GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Customized Deep Learning Classifier for Detection of Acute Lymphoblastic Leukemia Using Blood Smear Images
    MDPI AG ; 2022
    In:  Healthcare Vol. 10, No. 10 ( 2022-09-20), p. 1812-
    Details
    In: Healthcare, MDPI AG, Vol. 10, No. 10 ( 2022-09-20), p. 1812-
    Abstract: Acute lymphoblastic leukemia (ALL) is a rare type of blood cancer caused due to the overproduction of lymphocytes by the bone marrow in the human body. It is one of the common types of cancer in children, which has a fair chance of being cured. However, this may even occur in adults, and the chances of a cure are slim if diagnosed at a later stage. To aid in the early detection of this deadly disease, an intelligent method to screen the white blood cells is proposed in this study. The proposed intelligent deep learning algorithm uses the microscopic images of blood smears as the input data. This algorithm is implemented with a convolutional neural network (CNN) to predict the leukemic cells from the healthy blood cells. The custom ALLNET model was trained and tested using the microscopic images available as open-source data. The model training was carried out on Google Collaboratory using the Nvidia Tesla P-100 GPU method. Maximum accuracy of 95.54%, specificity of 95.81%, sensitivity of 95.91%, F1-score of 95.43%, and precision of 96% were obtained by this accurate classifier. The proposed technique may be used during the pre-screening to detect the leukemia cells during complete blood count (CBC) and peripheral blood tests.
    Type of Medium: Online Resource
    ISSN: 2227-9032
    URL: Article
    DOI: 10.3390/healthcare10101812
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2721009-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    The Impact of Microbiota on the Gut–Brain Axis: Examining the Complex Interplay and Implications
    MDPI AG ; 2023
    In:  Journal of Clinical Medicine Vol. 12, No. 16 ( 2023-08-11), p. 5231-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 12, No. 16 ( 2023-08-11), p. 5231-
    Abstract: The association and interaction between the central nervous system (CNS) and enteric nervous system (ENS) is well established. Essentially ENS is the second brain, as we call it. We tried to understand the structure and function, to throw light on the functional aspect of neurons, and address various disease manifestations. We summarized how various neurological disorders influence the gut via the enteric nervous system and/or bring anatomical or physiological changes in the enteric nervous system or the gut and vice versa. It is known that stress has an effect on Gastrointestinal (GI) motility and causes mucosal erosions. In our literature review, we found that stress can also affect sensory perception in the central nervous system. Interestingly, we found that mutations in the neurohormone, serotonin (5-HT), would result in dysfunctional organ development and further affect mood and behavior. We focused on the developmental aspects of neurons and cognition and their relation to nutritional absorption via the gastrointestinal tract, the development of neurodegenerative disorders in relation to the alteration in gut microbiota, and contrariwise associations between CNS disorders and ENS. This paper further summarizes the synergetic relation between gastrointestinal and neuropsychological manifestations and emphasizes the need to include behavioral therapies in management plans.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm12165231
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662592-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    A Nickel Coated Copper Substrate as a Hydrogen Evolution Catalyst
    MDPI AG ; 2022
    In:  Catalysts Vol. 12, No. 1 ( 2022-01-05), p. 58-
    Details
    In: Catalysts, MDPI AG, Vol. 12, No. 1 ( 2022-01-05), p. 58-
    Abstract: Replacing precious metals with low-cost metals is the best solution for large scale production. Copper is known for its excellent conductivity and thermal management applications. When it comes to hydrogen evolution reaction, it is highly unstable, especially in KOH solution. In this paper, we approached a simple method to reduce corrosion and improve the performance by depositing nickel-molybdenum oxide and nickel on copper substrates and the achieved tafel slopes of 115 mV/dec and 117 mV/dec at 10 mA/cm2. While at first, molybdenum oxide coated samples showed better performance after 100 cycles of stability tests, the onset potential rapidly changed. Cu-Ni, which was deposited using the electron gun evaporation (e-gun), has shown better performance with 0.28 V at 10 mA/cm2 and led to stability after 100 cycles. Our results show that when copper is alloyed with nickel, it acts as a promising hydrogen evolution reaction (HER) catalyst.
