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  • 1
    Online Resource
    Online Resource
    New Role for Growth/Differentiation Factor 15 in the Survival of Transplanted Brown Adipose Tissues in Cooperation with Interleukin-6
    MDPI AG ; 2020
    In:  Cells Vol. 9, No. 6 ( 2020-06-01), p. 1365-
    Details
    In: Cells, MDPI AG, Vol. 9, No. 6 ( 2020-06-01), p. 1365-
    Abstract: To identify factors involved in the earliest phase of the differentiation of human embryonic stem cells (hESCs) into brown adipocytes (BAs), we performed multi-time point microarray analyses. We found that growth/differentiation factor 15 (GDF15) expressions were specifically upregulated within three days of differentiation, when expressions of immature hESC markers were sustained. Although GDF15 expressions continued to increase in the subsequent differentiation phases, GDF15-deficient hESCs differentiated into mature BAs (Day 10) without apparent abnormalities. In addition, GDF15-deficient mice had normal brown adipose tissue (BAT) and were metabolically healthy. Unexpectedly, we found that interleukin-6 (IL6) expression was significantly lowered in the BAT of GDF15-/- mice. In addition, GDF15-/- hESCs showed abortive IL6 expressions in the later phase ( 〉 Day 6) of the differentiation. Interestingly, GDF15 expression was markedly repressed throughout the whole course of the differentiation of IL6-/- hESCs into BAs, indicating IL6 is essential for the induction of GDF15 in the differentiation of hESCs. Finally, intraperitoneally transplanted BAT grafts of GDF15-/- donor mice, but not those of wild-type (WT) mice, failed in the long-term survival (12 weeks) in GDF15-/- recipient mice. Collectively, GDF15 is required for long-term survival of BAT grafts by creating a mutual gene induction loop with IL6.
    Type of Medium: Online Resource
    ISSN: 2073-4409
    URL: Article
    DOI: 10.3390/cells9061365
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2661518-6
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  • 2
    Online Resource
    Online Resource
    Evaluation of Machine Learning Interatomic Potentials for the Properties of Gold Nanoparticles
    MDPI AG ; 2022
    In:  Nanomaterials Vol. 12, No. 21 ( 2022-11-03), p. 3891-
    Details
    In: Nanomaterials, MDPI AG, Vol. 12, No. 21 ( 2022-11-03), p. 3891-
    Abstract: We have investigated Machine Learning Interatomic Potentials in application to the properties of gold nanoparticles through the DeePMD package, using data generated with the ab-initio VASP program. Benchmarking was carried out on Au20 nanoclusters against ab-initio molecular dynamics simulations and show we can achieve similar accuracy with the machine learned potential at far reduced cost using LAMMPS. We have been able to reproduce structures and heat capacities of several isomeric forms. Comparison of our workflow with similar ML-IP studies is discussed and has identified areas for future improvement.
    Type of Medium: Online Resource
    ISSN: 2079-4991
    URL: Article
    DOI: 10.3390/nano12213891
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662255-5
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  • 3
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    Online Resource
    13-(2-Methylbenzyl) Berberine Is a More Potent Inhibitor of MexXY-Dependent Aminoglycoside Resistance than Berberine
    MDPI AG ; 2019
    In:  Antibiotics Vol. 8, No. 4 ( 2019-11-06), p. 212-
    Details
    In: Antibiotics, MDPI AG, Vol. 8, No. 4 ( 2019-11-06), p. 212-
    Abstract: We previously showed that berberine attenuates MexXY efflux-dependent aminoglycoside resistance in Pseudomonas aeruginosa. Here, we aimed to synthesize berberine derivatives with higher MexXY inhibitory activities. We synthesized 11 berberine derivatives, of which 13-(2-methylbenzyl) berberine (13-o-MBB) but not its regiomers showed the most promising MexXY inhibitory activity. 13-o-MBB reduced the minimum inhibitory concentrations (MICs) of various aminoglycosides 4- to 128 fold for a highly multidrug resistant P. aeruginosa strain. Moreover, 13-o-MBB significantly reduced the MICs of gentamicin and amikacin in Achromobacter xylosoxidans and Burkholderia cepacia. The fractional inhibitory concentration indices indicated that 13-o-MBB acted synergistically with aminoglycosides in only MexXY-positive P. aeruginosa strains. Time-kill curves showed that 13-o-MBB or higher concentrations of berberine increased the bactericidal activity of gentamicin by inhibiting MexXY in P. aeruginosa. Our findings indicate that 13-o-MBB inhibits MexXY-dependent aminoglycoside drug resistance more strongly than berberine and that 13-o-MBB is a useful inhibitor of aminoglycoside drug resistance due to MexXY.
