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  • 1
    In: Energies, MDPI AG, Vol. 13, No. 11 ( 2020-06-04), p. 2870-
    Abstract: Studies show that the valve lift (VL) of the cam-driven hydraulic variable valve actuation (VVA) can be continuously adjusted in the range of 0–8.2 mm by controlling the opening of the throttling valve. In the present study, an orthogonal experiment with interaction was designed to analyze the effect of multi-factor coupling on the VL, valve-seating velocity (VSV), and pressure fluctuation in the valve piston cavity. In order to reduce the pressure fluctuation, the Taguchi method was applied to find the optimal combination of the key parameters including the diameter of the piston, the spring preload of the valve-seating buffer mechanism (VSBM), the spring preload of the valve, and the valve piston mass. The correctness of the VVA simulation model is verified through experiments. Moreover, the pressure fluctuation is analyzed through a numerical simulation. The obtained results showed that as long as the VSV is less than 0.5 m·s−1, the pressure fluctuations in hydraulic VVA can be reduced by several means, such as increasing the spring stiffness of the VSBM and valve, increasing the valve piston area and diameter size of the thin-walled hole, and reducing the valve piston mass and total hydraulic oil volume.
    Type of Medium: Online Resource
    ISSN: 1996-1073
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2437446-5
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  • 2
    In: Vaccines, MDPI AG, Vol. 9, No. 9 ( 2021-09-15), p. 1024-
    Abstract: Introduction: Vaccine inequality inflames the COVID-19 pandemic. Ensuring equitable immunization, vaccine empathy is needed to boost vaccine donations among capable countries. However, damaging narratives built around vaccine donations such as “vaccine diplomacy” could undermine nations’ willingness to donate their vaccines, which, in turn, further exacerbate global vaccine inequality. However, while discussions on vaccine diplomacy are on the rise, there is limited research related to vaccine diplomacy, especially in terms of its characteristics and effects on vaccine distribution vis-à-vis vaccine empathy. Thus, to bridge the research gap, this study aims to examine the defining attributes of vaccine diplomacy and its potential effects on COVID-19 immunization, particularly in light of vaccine empathy. Methods: A narrative review was conducted to shed light on vaccine diplomacy’s defining attributes and effects in the context of COVID-19 vaccine distribution and dissemination. Databases such as PubMed and Medline were utilized for literature search. Additionally, to ensure up-to-date insights are included in the review, validated reports and reverse tracing of eligible articles’ reference lists in Google Scholar have also been conducted to locate relevant records. Results: Vaccine empathy is an individual or a nation’s capability to sympathize with other individuals or nations’ vaccine wants and needs, whereas vaccine diplomacy is a nation’s vaccine efforts that aim to build mutually beneficial relationships with other nations ultimately. Our findings show that while both vaccine empathy and vaccine diplomacy have their strengths and weaknesses, they all have great potential to improve vaccine equality, particularly amid fast-developing and ever-evolving global health crises such as COVID-19. Furthermore, analyses show that, compared to vaccine empathy, vaccine diplomacy might be a more sustainable solution to improve vaccine donations mainly because of its deeper and stronger roots in multilateral collaboration and cooperation. Conclusion: Similar to penicillin, automated external defibrillators, or safety belts amid a roaring global health disaster, COVID-19 vaccines are, essentially, life-saving consumer health products that should be available to those who need them. Though man-made and complicated, vaccine inequality is nonetheless a solvable issue—gaps in vaccine distribution and dissemination can be effectively addressed by timely vaccine donations. Overall, our study underscores the instrumental and indispensable role of vaccine diplomacy in addressing the vaccine inequality issue amid the COVID-19 pandemic and its potentials for making even greater contributions in forging global solidarity amid international health emergencies. Future research could investigate approaches that could further inspire and improve vaccine donations among capable nations at a global scale to advance vaccine equity further.
    Type of Medium: Online Resource
    ISSN: 2076-393X
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2703319-3
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  • 3
    In: Toxics, MDPI AG, Vol. 11, No. 2 ( 2023-02-09), p. 162-
    Abstract: Microcystin-LR (MCLR) is an aquatic toxin, which could lead to the development of hepatocellular carcinoma (HCC). Long non-coding RNAs (lncRNAs) are considered important regulatory elements in the occurrence and development of cancer. However, the roles and mechanisms of lncRNAs during the process of HCC, induced by MCLR, remain elusive. Here, we identified a novel lncRNA, namely lnc-GCLC-1 (lncGCLC), which is in close proximity to the chromosome location of glutamate–cysteine ligase catalytic subunit (GCLC). We then investigated the role of lncGCLC in MCLR-induced malignant transformation of WRL68, a human hepatic cell line. During MCLR-induced cell transformation, the expression of lncGCLC and GCLC decreased continuously, accompanied with a consistently high expression of miR-122-5p. Knockdown of lncGCLC promoted cell proliferation, migration and invasion, but reduced cell apoptosis. A xenograft nude mouse model demonstrated that knockdown of lncGCLC promoted tumor growth. Furthermore, knockdown of lncGCLC significantly upregulated miR-122-5p expression, suppressed GCLC expression and GSH levels, and enhanced oxidative DNA damages. More importantly, the expression of lncGCLC in human HCC tissues was significantly downregulated in the high-microcystin exposure group, and positively associated with GCLC level in HCC tissues. Together, these findings suggest that lncGCLC plays an anti-oncogenic role in MCLR-induced malignant transformation by regulating GCLC expression.
