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  • 1
    Online Resource
    Online Resource
    Antikinetoplastid Activity of Sesquiterpenes Isolated from the Zoanthid Palythoa aff. clavata
    MDPI AG ; 2021
    In:  Pharmaceuticals Vol. 14, No. 11 ( 2021-10-28), p. 1095-
    Details
    In: Pharmaceuticals, MDPI AG, Vol. 14, No. 11 ( 2021-10-28), p. 1095-
    Abstract: Leishmaniasis and Chagas disease are neglected tropical diseases that cause problems in developing countries. The causative agents, Leishmania spp. and Trypanosoma cruzi, produce a clinical picture that can be fatal for the patient, such as Chagas heart disease, visceral leishmaniasis and megacolon, among others. Current treatments for these diseases are not very effective and highly toxic, since they require very prolonged treatments. The development of innovative, effective and safe drugs to fight infections caused by these parasites remains a challenge. For this reason, in recent years, there has been an increase in the search for new therapies. In this study, the antikinetoplastid activity of 13 sesquiterpene lactones obtained from Palythoa aff. clavata was screened against L. amazonensis, L. donovani and T. cruzi. The results revealed that the sesquiterpene lactones anhydroartemorin (2), cis,trans-costunolide-14-acetate (3) and 4-hydroxyarbusculin A (11) were the most selective against the kinetoplastid species studied. These molecules seem to induce the mechanisms involved in an apoptotic-like death or programmed cell death (PCD) in the kinetoplastids, and since they do not cause necrosis, the inflammatory events associated with this type of cell death will not be triggered.
    Type of Medium: Online Resource
    ISSN: 1424-8247
    URL: Article
    DOI: 10.3390/ph14111095
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2193542-7
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Environmental Cross-Validation of NLOS Machine Learning Classification/Mitigation with Low-Cost UWB Positioning Systems
    MDPI AG ; 2019
    In:  Sensors Vol. 19, No. 24 ( 2019-12-10), p. 5438-
    Details
    In: Sensors, MDPI AG, Vol. 19, No. 24 ( 2019-12-10), p. 5438-
    Abstract: Indoor positioning systems based on radio frequency inherently present multipath-related phenomena. This causes ranging systems such as ultra-wideband (UWB) to lose accuracy when detecting secondary propagation paths between two devices. If a positioning algorithm uses ranging measurements without considering these phenomena, it will face critical errors in estimating the position. This work analyzes the performance obtained in a localization system when combining location algorithms with machine learning techniques applied to a previous classification and mitigation of the propagation effects. For this purpose, real-world cross-scenarios are considered, where the data extracted from low-cost UWB devices for training the algorithms come from a scenario different from that considered for the test. The experimental results reveal that machine learning (ML) techniques are suitable for detecting non-line-of-sight (NLOS) ranging values in this situation.
