fields, and it can cause different injuries to maize varieties, but little is studied about the systemic and comprehensive GST gene family responding to nicosulfuron stress in maize. In this research, pre-treatment with glutathione S-transferase inhibitor 4-chloro-7-nitrobenzoxadiazole (NBD-Cl) increased nicosulfuron phytotoxicity to both sensitive and tolerant maize genotypes. A total of 55 ZmGST genes belonging to six major sub-classes were identified in the maize genome and named according to the nomenclature system. Based on phylogenetic analyses, highly conserved gene structure and motif distribution were detected in the same class. Chromosome mapping results showed that ZmGST genes were distributed over the 10 chromosomes unevenly. There were thirteen and eight gene pairs identified as tandem and segmental duplication events, respectively, which played important roles in the expansion of the GST gene family in maize. RNA-seq and qRT-PCR analyses showed that there were great dissimilarities in ZmGST gene expression patterns between the tolerant and sensitive maize plants. More highly expressed ZmGST genes were found in the tolerant than in the sensitive without nicosulfuron stress. However, under 60 g a.i. ha−1 nicosulfuron stress, more ZmGST genes were significantly upregulated in HB41 than in HB09. This study provided experimental evidence showing that glutathione S-transferases were involved in nicosulfuron stress in maize. It will contribute to the further functional analysis of the GST gene family in maize.
    Type of Medium: Online Resource
    ISSN: 2073-4395
    URL: Article
    DOI: 10.3390/agronomy12112598
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2607043-1
    SSG: 23
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  • 8
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    Solitary Rectal Ulcer Syndrome Is Not Always Ulcerated: A Case Report
    MDPI AG ; 2022
    In:  Medicina Vol. 58, No. 8 ( 2022-08-22), p. 1136-
    Details
    In: Medicina, MDPI AG, Vol. 58, No. 8 ( 2022-08-22), p. 1136-
    Abstract: Solitary rectal ulcer syndrome (SRUS) is a benign and chronic disorder well known in young adults that is characterized by a series of symptoms such as rectal bleeding, copious mucus discharge, prolonged excessive straining, perineal and abdominal pain, a feeling of incomplete defecation, constipation and, rarely, rectal prolapse. The etiology of this syndrome remains obscure, and the diagnosis is easily confused with that of other diseases, contributing to difficulties in treatment. We present a case of a 37-year-old male with a nonulcerated rectal lesion grossly resembling a superficial depressed rectal cancer misdiagnosed in another hospital and describe its appearance on endoscopy and in the analysis of its pathological manifestations. The aim of this case report is to report an easily misdiagnosed case of SRUS, which needs to be distinguished from superficial rectal cancer, which should be educational for endoscopists.
    Type of Medium: Online Resource
    ISSN: 1648-9144
    URL: Article
    DOI: 10.3390/medicina58081136
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2088820-X
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