GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • MDPI AG  (118)
  • 1
    Online Resource
    Online Resource
    A Modeling Design Method for Complex Products Based on LSTM Neural Network and Kansei Engineering
    MDPI AG ; 2023
    In:  Applied Sciences Vol. 13, No. 2 ( 2023-01-04), p. 710-
    Details
    In: Applied Sciences, MDPI AG, Vol. 13, No. 2 ( 2023-01-04), p. 710-
    Abstract: Complex products (CPs) modeling design has a long development cycle and high cost, and it is difficult to accurately meet the needs of enterprises and users. At present, the Kansei Engineering (KE) method based on back-propagated (BP) neural networks is applied to solve the modeling design problem that meets users’ affective preferences for simple products quickly and effectively. However, the modeling feature data of CPs have a wide range of dimensions, long parameter codes, and the characteristics of time series. As a result, it is difficult for BP neural networks to recognize the affective preferences of CPs from an overall visual perception level as humans do. To address the problems above and assist designers with efficient and high-quality design, a CP modeling design method based on Long Short-Term Memory (LSTM) neural network and KE (CP-KEDL) was proposed. Firstly, the improved MA method was carried out to transform the product modeling features into feature codes with sequence characteristics. Secondly, the mapping model between perceptual images and modeling features was established based on the LSTM neural network to predict the evaluation value of the product’s perceptual images. Finally, the optimal feature sets were calculated by a Genetic Algorithm (GA). The experimental results show that the MSE of the LSTM model is only 0.02, whereas the MSE of the traditional Deep Neural Networks (DNN) and Convolutional Neural Networks (CNN) neural network models are 0.30 and 0.23, respectively. The results verified that the proposed method can effectively grapple with the CP modeling design problem with the timing factor, improve design satisfaction and shorten the R & D cycle of CP industrial design.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app13020710
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2704225-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    24-Epibrassinolide and 2,6-Dichlorobenzonitrile Promoted Celery Petioles and Hypocotyl Elongation by Altering Cellulose Accumulation and Cell Length
    MDPI AG ; 2022
    In:  Agronomy Vol. 12, No. 7 ( 2022-07-13), p. 1670-
    Details
    In: Agronomy, MDPI AG, Vol. 12, No. 7 ( 2022-07-13), p. 1670-
    Abstract: BRs (brassinosteroids), an endogenous hormone in plants, regulate cellulose accumulation, cell elongation and plant growth. Propiconazole (PCZ) is an effective inhibitor of BR biosynthesis. DCB (2,6-Dichlorobenzonitrile) can inhibit the synthesis of cellulose and affects the chemical composition of cell walls. Celery is one important leafy vegetable of the Apiaceae family with rich dietary fiber (including cellulose). The petioles length, leaf blades number and cellulose content determine the yield and quality of celery. The family members of AgCESAs are related to cellulose biosynthesis in higher plants. To investigate the effects of BRs, PCZ and DCB on the growth of celery, celery cv. ‘Jinnan Shiqin’ plants were treated with 24-epibrassinolide (24-EBL, most active form of BRs), PCZ and DCB, respectively. The results showed that exogenous application of BRs up-regulated the expression of AgCESAs genes and accumulated more cellulose in celery. The length of petioles and number of leaf blades in celery plants applied with exogenous BRs (1.24 × 10−6 mol/L 24-EBL) were increased 2.16 and 1.37 times of that in the control. The addition of PCZ inhibited the effects of exogenous BRs application. The lengths of hypocotyl and hypocotyl cells of celery plants treated with BRs were longer than that of the control. Under DCB treatments, the expression levels of AgCESAs genes in celery petioles and leaf blades were down-regulated compared with the control, and the celery plants showed decreased cellulose content, shorter petiole length and fewer leaf blades. The length of hypocotyl and hypocotyl cells of celery treated with DCB were shorter than that of the control. This study provided a reference for the functions of BRs and DCB on the growth and development of celery.