    Type of Medium: Online Resource
    ISSN: 1424-8220
    URL: Article
    DOI: 10.3390/s19245438
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2052857-7
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  • 3
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    Proliferation, Migration and Invasion of Breast Cancer Cell Lines Are Inhibited by 1,5-Disubstituted Tetrazol-1,2,3-triazole Hybrids through Interaction with p53
    MDPI AG ; 2023
    In:  Molecules Vol. 28, No. 22 ( 2023-11-15), p. 7600-
    Details
    In: Molecules, MDPI AG, Vol. 28, No. 22 ( 2023-11-15), p. 7600-
    Abstract: The anticarcinogenic potential of a series of 1,5-disubstituted tetrazole-1,2,3-triazole hybrids (T-THs) was evaluated in the breast cancer (BC)-derived cell lines MCF-7 (ER+, PR+, and HER2−), CAMA-1 (ER+, PR+/−, and HER2−), SKBR-3 (ER+, PR+, and HER2+), and HCC1954 (ER+, PR+, and HER2+). The T-THs 7f, 7l, and 7g inhibited the proliferation of MCF-7 and CAMA-1, HCC1954, and SKBR-3 cells, respectively. The compounds with stronger effect in terms of migration and invasion inhibition were 7o, 7b, 7n, and 7k for the CAMA-1, MCF-7, HCC1954, and SKBR-3 cells respectively. Interestingly, these T-THs were the compounds with a fluorine present in their structures. To discover a possible target protein, a molecular docking analysis was performed for p53, p38, p58, and JNK1. The T-THs presented a higher affinity for p53, followed by JNK1, p58, and lastly p38. The best-predicted affinity for p53 showed interactions between the T-THs and both the DNA fragment and the protein. These results provide an opportunity for these compounds to be studied as potential drug candidates for breast cancer treatment.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules28227600
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2008644-1
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  • 4
    Online Resource
    Online Resource
    Multi-Sensor Accurate Forklift Location and Tracking Simulation in Industrial Indoor Environments
    MDPI AG ; 2019
    In:  Electronics Vol. 8, No. 10 ( 2019-10-12), p. 1152-
    Details
    In: Electronics, MDPI AG, Vol. 8, No. 10 ( 2019-10-12), p. 1152-
    Abstract: Location and tracking needs are becoming more prominent in industrial environments nowadays. Process optimization, traceability or safety are some of the topics where a positioning system can operate to improve and increase the productivity of a factory or warehouse. Among the different options, solutions based on ultra-wideband (UWB) have emerged during recent years as a good choice to obtain highly accurate estimations in indoor scenarios. However, the typical harsh wireless channel conditions found inside industrial environments, together with interferences caused by workers and machinery, constitute a challenge for this kind of system. This paper describes a real industrial problem (location and tracking of forklift trucks) that requires precise internal positioning and presents a study on the feasibility of meeting this challenge using UWB technology. To this end, a simulator of this technology was created based on UWB measurements from a set of real sensors. This simulator was used together with a location algorithm and a physical model of the forklift to obtain estimations of position in different scenarios with different obstacles. Together with the simulated UWB sensor, an additional inertial sensor and optical sensor were modeled in order to test its effect on supporting the location based on UWB. All the software created for this work is published under an open-source license and is publicly available.
    Type of Medium: Online Resource
    ISSN: 2079-9292
    URL: Article
    DOI: 10.3390/electronics8101152
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2662127-7
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  • 5
    Online Resource
    Online Resource
    Silver-Copper Oxide Heteronanostructures for the Plasmonic-Enhanced Photocatalytic Oxidation of N-Hexane in the Visible-NIR Range
    MDPI AG ; 2019
    In:  Materials Vol. 12, No. 23 ( 2019-11-22), p. 3858-
    Details
    In: Materials, MDPI AG, Vol. 12, No. 23 ( 2019-11-22), p. 3858-
    Abstract: Volatile organic compounds (VOCs) are recognized as hazardous contributors to air pollution, precursors of multiple secondary byproducts, troposphere aerosols, and recognized contributors to respiratory and cancer-related issues in highly populated areas. Moreover, VOCs present in indoor environments represent a challenging issue that need to be addressed due to its increasing presence in nowadays society. Catalytic oxidation by noble metals represents the most effective but costly solution. The use of photocatalytic oxidation has become one of the most explored alternatives given the green and sustainable advantages of using solar light or low-consumption light emitting devices. Herein, we have tried to address the shortcomings of the most studied photocatalytic systems based on titania (TiO2) with limited response in the UV-range or alternatively the high recombination rates detected in other transition metal-based oxide systems. We have developed a silver-copper oxide heteronanostructure able to combine the plasmonic-enhanced properties of Ag nanostructures with the visible-light driven photoresponse of CuO nanoarchitectures. The entangled Ag-CuO heteronanostructure exhibits a broad absorption towards the visible-near infrared (NIR) range and achieves total photo-oxidation of n-hexane under irradiation with different light-emitting diodes (LEDs) specific wavelengths at temperatures below 180 °C and outperforming its thermal catalytic response or its silver-free CuO illuminated counterpart.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma12233858