    Type of Medium: Online Resource
    ISSN: 2073-4344
    URL: Article
    DOI: 10.3390/catal12010058
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662126-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Effect of Heating Modes on Reactive Sintering of Ca3Co4O9 Ceramics
    MDPI AG ; 2021
    In:  Materials Vol. 14, No. 2 ( 2021-01-07), p. 273-
    Details
    In: Materials, MDPI AG, Vol. 14, No. 2 ( 2021-01-07), p. 273-
    Abstract: The traditional solid-state reaction method was employed to synthesize bulk calcium cobaltite (Ca349/Ca3Co4O9) ceramics via ball milling the precursor mixture. The samples were compacted using conventional sintering (CS) and spark plasma sintering (SPS) at 850, 900, and 950 °C. The X-ray diffraction (XRD) pattern indicates the presence of the Ca349 phase for samples sintered at 850 and 900 °C. In addition, SPS fosters higher densification (81.18%) than conventional sintering (50.76%) at elevated sintering temperatures. The thermo-gravimetric analysis (TGA) and differential thermal analysis (DTA) performed on the precursor mixture reported a weight loss of ~25.23% at a temperature range of 600–820 °C. This current work aims to analyze the electrical properties (Seebeck coefficient (s), electrical resistivity (ρ), and power factor) of sintered samples as a function of temperature (35–500 °C). It demonstrates that the change in sintering temperature (conventional sintering) did not evince any significant change in the Seebeck coefficient (113–142 μV/K). However, it reported a low resistivity of 153–132 μΩ-m and a better power factor (82–146.4 μW/mK2) at 900 °C. On the contrary, the SPS sintered samples recorded a higher Seebeck coefficient of 121–181 μV/K at 900 °C. Correspondingly, the samples sintered at 950 °C delineated a low resistivity of 145–158 μΩ-m and a better power factor (97–152 μW/mK2).
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma14020273
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2487261-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Prospective of Pancreatic Cancer Diagnosis Using Cardiac Sensing
    MDPI AG ; 2023
    In:  Journal of Imaging Vol. 9, No. 8 ( 2023-07-25), p. 149-
    Details
    In: Journal of Imaging, MDPI AG, Vol. 9, No. 8 ( 2023-07-25), p. 149-
    Abstract: Pancreatic carcinoma (Ca Pancreas) is the third leading cause of cancer-related deaths in the world. The malignancies of the pancreas can be diagnosed with the help of various imaging modalities. An endoscopic ultrasound with a tissue biopsy is so far considered to be the gold standard in terms of the detection of Ca Pancreas, especially for lesions 〈 2 mm. However, other methods, like computed tomography (CT), ultrasound, and magnetic resonance imaging (MRI), are also conventionally used. Moreover, newer techniques, like proteomics, radiomics, metabolomics, and artificial intelligence (AI), are slowly being introduced for diagnosing pancreatic cancer. Regardless, it is still a challenge to diagnose pancreatic carcinoma non-invasively at an early stage due to its delayed presentation. Similarly, this also makes it difficult to demonstrate an association between Ca Pancreas and other vital organs of the body, such as the heart. A number of studies have proven a correlation between the heart and pancreatic cancer. The tumor of the pancreas affects the heart at the physiological, as well as the molecular, level. An overexpression of the SMAD4 gene; a disruption in biomolecules, such as IGF, MAPK, and ApoE; and increased CA19-9 markers are a few of the many factors that are noted to affect cardiovascular systems with pancreatic malignancies. A comprehensive review of this correlation will aid researchers in conducting studies to help establish a definite relation between the two organs and discover ways to use it for the early detection of Ca Pancreas.