    Type of Medium: Online Resource
    ISSN: 2073-4395
    URL: Article
    DOI: 10.3390/agronomy12071670
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2607043-1
    SSG: 23
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Indole Diterpenes from Mangrove Sediment-Derived Fungus Penicillium sp. UJNMF0740 Protect PC12 Cells against 6-OHDA-Induced Neurotoxicity via Regulating the PI3K/Akt Pathway
    MDPI AG ; 2023
    In:  Marine Drugs Vol. 21, No. 11 ( 2023-11-14), p. 593-
    Details
    In: Marine Drugs, MDPI AG, Vol. 21, No. 11 ( 2023-11-14), p. 593-
    Abstract: In our chemical investigation into Penicillium sp. UJNMF0740 derived from mangrove sediment, fourteen indole diterpene analogs, including four new ones, are purified by multiple chromatographic separation methods, with their structures being elucidated by the analyses of NMR, HR-ESIMS, and ECD data. The antibacterial and neuroprotective effects of these isolates were examined, and only compounds 6 and 9 exhibited weak antibacterial activity, while compounds 5, 8, and 10 showed protective effects against the injury of PC12 cells induced by 6-hydroxydopamine (6-OHDA). Additionally, compound 5 could suppress the apoptosis and production of reactive oxygen species (ROS) in 6-OHDA-stimulated PC12 cells as well as trigger the phosphorylation of PI3K and Akt. Taken together, our work enriches the structural diversity of indole diterpenes and hints that compounds of this skeleton can repress the 6-OHDA-induced apoptosis of PC12 cells via regulating the PI3K/Akt signaling pathway, which provides evidence for the future utilization of this fascinating class of molecules as potential neuroprotective agents.
    Type of Medium: Online Resource
    ISSN: 1660-3397
    URL: Article
    DOI: 10.3390/md21110593
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2175190-0
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    The Effect of Gut Bacteria on the Physiology of Red Palm Weevil, Rhynchophorus ferrugineus Olivier and Their Potential for the Control of This Pest
    MDPI AG ; 2021
    In:  Insects Vol. 12, No. 7 ( 2021-06-30), p. 594-
    Details
    In: Insects, MDPI AG, Vol. 12, No. 7 ( 2021-06-30), p. 594-
    Abstract: Red Palm Weevil (RPW), Rhynchophorus ferrugineus Olivier, is a notorious pest, which infests palm trees and has caused great economic losses worldwide. At present, insecticide applications are still the main way to control this pest. However, pesticide resistance has been detected in the field populations of RPW. Thus, future management strategies based on the novel association biological control need be developed. Recent studies have shown that the intestinal tract of RPW is often colonized by multiple microbial species as mammals and model insects, and gut bacteria have been found to promote the growth, development and immune activity of RPW larvae by modulating nutrient metabolism. Furthermore, two peptidoglycan recognition proteins (PGRPs), PGRP-LB and PGRP-S1, can act as the negative regulators to modulate the intestinal immunity to maintain the homeostasis of gut bacteria in RPW larvae. Here, we summarized the current knowledge on the gut bacterial composition of RPW and their impact on the physiological traits of RPW larvae. In contrast with metazoans, it is much easier to make genetic engineered microbes to produce some active molecules against pests. From this perspective, because of the profound effects of gut bacteria on host phenotypes, it is promising to dissect the molecular mechanisms behind their effect on host physiology and facilitate the development of microbial resource-based management methods for pest control.
    Type of Medium: Online Resource
    ISSN: 2075-4450
    URL: Article
    DOI: 10.3390/insects12070594
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2662247-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Public Willingness and Determinants of COVID-19 Vaccination at the Initial Stage of Mass Vaccination in China
    MDPI AG ; 2021
    In:  Vaccines Vol. 9, No. 10 ( 2021-10-13), p. 1172-
    Details
    In: Vaccines, MDPI AG, Vol. 9, No. 10 ( 2021-10-13), p. 1172-
    Abstract: The present study assessed the willingness of the general population to receive COVID-19 vaccines and identified factors that influence vaccine hesitancy and resistance. A national online survey was conducted from 29 January 2021 to 26 April 2021 in China. Multinomial logistic regression analyses were conducted to identify factors that influence vaccine hesitancy and resistance. Of the 34,041 participants surveyed, 18,810 (55.3%) were willing to get vaccinated, 13,736 (40.3%) were hesitant, and 1495 (4.4%) were resistant. Rates of vaccine acceptance increased over time, with geographical discrepancies in vaccine hesitancy and resistance between provinces in China. Vaccine safety was the greatest concern expressed by most participants (24,461 [71.9%]), and the major reason for participants’ refusing vaccination (974 [65.2%] ). Government agencies (23,131 [68.0%]) and social media (20,967 [61.6%] ) were the main sources of COVID-19 vaccine information. Compared with vaccination acceptance, female, young and middle-aged, high income, and perceived low-risk of infection were associated with vaccine hesitancy. Histories of allergic reactions to other vaccines and depression symptoms were related to vaccine resistance. Common factors that influenced vaccine hesitancy and resistance were residing in cities and perceiving less protection with vaccines than with other protective measures. The results indicate that the rate of vaccine resistance is relatively low, but vaccine hesitancy is common. Individuals who are female, young and middle-aged, with a high income, and residing in cities are more likely to be hesitant for vaccination and should be the target populations for vaccination campaigns. Specific vaccine messaging from the government and social media could alleviate public concerns about vaccine safety and efficacy.