    Type of Medium: Online Resource
    ISSN: 2079-6382
    URL: Article
    DOI: 10.3390/antibiotics8040212
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2681345-2
    SSG: 15,3
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  • 4
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    Online Resource
    Investigation of Optimal Light Source Wavelength for Cuffless Blood Pressure Estimation Using a Single Photoplethysmography Sensor
    MDPI AG ; 2023
    In:  Sensors Vol. 23, No. 7 ( 2023-04-02), p. 3689-
    Details
    In: Sensors, MDPI AG, Vol. 23, No. 7 ( 2023-04-02), p. 3689-
    Abstract: Routine blood pressure measurement is important for the early detection of various diseases. Recently, cuffless blood pressure estimation methods that do not require cuff pressurization have attracted attention. In this study, we investigated the effect of the light source wavelength on the accuracy of blood pressure estimation using only two physiological indices that can be calculated with photoplethysmography alone, namely, heart rate and modified normalized pulse volume. Using a newly developed photoplethysmography sensor that can simultaneously measure photoplethysmograms at four wavelengths, we evaluated its estimation accuracy for systolic blood pressure, diastolic blood pressure, and mean arterial pressure against a standard cuff sphygmomanometer. Mental stress tasks were used to alter the blood pressure of 14 participants, and multiple linear regression analysis showed the best light sources to be near-infrared for systolic blood pressure and blue for both diastolic blood pressure and mean arterial pressure. The importance of the light source wavelength for the photoplethysmogram in cuffless blood pressure estimation was clarified.
    Type of Medium: Online Resource
    ISSN: 1424-8220
    URL: Article
    DOI: 10.3390/s23073689
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2052857-7
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  • 5
    Online Resource
    Online Resource
    House Dust Avoidance during Pregnancy and Subsequent Infant Development: The Japan Environment and Children’s Study
    MDPI AG ; 2021
    In:  International Journal of Environmental Research and Public Health Vol. 18, No. 8 ( 2021-04-17), p. 4277-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 18, No. 8 ( 2021-04-17), p. 4277-
    Abstract: House dust, well known for causing allergy, contains chemicals that are harmful to fetal neurodevelopment. However, whether countermeasures for house dust allergy, such as frequent use of vacuum cleaners, frequent airing of futons, and the usage of anti-mite covers during pregnancy, are related to subsequent reduced risk of infant developmental delay remains unknown. Therefore, we examined this association by analyzing 81,106 mother-infant pairs who participated in a nationwide birth cohort in Japan. Infant developmental delays at 6 and 12 months postpartum were assessed using the Ages and Stages Questionnaire, Third Edition. A generalized linear model analysis was used to derive adjusted odds ratios (AORs) with the lowest care frequency as reference, while controlling 22 covariates. Our analysis showed that the above-mentioned cleaning measures were overall associated with a reduced risk of developmental delays, both at 6 and 12 months postpartum (AOR varied from 0.73 to 0.95, median: 0.84). Additionally, risks tended to decrease with an increase in the cleaning frequency. In conclusion, a negative dose-response association existed between these measures during pregnancy and infant developmental delay. Our results identify a potential role of frequent vacuum cleaning, airing bedding, and usage of anti-mite bedding covers in promoting intact infant development.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph18084277
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2175195-X
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  • 6
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    Online Resource
    Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS)
    MDPI AG ; 2020
    In:  Journal of Clinical Medicine Vol. 9, No. 6 ( 2020-06-19), p. 1924-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 9, No. 6 ( 2020-06-19), p. 1924-
    Abstract: Fetal exposure to particulate matter (PM) is associated with infant developmental delay likely via neuroinflammation and prefrontal cortex lesions; however, whether air-purifier usage, which can reduce indoor PM levels, is related to infant developmental delay remains unknown. We therefore examined the prospective relationship between air-purifier usage during pregnancy and infant developmental delay by analyzing 82,441 mother–infant pairs using a simple yes/no questionnaire. Developmental delays at 6 and 12 months were assessed in five areas using the Ages and Stages Questionnaire, Third Edition. A generalized linear mixed model analysis was used to derive adjusted odds ratios (AORs) and 95% confidence intervals (95% CIs) while controlling for 20 covariates. The analysis revealed that air-purifier usage was associated with developmental delays in fine motor (AOR: 0.91, 95% CI: 0.83–0.99) and problem solving (AOR: 0.83, 95% CI: 0.77–0.90) at 6 months and in communication (AOR: 0.86, 95% CI: 0.79–0.93), fine motor (AOR: 0.87, 95% CI: 0.82–0.92), problem solving (AOR: 0.83, 95% CI: 0.77–0.88), and personal–social (AOR: 0.79, 95% CI: 0.72–0.86) at 12 months. In conclusion, a negative association exists between air-purifier usage during pregnancy and infant neurodevelopmental delay that strengthens with time. Our results outline the potential role of air purifiers in inhibiting infant neurodevelopmental delay.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm9061924
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2662592-1
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