    Type of Medium: Online Resource
    ISSN: 2313-433X
    URL: Article
    DOI: 10.3390/jimaging9080149
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2824270-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    A Review on Green Synthesis of Nanoparticles and Their Diverse Biomedical and Environmental Applications
    MDPI AG ; 2022
    In:  Catalysts Vol. 12, No. 5 ( 2022-04-20), p. 459-
    Details
    In: Catalysts, MDPI AG, Vol. 12, No. 5 ( 2022-04-20), p. 459-
    Abstract: In recent times, metal oxide nanoparticles (NPs) have been regarded as having important commercial utility. However, the potential toxicity of these nanomaterials has also been a crucial research concern. In this regard, an important solution for ensuring lower toxicity levels and thereby facilitating an unhindered application in human consumer products is the green synthesis of these particles. Although a naïve approach, the biological synthesis of metal oxide NPs using microorganisms and plant extracts opens up immense prospects for the production of biocompatible and cost-effective particles with potential applications in the healthcare sector. An important area that calls for attention is cancer therapy and the intervention of nanotechnology to improve existing therapeutic practices. Metal oxide NPs have been identified as therapeutic agents with an extended half-life and therapeutic index and have also been reported to have lesser immunogenic properties. Currently, biosynthesized metal oxide NPs are the subject of considerable research and analysis for the early detection and treatment of tumors, but their performance in clinical experiments is yet to be determined. The present review provides a comprehensive account of recent research on the biosynthesis of metal oxide NPs, including mechanistic insights into biological production machinery, the latest reports on biogenesis, the properties of biosynthesized NPs, and directions for further improvement. In particular, scientific reports on the properties and applications of nanoparticles of the oxides of titanium, cerium, selenium, zinc, iron, and copper have been highlighted. This review discusses the significance of the green synthesis of metal oxide nanoparticles, with respect to therapeutically based pharmaceutical applications as well as energy and environmental applications, using various novel approaches including one-minute sonochemical synthesis that are capable of responding to various stimuli such as radiation, heat, and pH. This study will provide new insight into novel methods that are cost-effective and pollution free, assisted by the biodegradation of biomass.
    Type of Medium: Online Resource
    ISSN: 2073-4344
    URL: Article
    DOI: 10.3390/catal12050459
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662126-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Detecting Water Hyacinth Infestation in Kuttanad, India, Using Dual-Pol Sentinel-1 SAR Imagery
    MDPI AG ; 2022
    In:  Remote Sensing Vol. 14, No. 12 ( 2022-06-14), p. 2845-
    Details
    In: Remote Sensing, MDPI AG, Vol. 14, No. 12 ( 2022-06-14), p. 2845-
    Abstract: Water hyacinth (Pontederia crassipes, also known as Eichhornia crassipes) is a highly invasive aquatic macrophyte species, indigenous to Amazonia, Brazil and tropical South America. It was introduced to India in 1896 and has now become an environmental and social challenge throughout the country in community ponds, freshwater lakes, irrigation channels, rivers and most other surface waterbodies. Considering its large speed of propagation on the water surface under conducive conditions and the adverse impact the infesting weed has, constant monitoring is needed to aid civic bodies, governments and policy makers involved in remedial measures. The synoptic coverage provided by satellite imaging and other remote sensing practices make it convenient to find a solution using this type of data. While there is an established background for the practice of remote sensing in the detection of aquatic plants, the use of Synthetic Aperture Radar (SAR) has yet to be fully exploited in the detection of water hyacinth. This research focusses on detecting water hyacinth within Vembanad Lake, Kuttanad, India. Here, results show that the monitoring of water hyacinth has proven to be possible using Sentinel-1 SAR data. A quantitative analysis of detection performance is presented using traditional and state-of-the-art change detectors. Analysis of these more powerful detectors showed true positive detection ratings of ~95% with 0.1% false alarm, showing significantly greater positive detection ratings when compared to the more traditional detectors. We are therefore confident that water hyacinth can be monitored using SAR data provided the extent of the infestation is significantly larger than the resolution cell (bigger than a quarter of a hectare).
    Type of Medium: Online Resource
    ISSN: 2072-4292
    URL: Article
    DOI: 10.3390/rs14122845
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2513863-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Elevated Dkk1 Mediates Downregulation of the Canonical Wnt Pathway and Lysosomal Loss in an iPSC Model of Neuronopathic Gaucher Disease
    MDPI AG ; 2020
    In:  Biomolecules Vol. 10, No. 12 ( 2020-12-03), p. 1630-
    Details
    In: Biomolecules, MDPI AG, Vol. 10, No. 12 ( 2020-12-03), p. 1630-
    Abstract: Gaucher Disease (GD), which is the most common lysosomal storage disorder, is caused by bi-allelic mutations in GBA1—a gene that encodes the lysosomal hydrolase β-glucocerebrosidase (GCase). The neuronopathic forms of GD (nGD) are characterized by severe neurological abnormalities that arise during gestation or early in infancy. Using GD-induced pluripotent stem cell (iPSC)-derived neuronal progenitor cells (NPCs), we have previously reported that neuronal cells have neurodevelopmental defects associated with the downregulation of canonical Wnt signaling. In this study, we report that GD NPCs display elevated levels of Dkk1, which is a secreted Wnt antagonist that prevents receptor activation. Dkk1 upregulation in mutant NPCs resulted in an increased degradation of β-catenin, and there was a concomitant reduction in lysosomal numbers. Consistent with these results, incubation of the mutant NPCs with recombinant Wnt3a (rWnt3a) was able to outcompete the excess Dkk1, increasing β-catenin levels and rescuing lysosomal numbers. Furthermore, the incubation of WT NPCs with recombinant Dkk1 (rDkk1) phenocopied the mutant phenotype, recapitulating the decrease in β-catenin levels and lysosomal depletion seen in nGD NPCs. This study provides evidence that downregulation of the Wnt/β-catenin pathway in nGD neuronal cells involves the upregulation of Dkk1. As Dkk1 is an extracellular Wnt antagonist, our results suggest that the deleterious effects of Wnt/β-catenin downregulation in nGD may be ameliorated by the prevention of Dkk1 binding to the Wnt co-receptor LRP6, pointing to Dkk1 as a potential therapeutic target for GBA1-associated neurodegeneration.
