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  • 1
    Online Resource
    Online Resource
    Improved Macro- and Micronutrient Supply for Favorable Growth and Metabolomic Profile with Standardized Parenteral Nutrition Solutions for Very Preterm Infants
    MDPI AG ; 2022
    In:  Nutrients Vol. 14, No. 19 ( 2022-09-21), p. 3912-
    Details
    In: Nutrients, MDPI AG, Vol. 14, No. 19 ( 2022-09-21), p. 3912-
    Abstract: Very preterm infants are at high risk for suboptimal nutrition in the first weeks of life leading to insufficient weight gain and complications arising from metabolic imbalances such as insufficient bone mineral accretion. We investigated the use of a novel set of standardized parenteral nutrition (PN; MUC PREPARE) solutions regarding improving nutritional intake, accelerating termination of parenteral feeding, and positively affecting growth in comparison to individually prescribed and compounded PN solutions. We studied the effect of MUC PREPARE on macro- and micronutrient intake, metabolism, and growth in 58 very preterm infants and compared results to a historic reference group of 58 very preterm infants matched for clinical characteristics. Infants receiving MUC PREPARE demonstrated improved macro- and micronutrient intake resulting in balanced electrolyte levels and stable metabolomic profiles. Subsequently, improved energy supply was associated with up to 1.5 weeks earlier termination of parenteral feeding, while simultaneously reaching up to 1.9 times higher weight gain at day 28 in extremely immature infants ( 〈 27 GA weeks) as well as overall improved growth at 2 years of age for all infants. The use of the new standardized PN solution MUC PREPARE improved nutritional supply and short- and long-term growth and reduced PN duration in very preterm infants and is considered a superior therapeutic strategy.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu14193912
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518386-2
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  • 2
    Online Resource
    Online Resource
    Molecular Profiling Reveals Characteristic and Decisive Signatures in Patients after Allogeneic Stem Cell Transplantation Suffering from Invasive Pulmonary Aspergillosis
    MDPI AG ; 2022
    In:  Journal of Fungi Vol. 8, No. 2 ( 2022-02-10), p. 171-
    Details
    In: Journal of Fungi, MDPI AG, Vol. 8, No. 2 ( 2022-02-10), p. 171-
    Abstract: Despite available diagnostic tests and recent advances, diagnosis of pulmonary invasive aspergillosis (IPA) remains challenging. We performed a longitudinal case-control pilot study to identify host-specific, novel, and immune-relevant molecular candidates indicating IPA in patients post allogeneic stem cell transplantation (alloSCT). Supported by differential gene expression analysis of six relevant in vitro studies, we conducted RNA sequencing of three alloSCT patients categorized as probable IPA cases and their matched controls without Aspergillus infection (66 samples in total). We additionally performed immunoassay analysis for all patient samples to gain a multi-omics perspective. Profiling analysis suggested LGALS2, MMP1, IL-8, and caspase-3 as potential host molecular candidates indicating IPA in investigated alloSCT patients. MMP1, IL-8, and caspase-3 were evaluated further in alloSCT patients for their potential to differentiate possible IPA cases and patients suffering from COVID-19-associated pulmonary aspergillosis (CAPA) and appropriate control patients. Possible IPA cases showed differences in IL-8 and caspase-3 serum levels compared with matched controls. Furthermore, we observed significant differences in IL-8 and caspase-3 levels among CAPA patients compared with control patients. With our conceptual work, we demonstrate the potential value of considering the human immune response during Aspergillus infection to identify immune-relevant molecular candidates indicating IPA in alloSCT patients. These human host candidates together with already established fungal biomarkers might improve the accuracy of IPA diagnostic tools.