    Type of Medium: Online Resource
    ISSN: 2076-393X
    URL: Article
    DOI: 10.3390/vaccines9101172
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2703319-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Deguelin Inhibits the Migration and Invasion of U-2 OS Human Osteosarcoma Cells via the Inhibition of Matrix Metalloproteinase-2/-9 in Vitro
    MDPI AG ; 2014
    In:  Molecules Vol. 19, No. 10 ( 2014-10-15), p. 16588-16608
    Details
    In: Molecules, MDPI AG, Vol. 19, No. 10 ( 2014-10-15), p. 16588-16608
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules191016588
    Language: English
    Publisher: MDPI AG
    Publication Date: 2014
    detail.hit.zdb_id: 2008644-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    High-Rate Layered Cathode of Lithium-Ion Batteries through Regulating Three-Dimensional Agglomerated Structure
    MDPI AG ; 2020
    In:  Energies Vol. 13, No. 7 ( 2020-04-01), p. 1602-
    Details
    In: Energies, MDPI AG, Vol. 13, No. 7 ( 2020-04-01), p. 1602-
    Abstract: LiNixCoyMnzO2 (LNCM)-layered materials are considered the most promising cathode for high-energy lithium ion batteries, but suffer from poor rate capability and short lifecycle. In addition, the LiNi1/3Co1/3Mn1/3O2 (NCM 111) is considered one of the most widely used LNCM cathodes because of its high energy density and good safety. Herein, a kind of NCM 111 with semi-closed structure was designed by controlling the amount of urea, which possesses high rate capability and long lifespan, exhibiting 140.9 mAh·g−1 at 0.85 A·g−1 and 114.3 mAh·g−1 at 1.70 A·g−1, respectively. The semi-closed structure is conducive to the infiltration of electrolytes and fast lithium ion-transfer inside the electrode material, thus improving the rate performance of the battery. Our work may provide an effective strategy for designing layered-cathode materials with high rate capability.
    Type of Medium: Online Resource
    ISSN: 1996-1073
    URL: Article
    DOI: 10.3390/en13071602
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2437446-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Consensus of Experts on the Treatment of Sexual Dysfunction after Surgery for Prostate Cancer in Taiwan
    MDPI AG ; 2023
    In:  Journal of Clinical Medicine Vol. 12, No. 3 ( 2023-01-17), p. 740-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 12, No. 3 ( 2023-01-17), p. 740-
    Abstract: According to the Taiwan Cancer Report, in 2018, prostate cancer was one of the top five cancers reported in men. Each year, many patients with prostate cancer undergo radical prostatectomy (RP) therapy. One of the most common RP complications is erectile dysfunction (ED). Although consensus guidelines for the management of sexual dysfunction after prostate cancer surgery have been developed for many Western and Asian countries, no such clinical practice guidelines have been developed for Taiwan. The consensus opinions expressed in this article were discussed by numerous experienced physicians in Taiwan, based on both existing international guidelines and their individual experiences with clinical trials and providing advice to clinical physicians on how to inform patients of the risk of ED prior to surgery. This review also discusses how recovery and rehabilitation may be affected by socioeconomic status, the existence of an intimate relationship, comorbidities, or the need for cancer adjuvant therapy and how to determine rehabilitation goals and provide appropriate treatments to assist in the recovery of both short- and long-term sexual function.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm12030740
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662592-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Effects of Oxytocin on Fear Memory and Neuroinflammation in a Rodent Model of Posttraumatic Stress Disorder
    MDPI AG ; 2018
    In:  International Journal of Molecular Sciences Vol. 19, No. 12 ( 2018-12-03), p. 3848-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 19, No. 12 ( 2018-12-03), p. 3848-