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2487261-1
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  • 6
    Online Resource
    Online Resource
    Influence of Low-Pressure Plasma on the Surface Properties of CAD-CAM Leucite-Reinforced Feldspar and Resin Matrix Ceramics
    MDPI AG ; 2020
    In:  Applied Sciences Vol. 10, No. 24 ( 2020-12-10), p. 8856-
    Details
    In: Applied Sciences, MDPI AG, Vol. 10, No. 24 ( 2020-12-10), p. 8856-
    Abstract: The introduction of new ceramic materials for dental restorations is currently a reality; however, little information is available on their surface treatment for the bonding process. Furthermore, surface treatment with plasma on ceramic materials has been recently introduced, although not many studies are available. The aim of this study was to evaluate the surface properties of a leucite-reinforced feldspar ceramic (LIC) and resin matrix ceramic (RMC) after low-pressure plasma treatment. From each material, 48 discs were prepared and subject to surface treatment. The LIC group was treated by hydrofluoric acid (HF) (LIC-HF), plasma with oxygen (LIC-O2), and plasma with argon (LIC-Ar). The RMC group was treated by sandblasting with alumina (RMC-SB), plasma with oxygen (RMC-O2), and plasma with argon (RMC-Ar). The groups whose surfaces were not subjected to treatment were considered as the control group. Surface wettability and roughness was analyzed. The results showed significant differences among the treatments for both ceramics regarding wettability and roughness. Plasma treatments increased the wettability and had a very low effect on the roughness. Plasma treatments achieved similar values for both surface properties in each ceramic group with no differences between both treatments. Plasma treatment seems to be a promising alternative for ceramic surface treatments since it increased the surface energy of the ceramics analyzed and hardly affects the roughness. Further studies are necessary to evaluate the effect of plasma treatment on the bond strength of ceramics.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app10248856
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2704225-X
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  • 7
    Online Resource
    Online Resource
    Effect of Digital Technologies on the Marginal Accuracy of Conventional and Cantilever Co–Cr Posterior-Fixed Partial Dentures Frameworks
    MDPI AG ; 2021
    In:  Applied Sciences Vol. 11, No. 7 ( 2021-03-26), p. 2988-
    Details
    In: Applied Sciences, MDPI AG, Vol. 11, No. 7 ( 2021-03-26), p. 2988-
    Abstract: The introduction of new digital technologies represents an important advance to fabricate metal–ceramic restorations. However, few studies have evaluated the influence of these technologies on the fit of the restorations. The aim of this study was to evaluate the effect of different manufacturing techniques and pontic design on the vertical marginal fit of cobalt–-chromium (Co–Cr) posterior fixed partial dentures (FPDs) frameworks. Methods: Eighty stainless-steel dies were prepared to receive 3-unit FPDs frameworks with intermediate pontic (n = 40) and cantilever pontic (n = 40). Within each design, the specimens were randomly divided into four groups (n = 10 each) depending on the manufacturing technique: casting (CM), direct metal laser sintering (LS), soft metal milling (SM), and hard metal milling (HM). The frameworks were luted, and the vertical marginal discrepancy was assessed. Data analysis was made using Kruskal–Wallis and Mann–Whitney U tests (α = 0.05). Results: The vertical marginal discrepancy values of all FPDs were below 50 μm. The HM frameworks obtained the lowest misfit values in both designs. However, no differences were found among intermediate pontic groups or cantilevered groups. Likewise, when differences in a marginal discrepancy between both framework designs were analyzed, no differences were observed. Conclusions: The analyzed digital technologies demonstrated high precision of fit on Co–Cr frameworks and on both pontic designs.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app11072988
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
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  • 8
    Online Resource
    Online Resource