    Type of Medium: Online Resource
    ISSN: 2305-6304
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2733883-6
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  • 4
    Online Resource
    Online Resource
    MDPI AG ; 2017
    In:  Remote Sensing Vol. 9, No. 4 ( 2017-04-19), p. 386-
    In: Remote Sensing, MDPI AG, Vol. 9, No. 4 ( 2017-04-19), p. 386-
    Type of Medium: Online Resource
    ISSN: 2072-4292
    Language: English
    Publisher: MDPI AG
    Publication Date: 2017
    detail.hit.zdb_id: 2513863-7
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  • 5
    In: Energies, MDPI AG, Vol. 12, No. 7 ( 2019-04-08), p. 1337-
    Abstract: To quantitatively evaluate the complexities and heterogeneities of pore structures in sandstone reservoirs, we apply single fractal theory and multifractal theory to explore the fractal characteristics of pore size distributions based on mercury intrusion porosimetry. The fractal parameters were calculated and the relationships between the petrophysical parameters (permeability and entry pressure) and the fractal parameters were investigated. The results show that the single fractal curves exhibit two-stage characteristics and the corresponding fractal dimensions D1 and D2 can characterize the complexity of pore structure in different sizes. Favorable linear relationships between log(ε) and log(μ,(ε)) indicate that the samples satisfy multifractal characteristics and ε is the sub-intervals with size ε = J × 2−k. The multifractal singularity curves used in this study exhibit a right shape, indicating that the heterogeneity of the reservoir is mainly affected by pore size distributions in sparse regions. Multifractal parameters, D(0), D(1), and Δf, are positively correlated with permeability and entry pressure, while D(0), D(1), and Δf are negatively correlated with permeability and entry pressure. The ratio of larger pores volumes to total pore volumes acts as a control on the fractal dimension over a specific pore size range, while the range of the pore size distribution has a definite impact on the multifractal parameters. Results indicate that fractal analysis and multifractal analysis are feasible methods for characterizing the heterogeneity of pore structures in a reservoir. However, the single fractal models ignore the influence of microfractures, which could result in abnormal values for calculated fractal dimension. Compared to single fractal analysis, multifractal theory can better quantitatively characterize the heterogeneity of pore structure and establish favorable relationships with reservoir physical property parameters.
    Type of Medium: Online Resource
    ISSN: 1996-1073
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2437446-5
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  • 6
    In: Vaccines, MDPI AG, Vol. 9, No. 11 ( 2021-11-05), p. 1285-
    Abstract: Background: Following the initial manufacture of COVID-19 vaccines, numerous studies have investigated factors that influence people’s vaccination intentions. However, no studies have examined links of vaccination attitudes with body-related attitudes, especially body appreciation. To address this gap in the literature, we conducted this study to disentangle the relationship between college students’ COVID-19 vaccination intentions and body appreciation. Method: A cross-sectional study was conducted among Chinese college students. Participants completed the Body Appreciation Scale-2 (BAS-2) and other questionnaire measures of demographics, intentions to be vaccinated, and attitudes toward COVID-19 vaccination programs. Results: A total of 2058 college students participated in this study. Students who were willing to get COVID-19 vaccines had significantly higher BAS-2 scores than did those who were unwilling to receive a vaccine (3.61 ± 0.84 vs. 3.34 ± 0.92, p 〈 0.001). A hierarchical multiple logistic regression analysis was performed to test the association between body appreciation and COVID-19 vaccine intentions when controlling for other covariates; elevated BAS-2 scores were associated with greater willingness to receive COVID-19 vaccines (OR = 1.250, 95%CI: 1.112–1.406, p 〈 0.001), independent of other significant influences. Conclusion: Our study was the first to reveal that body appreciation is a significant factor related to college students’ COVID-19 vaccination intentions. Public health interventions designed to improve people’s body-appreciation levels may help in efforts to promote universal immunization.
