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  • 1
    In: Agronomy, MDPI AG, Vol. 10, No. 7 ( 2020-07-21), p. 1055-
    Abstract: Arid and semi-arid regions are characterized by high temperature and low rainfall, leading to degraded agricultural soils of alkaline calcareous nature with low organic matter contents. Less availability of indigenous nutrients and efficacy of applied fertilizers are the major issues of crop production in these soils. Biochar application, in combination with plant growth promoting rhizobacteria with the ability to solubilize nutrients, can be an effective strategy for improving soil health and nutrient availability to crops under these conditions. Experiments were planned to evaluate the impact of biochar obtained from different sources in combination with acid-producing, nutrient-solubilizing Bacillus sp. ZM20 on soil biological properties and growth of maize (Zea mays L.) crops under natural conditions. Various biochar treatments, viz. wheat (Triticum aestivum L.) straw biochar, Egyptian acacia (Vachellia nilotica L.) biochar, and farm-yard manure biochar with and without Bacillus sp. ZM20, were used along with control. Soil used for pot and field trials was sandy loam in texture with poor water holding capacity and deficient in nutrients. Results of the pot trial showed that fresh and dry biomass, 1000 grain weight, and grain yield was significantly improved by application of biochar of different sources with and without Bacillus sp. ZM20. Application of biochar along with Bacillus sp. ZM20 also improved soil biological properties, i.e., soil organic matter, microbial biomass carbon, ammonium, and nitrate nitrogen. It was also observed that a combined application of biochar with Bacillus sp. ZM20 was more effective than a separate application of biochar. The results of wheat straw biochar along with Bacillus sp. ZM20 were better as compared to farm-yard manure biochar and Egyptian acacia biochar. Maximum increase (25.77%) in grain yield was observed in the treatment where wheat straw biochar (0.2%) was applied in combination with Bacillus sp. ZM20. In conclusion, combined application of wheat straw biochar (0.2%) inoculated with Bacillus sp. ZM20 was the most effective treatment in improving the biological soil properties, plant growth, yield, and quality of maize crop as compared to all other treatments.
    Type of Medium: Online Resource
    ISSN: 2073-4395
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2607043-1
    SSG: 23
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  • 2
    In: Healthcare, MDPI AG, Vol. 10, No. 9 ( 2022-09-10), p. 1738-
    Abstract: The present study was undertaken to assess the current supply chain system of pharmaceuticals and vaccines in Pakistan in terms of structure, process, and outcomes, as well as related barriers and solutions for an effective supply chain system. A qualitative study was designed to explore stakeholders’ perceptions selected using the snowball sampling technique. A semi-structured interview guide was used to interview these respondents at a convenient time and place. After data collection, recorded interviews were transcribed verbatim and subjected to thematic analysis. The results highlighted that the standard operating procedures (SOPs), checklists, and government guidelines were available at different levels, except for community pharmacies. Timely delivery of quality products and services along with market reputation, experience, and authorization were the key criteria used for supplier selection and evaluation. Good inventory management, financial models, effective coordination, training, and skill development programs were identified as key factors responsible for an efficient supply chain process. Availability of vaccines, their appropriate temperature monitoring, and transportation are also highly compromised in Pakistan. The results of the present study concluded that the current supply chain system in Pakistan is not up to the mark; major factors include poor forecasting and inventory control, delayed order placement, lack of training, inadequate involvement of professionally qualified staff, inadequate financing and procurement processes, and poor coordination and integration among all stakeholders.
    Type of Medium: Online Resource
    ISSN: 2227-9032
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2721009-1
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  • 3
    In: Children, MDPI AG, Vol. 8, No. 11 ( 2021-11-04), p. 1007-
    Abstract: Immunization is one of the most cost-effective public health interventions, with considerable impacts on people’s health. Parents’ perception of their knowledge, attitude, and satisfaction is an important factor, as they may be targeted by interventions for better immunization coverage. Therefore, this study aimed to assess parents’ perceptions in terms of their knowledge, attitude, and satisfaction of the immunization of their children aged less than two years of age, in two cities of Pakistan. A descriptive cross-sectional study was conducted in the vicinity of Rawalpindi and Islamabad from March to August 2019. A semi-structured questionnaire was used for the data collection on a convenient sample of parents. The questionnaire was hand-delivered to the parents by data collectors. Descriptive and inferential statistics were used for data analysis via SPSS version 22. A total of n = 382 respondents were included in the data analysis. Statistically significant differences were found between the parents’ knowledge scores and their education levels and monthly incomes (p 〈 0.05). Parents with master’s education degrees and low monthly incomes had significantly better knowledge (p 〈 0.05). Additionally, 96.85% of the respondents believed that child immunization was important. In addition, more than half of the respondents (57.58%) thought that the affordability of vaccines was a principal factor for delays in immunization. Although the parents’ knowledge regarding the immunization of their children was not adequate, they had positive perceptions toward it.