    Prospective Clinical Evaluation of Posterior Third-Generation Monolithic Zirconia Crowns Fabricated with Complete Digital Workflow: Two-Year Follow-Up
    MDPI AG ; 2022
    In:  Materials Vol. 15, No. 2 ( 2022-01-17), p. 672-
    Details
    In: Materials, MDPI AG, Vol. 15, No. 2 ( 2022-01-17), p. 672-
    Abstract: Clinical studies on the behavior of posterior translucent monolithic zirconia restorations are lacking. We assessed the clinical outcome and survival rate of posterior third-generation monolithic zirconia crowns over a 2-year period. A total of 24 patients, requiring 30 posterior full-contour restorations were selected. All abutments were scanned, and crowns were milled and cemented with a self-adhesive dual cure cement. Crowns were assessed using the California Dental Association’s criteria. Gingival status was assessed by evaluating the gingival index, plaque index, periodontal probing depth of the abutments and control teeth, and the margin index of the abutment teeth. Statistical analyses were performed using the Friedman and the Wilcoxon signed-rank tests. During the 2-year follow-up, no biological or mechanical complications were observed, and the survival and success rate was 100%. All restorations ranked as satisfactory throughout the follow-up period. The gingival index and plaque index were worse at the end of the 2-year follow-up. The margin index was stable during the 2 years of clinical service. No significant differences were recorded in periodontal parameters between crowns and control teeth. Third-generation monolithic zirconia could be a reliable alternative to posterior metal–ceramic and second-generation monolithic zirconia posterior crowns.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma15020672
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2487261-1
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  • 9
    Online Resource
    Online Resource
    Evaluation of Milled Titanium versus Laser Sintered Co-Cr Abutments on the Marginal Misfit in Internal Implant-Abutment Connection
    MDPI AG ; 2020
    In:  Materials Vol. 13, No. 21 ( 2020-10-30), p. 4873-
    Details
    In: Materials, MDPI AG, Vol. 13, No. 21 ( 2020-10-30), p. 4873-
    Abstract: The precision of fit at the implant-abutment connection is an important criterion for the clinical success of restorations and implants. Several factors are involved among which are the abutment materials and manufacturing techniques. The aim of this study was to investigate the effect of two materials and methods of manufacturing implant abutments, milled titanium versus laser sintered Co-Cr, on the marginal misfit at the implant-abutment interface. Scanning electron microscopes (SEM) were used to geometrically measure the marginal vertical discrepancy of a total of 80 specimens, classified into eight categories, according to the implant system and abutment. The data were statistically analyzed by Student’s paired t test, one-way and two-way ANOVA with the Bonferroni-Holm correction at the significance level of p = 0.05. Milled titanium abutments demonstrated the lowest misfit values in the implant systems analyzed. The marginal fit of all the groups was within the clinically acceptable range for implant prostheses.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma13214873
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2487261-1
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  • 10
    Online Resource
    Online Resource
    Effect of Surface Treatments with Low-Pressure Plasma on the Adhesion of Zirconia
    MDPI AG ; 2023
    In:  Materials Vol. 16, No. 17 ( 2023-09-03), p. 6055-
    Details
    In: Materials, MDPI AG, Vol. 16, No. 17 ( 2023-09-03), p. 6055-
    Abstract: The purpose of this study was to investigate the effect of low-pressure plasma on the contact angle, shear bond strength (SBS), and the failure mode of zirconia ceramic. Zirconia specimens were divided into three groups according to the surface treatment methods as follows: sandblasting with aluminum oxide (ZR-C), sandblasting with aluminum oxide and oxygen plasma (ZR-CP), and argon plasma (ZR-P). The contact angle, SBS, and surface characteristics were tested after thermocycling. Data analysis was made using the Kruskal–Wallis test and one-way analysis of variance. Plasma treatment significantly reduced the contact angle (p 〈 0.001) with the lowest value for the Zr-P group. An increase in oxygen and a decrease in carbon was observed on the zirconia surface in both plasma groups. For the SBS, there were significant differences among the groups (p 〈 0.018), the Zr-CP group showing the highest bond strength. Mixed failures were the most frequent. Plasma treatment was effective in increasing the wettability, increasing the oxygen/carbon ratio without changing zirconia surface morphology. The sandblasting plus plasma with oxygen group exhibited the highest bond strength.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma16176055
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2487261-1
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