    Abstract: Posttraumatic stress disorder (PTSD) is a trauma-induced mental disorder characterized by fear extinction abnormalities, which involve biological dysfunctions among fear circuit areas in the brain. Oxytocin (OXT) is a neuropeptide that regulates sexual reproduction and social interaction and has recently earned specific attention due to its role in adjusting neurobiological and behavioral correlates of PTSD; however, the mechanism by which this is achieved remains unclear. The present study aimed to examine whether the effects of OXT on traumatic stress-induced abnormalities of fear extinction (specifically induced by single prolonged stress (SPS), an animal model of PTSD) are associated with pro-inflammatory cytokines. Seven days after SPS, rats received intranasal OXT 40 min before a cue-dependent Pavlovian fear conditioning-extinction test in which rats’ freezing degree was used to reflect the outcome of fear extinction. We also measured mRNA expression of IL-1β, IFN-γ, and TNF-α in the medial prefrontal cortex (mPFC), hippocampus, and amygdala at the end of the study, together with plasma oxytocin, corticosterone, IL-1β, IFN-γ, and TNF-α, to reflect the central and peripheral changes of stress-related hormones and cytokines after SPS. Our results suggested that intranasal OXT effectively amends the SPS-impaired behavior of fear extinction retrieval. Moreover, it neurochemically reverses the SPS increase in pro-inflammatory cytokines; thus, IL-1β and IFN-γ can be further blocked by the OXT antagonist atosiban (ASB) in the hippocampus. Peripheral profiles revealed a similar response pattern to SPS of OXT and corticosterone (CORT), and the SPS-induced increase in plasma levels of IL-1β and TNF-α could be reduced by OXT. The present study suggests potential therapeutic effects of OXT in both behavioral and neuroinflammatory profiles of PTSD.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms19123848
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2019364-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Verification of Saliva Matrix Metalloproteinase-1 as a Strong Diagnostic Marker of Oral Cavity Cancer
    MDPI AG ; 2020
    In:  Cancers Vol. 12, No. 8 ( 2020-08-13), p. 2273-
    Details
    In: Cancers, MDPI AG, Vol. 12, No. 8 ( 2020-08-13), p. 2273-
    Abstract: Oral squamous cell carcinoma (OSCC) accounts for 〉 90% of cases of oral cancer, including cancer at the lip and oral cavity and cancer at the oropharynx. Most OSCCs develop from oral potentially malignant disorders (OPMDs), which consist of heterogeneous lesions with different malignant transformation potentials that make early detection of OSCC a challenge. Using a targeted mass spectrometry-based assay to compare multiple candidate proteins, we previously identified matrix metalloproteinase-1 (MMP-1) as one of the most promising salivary OSCC biomarkers. To explore the clinical utility of MMP-1 in OSCC detection, we developed an in-house, sensitive enzyme-linked immunosorbent assay (ELISA) for measuring MMP-1 content, and tested it on saliva samples from 1160 subjects (313 healthy controls, and 578 OPMD and 269 OSCC patients) collected at two medical centers. Salivary MMP-1 levels measured by our in-house ELISA significantly discriminated OSCC patients from non-cancerous groups. A receiver operating characteristic curve analysis showed that MMP-1 was effective in separating non-cancer groups from patients with OSCCs at the oral cavity. Additionally, salivary MMP-1 levels in oral cavity cancer patients were highly correlated with tumor progression (tumor size, lymph node metastasis, and overall stage). Collectively, our results indicate that salivary MMP-1 is an effective biomarker for OSCC that can be sensitively detected using our newly developed ELISA. The newly developed MMP-1 ELISA may be used as a new adjunctive tool to aid in detecting and monitoring OSCC.
    Type of Medium: Online Resource
    ISSN: 2072-6694
    URL: Article
    DOI: 10.3390/cancers12082273
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2527080-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...