    Type of Medium: Online Resource
    ISSN: 2227-9067
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2732685-8
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  • 4
    In: Metals, MDPI AG, Vol. 10, No. 11 ( 2020-11-09), p. 1492-
    Abstract: The aim of this study is to investigate the structure–property relationship of the zirconium tungstate-reinforced casted A356 aluminum alloy. The reinforcement ceramic used was zirconium tungstate of the negative thermal coefficient type, which assists in the weldment of crack growth and enhances the fatigue life. The specimens used in this study were casted by stir casting method and prepared according to Compact Tension standard E-399, and microstructural, fatigue behavior, and mechanical properties were investigated systematically. Microstructural analysis showed reduction in porosity by the addition of ZrW2O8 particles. Fatigue results depict the increase in the fatigue life of aluminum reinforced ceramic as compared to the casted base aluminum alloy. Brinell hardness of ZrW2O8 reinforced alloy samples increased 7% as compared to the base aluminum alloy hardness value. Tensile strength also significantly improved from 176 MPa for the base A356 alloy to 198 MPa for the ZrW2O8 reinforced composite. Furthermore, addition of ZrW2O8 ceramic powder increased the fatigue life more than 50% of the base alloy. These results suggest that the ZrW2O8 reinforced A356 composites may be potential candidates for aerospace industry, military, transportation and in structural sites.
    Type of Medium: Online Resource
    ISSN: 2075-4701
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2662252-X
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  • 5
    In: Crystals, MDPI AG, Vol. 10, No. 11 ( 2020-11-16), p. 1043-
    Abstract: In this research, a facile and cost-effective method of graphene synthesis by the modified carburization process and its applications for supercapacitor electrodes is reported. In this simple approach, carbon was diffused into nickel foam and naturally cooled to obtain carbon precipitation for the in situ growth of graphene by decarburization. Phase-structure and surface-morphology analysis revealed the presence of a highly reduced structure of the graphene layer. Furthermore, the large-intensity D, substantial G, and 2D bands in Raman spectra were attributed to disordered multilayer graphene. The three-electrode systems were used to measure electrochemical efficiency. The electrode sample exhibited enhanced current density of 0.6 A/g, electrode energy of 1.0008 Wh/kg, and power density of 180 W/kg, showing significant electrochemical performance for supercapacitor electrode applications.
    Type of Medium: Online Resource
    ISSN: 2073-4352
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2661516-2
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  • 6
    In: Biomedicines, MDPI AG, Vol. 10, No. 12 ( 2022-12-08), p. 3186-
    Abstract: Axons in the peripheral nervous system have the ability to repair themselves after damage, whereas axons in the central nervous system are unable to do so. A common and important characteristic of damage to the spinal cord, brain, and peripheral nerves is the disruption of axonal regrowth. Interestingly, intrinsic growth factors play a significant role in the axonal regeneration of injured nerves. Various factors such as proteomic profile, microtubule stability, ribosomal location, and signalling pathways mark a line between the central and peripheral axons’ capacity for self-renewal. Unfortunately, glial scar development, myelin-associated inhibitor molecules, lack of neurotrophic factors, and inflammatory reactions are among the factors that restrict axonal regeneration. Molecular pathways such as cAMP, MAPK, JAK/STAT, ATF3/CREB, BMP/SMAD, AKT/mTORC1/p70S6K, PI3K/AKT, GSK-3β/CLASP, BDNF/Trk, Ras/ERK, integrin/FAK, RhoA/ROCK/LIMK, and POSTN/integrin are activated after nerve injury and are considered significant players in axonal regeneration. In addition to the aforementioned pathways, growth factors, microRNAs, and astrocytes are also commendable participants in regeneration. In this review, we discuss the detailed mechanism of each pathway along with key players that can be potentially valuable targets to help achieve quick axonal healing. We also identify the prospective targets that could help close knowledge gaps in the molecular pathways underlying regeneration and shed light on the creation of more powerful strategies to encourage axonal regeneration after nervous system injury.
    Type of Medium: Online Resource
    ISSN: 2227-9059
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2720867-9
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