    Type of Medium: Online Resource
    ISSN: 2218-273X
    URL: Article
    DOI: 10.3390/biom10121630
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2701262-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Definition and Measurement of Physical and Chemical Restraint in Long-Term Care: A Systematic Review
    MDPI AG ; 2021
    In:  International Journal of Environmental Research and Public Health Vol. 18, No. 7 ( 2021-03-31), p. 3639-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 18, No. 7 ( 2021-03-31), p. 3639-
    Abstract: This systematic review aimed to identify thematic elements within definitions of physical and chemical restraint, compare explicit and implicit definitions, and synthesize reliability and validity of studies examining physical and/or chemical restraint use in long-term care. Studies were included that measured prevalence of physical and/or chemical restraint use, or evaluated an intervention to reduce restraint use in long-term care. 86 papers were included in this review, all discussed physical restraint use and 20 also discussed chemical restraint use. Seven themes were generated from definitions including: restraint method, setting resident is restrained in, stated intent, resident capacity to remove/control, caveats and exclusions, duration, frequency or number, and consent and resistance. None of the studies reported validity of measurement approaches. Inter-rater reliability was reported in 27 studies examining physical restraint use, and only one study of chemical restraint. Results were compared to an existing consensus definition of physical restraint, which was found to encompass many of the thematic domains found within explicit definitions. However, studies rarely applied measurement approaches that reflected all of the identified themes of definitions. It is necessary for a consensus definition of chemical restraint to be established and for measurement approaches to reflect the elements of definitions.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph18073639
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2175195-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Plasma Metabolic Signature and Abnormalities in HIV-Infected Individuals on Long-Term Successful Antiretroviral Therapy
    MDPI AG ; 2019
    In:  Metabolites Vol. 9, No. 10 ( 2019-09-30), p. 210-
    Details
    In: Metabolites, MDPI AG, Vol. 9, No. 10 ( 2019-09-30), p. 210-
    Abstract: Targeted metabolomics studies reported metabolic abnormalities in both treated and untreated people living with human immunodeficiency virus (HIV) (PLHIV). The present study aimed to understand the plasma metabolomic changes and predicted the risk of accelerated aging in PLHIV on long-term suppressive antiretroviral therapy (ART) in a case-control study setting and its association with the plasma proteomics biomarkers of inflammation and neurological defects. Plasma samples were obtained from PLHIV on successful long-term ART for more than five years (n = 22) and matched HIV-negative healthy individuals (n = 22, HC herein). Untargeted metabolite profiling was carried out using ultra-high-performance liquid chromatography/mass spectrometry/mass spectrometry (UHPLC/MS/MS). Plasma proteomics profiling was performed using proximity extension assay targeting 184 plasma proteins. A total of 250 metabolites differed significantly (p 〈 0.05, q 〈 0.1) between PLHIV and HC. Plasma levels of several essential amino acids except for histidine, branched-chain amino acids, and aromatic amino acids (phenylalanine, tyrosine, tryptophan) were significantly lower in PLHIV compared to HC. Machine-learning prediction of metabolite changes indicated a higher risk of inflammatory and neurological diseases in PLHIV. Metabolic abnormalities were observed in amino-acid levels, energetics, and phospholipids and complex lipids, which may reflect known differences in lipoprotein levels in PLHIV that can resemble metabolic syndrome (MetS).
    Type of Medium: Online Resource
    ISSN: 2218-1989
    URL: Article
    DOI: 10.3390/metabo9100210
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2662251-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...