    Type of Medium: Online Resource
    ISSN: 2309-608X
    URL: Article
    DOI: 10.3390/jof8020171
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2784229-0
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  • 3
    Online Resource
    Online Resource
    Toward Mass Video Data Analysis: Interactive and Immersive 4D Scene Reconstruction
    MDPI AG ; 2020
    In:  Sensors Vol. 20, No. 18 ( 2020-09-22), p. 5426-
    Details
    In: Sensors, MDPI AG, Vol. 20, No. 18 ( 2020-09-22), p. 5426-
    Abstract: The technical progress in the last decades makes photo and video recording devices omnipresent. This change has a significant impact, among others, on police work. It is no longer unusual that a myriad of digital data accumulates after a criminal act, which must be reviewed by criminal investigators to collect evidence or solve the crime. This paper presents the VICTORIA Interactive 4D Scene Reconstruction and Analysis Framework (“ISRA-4D” 1.0), an approach for the visual consolidation of heterogeneous video and image data in a 3D reconstruction of the corresponding environment. First, by reconstructing the environment in which the materials were created, a shared spatial context of all available materials is established. Second, all footage is spatially and temporally registered within this 3D reconstruction. Third, a visualization of the hereby created 4D reconstruction (3D scene + time) is provided, which can be analyzed interactively. Additional information on video and image content is also extracted and displayed and can be analyzed with supporting visualizations. The presented approach facilitates the process of filtering, annotating, analyzing, and getting an overview of large amounts of multimedia material. The framework is evaluated using four case studies which demonstrate its broad applicability. Furthermore, the framework allows the user to immerse themselves in the analysis by entering the scenario in virtual reality. This feature is qualitatively evaluated by means of interviews of criminal investigators and outlines potential benefits such as improved spatial understanding and the initiation of new fields of application.
    Type of Medium: Online Resource
    ISSN: 1424-8220
    URL: Article
    DOI: 10.3390/s20185426
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2052857-7
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  • 4
    Online Resource
    Online Resource
    Effects of Short-Term Root Cooling before Harvest on Yield and Food Quality of Chinese Broccoli (Brassica oleracea var. Alboglabra Bailey)
    MDPI AG ; 2021
    In:  Agronomy Vol. 11, No. 3 ( 2021-03-19), p. 577-
    Details
    In: Agronomy, MDPI AG, Vol. 11, No. 3 ( 2021-03-19), p. 577-
    Abstract: Vegetable product quality is an important consideration for consumers. Long-term root cooling could improve certain food quality of horticultural crops, but often comes at the expense of reduced shoot biomass or yield. Since few studies have investigated how fast Chinese broccoli (Brassica oleracea var. alboglabra Bailey) responds to changes of root temperature, we shortened the duration of the root cooling treatment to one week before harvest to make the production system more effective. The aim of this study was to improve the food quality of Chinese broccoli without causing deleterious effects on plant growth and yield. The seedlings were cultivated hydroponically at two root temperatures (10 and 20 °C) during the last week prior to harvest in summer 2018 (Exp-1) and autumn 2019 (Exp-2). Plant growth, yield, physiological variables, soluble sugars, total chlorophyll, glucosinolates and mineral elements concentration were examined. The results showed that the yield reduction was alleviated compared to results over the long-term. Specifically, yield was not affected by root cooling in Exp-1 and reduced by 18.9% in Exp-2 compared to 20 °C. Glucose and fructose concentrations of the leaves were increased when the root temperature was 10 °C in both experiments with a more pronounced impact in Exp-2. In addition, root cooling produced a significant accumulation of individual glucosinolates, such as progoitrin, gluconapin, 4-methoxyglucobrassicin and 4-hydroxyglucobrassicin, in the stems of Exp-1 and the leaves of Exp-2. Minerals, such as N, showed reductions in the shoot, but accumulation in the root. Therefore, compared to long-term root cooling, short-term (one week) reduction of the root temperature is more economical and could help improve certain quality characteristics of Chinese broccoli with less or even no yield reduction.
    Type of Medium: Online Resource
    ISSN: 2073-4395
    URL: Article
    DOI: 10.3390/agronomy11030577
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2607043-1
    SSG: 23
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