    Type of Medium: Online Resource
    ISSN: 2076-393X
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2703319-3
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  • 7
    In: Agronomy, MDPI AG, Vol. 12, No. 8 ( 2022-08-04), p. 1844-
    Abstract: Fritillaria is a perennial herb with medicinal properties. There are 158 Fritillaria species worldwide, 33 of which have reported therapeutic efficacy. Alkaloids are the principal constituents in Fritillaria. Fritillaria species growing at 2700–4000 m are the sources of extract namely Chuan Beimu (the Pharmacopoeia of the People’s Republic of China, 2020 Edition), with low biomass, mainly containing more 5α-cevanine isosteroidal alkaloids with cis-configuration. In contrast, species growing below 1500 m are usually taller than 50 cm, and they mainly contain more trans-configuration isosteroidal alkaloids. There are two schemes of the biosynthetic pathways of steroidal alkaloids with different frameworks and catalytic reactions and combined high-throughput omics data. Based on the distributed elevations, Fritillaria species were divided into three major categories, which met classification features based on phylogenetic analysis or morphological features. Artificial or in vitro cultivations are effective strategies for balancing economical requirements and ecological protection. Fritillaria species growing at lower altitudes can be cultivated by bulb reproduction, but species growing at higher altitudes still rely mainly on gathering a large number of wild resources. Integration of asexual tissue culture and bulb reproduction with sexual artificial or imitated wild cultivation may create a very promising and effective way to maintain sustainable industrial development of Fritillaria.
    Type of Medium: Online Resource
    ISSN: 2073-4395
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2607043-1
    SSG: 23
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  • 8
    Online Resource
    Online Resource
    MDPI AG ; 2018
    In:  Metals Vol. 8, No. 6 ( 2018-06-13), p. 449-
    In: Metals, MDPI AG, Vol. 8, No. 6 ( 2018-06-13), p. 449-
    Type of Medium: Online Resource
    ISSN: 2075-4701
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2662252-X
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  • 9
    In: Sustainability, MDPI AG, Vol. 14, No. 12 ( 2022-06-09), p. 7075-
    Abstract: This research studies the data on air quality and construction activities from 29 January 2020 to 30 April 2020. The analysis focuses on three sample districts of Hangzhou’s Xiacheng, Gongshu, and Xiaoshan districts. The samples, respectively, represent low-level, mid-level, and high-level districts in the scale of construction projects. The correlative relationships are investigated, respectively, in the periods of ‘pandemic lockdown (29 January 2020–20 February 2020)’ and ‘after pandemic lockdown (21 February 2020–30 April 2020)’. The correlative equations are obtained. Based on the guideline values of air parameters provided by the Chinese criteria and standards, the recommended maximum scales of construction projects are defined. The numbers of construction sites are 16, 118, and 311 for the Xiacheng, Gongshu, and Xiaoshan districts during the imposed lockdown period, respectively, and 19, 88, 234, respectively, after the lockdown period. Because the construction site is only one influential factor on the air quality, and the database is not large enough, there are some limitations in the mathematical model and the management plan. Possible problem solving techniques and future studies are introduced at the end of the research study.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518383-7
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  • 10
    In: Sustainability, MDPI AG, Vol. 15, No. 8 ( 2023-04-17), p. 6744-
    Abstract: Developing indicators to monitor the dynamic equilibrium of sustainable ecosystem variables has been challenging for policymakers, companies, and researchers. The new method matrix decomposition analysis (MDA) is an adaptation of the Leontief input–output equations for the disaggregated structural decomposition of key performance indicators (KPI). The main problem that this work addresses is related to the behavior of MDA when compared to traditional methodologies such as data envelopment analysis (DEA) and stochastic frontier analysis (SFA). Can MDA be considered robust enough for wide applicability? To compare the models, we developed a methodology called marginal exponentiation experiments. This approach is a type of simulation that raises the inputs and outputs of an entity to a marginal power, thus making it possible to compare a large number of models with the same data. RMarkdown was used for methodological operationalization, wherein data science steps are coded in specific chunks, applying a layered process with modeling. The comparison between the models is operationalized in layers using techniques such as descriptive statistics, correlation, cluster, and linear discriminant analysis (LDA). Given the results, we argue that MDA is a Leontief partial equilibrium model that produces indicators with dual interpretation, enabling the measurement of the dynamic equilibrium of sustainable ecosystem variables. Furthermore, the method offers a new ranking system that detects relative changes in the use of resources correlated with efficiency analysis. The practical value for decision-makers relates to the fact that we found evidence that MDA can be considered robust enough to identify whether a given ecosystem is in equilibrium and that the excessive use of resources or abnormal productivity can cause instability.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2518383-7
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