In:
Diagnostics, MDPI AG, Vol. 13, No. 4 ( 2023-02-16), p. 756-
Abstract:
We investigated the relationship between MRI-arterial spin labeling (ASL) parameters and PET-cerebral blood flow (CBF)/cerebrovascular reactivity (CVR) simultaneously obtained by PET/MRI in Moyamoya disease. Twelve patients underwent 15O-water PET/MRI with the acetazolamide (ACZ) challenge test. PET-CBF and PET-CVR were measured using 15O-water PET. Pseudo-continuous ASL obtained the robust arterial transit time (ATT) and ASL-CBF estimation. ASL parameters were compared with PET-CBF and PET-CVR. Before ACZ loading, absolute and relative ASL-CBF were significantly correlated with absolute and relative PET-CBF (r = 0.44, p 〈 0.0001, and r = 0.55, p 〈 0.0001, respectively). After ACZ loading, absolute and relative ASL-CBF were significantly correlated with absolute and relative PET-CBF (r = 0.56, p 〈 0.001, and r = 0.75, p 〈 0.0001, respectively), and ΔASL-CBF was significantly correlated with ΔPET-CBF (r = 0.65, p 〈 0.0001). Baseline ASL-ATT had strong negative correlations with ΔPET-CBF and PET-CVR (r = −0.72, p 〈 0.0001, and r = −0.66, p 〈 0.0001, respectively). Baseline ASL-ATT of MCA territories with CVR 〈 30% (1546 ± 79 ms) was significantly higher than that with CVR 〉 30% (898 ± 197 ms). ASL-ATT ratio of MCA territories with CVR 〈 30% (94.0 ± 10.5%) was significantly higher than that with CVR 〉 30% (81.4 ± 11.3%). ATT correction using multiple postlabeling delays increased the accuracy of ASL-CBF quantitation. Baseline ASL-ATT is a hemodynamic parameter and may represent an efficient alternative to PET-CVR.
Type of Medium:
Online Resource
ISSN:
2075-4418
DOI:
10.3390/diagnostics13040756
Language:
English
Publisher:
MDPI AG
Publication Date:
2023
detail.hit.zdb_id:
2662336-5
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